Advanced search
Publication Cover
Amyotrophic Lateral Sclerosis Volume 12, 2011 - Issue 2
Journal homepage
860
Views
78
CrossRef citations to date
0
Altmetric
Research Article

Elevated CSF TDP-43 levels in amyotrophic lateral sclerosis: Specificity, sensitivity, and a possible prognostic value

Yu-Ichi Noto Department of Neurology, Graduate School of Medicine, Chiba University, Chiba; Department of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, KyotoCorrespondence[email protected]
,
Kazumoto Shibuya Department of Neurology, Graduate School of Medicine, Chiba University, Chiba
,
Yasunori Sato Clinical Research Center, Chiba University Hospital, Chiba
,
Kazuaki Kanai Department of Neurology, Graduate School of Medicine, Chiba University, Chiba
,
Sonoko Misawa Department of Neurology, Graduate School of Medicine, Chiba University, Chiba
,
Setsu Sawai Department of Neurology, Graduate School of Medicine, Chiba University, Chiba
,
Masahiro Mori Department of Neurology, Graduate School of Medicine, Chiba University, Chiba
,
Tomoyuki Uchiyama Department of Neurology, Graduate School of Medicine, Chiba University, Chiba
,
Sagiri Isose Department of Neurology, Graduate School of Medicine, Chiba University, Chiba
,
Saiko Nasu Department of Neurology, Graduate School of Medicine, Chiba University, Chiba
,
Yukari Sekiguchi Department of Neurology, Graduate School of Medicine, Chiba University, Chiba
,
Yumi Fujimaki Department of Neurology, Graduate School of Medicine, Chiba University, Chiba; Department of Neurology, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan
,
Takashi Kasai Department of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto
,
Takahiko Tokuda Department of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto
,
Masanori Nakagawa Department of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto
&
Satoshi Kuwabara Department of Neurology, Graduate School of Medicine, Chiba University, Chiba
 show all
Pages 140-143 | Received 20 Jul 2010, Accepted 14 Nov 2010, Published online: 02 Dec 2010

References

  • Arai T, Hasegawa M, Akiyama H, Ikeda K, Nonaka T, Mori H, . TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Biochem Biophys Res Commun. 2006;351:602–11.
  • Neumann M, Sampathu DM, Kwong LK, Truax AC, Micsenyi MC, Chou TT, . Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science. 2006;314:130–3.
  • Kasai T, Tokuda T, Ishigami N, Sasayama H, Foulds P, Mitchell DJ, . Increased TDP-43 protein in cerebrospinal fluid of patients with amyotrophic lateral sclerosis. Acta Neuropathol. 2009;117:55–62.
  • Brooks BR, Miller RG, Swash M, Munsat TL. El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord. 2000;1:293–9.
  • de Carvalho M, Dengler R, Eisen A, England JD, Kaji R, Kimura J, . Electrodiagnostic criteria for diagnosis of ALS. Clin Neurophysiol. 2008;119:497–503.
  • Steinacker P, Hendrich C, Sperfeld AD, Jesse S, von Arnim CA, Lehnert S, . TDP-43 in cerebrospinal fluid of patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Arch Neurol. 2008;65:1481–7.
  • Geser F, Lee VM, Trojanowski JQ. Amyotrophic lateral sclerosis and frontotemporal lobar degeneration: a spectrum of TDP-43 proteinopathies. Neuropathology. 2010;30:103–12.
  • Sussmuth SD, Sperfeld AD, Hinz A, Brettschneider J, Endruhn S, Ludolph AC, . CSF glial markers correlate with survival in amyotrophic lateral sclerosis. Neurology. 2010;74:982–7.
  • Fialová L, Svarcová J, Bartos A, Ridzon P, Malbohan I, Keller O, . Cerebrospinal fluid and serum antibodies against neurofilaments in patients with amyotrophic lateral sclerosis. Eur J Neurol. 2010;17:562–6.
  • Ryberg H, An J, Darko S, Lustgarten JL, Jaffa M, Gopalakrishnan V, . Discovery and verification of amyotrophic lateral sclerosis biomarkers by proteomics. Muscle Nerve. 2010;42:104–11.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.