Activation of the inflammasome by amorphous silica and TiO₂ nanoparticles in murine dendritic cells

References

• Abe K, Nguyen KP, Fine SD, Mo JH, Shen C, Shenouda S, Corr M, Jung S, Lee J, Eckmann L, Raz E. 2007. Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells. Proc Natl Acad Sci USA 104(43):17022–17027.
   PubMedGoogle Scholar
• Albrecht C, Schins RPF, Höhr D, Becker A, Shi T, Knaapen AM, Borm PJA. 2004. Inflammatory time course following quartz instillation: Role of TNF-alpha and particle surface. Am J Respir Cell Mol Biol 31:292–301.
   PubMedGoogle Scholar
• Albrecht C, Höhr D, Haberzettl P, Becker A, Borm PJ, Schins RP. 2007. Surface-dependent quartz uptake by macrophages: Potential role in pulmonary inflammation and lung clearance. Inhal Toxicol 19:39–48.
   PubMed Web of Science ®Google Scholar
• Aline F, Brand D, Pierre J, Roingeard P, Severine M, Verrier B, Dimier-Poisson I. 2009. Dendritic cells loaded with HIV-1 p24 proteins adsorbed on surfactant-free anionic PLA nanoparticles induce enhanced cellular immune responses against HIV-1 after vaccination. Vaccine 27(38):5284–5291.
   PubMedGoogle Scholar
• Amyere M, Mettlen M, Van Der Smissen P, Platek A, Payrastre B, Veithen A, Courtoy PJ. 2002. Origin, originality, functions, subversions and molecular signalling of macropinocytosis. Int J Med Microbiol 291(6–7):487–494.
   PubMedGoogle Scholar
• Bauer C, Loher F, Dauer M, Mayer C, Lehr HA, Schonharting M, Hallwachs R, Endres S, Eigler A. 2007. The ICE inhibitor pralnacasan prevents DSS-induced colitis in C57BL/6 mice and suppresses IP-10 mRNA but not TNF-alpha mRNA expression. Dig Dis Sci 52(7):1642–1652.
   PubMedGoogle Scholar
• Bauernfeind FG, Horvath G, Stutz A, Alnemri ES, Mac Donald K, Speert D, Fernandes-Alnemri T, Wu J, Monks BF, Fitzgerald KA, Hornung V, Latz E. 2009. Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J Immunol 15;183(2):787–791.
   PubMed Web of Science ®Google Scholar
• Behrens I, Pena AI, Alonso MJ, Kissel T. 2002. Comparative uptake studies of bioadhesive and non-bioadhesive nanoparticles in human intestinal cell lines and rats: The effect of mucus on particle adsorption and transport. Pharm Res 19(8):1185–1193.
   PubMed Web of Science ®Google Scholar
• Borges VM, Falcao H, Leite-Junior JH, Alvim L, Teixeira GP, Russo M, Nobrega AF, Lopes MF, Rocco PM, Davidson WF, 2001. Fas ligand triggers pulmonary silicosis. J Exp Med 194(2):155–164.
   PubMedGoogle Scholar
• Borm PJ, Schins RP, Albrecht C. 2004. Inhaled particles and lung cancer, part B: Paradigms and risk assessment. Int J Cancer 110(1):3–14.
   PubMedGoogle Scholar
• Bouwmeester H, Dekkers S, Noordam MY, Hagens WI, Bulder AS, de Heer C, ten Voorde SE, Wijnhoven SW, Marvin HJ, Sips AJ. 2009. Review of health safety aspects of nanotechnologies in food production. Regul Toxicol Pharmacol 53(1):52–62.
   PubMed Web of Science ®Google Scholar
• Broaddus VC, Yang L, Scavo LM, Ernst JD, Boylan AM. 1996. Asbestos induces apoptosis of human and rabbit pleural mesothelial cells via reactive oxygen species. J Clin Invest 98(9):2050–2059.
   PubMedGoogle Scholar
• Bryant C, Fitzgerald KA. 2009. Molecular mechanisms involved in inflammasome activation. Trends in Cell Biology 19(9):455–464.
