An Evidence-Based Systematic Review of Umckaloabo (Pelargonium sidoides) by the Natural Standard Research Collaboration

REFERENCES

• Beil W, Kilian P. EPs 7630, an extract from Pelargonium sidoides roots inhibits adherence of Helicobacter pylori to gastric epithelial cells. Phytomedicine. 2007; 14(Suppl 6): 5–8.
   PubMedGoogle Scholar
• Bereznoy VV, Riley DS, Wassmer G, Heger M. Efficacy of extract of Pelargonium sidoides in children with acute non-group A beta-hemolytic streptococcus tonsillopharyngitis: a randomized, double-blind, placebo-controlled trial. Altern Ther Health Med. 2003; 9(5): 68–79.
   PubMed Web of Science ®Google Scholar
• Chuchalin AG, Berman B, Lehmacher W. Treatment of acute bronchitis in adults with a Pelargonium sidoides preparation (EPs 7630): a randomized, double-blind, placebo-controlled trial. Explore (NY). 2005; 1(6): 437–445.
   PubMedGoogle Scholar
• Conrad A, Hansmann C, Engels I, Daschner FD, Frank U. Extract of Pelargonium sidoides (EPs 7630) improves phagocytosis, oxidative burst, and intracellular killing of human peripheral blood phagocytes in vitro. Phytomedicine. 2007a; 14(Suppl 6): 46–51.
   PubMedGoogle Scholar
• Conrad A, Jung I, Tioua D, Lallemand C, Carrapatoso F, Engels I, Daschner FD, Frank U. Extract of Pelargonium sidoides (EPs 7630) inhibits the interactions of group A-streptococci and host epithelia in vitro. Phytomedicine. 2007b; 14(Suppl 6): 52–59.
   PubMedGoogle Scholar
• Conrad A, Kolodziej H, Schulz V. [Pelargonium sidoides-extract (EPs 7630): registration confirms efficacy and safety]. Wien Med Wochenschr. 2007c; 157(13–14): 331–336.
   PubMedGoogle Scholar
• de Boer HJ, Hagemann U, Bate J, Meyboom RH. Allergic reactions to medicines derived from Pelargonium species. Drug Saf. 2007; 30(8): 677–680.
   PubMed Web of Science ®Google Scholar
• Fukuda H, Kishii R, Takei M, Hosaka M. Contributions of the 8-methoxy group of gatifloxacin to resistance selectivity, target preference, and antibacterial activity against Streptococcus pneumoniae. Antimicrob Agents Chemother. 2001; 45(6): 1649–1653.
   PubMedGoogle Scholar
• Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, McQuay HJ. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials. 1996; 17(1): 1–12.
   PubMedGoogle Scholar
• Kayser O, Kolodziej H. Antibacterial activity of extracts and constituents of Pelargonium sidoides and Pelargonium reniforme. Planta Med. 1997; 63(6): 508–510.
   PubMed Web of Science ®Google Scholar
• Kayser O, Kolodziej H, Kiderlen AF. Immunomodulatory principles of Pelargonium sidoides. Phytother Res. 2001; 15(2): 122–126.
   PubMed Web of Science ®Google Scholar
• Koch E, Lanzendörfer-Goossens Wohn C. Stimulation of interferon (IFN)-â-synthesis and natural killer (NK) cell activity by an aqueous-ethanolic extract from roots of Pelargonium sidoides (Umckaloabo). Naunyn-Schmiederbergs Arch Pharmacol. 2002; 365(Suppl 1): R75.
   Google Scholar
• Kolodziej H, Burmeister A, Trun W, Radtke OA, Kiderlen AF, Ito H, Hatano T, Yoshida T, Foo LY. Tannins and related compounds induce nitric oxide synthase and cytokines gene expressions in Leishmania major-infected macrophage-like RAW 264.7 cells. Bioorg Med Chem. 2005; 13(23): 6470–6476.
