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Journal of Dietary Supplements Volume 7, 2010 - Issue 3
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Research Article

An Open Label Study on the Supplementation of Gymnema sylvestre in Type 2 Diabetics

Smriti Nanda Kumar Smriti Nanda Kumar is affiliated with the Department of Foods and Nutrition, WHO Collaborating Centre for Research & Training in Promoting Nutrition in Health & Development, The M. S. University of Baroda, Vadodara, Gujarat 390 020, India.Correspondence[email protected].
, MSc,
Uliyar Vitaldas Mani Uliyar Vitaldas Mani is affiliated with the Department of Foods and Nutrition, WHO Collaborating Centre for Research & Training in Promoting Nutrition in Health & Development, Faculty of Family and Community Sciences, The M. S. University of Baroda, Vadodara, Gujarat 390 002, India.
, PhD, FICN &
Indirani Mani Indirani Mani is affiliated with The M. S. University of Baroda, Vadodara, Gujarat 390 007, India.
, PhD
Pages 273-282 | Published online: 10 Aug 2010

REFERENCES

  • Araki S, Haneda M, Koya D, Reduction in microalbuminuria as an integrated indicator for renal and cardiovascular risk reduction in patients with type 2 diabetes. Diabetes. 2007;56:1727–1730.
  • Bhaskaran K, Kizar B, Shanmughasundaram K, Antidiabetic effect of a leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients. J Enthnopharmacol. 1990;30(3):295–300.
  • Dey L, Attele A, Yuan C. Alternative therapies for type 2 diabetes. Altern Med Rev. 2002;7(1):45–58.
  • Fushiki T, Kojima A, Imoto T, An extract of Gymnema sylvestre leaves purified gymnemic acid inhibits glucose stimulated gastric inhibitory peptide secretion in rats. J Nutr. 1992;122: 2367–2373.
  • Kharamov V, Spaspov A, Samokhina M. Chemical composition of dry extracts of Gymnema sylvestre leaves. Phar Chem J. 2008;42(1):29–31.
  • Liu B, Ananne HA, Al Romaiyan A, Characterisation of the insulinotropic activity of an aqueous extract of Gymnema sylvestre in mouse β-cells and human islets of langerhangs. Cell Physiol Biochem. 2009;23:125–132.
  • Luo H, Kashiwagi A, Shibahara T, Decreased bodyweight without rebound and regulated lipoprotein by gymnemate in genetic multifactor syndrome animal. Mol Cell Biochem. 2006;299:93–98.
  • Mani UV, Desai S, Iyer UM. Studies on the long-term effect of spirulina supplementation on serum lipid profile and glycated proteins in NIDDM patients. J Nutraceuticals, Func & Med Foods. 2000;2(3):25–32.
  • Mani UV, Iyer UM, Mani I, Desikachar HSR. Long-term effect of cereal pulse mix supplementation on serum lipid profile in NIDDM subjects. J Nutr Environ Med. 1997;7:163–168.
  • Mani UV, Parulkar J, Iyer UM, Glycemic index of cereal-pulse mix (diabetic mix) in NIDDM subjects. Int J Fd Sci Nutr. 1994;45:141–145.
  • Murakami N, Mukarami T, Kadoya M, New hypoglycemic constituents in “gymnemic acid” from Gymnema sylvestre. Chem Phar Bul. 1996;44(2):469–471.
  • Pan A, Sun J, Chen Y, Ye X, Li H, Effects of a flaxseed-derived lignan supplement in type 2 diabetic patients: a randomized, double-blind, cross-over trial. PLoS ONE. 2007;2(11):e1148.
  • Parikh PM, Mani UV, Iyer UM. Role of Spirulina in the control of glycemia and lipidemia in type 2 diabetes mellitus. J Med Foods. 2001;4(4):193–199.
  • Persaud S, Majed H, Raman A, Gymnema sylvestre stimulates insulin release in vitro by increased membrane permeability. J Endocrino. 1999;163:207–212.
  • Rai V, Iyer UM, Mani UV. Effect of Tulasi (Ocimum sanctum) leaf powder on blood sugar levels, serum lipids, and tissue lipids in diabetic rats. Plant Foods Hum Nutr. 1997;50:9–16.
  • Rai V, Mani UV, Iyer UM. Effect of Ocimum sanctum leaf powder on blood lipoproteins, glycated proteins and total amino acids in patients with non-insulin-dependent diabetes mellitus. J Nutr & Envirn Med. 1997;7:113–118.
  • Ridker PM. Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Circulation. 2003;107:363–336.
  • Schroeder J, Schroeder E. Use of the herb Gymnema sylvestre to illustrate the principles of gustatory sensation. J Undergrad Neurosci Edu. 2005;3(2):A59–A62.
  • Shanmugasundaram ER, Gopinath KL, Shanmugasundaram K, Rajendran VM. Possible regeneration of the islets of langerhans in streptozotocin-diabetic rats given Gymnema sylvestre leaf extracts. J Enthnopharmacol. 1990a;30(3):265–279.
  • Shanmugasundaram ER, Rajeswari G, Baskaran K, Rajesh Kumar BR, Radha Shanmugasundaram K, Kizar Ahmath B. Use of Gymnema sylvestre leaf extract in the control of blood glucose in insulin-dependent diabetes mellitus. J Ethnopharmacol. 1990b;30(3):281–294.
  • Shastri SAS. Aryabhishek. Mumbai, India: Sastu Sahitya, 1994.
  • Shigematsu N, Asano R, Shimosaka M, Effect of administration with the extract of Gymnema sylvestre R Br leaves on lipid metabolism in rats. Biol Pharm Bull. 2001;24(6):713–717.
  • Stratton IM, Adler AI, Neil HA, Association of glycemia with macrovascular and microvascular complications in type 2 diabetes (UKPDS 35): prospective observational study. BMJ. 2000;321:405–412.
  • Warrier PK, Nambiar VPK, Ramankutty C. Indian medicinal plants: a compendium of 500 species, vol. 3, pp. 107–109. Madras, India: Orient Longman Ltd, 1995.
  • Wencai YE, Liu X, Zhang Q, Anti-sweet saponins from Gymnema sylvestre. J Nat Prod. 2001;64(2):232–235.

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