Mitochondrial dysfunction bridges negative affective disorders and cardiomyopathy in socially isolated rats: Pros and cons of fluoxetine

References

• Alano CC, Tran A, Tao R, Ying W, Karliner JS, Swanson RA. 2007. Differences among cell types in NAD(+) compartmentalization: a comparison of neurons, astrocytes, and cardiac myocytes. J Neurosci Res. 85:3378–3385.
   PubMed Web of Science ®Google Scholar
• Adzic M, Lukic I, Mitic M, Djordjevic J, Elaković I, Djordjevic A, Krstic-Demonacos M, Matic G, Radojcic M. 2013. Brain region- and sex-specific modulation of mitochondrial glucocorticoid receptor phosphorylation in fluoxetine treated stressed rats: effects on energy metabolism. Psychoneuroendocrinology. 38:2914–2924.
   PubMed Web of Science ®Google Scholar
• Amiri S, Haj-Mirzaian A, Rahimi-Balaei M, Razmi A, Kordjazy N, Shirzadian A, Ejtemaei Mehr S, Sianati H, Dehpour AR. 2005. Co-occurrence of, anxiety and depressive-like behaviors following adolescent social isolation in male mice; possible role of nitrergic system. Physiol Behav. 145:38–44.
   Web of Science ®Google Scholar
• Amiri S, Shirzadian A, Haj-Mirzaian A, Imran-Khan M, Balaei MR, Kordjazy N, Dehpour AR, Mehr SE. 2014. Involvement of the nitrergic system in the proconvulsant effect of social isolation stress in male mice. Epilepsy Behav. 41:158–163.
   PubMed Web of Science ®Google Scholar
• Anderson G, Maes M. 2014. Oxidative/nitrosative stress and immuno-inflammatory pathways in depression: treatment implications. Curr Pharm Des. 20:3812–3847.
   PubMed Web of Science ®Google Scholar
• Bagdy G, Graf M, Anheuer ZE, Modos EA, Kantor S. 2001. Anxiety-like effects induced by acute fluoxetine, sertraline or m-CPP treatment are reversed by pretreatment with the 5-HT2C receptor antagonist SB-242084 but not the 5-HT1A receptor antagonist WAY-100635. Int J Neuropsychopharmacol. 4:399–408.
   PubMed Web of Science ®Google Scholar
• Baracca A, Sgarbi G, Solaini G, Lenaz G. 2003. Rhodamine 123 as a probe of mitochondrial membrane potential: evaluation of proton flux through F(0) during ATP synthesis. Biochim Biophys Acta. 1606:137–146.
   PubMed Web of Science ®Google Scholar
• Bers DM. 2008. Calcium cycling and signaling in cardiac myocytes. Annu Rev Physiol. 70:23–49.
   PubMed Web of Science ®Google Scholar
• Bianchi M, Fone KC, Shah AJ, Atkins AR, Dawson LA, Heidbreder CA, Hagan JJ, Marsden CA. 2009. Chronic fluoxetine differentially modulates the hippocampal microtubular and serotonergic system in grouped and isolation reared rats. Eur Neuropsychopharmacol. 19:778–790.
   PubMed Web of Science ®Google Scholar
• Blomgren K, Hagberg H. 2006. Free radicals, mitochondria, and hypoxia-ischemia in the developing brain. Free Radic Biol Med. 40:388–397.
   PubMed Web of Science ®Google Scholar
• Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 72:248–254.
   PubMed Web of Science ®Google Scholar
• Brenes JC, Fornaguera J. 2009. The effect of chronic fluoxetine on social isolation induced changes on sucrose consumption, immobility behavior, and on serotonin and dopamine function in hippocampus and ventral striatum. Behav Brain Res. 198:199–205.
   PubMed Web of Science ®Google Scholar
• Brenes JC, Padilla M, Fornaguera J. 2009. A detailed analysis of open-field habituation and behavioral and neurochemical antidepressant-like effects in postweaning enriched rats. Behav Brain Res. 197:125–137.
   PubMed Web of Science ®Google Scholar
• Burgoyne JR, Mongue-Din H, Eaton P, Shah AM. 2012. Redox signaling in cardiac physiology and pathology. Circ Res. 111:1091–1106.
   PubMed Web of Science ®Google Scholar
• Cryan JF, Valentino RJ, Lucki I. 2005. Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test. Neurosci Biobehav Rev. 29:547–569.
