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Research Article

Organ biodistribution, clearance, and genotoxicity of orally administered zinc oxide nanoparticles in mice

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Pages 746-756 | Received 22 Sep 2010, Accepted 01 Sep 2011, Published online: 27 Sep 2011

References

  • Cheng YW, Lee WW, Li CH, Lee CC, Kang JJ. 2004. Genotoxicity of motorcycle exhaust particles in vivo and in vitro. Toxicol Sci 81:103–111.
  • Cross SE, Innes B, Roberts MS, Tsuzuki T, Robertson TA, McCormick P. 2007. Human skin penetration of sunscreen nanoparticles: in-vitro assessment of a novel micronized zinc oxide formulation. Skin Pharmacol Physiol 20:148–154.
  • Dufour EK, Kumaravel T, Nohynek GJ, Kirkland D, Toutain H. 2006. Clastogenicity, photo-clastogenicity or pseudo-photo-clastogenicity: genotoxic effects of zinc oxide in the dark, in pre-irradiated or simultaneously irradiated Chinese hamster ovary cells. Mutat Res 607:215–224.
  • Fröhlich E, Samberger C, Kueznik T, Absenger M, Roblegg E, Zimmer A, Pieber TR. 2009. Cytotoxicity of nanoparticles independent from oxidative stress. J Toxicol Sci 34:363–375.
  • Haase H, Overbeck S, Rink L. 2008. Zinc supplementation for the treatment or prevention of disease: current status and future perspectives. Exp Gerontol 43:394–408.
  • Hackenberg S, Scherzed A, Kessler M, Froelich K, Ginzkey C, Koehler C, 2010. Zinc oxide nanoparticles induce photocatalytic cell death in human head and neck squamous cell carcinoma cell lines in vitro. Int J Oncol 37:1583–1590.
  • Hackenberg S, Scherzed A, Technau A, Kessler M, Froelich K, Ginzkey C, 2011. Cytotoxic, genotoxic and pro-inflammatory effects of zinc oxide nanoparticles in human nasal mucosa cells in vitro. Toxicol In Vitro 25:657–663.
  • Heng BC, Zhao X, Xiong S, Ng KW, Boey FY, Loo JS. 2010. Toxicity of zinc oxide (ZnO) nanoparticles on human bronchial epithelial cells (BEAS-2B) is accentuated by oxidative stress. Food Chem Toxicol 48:1762–1766.
  • Huang CC, Aronstam RS, Chen DR, Huang YW. 2010. Oxidative stress, calcium homeostasis, and altered gene expression in human lung epithelial cells exposed to ZnO nanoparticles. Toxicol In Vitro 24:45–55.
  • Johnston HJ, Semmler-Behnke M, Brown DM, Kreyling W, Tran L, Stone V. 2010. Evaluating the uptake and intracellular fate of polystyrene nanoparticles by primary and hepatocyte cell lines in vitro. Toxicol Appl Pharmacol 242:66–78.
  • Karlsson HL. 2010. The comet assay in nanotoxicology research. Anal Bioanal Chem 398:651–666.
  • Klaine SJ, Alvarez PJ, Batley GE, Fernandes TF, Handy RD, Lyon DY, 2008. Nanomaterials in the environment: behavior, fate, bioavailability, and effects. Environ Toxicol Chem 27:1825–1851.
  • Kumar A, Pandey AK, Singh SS, Shanker R, Dhawan A. 2011. Cellular uptake and mutagenic potential of metal oxide nanoparticles in bacterial cells. Chemosphere (impress)[Epub ahead of print].
  • Li N, Sioutas C, Cho A, Schmitz D, Misra C, Sempf J, 2003. Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. Environ Health Persp 111:455–460.
  • Liao PL, Cheng YW, Li CH, Lo YL, Kang JJ. 2009. Cholesterol-3-beta, 5-alpha, 6-beta-triol induced PI(3)K-Akt-eNOS-dependent cyclooxygenase-2 expression in endothelial cells. Toxicol Lett 190:172–178.
  • Maron DM, Ames BN. 1983. Revised methods for the Salmonella mutagenicity test. Mutat Res 113:173–215.