   PubMedGoogle Scholar
• Cassel SL, Eisenbarth SC, Iyer SS, Sadler JJ, Colegio OR, Tephly LA, Carter AB, Rothman PB, Flavell RA, Sutterwala FS. 2008. The Nalp3 inflammasome is essential for the development of silicosis. Proc Natl Acad Sci USA 105(26):9035–9040.
   PubMed Web of Science ®Google Scholar
• Chaudhry Q, Scotter M, Blackburn J, Ross B, Boxall A, Castle L, Aitken R, Watkins R. 2008. Applications and implications of nanotechnologies for the food sector. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 25(3):241–258.
   PubMedGoogle Scholar
• Chen J, Dong X, Zhao J, Tang G. 2009. In vivo acute toxicity of titanium dioxide nanoparticles to mice after intraperitioneal injection. J Appl Toxicol 29(4):330–337.
   PubMed Web of Science ®Google Scholar
• Cho WS, Choi M, Han BS, Cho M, Oh J, Park K, Kim SJ, Kim SH, Jeong J. 2007. Inflammatory mediators induced by intratracheal instillation of ultrafine amorphous silica particles. Toxicol Lett 175(1–3):24–33.
   PubMedGoogle Scholar
• Choi M, Cho WS, Han BS, Cho M, Kim SY, Yi JY, Ahn B, Kim SH, Jeong J. 2008. Transient pulmonary fibrogenic effect induced by intratracheal instillation of ultrafine amorphous silica in A/J mice. Toxicol Lett 182(1–3):97–101.
   PubMedGoogle Scholar
• Dinarello CA. 2010. IL-1: Discoveries, controversies and future directions. Eur J Immunol 40:595–653.
   PubMedGoogle Scholar
• Dostert C, Petrilli V, Van Bruggen R, Steele C, Mossman BT, Tschopp J. 2008. Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science 320(5876):674–677.
   PubMed Web of Science ®Google Scholar
• Elamanchili P, Lutsiak CM, Hamdy S, Diwan M, Samuel J. 2007. ‘Pathogen-mimicking’ nanoparticles for vaccine delivery to dendritic cells. J Immunother 30(4):378–395.
   PubMed Web of Science ®Google Scholar
• Franchi L, Egnebrod T, Nunez G. 2009. Cutting edge: TNF-alpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation. J Immunol 15;183(2):792–796.
   PubMedGoogle Scholar
• Grassian VH, O'shaughnessy PT, Adamcakova-Dodd A, Pettibone JM, Thorne PS. 2007. Inhalation exposure study of titanium dioxide nanoparticles with a primary particle size of 2 to 5 nm. Environ Health Perspect 115(3):397–402.
   PubMed Web of Science ®Google Scholar
• Gerloff K, Albrecht C, Boots AW, Förster I, Schins RPF. 2009. Cytotoxicity and oxidative DNA damage by nanoparticles in human intestinal Caco-2 cells. Nanotoxicology 3(4):355–364.
   Google Scholar
• Guma M, Ronacher L, Liu-Bryan R, Takai S, Karin M, Corr M. 2009. Caspase 1-independent activation of interleukin-1 in neutrophil-predominant inflammation. Arthrit Rheumat 60(12):3642–3650.
   PubMedGoogle Scholar
• Haberzettl P, Schins RPF, Borm PJA, Albrecht C. 2007. Actin plays a crucial role in the phagocytosis and biological reponse to respirable quartz particles in macrophages. Arch Toxicol 81:459–470.
   PubMed Web of Science ®Google Scholar
• Haberzettl P, Schins RPF, Höhr D, Wilhelmi V, Borm PJA, Albrecht C. 2008. Impact of the FcII-receptor on quartz uptake and inflammatory response by alveolar macrophages. Am J Physiol Lung Cell Mol Physiol 294:L1137–1148.
   PubMed Web of Science ®Google Scholar
• Hillyer JF, Albrecht RM. 2001. Gastrointestinal persorption and tissue distribution of differently sized colloidal gold nanoparticles. J Pharm Sci 90(12):1927–1936.
   PubMed Web of Science ®Google Scholar
• Hornung V, Bauernfeind F, Halle A, Samstad EO, Kono H, Rock KL, Fitzgerald KA, Latz E. 2008. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol 9(8):847–856.