   PubMed Web of Science ®Google Scholar
• David DJ, Samuels BA, Rainer Q, Wang JW, Marsteller D, Mendez I, Drew M, Craig DA, Guiard BP, Guilloux JP, et al. 2009. Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression. Neuron. 62:479–493.
   PubMed Web of Science ®Google Scholar
• Djordjevic A, Djordjevic J, Elaković I, Adzic M, Matić G, Radojcic MB. 2012a. Effects of fluoxetine on plasticity and apoptosis evoked by chronic stress in rat prefrontal cortex. Eur J Pharmacol. 693:37–44.
   PubMed Web of Science ®Google Scholar
• Djordjevic A, Djordjevic J, Elaković I, Adzic M, Matić G, Radojcic MB. 2012b. Fluoxetine affects hippocampal plasticity, apoptosis and depressive-like behavior of chronically isolated rats. Prog Neuropsychopharmacol Biol Psychiatry. 36:92–100.
   PubMed Web of Science ®Google Scholar
• Fone KC, Porkess MV. 2008. Behavioural and neurochemical effects of post-weaning social isolation in rodents-relevance to developmental neuropsychiatric disorders. Neurosci Biobehav Rev. 32:1087–1102.
   PubMed Web of Science ®Google Scholar
• Fone KC, Shalders K, Fox ZD, Arthur R, Marsden CA. 1996. Increased 5-HT2C receptor responsiveness occurs on rearing rats in social isolation. Psychopharmacology. 123:346–352.
   PubMed Web of Science ®Google Scholar
• Gardner A, Boles RG. 2005. Is a “mitochondrial psychiatry” in the future? A review. Curr Psychiatry Rev. 1:255–271.
   Google Scholar
• Gardner A, Boles RG. 2008. Mitochondrial energy depletion in depression with somatization. Psychother Psychosom. 77:127–129.
   PubMed Web of Science ®Google Scholar
• Gardner A, Boles RG. 2011. Beyond the serotonin hypothesis: mitochondria, inflammation and neurodegeneration in major depression and affective spectrum disorders. Prog Neuropsychopharmacol Biol Psychiatry. 35:730–743.
   PubMed Web of Science ®Google Scholar
• Grippo AJ, Lamb DG, Carter CS, Porges SW. 2007. Social isolation disrupts autonomic regulation of the heart and influences negative affective behaviors. Biol Psychiatry. 62:1162–1170.
   PubMed Web of Science ®Google Scholar
• Grippo AJ. 2009. Mechanisms underlying altered mood and cardiovascular dysfunction: the value of neurobiological and behavioral research with animal models. Neurosci Biobehav Rev. 33:171–180.
   PubMed Web of Science ®Google Scholar
• Grippo AJ, Beltz TG, Weiss RM, Johnson AK. 2006. The effects of chronic fluoxetine treatment on chronic mild stress-induced cardiovascular changes and anhedonia. Biol Psychiatry. 59:309–316.
   PubMed Web of Science ®Google Scholar
• Grippo AJ, Wu KD, Hassan I, Carter CS. 2008. Social isolation in prairie voles induces behaviors relevant to negative affect: toward the development of a rodent model focused on co-occurring depression and anxiety. Depress Anxiety. 25:17–26.
   PubMedGoogle Scholar
• Gong Y, Chai Y, Ding JH, Sun XL, Hu G. 2011. Chronic mild stress damages mitochondrial ultrastructure and function in mouse brain. Neurosci Lett. 488:76–80.
   PubMed Web of Science ®Google Scholar
• Haj-Mirzaian A, Amiri S, Kordjazy N, Rahimi-Balaei M, Haj-Mirzaian A, Marzban H, Aminzadeh A, Dehpour AR, Mehr SE. 2015. Blockade of NMDA receptors reverses the depressant, but not anxiogenic effect of adolescence social isolation in mice. Eur J Pharmacol. 750:160–166.
   PubMed Web of Science ®Google Scholar
• Hanke ML, Powell ND, Stiner LM, Bailey MT, Sheridan JF. 2012. Beta adrenergic blockade decreases the immunomodulatory effects of social disruption stress. Brain Behav Immun. 26:1150–1159.
