Computational modeling as part of alternative testing strategies in the respiratory and cardiovascular systems: Inhaled nanoparticle dose modeling based on representative aerosol measurements and corresponding toxicological analysis

References

• Annapragada A, Mishchiy N. 2007. In silico modeling of aerosol deposition in lungs. Drug Discov Today Dis Model 4:155--61
   Google Scholar
• Asgharian B, Anjilvel S. 1994. Inertial and gravitational deposition of particles in a square cross section bifurcating airway. Aerosol Sci Technol 20:177--93
   Web of Science ®Google Scholar
• Baulig A, Blanchet S, Rumelhard M, Lacroix G, Marano F, Baeza-Squiban A. 2007. Fine urban atmospheric particulate matter modulates inflammatory gene and protein expression in human bronchial epithelial cells. Front Biosci 12:771--82
   PubMed Web of Science ®Google Scholar
• Bockenfeld D, Chen H, Kaminski MD, Rosengart AJ, Rempfer D. 2010. A parametric study of a portable magnetic separator for separation of nanospheres from circulatory system. Separ Sci Tech 45:355--63
   Web of Science ®Google Scholar
• Chen H, Ebner AD, Bockenfeld D, Ritter JA, Kaminski MD, Liu X, et al. 2007. A comprehensive in vitro investigation of a portable magnetic separator device for human blood detoxification. Phys Med Biol 52:6053--72
   PubMed Web of Science ®Google Scholar
• Chen H, Ebner AD, Ritter JA, Kaminski MD, Rosengart AJ. 2008a. Theoretical analysis of a magnetic separator device for ex-vivo blood detoxification. Separ Sci Tech 43:996--1020
   Web of Science ®Google Scholar
• Chen H, Kaminski MD, Rosengart AJ. 2008b. 2D modeling and preliminary in vitro investigation of a prototype high gradient magnetic separator for biomedical applications. Med Eng Phys 30:1–8
   PubMed Web of Science ®Google Scholar
• Comer JK, Kleinstreuer C, Zhang Z. 2001. Flow structures and particle deposition patterns in double-bifurcation airway models. Part 1. Air flow fields. J Fluid Mech 435:25–54
   Web of Science ®Google Scholar
• Drossinos Y, Housiadas C. 2006. Aerosol flows. In Crowe CT, ed. Multiphase Flow Handbook. Boca Raton: CRC Press, 6-1--6-53
   Google Scholar
• Dusinska M, Dusinska M, Fjellsbø L, Magdolenova Z, Rinna A, Runden Pran E, et al. 2009. Testing strategies for the safety of nanoparticles used in medical applications. Nanomedicine 4:605–7
   PubMed Web of Science ®Google Scholar
• Dvonch JT, Kannan S, Schulz AJ, Keeler GJ, Mentz G, House J, et al. 2009. Acute effects of ambient particulate matter on blood pressure. Hypertension 53:853–9
   PubMed Web of Science ®Google Scholar
• Fernandez De La Mora J, Rosner DE. 1982. Effects of inertia on the diffusional deposition of small particles to spheres and cylinders at low Reynolds numbers. J Fluid Mech 125:379–95
   Web of Science ®Google Scholar
• Gagnadoux F, Hureaux J, Vecellio L, Urban T, Le Pape A, Valo I, et al. 2008. Aerosolized chemotherapy. J Aerosol Med Pulm Drug Deliv 21:61–70
   PubMed Web of Science ®Google Scholar
• Grimm J, Scheinberg DA. 2011. Will nanotechnology influence targeted cancer therapy? Semin Radiat Oncol 21:80–7
   PubMed Web of Science ®Google Scholar
• Grobmyer SR, Morse DL, Fletcher B, Gutwein LG, Sharma P, Krishna V, et al. 2011. The promise of nanotechnology for solving clinical problems in breast cancer. J Surg Oncol 103:317–25
   PubMed Web of Science ®Google Scholar
• Housiadas C, Lazarides M. 2010. Inhalation dosimetry modelling. In Lazarides M & Colbeck I, eds. Human Exposure to Pollutants via Dermal Absorption and Inhalation. Netherlands: Springer, 185--236
   Google Scholar
• Iancu C, Ilie IR, Georgescu CE, Ilie R, Biris AR, Mocan T, et al. 2009. Applications of nanomaterials in cell stem therapies and the onset of nanomedicine. Particulate Sci Tech 27:562–74
   Web of Science ®Google Scholar
• Karanasiou A, Eleftheriadis K, Vratolis S, Zarbas P, Mihalopoulos N, Mitsakou C, et al. 2008. Size distribution of inorganic species and their inhaled dose in a detergent industrial workplace. Water Air Soil Pollut Focus 8:71–6
   Google Scholar
• Kim CS, Fisher DM, Lutz DJ, Gerrity TR. 1994. Particle deposition in bifurcating airway models with varying airway geometry. J Aerosol Sci 25:567–81
   Web of Science ®Google Scholar
• Kumar A, Jena PK, Behera S, Lockey RF, Mohapatra S, Mohapatra S. 2010. Multifunctional magnetic nanoparticles for targeted delivery. Nanomedicine 6:e64–9
   PubMed Web of Science ®Google Scholar
• Maccalman L, Tran CL, Kuempel E. 2009. Development of a bio-mathematical model in rats to describe clearance, retention and translocation of inhaled nano particles throughout the body. J Phys Conf 151:1--10
