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ORIGINAL ARTICLES

Pre-hospital treatment of STEMI patients. A scientific statement of the Working Group Acute Cardiac Care of the European Society of Cardiology

Acute Coronary Syndromes

, , , , , , , , , , , , , , , , , , , , , , , , , , & show all
Pages 56-67 | Received 02 Mar 2011, Accepted 06 Apr 2011, Published online: 31 May 2011

References

  • Jacobs AK, Antman EM, Ellrodt G, Faxon DP, Gregory T, Mensah GA, . American Heart Association's Acute Myocardial Infarction Advisory Working Group. Recommendation to develop strategies to increase the number of ST-segment-elevation myocardial infarction patients with timely access to primary percutaneous coronary intervention. Circulation. 2006;113:2152–63.
  • Jha P, Deboer D, Sykora K, Naylor CD. Outcomes of thrombolysis trial participants and nonparticipants: A population-based comparison J Am Coll Cardiol. 1996;27:1335–42.
  • Every NR, Frederick PD, Robinson M, Sugarman J, Bowlby L, Barron HV. A comparison of the National Registry of Myocardial Infarction 2 with the Cooperative Cardiovascular Project. J Am Coll Cardiol. 1999;33:1886–94.
  • Zeymer U, Senges J. Why do we need prospective registries in patients with acute myocardial infarction? Eur Heart J. 2003;24: 1611–2.
  • Huber K, De Caterina R, Kristensen SD, Verheugt FWA, Montalescot G, Badimon Maestro L, , for the Task Force on Pre-hospital Reperfusion Therapy of the Working Group on Thrombosis of the ESC. Pre-hospital reperfusion therapy: a strategy to improve therapeutic outcome in patients with ST-elevation myocardial infarction. Eur Heart J. 2005;26:2063–74.
  • Bassand JP, Danchin N, Filippatos G, Gitt A, Hamm C, Silber S, . Implementation of reperfusion therapy in acute myocardial infarction. A policy statement from the European Society of Cardiology. Eur Heart J. 2005;26:2733–41.
  • Boersma E. and The Primary Coronary Angioplasty versus Thrombolysis (PCAT)-2 Trialists’ Collaborative Group. Does time matter? A pooled analysis of randomized clinical trials comparing primary percutaneous coronary intervention and in- hospital fibrinolysis in acute myocardial infarction. Eur Heart J. 2006;27:779–88.
  • Nallamothu BK, Krumholz HM, Ko DT, LaBresh A, Rathore S, Roe MT, . Development of systems of care for ST-elevation myocardial infarction patients: Gaps, barriers, and implications. Circulation 2007;116:e68–e72.
  • Nallamothu BK, Bates ER, Herrin J, Wang Y, Bradley EH, Krumholz HM, for the NRMI Investigators. Times to treatment in transfer patients undergoing primary percutaneous coronary intervention in the United States: National Registry of Myocardial Infarction (NRMI)—3/4 analysis. Circulation. 2005;111: 761–7.
  • Fox K, Steg P, Eagle K, Goodman S, Anderson F, Granger C, . for the GRACE Investigators. Decline in rates of death and heart failure in acute coronary syndromes, 1999–2006. JAMA. 2007;297: 1892–900.
  • Saia F, Marrozzini C, Guastaroba P, Ortolani P, Palmerini T, Pavesi PC, . Lower long-term mortality within a regional system of care for ST-elevation myocardial infarction. Acute Card Care. 2010; 12:42–50.
  • Horne R, James D, Petrie K, Weinman J, Vincent R. Patients’ interpretation of symptoms as a cause of delay in reaching hospital during acute myocardial infarction. Heart. 2000;83:388–93.
  • McGinn AP, Rosamond WD, Goff DC Jr, Taylor HA, Miles JS, Chambless L. Trends in pre-hospital delay time and use of emergency medical services for acute myocardial infarction: Experience in 4 US communities from 1987–2000. Am Heart J. 2005;150:392–400.
  • Kainth A, Hewitt A, Sowden A, Duffy S, Pattenden J, Lewin R, . Systematic review of interventions to reduce delay in patients with suspected heart attack. Emerg Med J. 2004;21:506–8.
  • Luepker RV, Raczynski JM, Osparian S, Goldberg RJ, Finnegan JR, Hedges JR, . for the REACT study group. Effect of a community intervention on patients delay and emergency medical service in acute coronary heart disease. The rapid early action for coronary treatment (REACT) trial. JAMA. 2000;284:60–7.
  • Ting HH, Krumholz HM, Bradley EH, Cone DC, Curtis JP, Drew BJ, . American Heart Association Interdisciplinary Council on Quality of Care and Outcomes Research, Emergency Cardiovascular Care Committee; American Heart Association Council on Cardiovascular Nursing; American Heart Association Council on Clinical Cardiology. Implementation and integration of prehospital ECGs into systems of care for acute coronary syndrome: A scientific statement from the American Heart Association Interdisciplinary Council on Quality of Care and Outcomes Research, Emergency Cardiovascular Care Committee, Council on Cardiovascular Nursing, and Council on Clinical Cardiology. Circulation. 2008;118:1066–79.
