Methylenetetrahydrofolate reductase 677 C->T polymorphism: A link between birth weight and insulin resistance in obese adolescents

References

• Bokor S, Frelut ML, Vania A . Prevalence of metabolic syndrome in European obese children. Int J Pediatr Obes. 2008;3 Suppl 2:3–8.
   Web of Science ®Google Scholar
• Ekelund U, Ong KK, Linne Y . Association of weight gain in infancy and early childhood with metabolic risk in young adults. J Clin Endocrinol Metab. 2007;92:98–103.
   PubMed Web of Science ®Google Scholar
• Ong KK. Size at birth, postnatal growth and risk of obesity. Horm Res. 2006;65 Suppl 3:65–9.
   PubMedGoogle Scholar
• Harder T, Rodekamp E, Schellong K . Birth weight and subsequent risk of type 2 diabetes: a meta-analysis. Am J Epidemiol. 2007;165:849–57.
   PubMed Web of Science ®Google Scholar
• Lunde A, Melve KK, Gjessing HK . Genetic and environmental influences on birth weight, birth length, head circumference, and gestational age by use of population-based parent-offspring data. Am J Epidemiol. 2007;165:734–41.
   PubMed Web of Science ®Google Scholar
• Le Stunff C, Bougneres P. Early changes in postprandial insulin secretion, not in insulin sensitivity, characterize juvenile obesity. Diabetes. 1994;43:696–702.
   PubMed Web of Science ®Google Scholar
• Dos Santos C, Fallin D, Le Stunff C . INS VNTR is a QTL for the insulin response to oral glucose in obese children. Physiol Genomics. 2004;16:309–13.
   PubMed Web of Science ®Google Scholar
• Le Fur S, Auffray C, Letourneur F . Heterogeneity of class I INS VNTR allele association with insulin secretion in obese children. Physiol Genomics. 2006;25:480–4.
   PubMed Web of Science ®Google Scholar
• Hall JG, Solehdin F. Folate and its various ramifications. Adv Pediatr. 1998;45:1–35.
   PubMedGoogle Scholar
• Goyette P, Sumner JS, Milos R . Human methylenetetrahydrofolate reductase: isolation of cDNA mapping and mutation identification. Nat Genet. 1994;7:551.
   PubMed Web of Science ®Google Scholar
• Goyette P, Frosst P, Rosenblatt DS . Seven novel mutations in the methylenetetrahydrofolate reductase gene and genotype/phenotype correlations in severe methylenetetrahydrofolate reductase deficiency. Am J Hum Genet. 1995;56: 1052–9.
   PubMed Web of Science ®Google Scholar
• Gueant-Rodriguez RM, Gueant JL, Debard R . Prevalence of methylenetetrahydrofolate reductase 677T and 1298C alleles and folate status: a comparative study in Mexican, West African, and European populations. Am J Clin Nutr. 2006;83:701–7.
   PubMed Web of Science ®Google Scholar
• Donnelly JG. Folic acid. Crit Rev Clin Lab Sci. 2001;38: 183–223.
   PubMed Web of Science ®Google Scholar
• Lucock M, Yates Z. Folic acid - vitamin and panacea or genetic time bomb? Nat Rev Genet. 2005;6:235–40.
   PubMed Web of Science ®Google Scholar
• Sinclair KD, Allegrucci C, Singh R . DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status. Proc Natl Acad Sci U S A. 2007;104:19351–6.
   PubMed Web of Science ®Google Scholar
• Glanville T, Yates Z, Ovadia L . Fetal folate C677T methylenetetrahydrofolate reductase gene polymorphism and low birth weight. J Obstet Gynaecol. 2006;26:11–4.
   PubMedGoogle Scholar
• Lewis SJ, Lawlor DA, Nordestgaard BG . The methylenetetrahydrofolate reductase C677T genotype and the risk of obesity in three large population-based cohorts. Eur J Endocrinol. 2008;159:35–40.
   PubMed Web of Science ®Google Scholar
• Brulhart MC, Dussoix P, Ruiz J . The (Ala-Val) mutation of methylenetetrahydrofolate reductase as a genetic risk factor for vascular disease in non-insulin-dependent diabetic patients. Am J Hum Genet. 1997;60:228–9.
   PubMed Web of Science ®Google Scholar
• Frelut ML, Emery-Fillon N, Guilland JC . Alanine amino transferase concentrations are linked to folate intakes and methylenetetrahydrofolate reductase polymorphism in obese adolescent girls. J Pediatr Gastroenterol Nutr. 2006;43: 234–9.
   PubMed Web of Science ®Google Scholar
• Angulo P. Nonalcoholic fatty liver disease. N Engl J Med. 2002;346:1221–31.