   PubMedGoogle Scholar
• International Agency for Research on Cancer (IARC). 1997. IARC Working Group on the evaluation of carcinogenic risks to humans: Silica, some silicates, coal dust and para-aramid fibrils. Monographs on the Evaluation of the Carcinogenic Risks to Humans. Vol. 68, Lyon, France: IARC.
   Google Scholar
• Iyer R, Hamilton RF, Li L, Holian A. 1996. Silica-induced apoptosis mediated via scavenger receptor in human alveolar macrophages. Toxicol Appl Pharmacol 141(1):84–92.
   PubMedGoogle Scholar
• Johnston CJ, Driscoll KE, Finkelstein JN, Baggs R, O'Reilly MA, Carter J, Gelein R, Oberdörster G. 2000. Pulmonary chemokine and mutagenic responses in rats after subchronic inhalation of amorphous and crystalline silica. Toxicol Sci 56:405–413.
   PubMed Web of Science ®Google Scholar
• Karasuyama H, Melchers F. 1988. Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors. Eur J Immunol 18:97–104.
   PubMed Web of Science ®Google Scholar
• Kidd M, Gustafsson BI, Drozdov I, Modlin IM. 2009. IL1beta- and LPS-induced serotonin secretion is increased in EC cells derived from Crohn's disease. Neurogastroenterol Motil 21(4):439–450.
   PubMedGoogle Scholar
• Lamprecht A, Schafer U, Lehr CM. 2001. Size-dependent bioadhesion of micro- and nanoparticulate carriers to the inflamed colonic mucosa. Pharm Res 18(6):788–793.
   PubMed Web of Science ®Google Scholar
• Lamprecht A, Yamamoto H, Takeuchi H, Kawashima Y. 2005. Nanoparticles enhance therapeutic efficiency by selectively increased local drug dose in experimental colitis in rats. J Pharmacol Exp Ther 315(1):196–202.
   PubMedGoogle Scholar
• Li H, Ambade A, Re F. 2009a. Cutting edge: Necrosis activates the NLRP3 inflammasome. J Immunol 183(3):1528–1532.
   PubMedGoogle Scholar
• Li KS, Wang BY, Liu SY, Yao SP, Guo L, Mao DW. 2009b. The combination of polymorphisms within MCP-1 and IL-1beta associated with ulcerative colitis. Int J Immunogenet 36(3):135–139.
   PubMedGoogle Scholar
• Li MG, Lu WL, Wang JC, Zhang X, Wang XQ, Zheng AP, Zhang Q. 2007. Distribution, transition, adhesion and release of insulin loaded nanoparticles in the gut of rats. Int J Pharm 329(1–2):182–191.
   PubMedGoogle Scholar
• Li P, Allen H, Banerjee S, Franklin S, Herzog L, Johnston C, McDowell J, Paskind M, Rodman L, Salfeld J, . 1995. Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock. Cell 10;80(3):401–411.
   PubMedGoogle Scholar
• Long TC, Saleh N, Tilton RD, Lowry GV, Veronesi B. 2006. Titanium dioxide (P25) produces reactive oxygen species in immortalized brain microglia (BV2): Implications for nanoparticle neurotoxicity. Environ Sci Technol 40(14):4346–4352.
   PubMed Web of Science ®Google Scholar
• Mariathasan S, Weiss DS, Newton K, McBride J, O'Rourke K, Roose-Girma M, Lee WP, Weinrauch Y, Monack DM, Dixit VM. 2006. Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 9;440(7081):228–232.
   PubMedGoogle Scholar
• Martinon F, Mayor A, Tschopp J. 2009. The inflammasomes: Guardians of the body. Annu Rev Immunol 27:229–265.
   PubMed Web of Science ®Google Scholar
• Merget R, Bauer T, Küpper HU, Philippou S, Bauer HD, Breitstadt R, Bruening T. 2002. Health hazards due to the inhalation of amorphous silica. Arch Toxicol 75:625–634.
   PubMed Web of Science ®Google Scholar
• Moore BB, Hogaboam CM. 2008. Murine models of pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 294:L152–160.
   PubMed Web of Science ®Google Scholar
• Monteiller C, Tran L, MacNee W, Faux S, Jones A, Miller B, Donaldson K. 2007. The pro-inflammatory effects of low-toxicity low-solubility particles, nanoparticles and fine particles, on epithelial cells in vitro: The role of surface area. Occup Environ Med 64(9):609–615.