  • Chevalier V, Alauze C, Soland V, Cuny J, Goldstein P. Impact of a public-directed media campaign on emergency call to a mobile intensive care units center for acute chest pain. Ann Cardiol Angeiol. (Paris) 2003;52:150–8.
  • Kalla K, Christ G, Karnik R, Malzer R, Norman G, Prachar H, . Implementation of guidelines improves the standard of care: The Viennese registry on reperfusion strategies in ST-elevation myocardial infarction (Vienna STEMI registry). Circulation. 2006; 113:2398–405.
  • Wilson S, Cooke M, Morrell R, Bridge P, Allan T, Emergency medicine research group (EMeRG). A systematic review of the evidence supporting the use of priority dispatch of emergency ambulances. Prehosp Emerg Care. 2002;6:42–49.
  • Gellerstedt M, Bang A, Merlitz J. Could a computerized-based system including a prevalence function support emergency medical systems and improve the allocation of life support level? Eur J Emerg Med. 2006;13:290–4.
  • Salerno SM, Alguire PC, Waxman HS. Competency in interpretation of 12-lead electro-cardiograms: A summary and appraisal of published evidence. Ann Intern Med. 2003;138:751–60.
  • Quinn T, Butters A, Todd I. Implementing paramedic thrombolysis: An overview. Accid Emerg Nurs. 2002;10:189–96.
  • Widimsky P, Wijns W, Fajadet J, de Belder M, Knot J, Aaberge L, . Reperfusion therapy for ST elevation acute myocardial infarction in Europe: Description of the current situation in 30 countries. Eur Heart J. 2010;31:943–57.
  • Rasmussen CH, Munck A, Kragstrup J, Haghfelt T. Patient delay from onset of chest pain suggesting acute coronary syndrome to hospital admission. Scand Cardiovasc J. 2003;37:183–6. ACSIS—Acute Coronary Syndromes Israeli Survey.
  • ACSIS-2008 National Survey. Survey findings and temporal trends. Available at http://www.e-med.co.ol/e-med/mew/usersite/presen tations/acsis2006/acsis0409book.asp (accessed 29 April 2011).
  • National EMS Advisory Council. EMS makes a difference: Improved clinical outcomes and downstream healthcare savings. Available at http://www.ems.gov/pdf/nemsac-dec2009.pdf (accessed 29 April 2011).
  • Van de Werf F, Bax J, Betriu A, Blomstrom-Lundqvist C, Crea F, Falk V, . Management of acute myocardial infarction in patients presenting with persistent ST-segment elevation: The task force on the management of st-segment elevation acute myocardial infarction of the European Society of Cardiology. Eur Heart J. 2008;29:2909–45.
  • McLean S, Egan G, Connor P, Flaplan AD. Collaborative decision making between paramedics and CCU nurses based on 12-lead ECG telemetry expedites the delivery of thrombolysis in ST-elevation myocardial infarction. Emerg Med J. 2008;25:370–4.
  • Terkelsen CJ, Lassen JF, Nørgaard BL, Gerdes JC, Poulsen SH, Bendix K, . Reduction of treatment delay in patients with ST-elevation myocardial infarction: Impact of pre-hospital diagnosis and direct referral to primary percutaneous coronary intervention. Eur Heart J. 2005;26:770–7.
  • Bradley EH, Roumanis SA, Radford MJ, Webster TR, McNamara RL, Mattera JA, . Achieving door-to-balloon times that meet quality guidelines: how do successful hospitals do it? J Am Coll Cardiol. 2005;46:1236–41.
  • Afolabi BA, Novaro GM, Pinski SL, Fromkin KR, Bush HS. Use of the prehospital ECG improves door-to-balloon times in ST segment elevation myocardial infarction irrespective of time of day or day of week. Emerg Med J. 2007;24:588–91.
  • Le May MR, Davies RF, Dionne R, Maloney J, Trickett J, So D, . Comparison of early mortality of paramedic-diagnosed ST-segment elevation myocardial infarction with immediate transport to a designated primary percutaneous coronary intervention center to that of similar patients transported to the nearest hospital. Am J Cardiol. 2006;98:1329–33.
  • Welsh RC, Chang W, Goldstein P, Adgey J, Granger CB, Verheugt F, ; ASSENT-3 PLUS investigators. Time to treatment and the impact of a physician on prehospital management of acute ST elevation myocardial infarction: insights from the ASSENT-3 PLUS trial. Heart 2005;91:1400–6.
