Exogenous fibroblast growth factors-1 and -2 do not accelerate fracture healing in the rabbit

References

• Ashhurst D E. The influence of mechanical conditions on the healing of experimental fractures in the rabbit: a microscopical study. Philos Trans R Soc Lond 1986; 313: 271–302
   PubMed Web of Science ®Google Scholar
• Ashhurst D E, Hogg J, Perren S M. A method for making reproducible fractures of the rabbit tibia. Injury 1982; 14: 236–42
   PubMed Web of Science ®Google Scholar
• Aspenberg P, Lohmander L S. Fibroblast growth factor stimulates bone formation. Bone induction studied in rats. Acta Orthop Scand 1989; 60: 473–5
   PubMed Web of Science ®Google Scholar
• Aspenberg P, Thorngren K-G, Lohmander L S. Dose-dependent stimulation of bone induction by basic fibroblast growth factor in rats. Acta Orthop Scand 1991; 62: 481–4
   PubMed Web of Science ®Google Scholar
• Crabb I D, O'Keefe R J, Puzas J E, Rosier R N. Synergistic effect of transforming growth factor-B and fibroblast growth factor on DNA synthesis in chick growth plate chondrocytes. J Bone Min Res 1990; 5: 1105–12
   PubMedGoogle Scholar
• Critchlow M A, Bland Y S, Ashhurst D E. The effects of exogenous transforming growth factor-62 on healing fractures in the rabbit. Bone 1995; 16: 521–7
   PubMed Web of Science ®Google Scholar
• Eppley B L, Doucet M, Connolly D T, Feder J. Enhancement of angiogenesis by bFGF in mandibular bone graft healing in the rabbit. J Oral Maxillofac Surg 1988; 46: 391–8
   PubMed Web of Science ®Google Scholar
• Eppley B L, Connolly D T, Winkelmann T, Sadove A M, Heuvelman D, Feder J. Free bone graft reconstruction of irradiated facial tissue: experimental effects of basic fibroblast growth factor stimulation. Plast Reconstr Surg 1991; 88: 1–11
   PubMedGoogle Scholar
• Frenkel S R, Herskovits M S, Singh I J. Fibroblast growth factor: effects on osteogenesis and chondrogenesis in the chick embryo. Acta Anat 1992; 145: 265–8
   PubMedGoogle Scholar
• Globus R K, Patterson-Buckendahl P, Gospodarowicz D. Regulation of bovine bone cell proliferation by fibroblast growth factor and transforming growth factor-ŝ. Endocrinology 1988; 123: 98–105
   PubMed Web of Science ®Google Scholar
• Globus R K, Plouet J, Gospodarowicz D. Cultured bovine bone cells synthesize basic fibroblast growth factor and store it in their extracellular matrix. Endocrinology 1989; 124: 1539–47
   PubMed Web of Science ®Google Scholar
• Hill D J, Logan A, McGanry M, De Soussa D. Control of protein and matrix-molecule synthesis in isolated ovine fetal growth-plate chondrocytes by the interactions of basic fibroblast growth factor, insulin-like growth fac-tors-I and -II, insulin and transforming growth factor-ŝ1. J Endocrinol 1992; 133: 363–73
   PubMed Web of Science ®Google Scholar
• Hiraki Y, Inoue H, Asada A, Suzuki F. Differential modulation of growth and phenotypic expression of chondrocytes in sparse and confluent cultures by growth factors in cartilage. J Bone Miner Res 1990; 5: 1077–85
   PubMedGoogle Scholar
• Horton W E, Higginbotham J D, Chandrasekhar S. Transforming growth factor-beta and fibroblast growth factor act synergistically to inhibit collagen II synthesis through a mechanism involving regulatory DNA sequences. J Cell Physiol 1989; 141: 8–15
   PubMedGoogle Scholar
• Hurley M M, Kessler M, Gronowicz G, Raisz L G. The interaction of heparin and basic fibroblast growth factor on collagen synthesis in 21-day fetal rat calvariae. Endocrinology 1992; 130: 2675–82
