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ORIGINAL ARTICLE

A randomized, placebo-controlled trial of memantine for functional disability in amyotrophic lateral sclerosis

, , , , &
Pages 456-460 | Received 24 Apr 2010, Accepted 31 May 2010, Published online: 22 Jun 2010

References

  • van Damme P, Dewil M, Robberecht W, van den Bosh L. Excitoxicity in amyotrophic lateral sclerosis. Neurodegener Dis. 2005;2:147–59.
  • Wang R, Zhang D. Memantine prolongs survival in an amyotrophic lateral sclerosis mouse model. Eur J Neurosc. 2005;22:2376–80.
  • Lacomblez L, Bensimon G, Leigh PN, Guillet P, Meininger V. Dose ranging study of riluzole in amyotrophic lateral sclerosis. Lancet. 1996;347:1425–31.
  • Tariot PN, Farlow MR, Grossberg GT, Graham SM, McDonald S, Gergel I. Memantine treatment in patients with moderate to severe Alzheimer's disease already receiving donepezil: a randomized controlled trial. JAMA. 2004;291: 317–24.
  • Parsons CG, Stoffler A, Danysz W. Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system – too little activation is bad, too much is even worse. Neuropharmacol. 2007;53:699–723.
  • Joo IS, Hwang DH, Seok JI, Shin SK, Kim SU. Oral administration of memantine prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis. J Clin Neurol. 2007;3:181–6.
  • Brooks BR, Miller RG, Swash M, Munsat TL, for the World Federation of Neurology Research Group on Motor Neuron Diseases. El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2000;1:93–300.
  • Cedarbaum JM, Stambler N. Performance of the Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS) in multicentre clinical trials. J Neurol Sci. 1997;152(Suppl 1):1–8.
  • de Carvalho M, Swash M. Can selection of rapidly progressing patients shorten clinical trials in amyotrophic lateral sclerosis? Arch Neurol. 2006;63:558–62.
  • de Carvalho M, Swash M. Quantitating progression in ALS. Neurology. 2005;64:1783–5.
  • Remy AJ, Camu W, Ramos J, Blanc P, Larrey D. Acute hepatitis after riluzole administration. J Hepatol. 1999;30:527–30.
  • de Carvalho M, Chio A, Dengler R, Hecht M, Weber M, Swash M. Neurophysiological measures in amyotrophic lateral sclerosis: markers of progression in clinical trials. Amyotroph Lateral Scler. 2005;6:17–28.
  • Doble A. The pharmacology and mechanism of action of riluzole. Neurology. 1996;47:S233–41.
  • de Carvalho M, Costa J, Swash M. Clinical trials in ALS: a review of the role of clinical and neurophysiological measurements. Amyotroph Lateral Scler. 2005;6:202–12.
  • Cudkowicz ME, Shefner JM, Schoenfeld DA, Brown RH, Johnson H, Quareshi M, . A randomized, placebo-controlled trial of topiramate in amyotrophic lateral sclerosis. Neurology. 2003;61:456–64.

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