  • Bøtker MT, Bakke SA, Christensen EF. A systematic review of controlled studies: Do physicians increase survival with prehospital treatment? Scand J Trauma Resusc Emerg Med. 2009;17:12.
  • Christenszen EF, Melchiorsen H, Kilsmark J, Foldspang A, Søgaard J. Anesthesiologists in prehospital care make a difference to certain groups of patients. Acta Anaesthesiol Scand. 2003;47:146–52.
  • Löwel H, Meisinger C, Heier M, Hörmann A. The population-based Acute Myocardial infarction (AMI) registry of the MONICA/KORA study region of Augsburg. Gesundheitswesen 2005;67:S31–7.
  • Huikuri HV, Pekka Raatikainen MJ, Moerch-Joergensen R, Hartikainen J, Virtanen V, Boland J, ., for the cardiac arrhythmias and risk stratification after myocardial infarction (CARISMA) study group. Prediction of fatal and near-fatal cardiac arrhythmia events in patients with depressed left ventricular function after an acute myocardial infarction. Eur Heart J. 2009; 30:689–98.
  • McClure A, Nichol G. Toward efficient improvements in resuscitation for cardiac arrest. Circulation. 2010;122:567–9.
  • Iwami T, Nichol G, Hiraide A, Hayashi Y, Nishiuchi T, Kajino K, . Continuous improvements in ‘chain of survival’ increased survival after out-of-hospital cardiac arrest: A large-scale population-based study. Circulation. 2009;119:728–34.
  • O'Keeffe C, Nicholl J, Turner J, Goodacre S. Role of ambulance response times in the survival of patients with out-of-hospital cardiac arrest. Emerg Med J. doi:10.1136/emj.2009.086363.
  • Hollenberg J, Herlitz J, Lindqvist J, Riva G, Bohm K, Rosenqvist M, . Improved survival after out-of-hospital cardiac arrest is associated with an increase in proportion of emergency crew-witnessed cases and bystander cardiopulmonary resuscitation. Circulation. 2008;118:389–96.
  • Nichol G, Aufderheide TP, Eigel B, Neumar RW, Lurie KG, Bufalino VJ, . on behalf of the American Heart Association emergency cardiovascular care Committee, Council on atherosclerosis, thrombosis and vascular biology, Council on cardiopulmonary, critical care, perioperative and resuscitation, Council on cardiovascular nursing, Council on clinical cardiology, advocacy Committee, and Council on quality of care and outcome research. Regional systems of care for out-of-hospital cardiac arrest. A policy statement from the American Heart Association. Circulation. 2010;121:709–29.
  • Dudas K, Lappas G, Stewart S, Rosengren A. Trends in out-of-hospital deaths due to coronary heart disease in Sweden (1991–2006). Circulation. 2011;123:46–52.
  • Goraya TY, Jacobsen SJ, Kottke TE, Frye RL, Weston SA, Roger VL. Coronary heart disease death and sudden cardiac death: A 20-year population-based study. Am J Epidemiol. 2003;157:763–70.
  • Virmani R, Kolodgie FD, Burke AP, Farb A, Schwartz SM. Lessons from sudden coronary death: A comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol. 2000;20:1262–75.
  • Gheeraert PJ, De Buyzere ML, Taeymans YM, Gillebert TC, Henriques JPS, De Backer G, . Risk factors for primary ventricular fibrillation during acute myocardial infarction: A systematic review and meta-analysis. Eur Heart J. 2006;27:2499–510.
  • Scholz KH, Tebbe U, Herrmann C, Wojcik J, Lingen R, Chemnitius JM, . Frequency of complications of cardiopulmonary resuscitation after thrombolysis during acute myocardial infarction. Am J Cardiol. 1992;69:724–8.
  • Padosch SA, Motsch J, Böttiger BW. Thrombolysis during cardiopulmonary resuscitation. An Aesthesist. 2002;51:516–32.
  • Böttiger B, Arntz HR, Chamberlain D, Bluhmki E, Belmans A, Danays T, . Thrombolysis during resuscitation for out-of-hospital cardiac arrest. N Engl J Med. 2008;359:2651–62.
  • Spaulding CM, Joly LM, Rosenberg A, Monchi M, Weber SN, Dhainaut JF, . Immediate coronary angiography in survivors of out-of-hospital cardiac arrest. N Engl J Med. 1997;336:1629–33.
  • Dumas F, Cariou A, Manzo-Silberman S, Grimaldi D, Vivien B, Rosencher J, . Immediate percutaneous coronary intervention is associated with better survival after out-of-hospital cardiac arrest: Insights from the PROCAT (Parisian region out of hospital cardiac arrest) registry. Circ Cardiovasc Interv. 2010;3:200–7.
  • Arntz HR, Wenzel V, Dissmann R, Marschalk A, Breckwoldt J, Müller D. Out-of-hospital thrombolysis during cardiopulmonary resuscitation in patients with high likelihood of ST-elevation myocardial infarction. Resuscitation 2008;76:180–4.