   PubMed Web of Science ®Google Scholar
• Hurley M M, Abreu C, Harrison J R, Lichter A C, Raisz L G, Kream B E. Basic fibroblast growth factor inhibits type I collagen gene expression in osteoblastic MC3T3-El cells. J Biol Chem 1993; 268: 5588–93
   PubMed Web of Science ®Google Scholar
• Jingushi S, Heydemann A, Kana S K, Macey L R, Bolander M E. Acidic fibroblast growth factor (aFGF) injection stimulates cartilage enlargement and inhibits cartilage gene expression in rat fracture healing. J Orthop Res 1990; 8: 364–71
   PubMed Web of Science ®Google Scholar
• Kato Y, Iwamoto M. Fibroblast growth factor is an inhibitor of chondrocyte terminal differentiation. J Biol Chem 1990; 265: 5903–9
   PubMedGoogle Scholar
• Kawaguchi H, Kurokawa T, Hanada K, Hiyama Y, Tamura M, Ogata E, Matsumoto T. Stimulation of fracture repair by recombinant human basic fibroblast growth factor in normal and streptozocin-diabetic rats. Endocrinology 1994; 135: 774–81
   PubMed Web of Science ®Google Scholar
• Lind M, Schumacker B, Soballe K, Keller J, Melsen F, Bünger C. Transforming growth factor-ŝ enhances fracture healing in rabbit tibiae. Acta Orthop Scand 1993; 64: 553–6
   PubMed Web of Science ®Google Scholar
• Mayahara H, Ito T, Nagai H, Miyajima H, Tsukuda R, Taketomi S, Mizoguchi J, Kato K. In vivo stimulation of endosteal bone formation by basic fibroblast growth factor in rats. Growth Factors 1993; 9: 73–80
   PubMed Web of Science ®Google Scholar
• Mazué G, Bertolero F, Garofano L, Brughera M, Carminati P. Experience with the preclinical assessment of basic fibroblast growth factor (bFGF). Toxicol Lett 1992; 64-65: Spec. No: 329–38
   PubMedGoogle Scholar
• Mosekilde L, Bak B. The effects of growth hormone on fracture healing in rats: a histological description. Bone 1993; 14: 19–27
   PubMed Web of Science ®Google Scholar
• McCarthy T L, Centrella M, Canalis E. Effects of fibroblast growth factors on deoxyribonucleic acid and collagen synthesis in rat parietal bone cells. Endocrinology 1989; 125: 2118–26
   PubMed Web of Science ®Google Scholar
• Nagai H, Tsukuda R, Mayahara H. Effects of basic fibroblast growth factor (bFGF) on bone formation in growing rats. Bone 1995; 16: 367–73
   PubMed Web of Science ®Google Scholar
• Nataf V, Tsagris L, Dumontier M E, Bonaventure J, Corvol M. Modulation of sulphated proteoglycan synthesis and collagen gene expression by chondrocytes grown in the presence of bFGF alone or combined with IGF-1. Reprod NutrDev 1990; 30: 331–42
   PubMedGoogle Scholar
• Nielsen H M, Andreassen T T, Ledet T, Oxlund H. Local injection of TGF-ŝ increases the strength of tibial fractures in the rat. Acta Orthop Scand 1994; 65: 37–41
   PubMed Web of Science ®Google Scholar
• Noda M, Camilliere J J. In vivo stimulation of bone formation by transforming growth factor-ŝ. Endocrinology 1989; 124: 2991–4
   PubMed Web of Science ®Google Scholar
• Shen V, Kohler G, Huang J, Huang S S, Pack W A. An acidic fibroblast growth factor stimulates DNA synthesis, inhibits collagen and alkaline phosphatase synthesis and induces resorption in bone. Bone Miner 1989; 7: 205–19
   PubMedGoogle Scholar
• Suzuki F. Effects of various growth factors on a chondrocyte differentiation model. Prostate cancer and bone metastasis, J P Karr. Plenum Press, New York 1992; 101–6
   Google Scholar
• Wang J S, Aspenberg P. Basic fibroblast growth factor increases allograft incorporation. Acta Orthop Scand 1994; 65: 27–31
   PubMed Web of Science ®Google Scholar