   PubMed Web of Science ®Google Scholar
• Muller L, Riediker M, Wick P, Mohr M, Gehr P, Rothen-Rutishauser B. 2010. Oxidative stress and inflammation response after nanoparticle exposure: Differences between human lung cell monocultures and an advanced three-dimensional model of the human epithelial airways. J R Soc Interface 6;7(Suppl. 1):S27–40.
   PubMedGoogle Scholar
• Napierska D, Thomassen LC, Rabolli V, Lison D, Gonzalez L, Kirsch-Volders M, Martens JA, Hoet PH. 2009. Size-dependent cytotoxicity of monodisperse silica nanoparticles in human endothelial cells. Small 5(7):846–853.
   PubMed Web of Science ®Google Scholar
• Oberdörster G, Ferin J, Lehnert BE. 1994. Correlation between particle size, in vivo particle persistence, and lung injury. Environ Health Perspect 102(Suppl. 5):173–179.
   PubMed Web of Science ®Google Scholar
• Oberdörster G, Finkelstein JN, Johnston C, Gelein R, Cox C, Baggs R, Elder AC. 2000. Acute pulmonary effects of ultrafine particles in rats and mice. Res Rep Health Eff Inst 96:5–86.
   PubMedGoogle Scholar
• Oberdörster G, Oberdörster E, Oberdörster J. 2005. Nanotoxicology: An emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113(7):823–839.
   PubMed Web of Science ®Google Scholar
• Olson AD, Ayass M, Chensue S. 1993. Tumor necrosis factor and IL-1 beta expression in pediatric patients with inflammatory bowel disease. J Pediatr Gastroenterol Nutr 16(3):241–246.
   PubMedGoogle Scholar
• Palomäki J, Karisola P, Pylkkänen L, Savolainen K, Alenius H. 2010. Immunological effects of engineered nanomaterials on mouse antigen presenting cells in vitro. Toxicology 267(1–3):125–131.
   PubMedGoogle Scholar
• Park EJ, Park K. 2009. Oxidative stress and pro-inflammatory responses induced by silica nanoparticles in vivo and in vitro. Toxicol Lett 184(1):18–25.
   PubMedGoogle Scholar
• Petrilli V, Papin S, Dostert C, Mayor A, Martinon F, Tschopp J. 2007. Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration. Cell Death Differ 14(9):1583–1589.
   PubMedGoogle Scholar
• Powell JJ, Harvey RS, Ashwood P, Wolstencroft R, Gershwin ME, Thompson RP. 2000. Immune potentiation of ultrafine dietary particles in normal subjects and patients with inflammatory bowel disease. J Autoimmun 14(1):99–105.
   PubMedGoogle Scholar
• Powell JJ, Faria N, Thomas-McKay E, Pele LC. 2009. Origin and fate of dietary nanoparticles and microparticles in the gastrointestinal tract. J Autoimm 34(3):J226–233.
   Google Scholar
• Rahman Q, Lohani M, Dopp E, Pemsel H, Jonas L, Weiss DG, Schiffmann D. 2002. Evidence that ultrafine titanium dioxide induces micronuclei and apoptosis in Syrian hamster embryo fibroblasts. Environ Health Perspect 110(8):797–800.
   PubMed Web of Science ®Google Scholar
• Reindl W, Weiss S, Lehr HA, Forster I. 2007. Essential crosstalk between myeloid and lymphoid cells for development of chronic colitis in myeloid-specific signal transducer and activator of transcription 3-deficient mice. Immunology 120(1):19–27.
   PubMedGoogle Scholar
• Rescigno M. 2009. Before they were gut dendritic cells. Immunity 31(3):454–456.
   PubMedGoogle Scholar
• Rescigno M, Matteoli G. 2008. Lamina propria dendritic cells: For whom the bell TOLLs? Eur J Immunol 38(6):1483–1486.
   PubMedGoogle Scholar
• Saffiotti U. 2005. Silicosis and lung cancer: A fifty-year perspective. Acta Biomed 2(76 Suppl.):30–37.
   Google Scholar
• Sager TM, Kommineni C, Castranova V. 2008. Pulmonary response to intratracheal instillation of ultrafine versus fine titanium dioxide: Role of particle surface area. Part Fibre Toxicol 5:17.