   PubMedGoogle Scholar
• Kolodziej H, Kayser O, Radtke OA, Kiderlen AF, Koch E. Pharmacological profile of extracts of Pelargonium sidoides and their constituents. Phytomedicine. 2003; 10(Suppl 4): 18–24.
   PubMedGoogle Scholar
• Kolodziej H, Kiderlen AF. In vitro evaluation of antibacterial and immunomodulatory activities of Pelargonium reniforme, Pelargonium sidoides and the related herbal drug preparation EPs 7630. Phytomedicine. 2007; 14(Suppl 6): 18–26.
   PubMedGoogle Scholar
• Lewu FB, Grierson DS, Afolayan AJ. Clonal propagation of Pelargonium sidoides: a threatened medicinal plant of South Africa. Afr J Biotechnol. 2006; 5: 123–125.
   Google Scholar
• Lizogub VG, Riley DS, Heger M. Efficacy of a Pelargonium sidoides preparation in patients with the common cold: a randomized, double-blind, placebo-controlled clinical trial. Explore (NY). 2007; 3(6): 573–584.
   PubMedGoogle Scholar
• Matthys H, Eisebitt R, Seith B, Heger M. Efficacy and safety of an extract of Pelargonium sidoides (EPs 7630) in adults with acute bronchitis. A randomized, double-blind, placebo-controlled trial. Phytomedicine. 2003; 10(Suppl 4): 7–17.
   PubMed Web of Science ®Google Scholar
• Matthys H, Heger M. EPs 7630-solution—an effective therapeutic option in acute and exacerbating bronchitis. Phytomedicine. 2007a; 14(Suppl 6): 65–68.
   PubMedGoogle Scholar
• Matthys H, Heger M. Treatment of acute bronchitis with a liquid herbal drug preparation from Pelargonium sidoides (EPs 7630): a randomized, double-blind, placebo-controlled, multicentre study. Curr Med Res Opin. 2007b; 23(2): 323–331.
   PubMed Web of Science ®Google Scholar
• Matthys H, Kamin W, Funk P, Heger M. Pelargonium sidoides preparation (EPs 7630) in the treatment of acute bronchitis in adults and children. Phytomedicine. 2007; 14(Suppl 6): 69–73.
   PubMedGoogle Scholar
• Neugebauer P, Mickenhagen A, Siefer O, Walger M. A new approach to pharmacological effects on ciliary beat frequency in cell cultures—exemplary measurements under Pelargonium sidoides extract (EPs 7630). Phytomedicine. 2005; 12(1–2): 46–51.
   PubMed Web of Science ®Google Scholar
• Noldner M, Schotz K. Inhibition of lipopolysaccharid-induced sickness behavior by a dry extract from the roots of Pelargonium sidoides (EPs 7630) in mice. Phytomedicine. 2007; 14(Suppl 6): 27–31.
   PubMedGoogle Scholar
• Schulz V. Liquid herbal drug preparation from the root of Pelargonium sidoides is effective against acute bronchitis: results of a double-blind study with 124 patients. Phytomedicine. 2007; 14(Suppl 6): 74–75.
   PubMedGoogle Scholar
• Trun W, Kiderlen AF, Kolodziej H. Nitric oxide synthase and cytokines gene expression analyses in Leishmania-infected RAW 264.7 cells treated with an extract of Pelargonium sidoides (EPs 7630). Phytomedicine. 2006; 13(8): 570–575.
   PubMed Web of Science ®Google Scholar
• Wittschier N, Faller G, Hensel A. An extract of Pelargonium sidoides (EPs 7630) inhibits in situ adhesion of Helicobacter pylori to human stomach. Phytomedicine. 2007a; 14(4): 285–288.
   Google Scholar
• Wittschier N, Lengsfeld C, Vorthems S, Stratmann U, Ernst JF, Verspohl EJ, Hensel A. Large molecules as anti-adhesive compounds against pathogens. J Pharm Pharmacol. 2007b; 59(6): 777–786.
   PubMedGoogle Scholar