Effects of levosimendan on heart failure in normotensive patients: Does loading dose matter?

References

• Task force for the diagnosis and treatment of acute and chronic heart failure 2012 of the European Society of Cardiology, ESC Committee for Practice Guidelines et al. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The task force for the diagnosis and treatment of acute and chronic heart failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail. 2012;14:803–69.
   PubMed Web of Science ®Google Scholar
• Innes CA, Wagstaff AJ. Levosimendan: A review of its use in the management of acute decompensated heart failure. Drugs 2003:63;2651–71.
   PubMed Web of Science ®Google Scholar
• Mebazaa A, Nieminen MS, Packer M, Cohen-Solal A, Kleber FX, Pocock SJ, et al. Levosimendan vs dobutamine for patients with acute decompensated heart failure: The SURVIVE randomized trial. JAMA 2007;297:1883–91.
   PubMed Web of Science ®Google Scholar
• Papp Z, Csapo K, Pollesello P, Haikala H, Edes I. Pharmacological mechanisms contributing to the clinical efficacy of levosimendan. Cardiovasc Drug Rev. 2005;23:71–98.
   PubMed Web of Science ®Google Scholar
• Yildiz O. Vasodilating mechanisms of levosimendan: Involvement of K+ channels. J Pharmacol Sci. 2007;104:1–5.
   Google Scholar
• Antila S, Sundberg S, Lehtonen LA. Clinical pharmacology of levosimendan. Clin Pharmacokinet. 2007;46:535–52.
   PubMed Web of Science ®Google Scholar
• Lilleberg J, Laine M, Palkama T, Kivikko M, Pohjanjousi P, Kupari M. Duration of the haemodynamic action of a 24-h infusion of levosimendan in patients with congestive heart failure. Eur J Heart Fail. 2007;9:75–82.
   PubMed Web of Science ®Google Scholar
• Moiseyev VS, Poder P, Andrejevs N, Ruda MY, Golikov AP, Lazebnik LB, et al. Safety and efficacy of a novel calcium sensitizer, levosimendan, in patients with left ventricular failure due to an acute myocardial infarction. A randomized, placebo-controlled, double blind study (RUSSLAN). Eur Heart J. 2002;23:1422–32.
   PubMed Web of Science ®Google Scholar
• Landoni G, Biondi-Zoccai G, Greco M, Greco T, Bignami E, Morelli A, et al. Effects of levosimendan on mortality and hospitalization. A meta-analysis of randomized controlled studies. Crit Care Med. 2012;40:634–46.
   PubMed Web of Science ®Google Scholar
• Aidonidis G, Kanonidis I, Koutsimanis V, Neumann T, Erbel R, Sakadamis G. Efficiency and safety of prolonged levosimendan infusion in patients with acute heart failure. Cardiol Res Pract. 2011;2011:342302.
   Google Scholar
• Parissis JT, Panou F, Farmakis D, Adamopoulos S, Filippatos G, Paraskevaidis I, et al. Effects of levosimendan on markers of left ventricular diastolic function and neurohormonal activation in patients with advanced heart failure. Am J Cardiol. 2005;96:423–6.
   PubMed Web of Science ®Google Scholar
• Parissis JT, Paraskevaidis I, Bistola V, Farmakis D, Panou F, Kourea K, et al. Effects of levosimendan on right ventricular function in patients with advanced heart failure. Am J Cardiol. 2006;98:1489–92.
   PubMed Web of Science ®Google Scholar
• Yilmaz MB, Yontar C, Erdem A, Karadas F, Yalta K, Turgut O, et al. Comparative effects of levosimendan and dobutamine on right ventricular function in patients with biventricular heart failure. Heart Vessels 2009;24;16–21.
   PubMed Web of Science ®Google Scholar
• Mizuguchi Y, Oishi Y, Miyoshi H, Iuchi A, Nagase N, Oki T. The functional role of longitudinal, circumferential, and radial myocardial deformation for regulating the early impairment of left ventricular contraction and relaxation in patients with cardiovascular risk factors: A study with two-dimensional strain imaging. JASE 2008;21:1138–44.
   PubMed Web of Science ®Google Scholar
• Lunghetti S, Palmerini E, Urselli R, Maffei S, Guarino E, Mondillo S, et al. Effects of levosimendan without loading dose on systolic and diastolic function in patients with end-stage heart failure. Cardiol J. 2011;18:532–7.