   PubMed Web of Science ®Google Scholar
• Matthews DR, Hosker JP, Rudenski AS . Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–9.
   PubMed Web of Science ®Google Scholar
• Barker DJ. Intrauterine programming of adult disease. Mol Med Today. 1995;1:418–23.
   PubMedGoogle Scholar
• Le Stunff C, Dechartres A, Miraglia Del Giudice E . A single-nucleotide polymorphism in the p110beta gene promoter is associated with partial protection from insulin resistance in severely obese adolescents. J Clin Endocrinol Metab. 2008;93:212–5.
   PubMed Web of Science ®Google Scholar
• Le Stunff C, Fallin D, Schork NJ . The insulin gene VNTR is associated with fasting insulin levels and development of juvenile obesity. Nat Genet. 2000;26:444–6.
   PubMed Web of Science ®Google Scholar
• Gluckman PD, Hanson MA, Cooper C . Effect of in utero and early-life conditions on adult health and disease. N Engl J Med. 2008;359:61–73.
   PubMed Web of Science ®Google Scholar
• Wilson PW, Umpierrez GE. Insulin resistance and pubertal changes. J Clin Endocrinol Metab. 2008;93:2472–3.
   PubMed Web of Science ®Google Scholar
• Morino K, Petersen KF, Shulman GI. Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction. Diabetes. 2006;55 Suppl 2:S9–15.
   PubMed Web of Science ®Google Scholar
• Dao HH, Frelut ML, Peres G . Effects of a multidisciplinary weight loss intervention on anaerobic and aerobic aptitudes in severely obese adolescents. Int J Obes Relat Metab Disord. 2004;28:870–8.
   PubMed Web of Science ®Google Scholar
• Le Fur S, Le Stunff C, Bougneres P. Increased insulin resistance in obese children who have both 972 IRS-1 and 1057 IRS-2 polymorphisms. Diabetes. 2002;51 Suppl 3:S304–7.
   PubMed Web of Science ®Google Scholar
• Ong KK, Emmett P, Northstone K . Infancy weight gain predicts childhood body fat and age at menarche in girls. J Clin Endocrinol Metab. 2009;94(5):1527–32.
   PubMed Web of Science ®Google Scholar
• Vidailhet M, Bocquet A, Bresson JL . [Folic acid and prevention of neural tube closure defects: the question is not solved yet]. Arch Pediatr. 2008;15:1223–31.
   PubMed Web of Science ®Google Scholar
• Nurk E, Tell GS, Refsum H . Associations between maternal methylenetetrahydrofolate reductase polymorphisms and adverse outcomes of pregnancy: the Hordaland Homocysteine Study. Am J Med. 2004;117:26–31.
   PubMed Web of Science ®Google Scholar
• Hernandez-Diaz S, Wu XF, Hayes C . Methylenetetrahydrofolate reductase polymorphisms and the risk of gestational hypertension. Epidemiology. 2005;16:628–34.
   PubMed Web of Science ®Google Scholar
• Relton CL, Pearce MS, Burn J . An investigation of folate-related genetic factors in the determination of birthweight. Paediatr Perinat Epidemiol. 2005;19:360–7.
   PubMed Web of Science ®Google Scholar
• Yajnik CS, Deshpande SS, Jackson AA . Vitamin B12 and folate concentrations during pregnancy and insulin resistance in the offspring: the Pune Maternal Nutrition Study. Diabetologia. 2008;51:29–38.
   PubMed Web of Science ®Google Scholar
• Klerk M, Verhoef P, Clarke R . MTHFR 677C->T polymorphism and risk of coronary heart disease: a meta-analysis. JAMA. 2002;288:2023–31.
   PubMed Web of Science ®Google Scholar
• Lewis SJ, Ebrahim S, Davey Smith G. Meta-analysis of MTHFR 677C->T polymorphism and coronary heart disease: does totality of evidence support causal role for homocysteine and preventive potential of folate? BMJ. 2005; 331:1053.
   PubMed Web of Science ®Google Scholar
• Cardo E, Monros E, Colome C . Children with stroke: polymorphism of the MTHFR gene, mild hyperhomocysteinemia, and vitamin status. J Child Neurol. 2000;15: 295–8.
   PubMed Web of Science ®Google Scholar
• Tounian P, Aggoun Y, Dubern B . Presence of increased stiffness of the common carotid artery and endothelial dysfunction in severely obese children: a prospective study. Lancet. 2001;358:1400–4.
   PubMed Web of Science ®Google Scholar
• Dunger DB, Petry CJ, Ong KK. Genetic variations and normal fetal growth. Horm Res. 2006;65 Suppl 3:34–40.
   PubMedGoogle Scholar