Advanced search
Publication Cover
Acta Orthopaedica Volume 87, 2016 - Issue 1
Journal homepage
4,100
Views
83
CrossRef citations to date
0
Altmetric
Original Articles

The role of “cell therapy” in osteonecrosis of the femoral head

A systematic review of the literature and meta-analysis of 7 studies

Costas Papakostidis Department of Trauma and Orthopaedics, G. Hatzikostas General Hospital, Ioannina, GreeceCorrespondence[email protected]
,
Theodoros H Tosounidis Academic Department of Trauma and Orthopaedic Surgery, University of Leeds, Leeds;NIHR Leeds Biomedical Research Unit, Chapel Allerton Hospital, Leeds, UKCorrespondence[email protected]
,
Elena Jones Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, LeedsCorrespondence[email protected]
&
Peter V Giannoudis Academic Department of Trauma and Orthopaedic Surgery, University of Leeds, Leeds;NIHR Leeds Biomedical Research Unit, Chapel Allerton Hospital, Leeds, UKCorrespondence[email protected]
Pages 72-78 | Received 03 May 2015, Accepted 19 Jun 2015, Published online: 29 Jul 2015

  • Baksh D, Song L, Tuan RS. Adult mesenchymal stem cells: characterization, differentiation, and application in cell and gene therapy. J Cell Mol Med 2004; 8(3): 301–16.
  • Calori GM, Mazza E, Colombo M, Mazzola S, Mineo GV, Giannoudis PV. Treatment of AVN using the induction chamber technique and a biological-based approach: indications and clinical results. Injury 2014; 45(2): 369–73.
  • Cochran W. The combination of estimates from different experiments. Biometrics 1954; 10: 101–29.
  • Ficat RP. Idiopathic bone necrosis of the femoral head. Early diagnosis and treatment. J Bone Joint Surg Br 1985; 67(1): 3–9.
  • Gangji V, Hauzeur JP. Treatment of osteonecrosis of the femoral head with implantation of autologous bone-marrow cells. Surgical technique. J Bone Joint Surg Am 2005; 87 Suppl 1 (Pt 1): 106–12.
  • Gangji V, Hauzeur JP. Cellular-based therapy for osteonecrosis. Orthop Clin North Am 2009; 40(2): 213–21.
  • Gangji V, De Maertelaer V, Hauzeur JP. Autologous bone marrow cell implantation in the treatment of non-traumatic osteonecrosis of the femoral head: Five year follow-up of a prospective controlled study. Bone 2011; 49(5):1005–9.
  • Gangji V, Hauzeur JP, Matos C, De Maertelaer V, Toungouz M, Lambermont M. Treatment of osteonecrosis of the femoral head with implantation of autologous bone-marrow cells. A pilot study. J Bone Joint Surg Am 2004; 86-A(6): 1153–60.
  • Gangji V, Hauzeur JP, Schoutens A, Hinsenkamp M, Appelboom T, Egrise D. Abnormalities in the replicative capacity of osteoblastic cells in the proximal femur of patients with osteonecrosis of the femoral head. J Rheumatol 2003; 30(2): 348–51.
  • Hernigou P, Beaujean F. Treatment of osteonecrosis with autologous bone marrow grafting. Clin Orthop Relat Res 2002; (405): 14–23.
  • Hernigou P, Manicom O, Poignard A, Nogier A, Filippini P, De Abreu L. Core decompression with marrow stem cells. Operative Tech Orthop 2004; 14(2): 68–74.
  • Hernigou P, Poignard A, Zilber S, Rouard H. Cell therapy of hip osteonecrosis with autologous bone marrow grafting. Indian J Orthop 2009; 43(1): 40–45.
  • Higgins JP, Altman DG, Gotzsche PC, Juni P, Moher D, Oxman AD, Savovic J, Schulz KF, Weeks L, Sterne JA. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ 2011; 343: d5928.
  • Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ 2003; 327(7414): 557–560.
  • Jones JP, Jr. Fat embolism and osteonecrosis. Orthop Clin North Am 1985; 16(4): 595–633.
  • Kasten P, Beyen I, Egermann M, Suda AJ, Moghaddam AA, Zimmermann G, Luginbuhl R. Instant stem cell therapy: characterization and concentration of human mesenchymal stem cells in vitro. Eur Cell Mater 2008; 16: 47–55.