  • Neumar RW, Nolan JP, Adrie C, Aibiki M, Berg RA, Bottiger BW, . Post cardiac arrest syndrome. Epidemiology, pathophysiology, treatment and prognostication. A consensus statement from the Interventional Liaison Committee on Resuscitation (European Resuscitation Council, Heart and Stroke Foundation of Canada, InterAmerican Foundation, Resuscitation Council of Asia, and the Resuscitation Council of Southern Africa); the American Heart Association Emergency Cardiovascular Core Committee; the Council of Cardiovascular Surgery and Anaesthesia; the Council of Cardiopulmonary, Perioperative and Critical Care; the Council of Clinical Cardiology; and the Stroke Council. Circulation 2008;118:2452–83.
  • Arrich J, Holzer M, Herkner H, Müllner M. Hypothermia for neuroprotection in adults after cardiopulmonary resuscitation. Cochrane Database Syst Rev. 2009;4:CD004128.
  • Rokos IC, French WJ, Mattu A, Nichol G, Farkout ME, Reiffel J, . Appropriate cardiac cath lab activation: Optimizing electrocardiogram interpretation and clinical decision-making for acute ST-elevation myocardial infarction. Am Heart J. 2010;160: 995–1003.
  • Sejersten M, Sillesen M, Hansen PR, Nielsen SL, Nielsen H, Trautner S, . Effect on treatment delay of prehospital teletransmission of 12-lead electrocardiogram to a cardiologist for immediate triage and direct referral of patients with ST-segment elevation acute myocardial infarction to primary percutaneous coronary intervention. Am J Cardiol. 2008;101:941–6.
  • Diercks DB, Kontos MC, Chen AY, Pollack CV Jr, Wiviott SD, Rumsfeld JS, ., on behalf of the NCDR ACTION Registry participants. Utilization and impact of pre-hospital electrocardiograms for patients with acute ST-segment elevation myocardial infarction: Data from the NCDR (National Cardiovascular Data Registry) ACTION (acute coronary treatment and intervention outcomes network) registry. J Am Coll Cardiol. 2009;53:161–6.
  • Jacobs AK, Antman EM, Faxon DP, Gregory T, Solis P. Development of systems of care for ST-elevation myocardial infarction patients. Executive summary. Endorsed by Aetna, the American ambulance association , the American association of critical-care nurses, the American college of emergency physicians, the emergency nurses association, the national association of emergency medical technicians, the national association of EMS physicians, the national association of State EMS officials, the national EMS information system project, the national rural health association, the society for cardiovascular angiography and interventions, the society of chest pain centers and United Health networks. Circulation. 2007;116:217–30.
  • Daudelin DH, Sayah AJ, Kwong M, Restuccia MC, Porcaro WA, Ruthazer R, . Improving use of prehospital 12-lead ECG for early identification and treatment of acute coronary syndrome and ST-elevation myocardial infarction. Circ Cardiovasc Qual Outcomes. 2010;3:316–23.
  • Björklund E, Stenestrand U, Lindbäck J, Svensson L, Wallentin L, Lindahl B. Pre-hospital thrombolysis delivered by paramedics is associated with reduced time delay and mortality in ambulance-transported real-life patients with ST-elevation myocardial infarction. Eur Heart J. 2006; 27:1146–52.
  • Wagner GS, Macfarlane P, Wellens H, Josephson M, Gorgels A, Mirvis DM, . American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; American College of Cardiology Foundation; Heart Rhythm Society. AHA/ACCF/HRS recommendations for the standardization and interpretation of the electrocardiogram: Part VI: Acute ischaemia/infarction. Circulation. 2009;119:e262–70.
  • Pedersen SH, Galatius S, Hansen PR, Mogelvang R, Abildstrom SZ, Sørensen R, . Field triage reduces treatment delay and improves long-term clinical outcome in patients with acute ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention. J Am Coll Cardiol. 2009;54: 2296–302.
  • Le May MR, Dionne R, Maloney J, Poirier P. The role of paramedics in a primary PCI program for ST-elevation myocardial infarction. Progress Cardiovasc Dis. 2010;53:183–7.
  • Sillesen M, Sejersten M, Strange S, Nielsen SL, Lippert F, Clemmensen P. Referral of patients with ST-segment elevation acute myocardial infarction directly to the catheterization suite based on prehospital teletransmission of 12-lead electrocardiogram. J Electrocardiol. 2008;41:49–53.
  • Ting HH, Rihal CS, Gersh BJ, Haro LH, Bjerke CM, Lennon RI, . Regional systems of care to optimize timeliness of reperfusion therapy for ST-elevation myocardial infarction: The Mayo Clinic STEMI Protocol. Circulation. 2007;116:729–36.