   PubMed Web of Science ®Google Scholar
• Sarih M, Souvannavong V, Brown SC, Adam A. 1993. Silica induces apoptosis in macrophages and the release of interleukin-1 alpha and interleukin-1 beta. J Leukoc Biol 54(5):407–413.
   PubMedGoogle Scholar
• Sayes CM, Wahi R, Kurian PA, Liu Y, West JL, Ausman KD, Warheit DB, Colvin VL. 2006. Correlating nanoscale titania structure with toxicity: A cytotoxicity and inflammatory response study with human dermal fibroblasts and human lung epithelial cells. Toxicol Sci 92(1):174–185.
   PubMedGoogle Scholar
• Siegmund B, Lehr HA, Fantuzzi G, Dinarello CA. 2001. IL-1 beta -converting enzyme (caspase-1) in intestinal inflammation. Proc Natl Acad Sci USA 98(23):13249–13254.
   PubMedGoogle Scholar
• Singh S, Shi T, Duffin R, Albrecht C, van Berlo D, Hohr D, Fubini B, Martra G, Fenoglio I, Borm PJ, 2007. Endocytosis, oxidative stress and IL-8 expression in human lung epithelial cells upon treatment with fine and ultrafine TiO2: Role of the specific surface area and of surface methylation of the particles. Toxicol Appl Pharmacol 222(2):141–151.
   PubMedGoogle Scholar
• Stoeger T, Reinhard C, Takenaka S, Schroeppel A, Karg E, Ritter B, Heyder J, Schulz H. 2006. Instillation of six different ultrafine carbon particles indicates a surface-area threshold dose for acute lung inflammation in mice. Environ Health Perspect 114:328–333.
   PubMed Web of Science ®Google Scholar
• Takeda K, Clausen BE, Kaisho T, Tsujimura T, Terada N, Forster I, Akira S. 1999. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 10(1):39–49.
   PubMed Web of Science ®Google Scholar
• Thakur SA, Hamilton R Jr, Pikkarainen T, Holian A. 2009. Differential binding of inorganic particles to MARCO. Toxicol Sci 107(1):238–246.
   PubMedGoogle Scholar
• Trouiller B, Reliene R, Westbrook A, Solaimani P, Schiestl RH. 2009. Titanium dioxide nanoparticles induce DNA damage and genetic instability in vivo in mice. Cancer Res 69:8784–8789.
   PubMed Web of Science ®Google Scholar
• Turnbull EL, Yrlid U, Jenkins CD, Macpherson GG. 2005. Intestinal dendritic cell subsets: Differential effects of systemic TLR4 stimulation on migratory fate and activation in vivo. J Immunol 174(3):1374–1384.
   PubMedGoogle Scholar
• Unfried K, Albrecht C, Klotz LO, von Mikecz A, Grether-Beck S, Schins RPF. 2007. Cellular responses to nanoparticles: Target structures and mechanisms. Nanotoxicology 1:52–71.
   Web of Science ®Google Scholar
• Varol C, Vallon-Eberhard A, Elinav E, Aychek T, Shapira Y, Luche H, Fehling HJ, Hardt WD, Shakhar G, Jung S. 2009. Intestinal lamina propria dendritic cell subsets have different origin and functions. Immunity 31(3):502–512.
   PubMedGoogle Scholar
• Wang JJ, Sanderson BJ, Wang H. 2007. Cyto- and genotoxicity of ultrafine TiO2 particles in cultured human lymphoblastoid cells. Mutat Res 628(2):99–106.
   PubMed Web of Science ®Google Scholar
• Waters KM, Masiello LM, Zangar RC, Tarasevich BJ, Karin NJ, Quesenberry RD, Bandyopadhyay S, Teeguarden JG, Pounds JG, Thrall BD. 2009. Macrophage responses to silica nanoparticles are highly conserved across particle sizes. Toxicol Sci 107(2):553–569.
   PubMedGoogle Scholar
• Xia T, Kovochich M, Brant J, Hotze M, Sempf J, Oberley T, Sioutas C, Yeh JI, Wiesner MR, Nel AE. 2006. Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm. Nano Lett 6(8):1794–1807.
   PubMed Web of Science ®Google Scholar