Tracking translocation of industrially relevant engineered nanomaterials (ENMs) across alveolar epithelial monolayers in vitro

References

• Aitken RC, Chaudhry MQ, Boxall AB, Hull M. 2006. Manufacture and use of nanomaterials: current status in the UK and global trends. Occup Med 56:300–6
   Google Scholar
• Bello D, Martin J, Santeufemio C, Sun Q, Lee Bunker K, Shafer M, Demokritou P. 2012. Physicochemical and morphological characterisation of nanoparticles from photocopiers: implications for environmental health. Nanotoxicology 7:989–1003
   PubMed Web of Science ®Google Scholar
• Brain J. 2009. Biologic responses to nanomaterials depend on exposure, clearance, and material characteristics. Nanotoxicology 3:1–7
   Web of Science ®Google Scholar
• Chen JK, Shih MH, Pier JJ, Liue CH, Chou FI, Lai WH, et al. 2010. The use of radioactive zinc oxide nanoparticles in determination of their tissue concentrations following intravenous administration in mice. Analyst 135:1742–6
   PubMed Web of Science ®Google Scholar
• Chithrani BD, Ghazani AA, Chan WCW. 2006. Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells. Nano Lett 6:662–8
   PubMed Web of Science ®Google Scholar
• Choi HS, Ashitate Y, Lee JH, Kim SH, Matsui A, Insin N, et al. 2010. Rapid translocation of nanoparticles from the lung airspaces to the body. Nat Biotechnol 28:1300–3
   PubMed Web of Science ®Google Scholar
• Cohen J, Deloid G, Pyrgiotakis G, Demokritou P. 2012. Interactions of engineered nanomaterials in physiological media and implications for in vitro dosimetry. Nanotoxicology 7:417–31
   PubMed Web of Science ®Google Scholar
• Conner SD, Schmid SL. 2003. Regulated portals of entry into the cell. Nature 422:37–44
   PubMed Web of Science ®Google Scholar
• Deloid G, Cohen JM, Darrah T, Derk R, Rojanasakul L, Pyrgiotakis G, et al. 2013. Estimating effective density of engineered nanomaterials for in vitro dosimetry. Nat Commun
   Google Scholar
• Demokritou P, Buchel R, Molina RM, Deloid GM, Brain JD, Pratsinis SE. 2010. Development and characterization of a Versatile Engineered Nanomaterial Generation System (VENGES) suitable for toxicological studies. Inhal Toxicol 22(Suppl. 2):107–16
   Web of Science ®Google Scholar
• Demokritou P, Cohen JM, Deloid G. 2012. Novel methods of measuring effective density of nanoparticles in fluids. US Provisional Patent Application No. 61/661,895
   Google Scholar
• Demokritou P, Gass S, Pyrgiotakis G, Cohen JM, Goldsmith W, Mckinney W, et al. 2013. An in vivo and in vitro toxicological characterization of realistic nanoscale CeO2 inhalation exposures. Nanotoxicology 7:1338–50
   PubMed Web of Science ®Google Scholar
• Du Z, Zhao D, Jing L, Cui G, Jin M, Li Y, et al. 2013. Cardiovascular toxicity of different sizes amorphous silica nanoparticles in rats after intratracheal instillation. Cardiovasc Toxicol 13:194–207
   PubMed Web of Science ®Google Scholar
• Gass S, Cohen JM, Pyrgiotakis G, Sotiriou GA, Buechel R, Pratsinis SE, Demokritou P. 2013. A safer formulation concept for flame-generated engineered nanomaterials. ACS Sustain Chem Eng 1:843–57
   PubMed Web of Science ®Google Scholar
• Geiser M, Casaulta M, Kupferschmid B, Schulz H, Semmler-Behnke M, Kreyling W. 2008. The role of macrophages in the clearance of inhaled ultrafine titanium dioxide particles. Am J Respir Cell Mol Biol 38:371–6
   PubMed Web of Science ®Google Scholar
• Geiser M, Kreyling WG. 2010. Deposition and biokinetics of inhaled nanoparticles. Part Fibre Toxicol 7:2
   PubMed Web of Science ®Google Scholar
• Geiser M, Rothen-Rutishauser B, Kapp N, Schurch S, Kreyling W, Schulz H, et al. 2005. Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells. Environ Health Perspect 113:1555–60
   PubMed Web of Science ®Google Scholar