   PubMed Web of Science ®Google Scholar
• Hosseini M-J, Shaki F, Ghazi-Khansari M, Pourahmad J. 2014. Toxicity of copper on isolated liver mitochondria: impairment at complexes I, II and IV leads to increased ROS production. Cell Biochem Biophys. 70:367–381.
   PubMed Web of Science ®Google Scholar
• Ikonomidou C, Kaindl AM. 2011. Neuronal death and oxidative stress in the developing brain. Antioxid Redox Signal. 14:1535–1550.
   PubMed Web of Science ®Google Scholar
• Ingwall JS. 2009. Energy metabolism in heart failure and remodelling. Cardiovasc Res. 81:412–419.
   PubMed Web of Science ®Google Scholar
• Jafarian I, Eskandari MR, Mashayekhi V, Ahadpour M, Hosseini M-J. 2013. Toxicity of valproic acid in isolated rat liver mitochondria. Toxicol Mech Methods. 23:617–623.
   PubMed Web of Science ®Google Scholar
• Kohlhaas M, Christoph M. 2013. Calcium release microdomains and mitochondria. Cardiovasc Res. 98:259–268.
   PubMed Web of Science ®Google Scholar
• Kessler RC, Aguilar-Gaxiola S, Alonso J, Chatterji S, Lee S, Ormel J, Ustün TB, Wang PS. 2009. The global burden of mental disorders: an update from the WHO World Mental Health (WMH) surveys. Epidemiol Psichiatr Soc. 18:23–33.
   PubMed Web of Science ®Google Scholar
• Klinedinst NJ, Regenold WT. 2014. A mitochondrial bioenergetic basis of depression. J Bioenerg Biomembr. 47:155–171.
   PubMed Web of Science ®Google Scholar
• Koolhaas JM, Coppens CM, de Boer SF, Buwalda B, Meerlo P, Timmermans PJ. 2013. The resident-intruder paradigm: a standardized test for aggression, violence and social stress. J Vis Exp. 77:e4367.
   PubMed Web of Science ®Google Scholar
• Kordjazy N, Haj-Mirzaian A, Amiri S, Ostadhadi S, Kordjazy M, Sharifzadeh M, Dehpour AR. 2015. Elevated level of nitric oxide mediates the anti-depressant effect of rubidium chloride in mice. Eur J Pharmacol. 762:411–418.
   PubMed Web of Science ®Google Scholar
• Krysko DV, Agostinis P, Krysko O, Garg AD, Bachert C, Lambrecht BN, Vandenabeele P. 2011. Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation. Trends Immunol. 32:157–164.
   PubMed Web of Science ®Google Scholar
• Lambowitz AM. 1979. Preparation and analysis of mitochondrial ribosomes. Meth Enzymol. 59:421–433.
   PubMedGoogle Scholar
• Lukkes JL, Mokin MV, Scholl J, Forster L. 2009. Adult rats exposed to early-life social isolation exhibit increased anxiety and conditioned fear behavior, and altered hormonal stress responses. Horm Behav. 55:248–256.
   PubMed Web of Science ®Google Scholar
• Lupien SJ, McEwen BS, Gunnar MR, Heim C. 2009. Effects of stress throughout the lifespan on the brain, behaviour and cognition. Nat Rev Neurosci. 10:434–445.
   PubMed Web of Science ®Google Scholar
• Maes M, Ruckoanich P, Chang YS, Mahanonda N, Berk M. 2011. Multiple aberrations in shared inflammatory and oxidative & nitrosative stress (IO & NS) pathways explain the co-association of depression and cardiovascular disorder (CVD), and the increased risk for CVD and due mortality in depressed patients. Prog Neuropsychopharmacol Biol Psychiatry. 35:769–783.
   PubMed Web of Science ®Google Scholar
• Malzberg B. 1937. Mortality among patients with involution melancholia. Am J Psychiatry. 93:1231–1238.
   Google Scholar
• Marchant DJ, Boyd JH, Lin DC, Granville DJ, Garmaroudi FS, McManus BM. 2012. Inflammation in myocardial diseases. Circ Res. 110:126–144.
   PubMed Web of Science ®Google Scholar
• Marrocco J, Reynaert ML, Gatta E, Gabriel C, Mocaër E, Di Prisco S, Merega E, Pittaluga A, Nicoletti F, Maccari S, et al. 2014. The effects of antidepressant treatment in prenatally stressed rats support the glutamatergic hypothesis of stress-related disorders. J Neurosci. 34:2015–2024.