  • Rokos IC, Larson DM, Henry TD, Koening WJ, Eckstein M, French WJ, . Rationale for establishing regional ST-elevation myocardial infarction receiving center (SRC) networks. Am Heart J. 2006;152:661–7.
  • Solis P, Amsterdam EA, Bufalino V, Drew BJ, Jacobs AK. Development of systems of care for ST-elevation myocardial infarction patients: Policy recommendations. Circulation. 2007;116:e73–6.
  • Bradley EH, Herrin J, Wang Y, Barton BA, Webster TR, Mattera JA. Strategies for reducing the door-to-balloon time in acute myocardial infarction. N Engl J Med. 2006;355:2308–20.
  • Schiele F, Hochadel M, Tubaro M, Meneveau N, Wojakowski W, Gierlotka M, . Reperfusion strategy in Europe: Temporal trends in performance measures for reperfusion therapy in ST-elevation myocardial infarction. Eur Heart J. 2010;31:2614–24.
  • Saia F, Marozzini C, Ortolani P, Palmerini T, Guastaroba P, Cortesi P, . Optimization of therapeutic strategies for ST-elevation acute myocardial infarction: the impact of a territorial network on reperfusion therapy and mortality. Heart. 2009;95:370–6.
  • Ortolani P, Marzocchi A, Marrozzini C, Palmerini T, Saia F, Baldazzi F, . Usefulness of prehospital triage in patients with cardiogenic shock complicating ST-elevation myocardial infarction treated with primary percutaneous coronary intervention. Am J Cardiol. 2007;100:787–92.
  • Henry TD, Sharkey SW, Burke MN, Chavez IJ, Graham KJ, Henry CR, . A regional system to provide timely access to percutaneous coronary intervention for ST-elevation myocardial infarction. Circulation. 2007;116:721–8.
  • Andersen HR, Nielsen TT, Rasmussen K, Thuesen L, Kelbaek H, Thayssen P, . for the DANAMI-2 investigators. A comparison of coronary angioplasty with fibrinolytic therapy in acute myocardial infarction. N Engl J Med. 2003;349;733–42.
  • Nielsen PH, Maeng M, Busk M, Mortensen LS, Kristensen SD, Nielsen TT, ., for the DANAMI-2 investigators. Primary angioplasty versus fibrinolysis in acute myocardial infarction. Long-term follow-up in the Danish acute myocardial infarction 2 trial. Circulation. 2010;121:1484–91.
  • Sørensen JT, Terkelsen CJ, Nørgaard BL, Trautner S, Hansen TM, Bøtker HE, . Urban and rural implementation of pre-hospital diagnosis and direct referral for primary percutaneous coronary intervention in patients with acute ST-elevation myocardial infarction. Eur Heart J. 2011;32:430–6.
  • Pinto D, Kirtane A, Nallamothu B, Murphy S, Cohen D, Laham R, . Hospital delays in reperfusion for ST-elevation myocardial infarction. Implications when selecting a reperfusion strategy. Circulation. 2006;114:2019–25.
  • Tarantini G, Razzolini R, Napodano M, Bilato C, Ramondon A, Iliceto S. Acceptable reperfusion delay to prefer primary angioplasty over fibrin-specific thrombolytic therapy is affected (mainly) by the patient's mortality risk: 1 h does not fit all. Eur Heart J. 2010;31:676–83.
  • Rokos IC, French WJ, Koenig WJ, Stratton SJ, Nightswonger B, Strunk B, . Integration of pre-hospital electrocardiograms and ST-elevation myocardial infarction receiving center (SRC) networks. Impact of door-to-balloon times across 10 independent regions. J Am Coll Cardiol Interv. 2009;2:339–46.
  • Mandelzweig L, Battler A, Boyko V, Bueno H, Danchin N, Filippatos G, . on behalf of the Euro Heart Survey Investigators. The second Euro Heart Survey on acute coronary syndromes: characteristics, treatment, and outcome of patients with ACS in Europe and the Mediterranean Basin in 2004. Eur Heart J. 2006; 27:2285–93.
  • Eagle KA, Nallamothu BK, Mehta RH, Granger CB, Steg PG, van de Werf F, ., for the Global Registry of Acute Coronary Events (GRACE) Investigators. Trends in acute reperfusion therapy for ST-segment elevation myocardial infarction from 1999 to 2006: We are getting better but we have got a long way to go. Eur Heart J. 2008;29:609–17.
  • Silber S, Albertsson P, Aviles F, Camici PG, Colombo A, Hamm C, . Guidelines for percutaneous coronary interventions. The task force for percutaneous coronary interventions of the European Society of Cardiology. Eur Heart J. 2005;26:804–47.
  • Keeley EC, Boura JA, Grines CL. Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction: A quantitative review of 23 randomized trials. Lancet. 2003; 361:13–20.
