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Amyotrophic Lateral Sclerosis Volume 11, 2010 - Issue 5
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ORIGINAL ARTICLE

The association between ALS and population density: A population based study

Kirsten M. Scott King's College Hospital, London, UK
,
Kumar Abhinav MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, London, UK
,
Lokesh Wijesekera MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, London, UK
,
Jeban Ganesalingam MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, London, UK
,
Laura H. Goldstein MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, London, UK
,
Anna Janssen MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, London, UK
,
Andrew Dougherty MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, London, UK
,
Emma Willey MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, London, UK
,
Biba R. Stanton MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, London, UK
,
Martin R. Turner Oxford University Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK
,
Mary-Ann Ampong King's College Hospital, London, UK
,
Mohammed Sakel NeuroRehabilitation Unit, Buckland Hospital, East Kent Hospitals Trust, Dover, UK
,
Richard Orrell Clinical Neurosciences, UCL Institute of Neurology, London, UK; The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
,
Robin Howard The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
,
Christopher E. Shaw MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, London, UK
,
P. Nigel Leigh MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, London, UK
&
Ammar Al-Chalabi MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, London, UKCorrespondence[email protected]
 show all
Pages 435-438 | Received 30 Sep 2009, Accepted 26 Feb 2010, Published online: 29 Apr 2010

References

  • Mitchell JD, Borasio GD. Amyotrophic Lateral Sclerosis. Lancet. 2007;369:2031–41.
  • Govoni V, Granieri E, Fallica E, Casetta I. Amyotrophic lateral sclerosis, rural environment and agricultural work in the local health district of Ferrara, Italy, in the years 1964–1998. J Neurol. 2005;252:1322–7.
  • Johnston CA, Stanton BR, Turner MR, Gray R, Blunt AH, Butt D, . Amyotrophic lateral sclerosis in an urban setting: a population based study of inner city London. J Neurol. 2006;253:1642–3.
  • Logroscino G, Traynor BJ, Hardiman O, Chiò A, Couratier P, Mitchell JD, . EURALS. Descriptive epidemiology of amyotrophic lateral sclerosis: new evidence and unsolved issues. J Neurol Neurosurg Psychiatry. 2008;79:6–11.
  • Simpson CL, Al-Chalabi A. Amyotrophic lateral sclerosis as a complex genetic disease. Biochim Biophys Acta. 2006;1762: 973–85.
  • Nelson LM, McGuire V, , Longstreth WT JrMatkin C. Population based case-control study of amyotrophic lateral sclerosis in Western Washington State: cigarette smoking and alcohol consumption. Am J Epidemiol. 2000;151:156–63.
  • Mitchell JD. Amyotrophic lateral sclerosis: toxins and environment. Amyotroph Lateral Scler Other Motor Neuron Disord. 2000;1:235–50.
  • Mandrioli J, Faglioni P, Merelli E, Sola P. The epidemiology of ALS in Modena, Italy. Neurology. 2003;60:683–9.
  • Chio A, Benzi G, Dossena M, Mutani R, Mora G. Severely increased risk of amyotrophic lateral sclerosis among Italian professional football players. Brain. 2005;128:472–6.
  • Haley RW. Excess incidence of ALS in young Gulf War veterans. Neurology. 2003;61:750–6.
  • Cronin S, Greenway MJ, Prehn JH, Hardiman O. Paraoxonase promoter and intronic variants modify risk of sporadic amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry. 2007;78:984–6.
  • Saeed M, Siddique N, Hung WY, Ushacheva E, Liu E, Sufit RL, . Paraoxonase cluster polymorphisms are associated with sporadic ALS. Neurology. 2006;67:771–6.
  • Landers JE, Melki J, Meininger V, Glass JD, van den Berg LH, van Es MA, . Reduced expression of the kinesin-associated protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 2009; 106:9004–9.
  • Diekstra FP, Beleza-Meireles A, Leigh NP, Shaw CE, Al-Chalabi A. Interaction between PON1 and population density in amyotrophic lateral sclerosis. Neuroreport. 2009;20:186–90.
  • Wills AM, Cronin S, Slowik A, Kasperaviciute D, van Es MA, Morahan JM, . A large scale international meta-analysis of paraoxonase gene polymorphisms in sporadic ALS. Neurology. 2009;73:16–24.
  • Scott KM, Abhinav K, Stanton BR, Johnston C, Turner MR, Ampong MA, . Geographical clustering of amyotrophic lateral sclerosis in south-east England: a population study. Neuroepidemiology. 2009;32:81–8.
  • Abhinav K, Stanton B, Johnston C, Hardstaff J, Orrell RW, Howard R, . Amyotrophic lateral sclerosis in south-east England: a population based study (South-East England register for Amyotrophic Lateral Sclerosis (SEALS) registry). Neuroepidemiol. 2007;29:44–8.
  • Office of National Statistics. Neighbourhood statistics (online). Available at: http://neighbourhood.statistics.gov.uk/dissemination/. Accessed 17/05/06.
  • Logroscino G, Traynor BJ, Hardiman O, Chiò A, Mitchell D, Swingler RJ, . Incidence of amyotrophic lateral sclerosis in Europe. J Neurol Neurosurg Psychiatry. 2009, Aug 25 (Epub ahead of print).
  • Zaldivar T, Gutierrez J, Lara G, Carbonara M, Logroscino G, Hardiman O. Reduced frequency of ALS in an ethnically mixed population: a population based mortality study. Neurology. 2009;72:1640–5.
  • Leone M, Chiò A, Mortara P, Rosso MG, Schiffer D. Motor neuron disease in the province of Turin, Italy, 1971–1980. Acta Neurol Scand. 1983;68:316–27.
  • Armon C. An evidence based medicine approach to the evaluation of the role of exogenous risk factors in sporadic amyotrophic lateral sclerosis. Neuroepidemiology. 2003;22: 217–28.
  • Office of National Statistics. Internal migration within the UK by five-year age group and sex, mid-2007 to mid-2008. Available at: http://www.statistics.gov.uk/statbase/Product.asp?vlnk=15148. Accessed 15/11/09.

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