   PubMed Web of Science ®Google Scholar
• Mashayekhi V, Tehrani KHME, Hashemzaei M, Tabrizian K, Shahraki J, Hosseini M-J. 2015. Mechanistic approach for the toxic effects of perfluorooctanoic acid on isolated rat liver and brain mitochondria. Hum Exp Toxicol. 762:411–418.
   Google Scholar
• Merz B, Dwyer J, Nordstrom CK, Walton KG, Salerno JW, Schneider RH. 2002. Psychosocial stress and cardiovascular disease: pathophysiological links. Behav Med. 27:141–147.
   PubMed Web of Science ®Google Scholar
• Mitic M, Simic I, Djordjevic J, Radojcic MB, Adzic M. 2013. Gender-specific effects of fluoxetine on hippocampal glucocorticoid receptor phosphorylation and behavior in chronically stressed rats. Neuropharmacol. 70:100–111.
   PubMed Web of Science ®Google Scholar
• Morava É, Kozicz T. 2013. Mitochondria and the economy of stress (mal) adaptation. Neurosci Biobehav Rev. 37:668–680.
   PubMed Web of Science ®Google Scholar
• Mueller TI, Leon AC, Keller MB, Solomon DA, Endicott J, Coryell W, Warshaw M. 1999. Recurrence after recovery from major depressive disorder during 15 years of observational follow-up. Am J Psychiatry. 156:1000–1006.
   PubMed Web of Science ®Google Scholar
• Nahon E, Israelson A, Abu-Hamad S, Varda SB. 2005. Fluoxetine (Prozac) interaction with the mitochondrial voltage-dependent anion channel and protection against apoptotic cell death. FEBS Lett. 579:5105–5110.
   PubMed Web of Science ®Google Scholar
• Nestler EJ, Hyman SE. 2010. Animal models of neuropsychiatric disorders. Nat Neurosci. 13:1161–1169.
   PubMed Web of Science ®Google Scholar
• Nikoui V, EjtemaeiMehr S, Jazaeri F, Ostadhadi S, Eftekhari G, Dehpour AR, Mani AR, Bakhtiarian A. 2015. ProstaglandinF2α modulates atrial chronotropic hyporesponsiveness to cholinergic stimulation in endotoxemic rats. Eur J Pharmacol. 748:149–156.
   PubMed Web of Science ®Google Scholar
• Okun E, Griffioen KJ, Rothman S, Wan R, Cong WN, De Cabo R, Martin-Montalvo A, Levette A, Maudsley S, Martin B. 2014. Toll-like receptors 2 and 4 modulate autonomic control of heart rate and energy metabolism. Brain Behav Immun. 36:90–100.
   PubMed Web of Science ®Google Scholar
• Pellow S, File SE. 1986. Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: a novel test of anxiety in the rat. Pharmacol Biochem Behav. 24:525–529.
   PubMed Web of Science ®Google Scholar
• Peng TI, Jou MJ. 2010. Oxidative stress caused by mitochondrial calcium overload. Ann N Y Acad Sci. 1201:183–188.
   PubMed Web of Science ®Google Scholar
• Picard M, Juster R, McEwen BS. 2014. Mitochondrial allostatic load puts the 'gluc' back in glucocorticoids. Nat Rev Endocrinol. 10:303–310.
   PubMed Web of Science ®Google Scholar
• Remondino A, Kwon SH, Communal C, Pimentel DR, Sawyer DB, Singh K, Colucci WS. 2003. Beta-adrenergic receptor-stimulated apoptosis in cardiac myocytes is mediated by reactive oxygen species/c-Jun NH2-terminal kinase-dependent activation of the mitochondrial pathway. Circ Res. 92:136–138.
   PubMed Web of Science ®Google Scholar
• Rezin GT, Amboni G, Zugno AI, Quevedo J, Streck EL. 2009. Mitochondrial dysfunction and psychiatric disorders. Neurochem Res. 34:1021–1029.
   PubMed Web of Science ®Google Scholar
• Shaki F, Hosseini M-J, Ghazi-Khansari M, Pourahmad J. 2012. Toxicity of depleted uranium on isolated rat kidney mitochondria. Biochim Biophys Acta. 1820:1940–1950.