  • Terkelsen CJ, Sørensen JT, Maeng M, Jensen LO, Tilsted M-H, Trautner S, . System delay and mortality among patients with STEMI treated with primary percutaneous coronary intervention. JAMA. 2010;304:763–71.
  • Stenestrand U, Lindbäck J, Wallentin L, for the RIKS-HIA Registry. Long-term outcome of primary percutaneous coronary intervention vs prehospital and in-hospital thrombolysis for patients with ST-elevation myocardial infarction. JAMA. 2006;296:1749–56.
  • The European Myocardial Infarction Project group. Prehospital thrombolytic therapy in patients with suspected acute myocardial infarction. N Engl J Med. 1993;329:383–9.
  • Morrison L, Verbeek P, McDonald A, Sawadsky B, Cook D. Mortality and prehospital thrombolysis for acute myocardial infarction. A meta-analysis. JAMA. 2000;283:2686–92.
  • Lamfers EJP, Hooghoudt TEH, Hertzberger DP, Schut A, Stolwijk PWJ, Verheugt FWA. Abortion of acute ST segment elevation myocardial infarction after reperfusion: Incidence, patients’ characteristics, and prognosis. Heart 2003;89:496–501.
  • Fibrinolytic Therapy Trialists’ (FTT) Collaborative Group. Indications for fibrinolytic therapy in suspected acute myocardial infarction: collaborative overview of early mortality and major morbidity results from all randomised trials of more than 1000 patients. Lancet. 1994;343:311–22.
  • Bonnefoy E, Lapostolle F, Leizorovicz A, Steg G, McFadden EP, Dubien PY, . Primary angioplasty versus prehospital fibrinolysis in acute myocardial infarction: A randomised study. Lancet. 2002;360:825–9.
  • Di Mario C, Dudek D, Piscione F, Mielecki W, Savonitto S, Murena E, . Immediate angioplasty versus standard therapy with rescue angioplasty after thrombolysis in the combined abciximab reteplase stent study in acute myocardial infarction (CARESS-in-AMI): An open, prospective, randomised, multicentre trial. Lancet. 2008;371:559–68.
  • Bøhmer E, Hoffmann P, Abdelnoor M, Arnesen H, Halvorsen S. Efficacy and safety of immediate angioplasty versus ischaemia-guided management after thrombolysis in acute myocardial infarction in areas with very large transfer distances. Results of the NORDISTEMI (Norwegian study of district treatment of ST-elevation myocardial infarction). J Am Coll Cardiol. 2010;55: 102–10.
  • Danchin N, Coste P, Ferrieres J, Steg P-G, Cottin Y, Blanchard D, ., for the FAST-MI Investigators. Comparison of thrombolysis followed by broad use of percutaneous coronary intervention with primary percutaneous coronary intervention for ST-elevation acute myocardial infarction: data from the French Registry of acute ST-elevation myocardial infarction (FAST-MI). Circulation. 2008;118:268–76.
  • Kushner FG, Hand M, Smith Sc Jr, King SB III, Anderson JL, Antman EM, . 2009 focused update: ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction (updating the 2004 guidelines and the 2007 focused update) and ACC/AHA/SCAI guidelines on percutaneous coronary intervention (updating the 2005 guidelines and 2007 focused update): A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2009;120:2271–306.
  • Barbash IM, Freimark D, Gottlieb S, Hod H, Hasin Y, Battler A, ., for the Israeli Working Group on Intensive Cardiac Care. Outcome of myocardial infarction in patients treated with aspirin is enhanced by pre-hospital administration. Cardiology. 2002;98:141–7.
  • Sabatine MS, Cannon CP, Gibson CM, Lopez-Sendon JL, Montalescot G, Theroux P, ., for the CLARITY-TIMI 28 Investigators. Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with ST-elevation. N Engl J Med. 2005;352:1179–89.
  • Chen ZM, Jiang LX, Chen YP, Xie JX, Pan HC, Peto R, . Addition of clopidogrel to aspirin in 45,852 patients with acute myocardial infarction: Randomised placebo-controlled trial. Lancet. 2005;366:1607–21.
  • Vlaar PJ, Svilaas T, Damman K, de Smet BJGJ, Tijssen JGP, Hillege HL, . Impact of pretreatment with clopidogrel on initial patency and outcome in patients treated with primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. A systematic review. Circulation. 2008;118:1828–36.
  • Mehta S, Tanguay J-F, Eikelboom JW, Jolly SS, Joyner CD, Granger CB, . Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): A randomized factorial trial. Lancet. 2010;376: 1233–43.
  • Montalescot G, Wiviott SD, Braunwald E, Murphy SA, Gibson CM, McCabe CH, ., for the TRITON-TIMI 38 Investigators. Prasugrel compared with clopidogrel in patients undergoing percutaneous coronary intervention for ST-elevation myocardial infarction (TRITON-TIMI 38): double blind, randomized controlled trial. Lancet. 2009;373:723–31.
