184
Views
29
CrossRef citations to date
0
Altmetric
Original Article

Longer survival of rat limb allograft: Combined immunosuppression of FK-506 and 15-deoxyspergualin

, , , &
Pages 581-585 | Received 25 Jan 1997, Accepted 01 Jul 1997, Published online: 08 Jul 2009

References

  • Arai K, Hotokebuchi T, Miyahara H. Limb allografts in rats immunosuppressed with FK-506. Transplantation 1989; 48: 782–6
  • Black K S, Hewitt C W, Fraser L A. Comas and damian in the laboratory. N Eng J Med 1982; 306: 368–9
  • Borel J F, Feurer C, Gubler H U, Stahlin H. Biological effects of Cyclosporin A: A new anti-lymphocytic agent. Agents Actions 1976; 6: 468–75
  • Carobbi A, Arenada D, Patselas T. Effect of splenectomy in combination with FK-506 and 15-deoxyspergualin on cardiac xenograft survival. Transplant Proc 1993; 23: 549–50
  • Collier D, Calne R, Thiru S. 15-deoxyspergualin in experimental dog renal allografts. Transplant Proc 1988; 20: 240–1
  • Doi K. Homotransplantation of limbs in rats. Plast Reconstr Surg 1979; 64: 613–21
  • Fealy M J, Umansky W S, Bickel K D, Nino J J. Efficacy of rapamycin and FK-506 in prolonging rat hind limb allograft survival. Ann Surg 1994; 219: 88–93
  • Goto T, Kino T, Hatanaka H. Discovery of FK-506, a novel immunosuppressant isolated from Streptomyces tsuku-baensis. Transplant Proc 1987; 19: 4–8
  • Hotokebuchi T, Arai K, Arita C, Sugioka Y, Kaibara N. Limb allografts in rats immunosuppressed with Cyclosporine: as a whole joint allograft. Plast Reconstr Surg 1989; 83: 1027–36
  • Kuroki H, Ishida O, Ikuta Y. Morphological and immunological analysis of rats with long-term surviving limb allografts induced by a short course of FK-506 or Cyclosporine. Transplant Proc 1991; 23: 516–20
  • Min Z, Jones N F. Limb transplantation in rats: immunosuppression with FK-506. J Hand Surg 1995; 20A: 77–87
  • Muramatsu K, Doi K, Kawai S. Vascularized allogeneic joint, muscle and peripheral nerve transplantation. Clin Orthop 1995; 320: 194–204
  • Nakajima K, Sakamoto K, Ochiai T. Prolongation of cardiac xenograft survival in rats treated with 15-deoxyspergualin alone and in combination with FK-506. Transplantation 1988; 45: 1146–51
  • Nemoto K, Sugawara Y, Mae T. Therapeutic activity of deoxyspergualin in comparison with cyclosporin A and its combined use with cyclosporin A and prednisolone in highly allogeneic skin transplantation in the rat. Agents Actions 1992; 36: 306–11
  • Schubert G, Stoffregen C, Loske G. Synergistic effect of 15-deoxyspergualin and Cyclosporin A in pancreatic transplantation. Transplant Proc 1989; 21: 1096
  • Suzuki S, Kanashiro M, Amemiya H. Effect of 15-deoxy-spergualin on rejection detected by 31P nuclear magnetic resonance spectroscopy and in vivo mechanisms of action in rat heart transplantation. Deoxyspergualin immunosuppressive properties, H Amemiya. Appleton & Lange, New York 1989; 9–10
  • Tufveson G, Gannedahl G. Deoxyspergualin- A different and intriguing immunosuppressant. Transplant Proc 1994; 26: 3029–39
  • Umezawa H, Moriguchi M, Takeuchi T. Suppression of tissue graft rejection by spergualin. J Antibiot 1985; 38: 283–93
  • Walter P, Dickenite G, Feifel G, Thies J. Deoxyspergualin induces tolerance in allogeneic kidney transplantation. Transplant Proc 1987; 19: 3980–1
  • Walter P, Menger J, Dickenite G. Prolongation of graft survival in allogeneic limb transplantation by 15-deoxysper-gualin. Deoxyspergualin immunosuppressive properties, H Amemiya. Appleton & Lange, New York 1989; 41–3
  • Yuh D D, Morris R E. The immunopharmacology of immunosuppression by 15-deoxyspergualin. Transplantation 1993; 55: 578–91

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.