   PubMed Web of Science ®Google Scholar
• Silva MT, Alves CR, Santarem EM. 1999. Anxiogenic-like effect of acute and chronic fluoxetine on rats tested on the elevated plus-maze. Braz J Med Biol Res. 32:333–339.
   PubMed Web of Science ®Google Scholar
• Slattery DA, Cryan JF. 2012. Using the rat forced swim test to assess antidepressant-like activity in rodents. Nat Protoc. 7:1009–1014.
   PubMed Web of Science ®Google Scholar
• Slavich GM, Irwin MR. 2014. From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. Psychol Bull. 140:774–815.
   PubMed Web of Science ®Google Scholar
• Steinberg L. 2005. Cognitive and affective development in adolescence. Trends Cogn Sci (Regul Ed). 9:69–74.
   PubMed Web of Science ®Google Scholar
• Strike PC, Steptoe A. 2004. Psychosocial factors in the development of coronary artery disease. Prog Cardiovasc Dis. 46:337–347.
   PubMed Web of Science ®Google Scholar
• Tafreshi NK, Hosseinkhani S, Sadeghizadeh M, Sadeghi M, Ranjbar B, Naderi-Manesh H. 2007. The influence of insertion of a critical residue (Arg356) in structure and bioluminescence spectra of firefly luciferase. J Biol Chem. 282:8641–8647.
   PubMed Web of Science ®Google Scholar
• Toth M, Mikics E, Tulogdi A, Aliczki M, Haller J. 2011. Post-weaning social isolation induces abnormal forms of aggression in conjunction with increased glucocorticoid and autonomic stress responses. Horm Behav. 60:28–36.
   PubMed Web of Science ®Google Scholar
• Trivedi MH, Rush AJ, Wisniewski SR, Nierenberg AA, Warden D, Ritz L, Norquist G, Howland RH, Lebowitz B, McGrath PJ, et al. 2006. Evaluation of outcomes with citalopram for depression using measurement-based care in STAR* D: implications for clinical practice. Am J Psychiatry. 163:28–40.
   PubMed Web of Science ®Google Scholar
• Turdi S, Yuan M, Leedy GM, Wu Z, Ren J. 2012. Chronic social stress induces cardiomyocyte contractile dysfunction and intracellular Ca2+ derangement in rats. Physiol Behav. 105:498–509.
   PubMed Web of Science ®Google Scholar
• Vicente MA, Zangrossi H. 2012. Serotonin-2C receptors in the basolateral nucleus of the amygdala mediate the anxiogenic effect of acute imipramine and fluoxetine administration. Int J Neuropsychopharmacol. 15:389–400.
   PubMed Web of Science ®Google Scholar
• Vizi ES, Kisfali M, Lőrincz T. 2013. Role of nonsynaptic GluN2B-containing NMDA receptors in excitotoxicity: evidence that fluoxetine selectively inhibits these receptors and may have neuroprotective effects. Brain Res Bull. 93:32–38.
   PubMed Web of Science ®Google Scholar
• Walker FR. 2013. A critical review of the mechanism of action for the selective serotonin reuptake inhibitors: do these drugs possess anti-inflammatory properties and how relevant is this in the treatment of depression? Neuropharmacol. 67:304–317.
   PubMed Web of Science ®Google Scholar
• Whitaker LR, Degoulet M, Morikawa H. 2013. Social deprivation enhances VTA synaptic plasticity and drug-induced contextual learning. Neuron. 77:335–345.
   PubMed Web of Science ®Google Scholar
• Xinxing W, Wei L, Lei W, Rui Z, Baoying J, Lingjia Q. 2014. A neuroendocrine mechanism of co-morbidity of depression-like behavior and myocardial injury in rats. PLoS One. 9:e88427
   Google Scholar
• Zhang F, Xu Z, Gao J, Xu B, Deng Y. 2008. In vitro effect of manganese chloride exposure on energy metabolism and oxidative damage of mitochondria isolated from rat brain. Environ. Toxicol Pharmacol. 26:232–236.
   PubMed Web of Science ®Google Scholar
• Zhao Y, Ye L, Liu H, Xia Q, Zhang Y, Yang X, Wang K. 2010. Vanadium compounds induced mitochondria permeability transition pore (MPT) opening related to oxidative stress. J Inorg Biochem. 104:371–378.
   PubMed Web of Science ®Google Scholar