• Geys J, Coenegrachts L, Vercammen J, Engelborghs Y, Nemmar A, Nemery B, Hoet PH. 2006. In vitro study of the pulmonary translocation of nanoparticles: a preliminary study. Toxicol Lett 160:218–26
   PubMed Web of Science ®Google Scholar
• Geys J, Nemery B, Hoet PH. 2007. Optimisation of culture conditions to develop an in vitro pulmonary permeability model. Toxicol In Vitro 21:1215–19
   PubMed Web of Science ®Google Scholar
• Gratton SEA, Roop PA, Pohihaus PD, Luft JC, Madden VJ, Napier ME, Desimone JM. 2008. The effect of particle design on cellular internalization pathways. Proc Natl Acad Sci USA 105:11613–18
   PubMed Web of Science ®Google Scholar
• Haynes WM. 2012. CRC Handbook of Chemistry and Physics, 92nd edn. Boca Raton (FL): CRC Press
   Google Scholar
• He X, Zhang H, Ma Y, Bai W, Zhang Z, Lu K, et al. 2010. Lung deposition and extrapulmonary translocation of nano-ceria after intratracheal instillation. Nanotechnology 21:285103–11
   PubMed Web of Science ®Google Scholar
• Hinderliter PM, Minard KR, Orr G, Chrisler WB, Thrall BD, Pounds JG, Teeguarden JG. 2010. ISDD: a computational model of particle sedimentation, diffusion and target cell dosimetry for in vitro toxicity studies. Part Fibre Toxicol 7:36
   PubMed Web of Science ®Google Scholar
• Kim KJ, Crandall ED. 1983. Heteropore populations of bullfrog alveolar epithelium. J Appl Physiol 54:140–6
   PubMed Web of Science ®Google Scholar
• Kim YH, Fazlollahi F, Kennedy IM, Yacobi NR, Hamm-Alvarez SF, Borok ZEA, et al. 2010. Alveolar epithelial cell injury due to zinc oxide nanoparticle exposure. Am J Respir Crit Care Med 182:1398–409
   PubMed Web of Science ®Google Scholar
• Kreyling WG, Semmler-Behnke M, Seitz J, Scymczak W, Wenk A, Mayer P, et al. 2009. Size dependence of the translocation of inhaled iridium and carbon nanoparticle aggregates from the lung of rats to the blood and secondary target organs. Inhal Toxicol 21(Suppl. 1):55–60
   Google Scholar
• Kroll A, Dierker C, Rommel C, Hahn D, Wohlleben W, Schulze-Isfort C, et al. 2011. Cytotoxicity screening of 23 engineered nanomaterials using a test matrix of ten cell lines and three different assays. Part Fibre Toxicol 8:9
   PubMed Web of Science ®Google Scholar
• Lehmann AD, Daum N, Bur M, Lehr CM, Gehr P, Rothen-Rutishauser BM. 2011. An in vitro triple cell co-culture model with primary cells mimicking the human alveolar epithelial barrier. Eur J Pharm Biopharm 77:398–406
   PubMed Web of Science ®Google Scholar
• Limbach L. 2005. Oxide nanoparticle uptake in human lung fibroblasts: effects of particle size, agglomeration, and diffusion at low concentrations. Environ Sci Technol 39:9370–6
   PubMed Web of Science ®Google Scholar
• Matsukawa Y, Lee VH, Crandall ED, Kim KJ. 1997. Size-dependent dextran transport across rat alveolar epithelial cell monolayers. J Pharm Sci 86:305–9
   PubMed Web of Science ®Google Scholar
• Mills NL, Donaldson K, Hadoke PW, Boon NA, Macnee W, Cassee FR, et al. 2009. Adverse cardiovascular effects of air pollution. Nat Clin Pract Cardiovasc Med 6:36–44
   PubMedGoogle Scholar
• Muller LG, Gasser M, Raemy DO, Herzog F, Brandenberger C, Schmid O, et al. 2011. Realistic exposure methods for investigating the interaction of nanoparticles with the lung at the air-liquid interface in vitro. Insciences J 1:30–64
   Google Scholar
• Nel AE, Madler L, Velegol D, Xia T, Hoek EM, Somasundaran P, et al. 2009. Understanding biophysicochemical interactions at the nano-bio interface. Nat Mater 8:543–57
   PubMed Web of Science ®Google Scholar
• Oberdorster G. 1995. Lung particle overload: implications for occupational exposures to particles. Regul Toxicol Pharmacol 21:123–35
   PubMed Web of Science ®Google Scholar
• Pirela S, Molina R, Watson C, Cohen JM, Bello D, Demokritou P, Brain J. 2013. Effects of copy center particles on the lungs: a toxicological characterization using a Balb/c mouse model. Inhal Toxicol 25:498–508