  • Learmonth ID, Maloon S, Dall G. Core decompression for early atraumatic osteonecrosis of the femoral head. J Bone Joint Surg Br 1990; 72(3): 387–90.
  • Lee K, Chan CK, Patil N, Goodman SB. Cell therapy for bone regeneration--bench to bedside. J Biomed Mater Res B Appl Biomater 2009; 89(1): 252–63.
  • Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JP, Clarke M, Devereaux PJ, Kleijnen J, Moher D. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ 2009; 339: b2700.
  • Lieberman JR, Berry DJ, Mont MA, Aaron RK, Callaghan JJ, Rajadhyaksha AD, Urbaniak JR. Osteonecrosis of the hip: management in the 21st century. Instr Course Lect 2003; 52: 337–55.
  • Lim YW, Kim YS, Lee JW, Kwon SY. Stem cell implantation for osteonecrosis of the femoral head. Exp Mol Med 2013; 45: e61.
  • Liu Y, Liu S, Su X. Core decompression and implantation of bone marrow mononuclear cells with porous hydroxylapatite composite filler for the treatment of osteonecrosis of the femoral head. Arch Orthop Trauma Surg 2013; 133(1): 125–33.
  • Ma Y, Wang T, Liao J, Gu H, Lin X, Jiang Q, Bulsara MK, Zheng M, Zheng Q. Efficacy of autologous bone marrow buffy coat grafting combined with core decompression in patients with avascular necrosis of femoral head: a prospective, double-blinded, randomized, controlled study. Stem Cell Res Ther 2014; 5(5):115.
  • Markel DC, Miskovsky C, Sculco TP, Pellicci PM, Salvati EA. Core decompression for osteonecrosis of the femoral head. Clin Orthop Relat Res 1996; (323): 226–33.
  • McGrory BJ, York SC, Iorio R, Macaulay W, Pelker RR, Parsley BS, Teeny SM. Current practices of AAHKS members in the treatment of adult osteonecrosis of the femoral head.. J Bone Joint Surg Am 2007; 89(6): 1194–204.
  • Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ 2009; 339: b2535.
  • Mont MA, Hungerford DS. Non-traumatic avascular necrosis of the femoral head. J Bone Joint Surg Am 1995; 77(3): 459–74.
  • Saito S, Ohzono K, Ono K. Joint-preserving operations for idiopathic avascular necrosis of the femoral head. Results of core decompression, grafting and osteotomy. J Bone Joint Surg Br 1988; 70(1): 78–84.
  • Sen RK, Tripathy SK, Aggarwal S, Marwaha N, Sharma RR, Khandelwal N. Early results of core decompression and autologous bone marrow mononuclear cells instillation in femoral head osteonecrosis: a randomized control study. J Arthroplasty 2012; 27(5): 679–86.
  • Slobogean GP, Sprague SA, Scott T, Bhandari M. Complications following young femoral neck fractures. Injury 2015; 46(3): 484–91.
  • Vail TP, Covington DB. The incidence of osteonecrosis. In: (Urbaniak JR, Jones JR, eds.) Osteonecrosis: Etiology, Diagnosis, Treatment. Rosemont, IL: American Academy of Orthopedic Surgeons 1997: 43–49.
  • Yamasaki T, Yasunaga Y, Ishikawa M, Hamaki T, Ochi M. Bone-marrow-derived mononuclear cells with a porous hydroxyapatite scaffold for the treatment of osteonecrosis of the femoral head: a preliminary study. J Bone Joint Surg Br 2010; 92(3): 337–41.
  • Yan Z, Hang D, Guo C, Chen Z. Fate of mesenchymal stem cells transplanted to osteonecrosis of femoral head. J Orthop Res 2009; 27(4): 442–46.
  • Yoon TR, Song EK, Rowe SM, Park CH. Failure after core decompression in osteonecrosis of the femoral head. Int Orthop 2001; 24(6): 316–8.
  • Zhao D, Cui D, Wang B, Tian F, Guo L, Yang L, Liu B, Yu X. Treatment of early stage osteonecrosis of the femoral head with autologous implantation of bone marrow-derived and cultured mesenchymal stem cells. Bone 2012; 50(1): 325–30.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.