Human low molecular weight neurofilament (NFL) mRNA interacts with a predicted p190RhoGEF homologue (RGNEF) in humans

References

• Julien J-P. A role for neurofilaments in the pathogenesis of amyotrophic lateral sclerosis. Biochem Cell Biol 1995; 73: 593–7
   PubMed Web of Science ®Google Scholar
• Julien J-P. Neurofilament functions in health and disease. Curr Opin Neurol 1999; 9: 554–60
   Google Scholar
• Meier J, Couillard-Després S, Jacomy H, Gravel C, Julien J-P. Extra neurofilament NF-L subunits rescue motor neuron disease caused by overexpression of the human NF-H gene in mice. J Neuropathol Exp Neurol 1999; 58: 1099–1110
   PubMed Web of Science ®Google Scholar
• Beaulieu J-M, Jacomy H, Julien J-P. Formation of intermediate filament protein aggregates with disparate effects in two transgenic mouse models lacking the neurofilament light subunit. J Neurosci 2000; 20: 5321–8
   PubMed Web of Science ®Google Scholar
• Xao S, McLean J, Robertson J. Neuronal intermediate filaments and ALS: a new look at an old question. Biochim Biophys Acta 2006; 1762: 1001–12
   PubMed Web of Science ®Google Scholar
• Strong MJ, Kesavapany S, Pant HC. The pathobiology of amyotrophic lateral sclerosis: a proteinopathy?. J Neuropathol Exp Neurol. 2005; 64: 649–64
   PubMed Web of Science ®Google Scholar
• Bergeron C, Beric-Maskarel K, Muntasser S, Weyer L, Somerville M, Percy ME. Neurofilament light and polyadenylated mRNA levels are decreased in amyotrophic lateral sclerosis motor neurons. J Neuropathol Exp Neurol 1994; 53: 221–30
   PubMed Web of Science ®Google Scholar
• Wong N, He BP, Strong MJ. Characterization of neuronal intermediate filament protein expression in cervical spinal motor neurons in sporadic amyotrophic lateral sclerosis (ALS). J Neuropathol Exp Neurol. 2000; 59: 972–82
   PubMed Web of Science ®Google Scholar
• Menzies FM, Grierson AJ, Cookson MR, Heath PR, Tomkins J, Figlewicz DA, et al. Selective loss of neurofilament expression in Cu/Zn superoxide dismutase (SOD1) linked amyotrophic lateral sclerosis. J Neurochem. 2002; 82: 1118–28
   PubMed Web of Science ®Google Scholar
• Ge WW, Wen W, Strong WL, Leystra-Lantz C, Strong MJ. Mutant copper/zinc superoxide dismutase binds to and destabilizes human low molecular weight neurofilament mRNA. J Biol Chem. 2005; 280: 118–24
   PubMed Web of Science ®Google Scholar
• Strong MJ, Volkening K, Hammond R, Yang W, Strong WL, Leystra-Lantz C, Shoesmith C. TDP-43 is a human low molecular weight neurofilament (hNFL) mRNA-binding protein. Mol Cell Neurosci. 2007; 35: 320–7
   PubMed Web of Science ®Google Scholar
• Ge WW, Volkening K, Leystra-Lantz C, Jaffe H, Strong MJ. 14-3-3 protein binds to the low molecular weight neurofilament (NFL) mRNA 3' UTR. Mol Cell Neurosci 2007; 34: 80–7
   PubMed Web of Science ®Google Scholar
• Cañete-Soler, R, Wu, J, Zhai, J, Shamim, M, Schlaepfer, WW. p190RhoGEF binds to a destabilizing element in the 3' untranslated region of light neurofilament subunit mRNA and alters the stability of the transcript. J Biol Chem. 2001;276:32046–50.
   PubMed Web of Science ®Google Scholar
• Lin H, Zhai J, Schlaepfer WW. RNA-binding protein is involved in aggregation of light neurofilament protein and is implicated in the pathogenesis of motor neuron degeneration. Human Molecular Genetics 2005; 14: 3643–59
   PubMed Web of Science ®Google Scholar
• Ohara O, Nagase T, Mitsui G, Kohga H, Kikuno R, Hiraoka S, et al. Characterization of the size-fractionated cDNA libraries generated by the in vitro recombination-assisted method. DNA Res 2002; 9: 47–57
   PubMed Web of Science ®Google Scholar
• Cañete-Soler R, Schwartz ML, Hua Y, Schlaepfer WW. Stability determinants are localized to the 3'-untranslated region and 3'-coding region of the neurofilament light subunit mRNA using a tetracycline-inducible promoter. J Biol Chem 1998; 273: 12650–4
   PubMed Web of Science ®Google Scholar
• Li Y, Jiang Z, Chen H, Ma W-J. A modified quantitative EMSA and its application in the study of RNA-protein interactions. J Biochem Biophys Methods 2004; 60: 85–96
   PubMedGoogle Scholar
• Thyagarajan A, Strong MJ, Szaro BG. Post-transcriptional regulation of neurofilaments in development and disease. Exp Cell Res 2007; 313: 2088–97
   PubMed Web of Science ®Google Scholar
• Stefanizzi I, Cañete-Soler R. Coregulation of light neurofilament mRNA by poly(A)-binding protein and aldolase C: implications for neurodegeneration. Brain Res 2007; 1139: 15–28
   PubMed Web of Science ®Google Scholar
• Cañete-Soler R, Reddy KS, Tolan DR, Zhai J. Aldolases A and C are ribonucleolytic components of a neuronal complex that regulates the stability of the light-neurofilament mRNA. J Neurosci 2005; 25: 4353–64
   PubMed Web of Science ®Google Scholar
• Strong MJ, Leystra-Lantz C, Ge W. Intermediate filament steady state mRNA levels in amyotrophic lateral sclerosis (ALS). Biochem Biophys Res Comm 2004; 316: 317–22
   PubMed Web of Science ®Google Scholar