  • Cannon CP, Harrington RA, James S, Ardissino D, Becker RC, Emanuelsson H, . for the PLATO Study Group. Comparison of ticagrelor with clopidogrel in patients with a planned invasive strategy for acute coronary syndromes (PLATO): A randomized double-blind study. Lancet. 2010;375:283–93.
  • Ellis SG, Tendera M, de Belder MA, van Boven AD Jr, Widimsky P, Janssens L, . for the FINESSE Investigations. Facilitated PCI in patients with ST-elevation myocardial infarction. N Engl J Med. 2008;358:2205–17.
  • Mehilli J, Kastrati A, Schulz S, Frungel S, Nekolla SG, Moshage W, . Abciximab in patients with acute ST-segment-elevation myocardial infarction undergoing primary percutaneous coronary intervention after clopidogrel loading: A randomized double-blind trial. Circulation. 2009;119:1933–40.
  • Van't Hof AW, Ten Berg J, Heestermans T, Dill T, Funck RC, van Werkum W, . Pre-hospital initiation of tirofiban in patients with ST-elevation myocardial infarction undergoing primary angioplasty (On-TIME 2): A multicentre, double-blind, randomised controlled trial. Lancet. 2008; 372:537–46.
  • The GUSTO Angiographic Investigators. The effects of tissue plasminogen activator, streptokinase, or both on coronary artery patency, ventricular function and survival after acute myocardial infarction. N Engl J Med. 1993;329:1615–22.
  • Horne S, Weston C, Quinn T, Hicks A, Walker L, Chen R, . The impact of pre-hospital thrombolytic treatment on re-infarction rates: Analysis of the myocardial infarction national audit project (MINAP). Heart. 2009;95:559–63.
  • Antman EM, Morrow EA, McCabe CH, Murphy SA, Ruda M, Sadowski Z, . for the ExTRACT TIMI 25 Investigators. Enoxaparin versus unfractionated heparin with fibrinolysis for ST-elevation myocardial infarction. N Engl J Med. 2006;354: 1477–88.
  • Wallentin L, Goldstein P, Armstrong PW, Granger CB, Adgey AAJ, Arntz HR, . Efficacy and safety of tenecteplase in combination with the low-molecular-weight heparin enoxaparin vs unfractionated heparin in the prehospital setting. The assessment of the safety and efficacy of a new thrombolytic regimen (ASSENT)-3 PLUS randomized trial in acute myocardial infarction. Circulation. 2003;108:135–42.
  • Murphy SA, Gibson CM, Morrow DA, Van de Werf F, Menown IA, Goodman SG, . Efficacy and safety of the low-molecular-weight heparin enoxaparin compared with unfractionated heparin across the acute coronary syndrome spectrum: A meta-analysis. Eur Heart J. 2007;28:2077–86.
  • Brieger D, Collet J-P, Silvain J, Landivier A, Barthelemy O, Beygin F, . Heparin or enoxaparin anticoagulation for primary PCI. Eur Heart J. 2010;31(abstr Suppl.):207.
  • The OASIS-6 Trial Group. Effects of fondaparinux on mortality and reinfarction in patients with acute ST-segment elevation myocardial infarction. The OASIS-6 randomized trial. JAMA. 2006;295:1519–30.
  • Stone GW, Witzenbichler B, Guagliumi G, Peruga JZ, Brodie BR, Dudek D, . for the HORIZONS-AMI trial investigators. Bivalirudin during primary PCI in acute myocardial infarction. N Engl J Med. 2008;358:2218–30.
  • Steg PG, Dabbous OH, Feldman LJ, Cohen-Solal A, Aumont M-C, López-Sendón J, . for the Global Registry of Acute Coronary Events (GRACE) Investigators. Determinants and prognostic impact of heart failure complicating acute coronary syndromes: Observations from the global registry of acute coronary events (GRACE). Circulation. 2004;109:494–9.
  • Dickstein K, Cohen-Solal A, Filippatos G, McMurray JJV, Ponikowski P, Poole-Wilson PA, . ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: The task force for the diagnosis and treatment of acute and chronic heart failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM) ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008. Eur Heart J. 2008;29:2388–442.
  • McAlister FA, Quan H, Fong A, Jin Y, Cujec B, Johnson D. Effect of invasive coronary revascularization in acute myocardial infarction on subsequent death rate and frequency of chronic heart failure. Am J Cardiol. 2008;102:1–5.
  • Peacock WF, Hollander JE, Diercks DB, Lopatin M, Fonarow G, Emerman CL. Morphine and outcomes in acute decompensated heart failure: An ADHERE analysis. Emerg Med J. 2008:25:205–9.
  • Assali AR, Teplitsky I, Ben-Dor I, Solodky A, Brosh D, Battler A, . Prognostic importance of right ventricular infarction in an acute myocardial infarction cohort referred for contemporary percutaneous reperfusion therapy. Am Heart J. 2007;153: 231–7.
