The heart and potassium: A banana republic

References

• Boyett MR, Honjo H, Kodama I. The sinoatrial node, a heterogeneous pacemaker structure. Cardiovasc Res. 2000;47: 658–87.
   PubMed Web of Science ®Google Scholar
• Verkerk AO, van Ginneken AC, Wilders R. Pacemaker activity of the human sinoatrial node: Role of the hyperpolarization-activated current, I(f). Int J Cardiol. 2009;132:318–36.
   Google Scholar
• Liu J, Noble PJ, Xiao G, Abdelrahman M, Dobrzynski H, Boyett MR, . Role of pacemaking current in cardiac nodes: Insights from a comparative study of sinoatrial node and atrioventricular node. Prog Biophys Mol Biol. 2008;96:294–304.
   PubMed Web of Science ®Google Scholar
• Stillitano F, Lonardo G, Zicha S, Varro A, Cerbai E, Mugelli A, . Molecular basis of funny current (If) in normal and failing human heart. J Mol Cell Cardiol. 2008;45:289–99.
   PubMed Web of Science ®Google Scholar
• Bertaso F, Sharpe C, Hendry BM, James AF. Expression of voltage-gated K+ channels in human atrium. Basic Res Cardiol. 2002;97:424–33.
   Google Scholar
• Nattel S, Yue L,Wang Z. Cardiac ultrarapid delayed rectifiers: a novel potassium current family of functional similarity and molecular diversity. Cell Physiol Biochem. 1999;9:217–26.
   PubMed Web of Science ®Google Scholar
• Nattel S, Maguy A, Le Bouter S, Yeh Y-H. Arrhythmogenic ion-channel remodeling in the heart: Heart failure, myocardial infarction, and atrial fibrillation. Physiol Rev. 2007;87:425–56.
   PubMed Web of Science ®Google Scholar
• Li D, Sun H, Levesque P. Antiarrhythmic drug therapy for atrial fibrillation: Focus on atrial selectivity and safety. Cardiovasc Hematol Agents Med Chem. 2009;7:64–75.
   PubMedGoogle Scholar
• Burashnikov A, Antzelevitch C. Can inhibition of IKur promote atrial fibrillation? Heart Rhythm 2008;5:1304–9.
   PubMed Web of Science ®Google Scholar
• Ravens U, Cerbai E. Role of potassium currents in cardiac arrhythmias. Europace: European pacing, arrhythmias, and cardiac electrophysiology. 2008;10:1133–7.
   Google Scholar
• Jespersen T, Grunnet M, Olesen S-P. The KCNQ1 potassium channel: from gene to physiological function. Physiology 2005;20:408–16.
   PubMed Web of Science ®Google Scholar
• Terrenoire C, Houslay MD, Baillie GS, Kass RS. The cardiac IKS potassium channel macromolecular complex includes the phosphodiesterase PDE4D3. J Biol Chem. 2009;284;9140–6.
   Google Scholar
• Antzelevitch C. Role of spatial dispersion of repolarization in inherited and acquired sudden cardiac death syndromes. Am J Physiol Heart Circ Physiol. 2007;293:H2024–38.
   PubMed Web of Science ®Google Scholar
• Rautaharju PM, Surawicz B, Gettes LS, Bailey JJ, Childers R, Deal BJ, . AHA/ACCF/HRS recommendations for the standardization and interpretation of the electrocardiogram: Part IV: the ST segment, T and U waves, and the QT interval: A scientific statement from the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society. Endorsed by the International Society for Computerized Electrocardiology. J Am Coll Cardiol. 2009;53:82–91.
   Google Scholar
• Hedley PL, Jørgensen P, Schlamowitz S, Wangari R, Moolman-Smook J, Brink PA, . The genetic basis of long QT and short QT syndromes: A mutation update. Hum Mutat. 2009;30:1486–511.
   PubMed Web of Science ®Google Scholar
• Gussak I, Brugada P, Brugada J, Wright RS, Kopecky SL, Chaitman BR, Bjerregaard P. Idiopathic short QT interval: A new clinical syndrome? Cardiology 2000;94:99–102.
   PubMed Web of Science ®Google Scholar
• Giudicessi JR, Ackerman MJ. Potassium-channel mutations and cardiac arrhythmias—diagnosis and therapy. Nat Rev Cardiol. 2012;9:319–32.
   PubMed Web of Science ®Google Scholar
• Fernandez D, Ghanta A, Kauffman GW, Sanguinetti MC. Physicochemical features of the HERG channel drug binding site. J Biol Chem. 2004;279:10120–7.
   PubMed Web of Science ®Google Scholar
• Pickham D, Helfenbein E, Shinn JA, Chan G, Funk M, Weinacker A, . High prevalence of corrected QT interval prolongation in acutely ill patients is associated with mortality: Results of the QT in practice (QTIP) study. Crit Care Med. 2012;40:394–9.
   PubMed Web of Science ®Google Scholar
• Khan EU. The basics of pharmacokinetics in prescribing and clinical practice. Nurse Prescribing. 2011;9:557–66.
   Google Scholar
• McCance KL, Huether SE. Pathophysiology: The biologic basis for disease in adults and children fifth edition. Mosby St Louis: Elsevier; 2006.
   Google Scholar
• Humphreys M. Potassium disturbances and associated electrocardiogram changes Emerg Nurse 2007;15:28–33.
   Google Scholar
• Opie LH. The heart: Physiology from cell to circulation. (Ed) 3rd edition. New York, Baltimore, London, Sydney, Hong Kong: Lipincott Williams and Wilkins; 1997.
   Google Scholar
• Michaud GF, Sticherling C, Tada H, Oral H, Pelosi F Jr, Knight BP, Morady F, Strickberger SA. Relationship between serum potassium concentration and risk of recurrent ventricular tachycardia or ventricular fibrillation. J Cardiovasc Electro-physiol. 2001;12:1109–12.
   Google Scholar
• Webster A, Brady W, Morris F. Recognising signs of danger: ECG changes resulting from an abnormal serum potassium concentration Emerg Med J. 2002;19:74–7.
   Google Scholar