   Google Scholar
• Dickstein K, Cohen-Solal A, Filippatos G, McMurray JJV, Ponikowski P, Poole-Wilson PA, et al. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008. The task force for the diagnosis and treatment of acute and chronic heart failure 2008 of the European Society of Cardiology. Eur Heart J. 2008;29:2388–442.
   PubMedGoogle Scholar
• Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, et al. Recommendations for chamber quantification: A report from the American Society of Echocardiography's guidelines and standards committee and the chamber quantification writing group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr. 2005;18:1440–63.
   PubMed Web of Science ®Google Scholar
• Nagueh SF, Appleton CP, Gillebert TC, Marino PN, Oh JK, Smiseth OA, et al. Recommendations for the evaluation of left ventricular diastolic function by echocardiography. J Am Soc Echocardiogr. 2009:22;107–33.
   PubMed Web of Science ®Google Scholar
• Nikitin NP, Witte KK, Thackray SD, de Silva R, Clark AL, Cleland JG. Longitudinal ventricular function: Normal values of atrioventricular annular and myocardial velocities measured with quantitative two-dimensional color Doppler tissue imaging. J Am Soc Echocardiogr. 2003:16; 906–21.
   PubMed Web of Science ®Google Scholar
• Ommen SR, Nishimura RA, Appleton CP, Miller FA, Oh JK, Redfield MM, et al. Clinical utility of Doppler echocardiography and tissue Doppler imaging in the estimation of left ventricular filling pressures: A comparative simultaneous Doppler-catheterization study. Circulation 2000;102:1788–94.
   PubMed Web of Science ®Google Scholar
• Kazik A, Wilczek K, Poloński L. Management of diastolic heart failure. Cardiol J. 2010;17:558–65.
   PubMed Web of Science ®Google Scholar
• Nieminen MS, Akkila J, Hasenfuss G, Kleber FX, Lehtonen LA, Mitrovic V, et al. Hemodynamic and neurohumoral effects of continuous infusion of levosimendan in patients with congestive heart failure. J Am Cardiol. 2000;36:1903–12.
   Google Scholar
• Thackray S, Easthaugh J, Freemantle N, Cleland JG. The effectiveness and relative effectiveness of intravenous inotropic drugs acting through the adrenergic pathway in patients with heart failure—a meta-regression analysis. Eur J Heart Fail. 2002; 4:515–29.
   PubMed Web of Science ®Google Scholar
• Berger R, Moertl D, Peter S, Ahmadi R, Huelsmann M, Yamuti S, et al. N-terminal pro-B-type natriuretic peptide-guided, intensive patient management in addition to multidisciplinary care in chronic heart failure a 3-arm, prospective, randomized pilot study. J Am Coll Cardiol. 2010;55:645–53.
   PubMed Web of Science ®Google Scholar
• Parekh N, Maisel AS. Utility of B-natriuretic peptide in the evaluation of left ventricular diastolic function and diastolic heart failure. Curr Opin Cardiol. 2009;24:155–60.
   PubMed Web of Science ®Google Scholar
• Marwick TH, Clinical applications of tissue Doppler Imaging: A promise fulfilled. Heart 2003;89:1377–8.
   Google Scholar
• Follath F, Cleland JG, Just H, Papp JGY, Scholz H, Peuhkurinen K, et al. Steering committee and investigators of the levosimendan infusion versus dobutamine (LIDO) study. Efficacy and safety of intravenous levosimendan compared with dobutamine in severe low-output heart failure (the LIDO study): A randomized double-blind trial. Lancet 2002;360:196–202.
   PubMed Web of Science ®Google Scholar
• Maharaj R, Metaxa V. Levosimendan and mortality after coronary revascularisation: A meta-analysis of randomised controlled trials. Crit Care 2011;15:R140.
   PubMed Web of Science ®Google Scholar
• Fedele F, D’Ambrosi A, Bruno N, Caira C, Brasolin B, Mancone M. Cost-effectiveness of levosimendan in patients with acute heart failure. J Cardiovasc Pharmacol. 2011;58:363–6.
   PubMed Web of Science ®Google Scholar
• Bayram M, De Luca L, Massie MB, Gheorghiade M. Reassessment of dobutamine, dopamine, and milrinone in the management of acute heart failure syndromes. Am J Cardiol. 2005;96:47G–58G.
   PubMed Web of Science ®Google Scholar
• Archan S, Toller W. Levosimandan: Current status and future prospects. Curr Opin Anaesthesiol. 2008;21:78–84.
   PubMed Web of Science ®Google Scholar