  • Massalski TB, Murray JL, Bennett LH, Baker H. 1990. Binary alloy phase diagrams. Vol. 3, 2nd ed. OH: ASM, Metals Park. pp. 2938–2939.
  • Matsumura M, Takasu N, Nagata M, Nakamura K, Kawai M, Yoshino S. 2010. Effect of ultrafine zinc oxide (ZnO) nanoparticles on induction of oral tolerance in mice. J Immunotoxicol 7:232–237.
  • Maynard AD, Aitken RJ, Butz T, Colvin V, Donaldson K, Oberdörster G, 2007. Safe handling of nanotechnology. Nature 444:267–269.
  • Nel A, Xia T, Madler L, Li N. 2006. Toxic potential of materials at the nanolevel. Science 311:622–627.
  • Oberdörster G, Oberdörster E, Oberdörster J. 2005. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Persp 113:823–839.
  • Oberdörster G, Sharp Z, Atudorei V, Elder A, Gelein R, Lunts A, 2002. Extrapulomnary translocation of ultrafine carbon particles following whole-body inhalation exposure of rats. J Toxicol Environ Health Part A 65:1531–1543.
  • Pujalté I, Passagne I, Brouillaud B, Tréguer M, Durand E, Ohayon-Courtès C, L'azou B. 2011. Cytotoxicity and oxidative stress induced by different metallic nanoparticles on human kidney cells. Part Fibre Toxicol 3:8–10.
  • Raghupathi KR, Koodali RT, Manna AC. 2011. Size-dependent bacterial growth inhibition and mechanism of antibacterial activity of zinc oxide nanoparticles. Langmuir 27:4020–4028.
  • Reddy KM, Feris K, Bell J, Wingett DG, Hanley C, Punnoose A. 2007. Selective toxicity of zinc oxide nanoparticles to prokaryotic and eukaryotic systems. Appl Phys Lett 90:2139021–2139023.
  • Riehemann K, Schneider SW, Luger TA, Godin B, Ferrari M, Fuchs H. 2009. Nanomedicine – challenge and perspectives. Angew Chem Int Ed Engl 48:872–897.
  • Rothen-Rutishauser BM, Schurch S, Haenni B, Kapp N, Gehr P. 2006. Interaction of fine particles and nanoparticles with red blood cells visualized with advanced microscopic techniques. Environ Sci Technol 40:4353–4359.
  • Sawai J, Kojima H, Kano F, Igarashi H, Hashimoto A, Kawada E, 1998. Short communication: Ames assay with Salmonella typhimurium TA102 for mutagenicity and antimutagenicity of metallic oxide powders having antibacterial activities. World J Microbiol Biotechnol 14:773–775.
  • Semmler-Behnke M, Kreyling WG, Lipka J, Fertsch S, Wenk A, Takenaka S, 2008. Biodistribution of 1.4- and 18-nm gold particles in rats. Small 4:2108–2111.
  • Sevinc BA, Hanley L. 2010. Antibacterial activity of dental composites containing zinc oxide nanoparticles. J Biomed Mater Res B Appl Biomater 94B:22–31.
  • Sharma V, Shukla RK, Saxena N, Parmar D, Das M, Dhawan A. 2009. DNA damaging potential of zinc oxide nanoparticles in human epidermal cells. Toxicol Lett 185:211–218.
  • Stone V, Donaldson K. 2006. Nanotoxicology: signs of stress. Nat Nanotechnol 1:23–24.
  • Yamaki K, Yoshino S. 2009. Comparison of inhibitory activities of zinc oxide ultrafine and fine particulates on IgE-induced mast cell activation. Biometals 22:1031–1040.
  • Yoshida R, Kitamura D, Maenosono S. 2009. Mutagenicity of water-soluble ZnO nanoparticles in Ames test. J Toxicol Sci 34:119–122.
  • Zhu X, Zhu L, Duan Z, Qi R, Li Y, Lang Y. 2008. Comparative toxicity of several metal oxide nanoparticle aqueous suspensions to Zebrafish (Danio rerio) early developmental stage. J Environ Sci Health A Tox Hazard Subst Environ Eng 43:278–284.

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