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Acta Orthopaedica Volume 84, 2013 - Issue 1
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Bone experiment

Augmentation of autologous bone graft by a combination of bone morphogenic protein and bisphosphonate increased both callus volume and strength

Per BosemarkDepartment of Orthopaedics, Clinical SciencesCorrespondence[email protected]
,
Hanna IsakssonDivision of Solid Mechanics, Lund University, Lund, Sweden;Department of Applied Physics, University of Eastern Finland, Kuopio, Finland
,
Michelle M McDonaldOrthopaedic Research and Biotechnology, The Children’s Hospital at Westmead, University of Sydney, Australia.
,
David G LittleOrthopaedic Research and Biotechnology, The Children’s Hospital at Westmead, University of Sydney, Australia.
&
Magnus TägilDepartment of Orthopaedics, Clinical Sciences
Pages 106-111 | Received 17 May 2012, Accepted 23 Nov 2012, Published online: 14 Feb 2013

  • Amanat N, McDonald M, Godfrey C, Bilston L, Little D. Optimal timing of a single dose of zoledronic acid to increase strength in rat fracture repair. J Bone Miner Res 2007; 22 (6): 867-76.
  • Belfrage O, Flivik G, Sundberg M, Kesteris U, Tägil M. Local treatment of cancellous bone grafts with BMP-7 and zoledronate increases both the bone formation rate and bone density. A bone chamber study in rats. Acta Orthop 2011; 82 (2): 228-33.
  • Calori GM, Albisetti W, Agus A, Iori S, Tagliabue L. Risk factors contributing to fracture non-unions. Injury. 2007 38 Suppl 2:S11-8. Erratum in: Injury 2007; 38 (10): 1224.
  • Doi Y, Miyazaki M, Yoshiiwa T, Hara K, Kataoka M, Tsumura H. Manipulation of the anabolic and catabolic responses with BMP-2 and zoledronic acid in a rat femoral fracture model. Bone 2011; 49 (4): 777-82.
  • Giannoudis PV, Kanakaris NK, Einhorn TA. Interaction of bone morphogenetic proteins with cells of the osteoclast lineage: review of the existing evidence. Osteoporos Int 2007; 18 (12): 1565-81.
  • Hak DJ, Makino T, Niikura T, Hazelwood SJ, Curtiss S, Reddi AH. Recombinant human BMP-7 effectively prevents non-union in both young and old rats. J Orthop Res 2006; 24: 11-20.
  • Harding AK, Aspenberg P, Kataoka M, Bylski D, Tägil M. Manipulating the anabolic and catabolic response in bone graft remodeling: Synergism by a combination of local BMP-7 and a single systemic dosis of zoledronate. J Orthop Res 2008; 26 (9): 1245-9.
  • Isaksson H, Grongroft I, Wilson W, van Donkelaar CC, van Rietbergen B, Tami A, Huiskes R, Ito K. Remodeling of fracture callus in mice is consistent with mechanical loading and bone remodeling theory. J Orthop Res 2009; 27: 664-72.
  • Jones AL, Bucholz RW, Bosse MJ . Recombinant human BMP-2 and allograft compared with autogenous bone graft for reconstruction of diaphyseal tibial fractures with cortical defects. A randomized controlled trial. J Bone Joint Surg (Am) 2006; 88: 1431-41.
  • Kanakaris NK, Calori GM, Verdonk R . Application of BMP-7 to tibial non unions: a 3-year multicenter experience. Injury 2008; 39: 83-90.
  • Little DG, McDonald M, Bransford R, Godfrey CB, Amanat N. Manipulation of the anabolic and catabolic responses with OP-1 and zoledronic acid in a rat critical defect model. J Bone Miner Res 2005; 20 (11): 2044-52.
  • Little DG, Ramachandran M, Schindeler A. The anabolic and catabolic responses in bone repair. J Bone Joint Surg (Br) 2007; 89 (4): 425-33.
  • McDonald MM, Dulai S, Godfrey C, Amanat N, Sztynda T, Little DG. Bolus or weekly zoledronic acid administration does not delay endochondral fracture repair but weekly dosing enhances delays in hard callus remodeling. Bone 2008; 43 (4): 653-62.
  • Morgan EF, Mason ZD, Chien KB, Pfeiffer AJ, Barnes GL, Einhorn TA, Gerstenfeld LC. Micro-computed tomography assessment of fracture healing: relationships among callus structure, composition, and mechanical function. Bone 2009; 44: 335-44.
  • Nozaka K, Miyakoshi N, Kasukawa Y, Maekawa S, Noguchi H, Shimada Y. Intermittent administration of human parathyroid hormone enhances bone formation and union at the site of cancellous bone osteotomy in normal and ovariectomised rats. Bone 2008; 42: 90-7.
  • Nyman J, Munoz S, Jadhav S. Quantitative measures of femoral fracture repair in rats derived by micro-computed tomography. J Biomech 2009;42: 891-8.
  • Perumal V, Roberts CS. Factors contributing to non union of fractures. Curr Orthop 2007; 21: 258-61.
  • Ristniemi J, Flinkkilä T, Hyvönen P, Lakovaara M, Pakarinen H, Jalovaara P. RhBMP-7 accelerates the healing in distal tibial fractures treated by external fixation. J Bone Joint Surg (Br) 2007; 89: 265-72.
  • Rogers MJ, Crockett JC, Coxon FP, Mönkkonen J. Biochemical and molecular mechanisms of action of bisphosphonates. Bone 2011; 49 (1): 34-41.
  • Tägil M, McDonald MM, Morse A, Peacock L, Mikulec K, Amanat N, Godfrey C, Little DG. Intermittent PTH (1-34) does not increase union rates in open rat femoral fractures and exhibits attenuated anabolic effects compared to closed fractures. Bone 2010; 46 (3): 852-9

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