   PubMed Web of Science ®Google Scholar
• Rothen-Rutishauser BM, Kiama SG, Gehr P. 2005. A three-dimensional cellular model of the human respiratory tract to study the interaction with particles. Am J Respir Cell Mol Biol 32:281–9
   PubMed Web of Science ®Google Scholar
• Semmler M, Seitz J, Erbe F, Mayer P, Heyder J, Oberdorster G, Kreyling WG. 2004. Long-term clearance kinetics of inhaled ultrafine insoluble iridium particles from the rat lung, including transient translocation into secondary organs. Inhal Toxicol 16:453–9
   PubMed Web of Science ®Google Scholar
• Sotiriou GA, Diaz E, Long MS, Godleski J, Brain J, Pratsinis SE, Demokritou P. 2011. A novel platform for pulmonary and cardiovascular toxicological characterization of inhaled engineered nanomaterials. Nanotoxicology 11:680--90
   Google Scholar
• Sotiriou GA, Franco D, Poulikakos D, Ferrari A. 2012. Optically stable biocompatible flame-made SiO2-coated Y2O3: Tb3+ nanophosphors for cell imaging. ACS Nano 6:680–90
   Web of Science ®Google Scholar
• Teeguarden JG, Hinderliter PM, Orr G, Thrall BD, Pounds JG. 2007. Particokinetics in vitro: dosimetry considerations for in vitro nanoparticle toxicity assessments. Toxicol Sci 95:300–12
   PubMed Web of Science ®Google Scholar
• Tenuta T, Monopoli MP, Kim J, Salvati A, Dawson KA, Sandin P, Lynch I. 2011. Elution of labile fluorescent dye from nanoparticles during biological use. PLoS One 6:e25556
   PubMed Web of Science ®Google Scholar
• Wang B, Wang Z, Feng W, Wang M, Hu Z, Chai Z, Zhao Y. 2010. New methods for nanotoxicology: synchrotron radiation-based techniques. Anal Bioanal Chem 398:667–76
   PubMed Web of Science ®Google Scholar
• Wegner KP, Pratsinis SE. 2003. Scale-up of nanoparticle synthesis in diffusion flame reactors. Chem Eng Sci 58:4581–9
   Web of Science ®Google Scholar
• West JB. 2008. Respiratory Physiology: the Essentials. Philadelphia (PA): Lippincott Williams & Wilkins
   Google Scholar
• Xia T, Kovochich M, Liong M, Madler L, Gilbert B, Shi H, et al. 2008a. Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties. ACS Nano 2:2121–34
   PubMed Web of Science ®Google Scholar
• Xia T, Kovochich M, Liong M, Zink JI, Nel AE. 2008b. Cationic polystyrene nanosphere toxicity depends on cell-specific endocytic and mitochondrial injury pathways. ACS Nano 2:85–96
   PubMed Web of Science ®Google Scholar
• Yacobi NR, Malmstadt N, Fazlollahi F, Demaio L, Marchelletta R, Hamm-Alvarez SF, et al. 2010. Mechanisms of alveolar epithelial translocation of a defined population of nanoparticles. Am J Respir Cell Mol Biol 42:604–14
   PubMed Web of Science ®Google Scholar
• Yang S, Song C, Qiu T, Guo L, Li X. 2013. Synthesis of polystyrene/polysilsesquioxane core/shell composite particles via emulsion polymerization in the existence of poly(gamma-methacryloxypropyl trimethoxysilane) sol. Langmuir 29:92–101
   PubMed Web of Science ®Google Scholar
• Ye P, Nadkarni MA, Simonian M, Hunter N. 2009. CD24 regulated gene expression and distribution of tight junction proteins is associated with altered barrier function in oral epithelial monolayers. BMC Cell Biol 10:2
   PubMed Web of Science ®Google Scholar
• Yeh TK, Chen JK, Lin CH, Yang MH, Yang CS, Chou FI, et al. 2012. Kinetics and tissue distribution of neutron-activated zinc oxide nanoparticles and zinc nitrate in mice: effects of size and particulate nature. Nanotechnology 23:085102--085111
   PubMed Web of Science ®Google Scholar
• Zhang H, Ji Z, Xia T, Meng H, Low-Kam C, Liu R, et al. 2012. Use of metal oxide nanoparticle band gap to develop a predictive paradigm for oxidative stress and acute pulmonary inflammation. ACS Nano 6:4349–68
   PubMed Web of Science ®Google Scholar