  • Webb JG, Sleeper LA, Buller CE, Boland J, Palazzo A, Buller E, . Implications of the timing of onset of cardiogenic shock after acute myocardial infarction: A report from the SHOCK Trial Registry. Should we emergently revascularize occluded coronaries for cardiogenic shock? J Am Coll Cardiol. 2000;3(Suppl. A):1084–90.
  • Hasdai D, Holmes DR Jr, Topol EJ, Berger PB, Criger DA, Hochman JS, . Frequency and clinical outcome of cardiogenic shock during acute myocardial infarction among patients receiving reteplase or alteplase. Results from GUSTO-III. Global use of strategies to open occluded coronary arteries. Eur Heart J. 1999;20:128–35.
  • Hasdai D, Califf RM, Thompson TD, Hochman JS, Ohman EM, Pfisterer M, . Predictors of cardiogenic shock after thrombolytic therapy for acute myocardial infarction. J Am Coll Cardiol. 2000;35:136–43.
  • Jeger RV, Urban P, Harkness SM, Tseng CH, Stauffer JC, Lejemtel TH, . Early revascularization is beneficial across all ages and a wide spectrum of cardiogenic shock severity: A pooled analysis of trials. Acute Card Care. 2011;13:14–20.
  • Hochman JS, Sleeper LA, Webb JG, Sanborn TA, White HD, Talley JD, . Early revascularization in acute myocardial infarction complicated by cardiogenic shock. N Engl J Med. 1999;341: 625–34.
  • Hochman JS, Sleeper LA, Webb JG, Dzavik V, Buller CE, Aylward P, ., SHOCK Investigators. Early revascularization and long-term survival in cardiogenic shock complicating acute myocardial infarction. JAMA. 2006;295:2511–5.
  • De Backer D, Biston P, Devriendt J, Madl C, Chochrad D, Aldecoa C, ., for the SOAP II Investigators. Comparison of dopamine and norepinephrine in the treatment of shock. N Engl J Med. 2010;362:779–89.
  • Rawles J, Marsden A. Impact of ‘dual response’ on prehospital thrombolysis in remote and rural areas of Scotland: Prospective observational study. Emerg Med J. 2004;21:720–1.
  • Peacock WF, Bhatt DL, Diercks D, Amsterdam E, Chandra A, Ohman EM, . Cardiologists’ and emergency physicians’ perspectives on and knowledge of reperfusion guidelines pertaining to ST-segment-elevation myocardial infarction. Tex Heart Inst J. 2008;35:152–61.
  • Core Curriculum for the General Cardiologist, update 2008, European Society of Cardiology Available at http://www.escardio.org/education/coresyllabus/pages/core-curriculum.aspx (accessed 29 April 2011).
  • Riley J, Brodie L, Shuldham C. Cardiac nursing: Achieving competent practitioners. Eur J Cardiovasc Nurs. 2004;4: 115–21.
  • Goodacre S, Coats T, Clancy M. Good clinical practice in clinical trials: Core knowledge for emergency physicians. Emerg Med J. 2008;25:789.
  • Wayne DB, Butter JB, Siddall VJ, Fudala MJ, Wade LD, Feinglass J, . Mastery learning of advanced cardiac life support skills by internal medicine residents using simulation technology and deliberate practice. J Gen Internal Med. 2006;21:251–6.
  • Clements R, Mackenzie R. Competence in prehospital care: Evolving concepts. Emerg Med J. 2005;22:516–9.
  • EuSEM core curriculum for emergency medicine. Eur J Emerg Med. 2008. Available at http://www.eusem.org (accessed 29 April 2011).
  • Working Group on Acute Cardiac Care, European Society of Cardiology. Core curriculum for training in Intensive and Acute Cardiac Care. Available at http://www.escardio.org/communities/Working-Groups/acute-cardiac-care/Documents/ESC-Curriculum-Training-Intensive-ACC-europe.pdf (accessed 29 April 2011).
  • Eagle KA, Montoye CK, Riba AL, DeFranco AC, Parrish R, Skorcz S, . Guideline-based standardized care is associated with substantially lower mortality in Medicare patients with acute myocardial infarction. The American College of Cardiology's guidelines applied in practice (GAP) projects in Michigan. J Am Coll Cardiol. 2005;46:1242–8.
  • Lewis WR, Peterson ED, Cannon CP, Super DM, LaBresh KA, Quealy K, . An organized approach to improvement in guideline adherence for acute myocardial infarction. Results with the get with the guidelines quality improvement program. Arch Intern Med. 2008;168:1813–9.
  • Fox KA, Huber K. A European perspective on improving acute systems of care in STEMI: We know what to do, but how can we do it? Nat Clin Pract Cardiovasc Med. 2008;5:708–14.

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