   Google Scholar
• Makris E, Gkanis V, Tsangaris S, Housiadas C. 2011a. A methodology to generate structured computational grids from DICOM data: application to a patient-specific abdominal aortic aneurysm (AAA) model. Comput Methods Biomech Biomed Eng 15:173--83
   Google Scholar
• Makris E, Tsangaris S, Housiadas C. 2011b. A methodology to generate a patient specific high quality structured computational domain from medical imaging data. Brussels: ECCOMAS Thematic International Conference on Simulation and Modeling of Biological Flows (SIMBIO 2011)
   Google Scholar
• Mavrofrydi O, Papazafiri P. 2012. Hypoxia-inducible factor-1α increase is an early and sensitive marker of lung cells responding to benzo[a]pyrene. J Environ Pathol Toxicol Oncol 31:335–47
   PubMed Web of Science ®Google Scholar
• Mills NL, Donaldson K, Hadoke PW, Boon NA, Macnee W, Cassee FR, et al. 2009. Adverse cardiovascular effects of air pollution. Nat Clin Pract Cardiovasc Med 6:36–44
   PubMedGoogle Scholar
• Misra A, Hickey AJ, Rossi C, Borchard G, Terada H, Makino K, et al. 2011. Inhaled drug therapy for treatment of tuberculosis. Tuberculosis (Edinb) 91:71–81
   PubMed Web of Science ®Google Scholar
• Mitsakou C, Helmis C, Housiadas C. 2005. Eulerian modelling of lung deposition with sectional representation of aerosol dynamics. J Aerosol Sci 36:75–94
   Web of Science ®Google Scholar
• Mitsakou C, Housiadas C, Eleftheriadis K, Vratolis S, Helmis C, Asimakopoulos D. 2007a. Lung deposition of fine and ultrafine particles outdoors and indoors during a cooking event and a no activity period. Indoor Air 17:143–52
   PubMed Web of Science ®Google Scholar
• Mitsakou C, Mitrakos D, Neofytou P, Housiadas C. 2007b. A simple mechanistic model of deposition of water-soluble aerosol particles in the mouth and throat. J Aerosol Med 20:519–29
   PubMedGoogle Scholar
• Neofytou P, Tsangaris S. 2006. Flow effects of blood constitutive equations in 3D models of vascular anomalies. Int J Num Methods Fluids 51:489–510
   Web of Science ®Google Scholar
• Pilou M, Antonopoulos V, Makris E, Neofytou P, Tsangaris S, Housiadas C. 2013. A fully Eulerian approach to particle inertial deposition in a physiologically realistic bifurcation. Appl Math Model 37:5591–605
   Web of Science ®Google Scholar
• Pilou M, Tsangaris S, Neofytou P, Housiadas C, Drossinos Y. 2011. Inertial particle deposition in a 90-degree laminal-flow bend: an Eulerian fluid-particle approach. Aerosol Sci Technol 45:1376–87
   Web of Science ®Google Scholar
• Plank C. 2008. Nanomagnetosols: magnetism opens up new perspectives for targeted aerosol delivery to the lung. Trends Biotechnol 26:59–63
   PubMed Web of Science ®Google Scholar
• Russell AG, Brunekreef B. 2009. A focus on particlulate matter and health. Environ Sci Technol 43:4620–5
   PubMed Web of Science ®Google Scholar
• Schlesinger RB, Bohning DE, Chan TL. 1977. Particle deposition in a hollow cast of the human trancheobronchial tree. J Aerosol Sci 8:429–45
   Google Scholar
• Simkhovich BZ, Kleinman MT, Kloner RA. 2008. Air pollution and cardiovascular injury: epidemiology, toxicology, and mechanisms. J Am Coll Cardiol 52:719–26
   PubMed Web of Science ®Google Scholar
• Slevin M, Badimon L, Grau-Olivares M, Ramis M, Sendra J, Morrison M, Krupinski J. 2010. Combining nanotechnology with current biomedical knowledge for the vascular imaging and treatment of atherosclerosis. Mol Biosyst 6:444–50
   PubMedGoogle Scholar
• Sung JC, Pulliam BL, Edwards DA. 2007. Nanoparticles for drug delivery to the lungs. Trends Biotechnol 25:563–70
   PubMed Web of Science ®Google Scholar
• Tran CL, Jones AD, Cullen RT, Donaldson K. 1999. Mathematical modelling of the retention and clearance of low-toxicity particles in the lung. Inhal Toxicol 11:1059–76
   PubMed Web of Science ®Google Scholar
• Tran CL, Kuempel E. 2007. Biologically based lung dosimetry and exposure-dose-response models for poorly soluble inhaled particles. In Donaldson K & Born P, eds. Particle Toxicology. Boca Raton: CRC Press, 351--86
   Google Scholar
• Weibel ER. 1963. Morphometry of the Human Lung. Berlin-Göttingen-Heidelberg: Springer-Verlag
   Google Scholar
• Wolfnbarger JK, Seinfeld JH. 1990. Inversion of aerosol size distribution data. J Aerosol Sci 21:227--47
   Web of Science ®Google Scholar
• Yallapu MM, Othman SF, Curtis ET, Gupta BK, Jaggi M, Chauhan SC. 2011. Multi-functional magnetic nanoparticles for magnetic resonance imaging and cancer therapy. Biomaterials 32:1890–905
   PubMed Web of Science ®Google Scholar