93
Views
4
CrossRef citations to date
0
Altmetric
Research Article

Folate Supplementation Induces Differential Dose-Dependent Modulation of Proliferative Phenotypes Among Cancerous and Noncancerous Oral Cell Lines In Vitro

, , , , , , , , , & show all
Pages 325-340 | Published online: 18 Oct 2010

REFERENCES

  • Bailey RL, Dodd KW, Gahche JJ, Dwyer JT, McDowell MA, Yetley EA, Sempos CA, Burt VL, Radimer KL, Picciano MF. Total folate and folic acid intake from foods and dietary supplements in the United States: 2003–2006. Am J Clin Nutr. 2010;91(1):231–237.
  • Bunnell A, Pettit N, Reddout N, Sharma K, O'Malley S, Chino M, Kingsley K. Analysis of primary risk factors for oral cancer from select US states with increasing rates. Tob Induc Dis. 2010;8(1):5 (epub ahead of print).
  • Campo-Trapero J, Cano-Sanchez J, Palacios-Sanchez B, Sanchez-Gutierrez JJ, Gonzalez-Moles MA, Bascones-Martinez A. Update on molecular pathology in oral cancer and precancer. Anticancer Res. 2008;28:1197–1205.
  • Capaccio P, Ottaviani F, Cuccarini V, Cenzuales S, Cesana BM, Pignataro L. Association between methylenetetrahydrofolate reductase polymorphisms, alcohol intake and oropharyngolaryngeal carcinoma in northern Italy. J Laryngol Otol. 2005;119:371–376.
  • Centers for Disease Control and Prevention. Spina bifida and anecephaly before and after folic acid mandate—United States, 1995–1996 and 1999–2000. MMWR Morb Mortal Wkly Rep. 2004;53:362–365.
  • Chatelain K, Phippen S, McCabe J, Teeters CA, O'Malley S, Kingsley K. Cranberry and grape seed extracts inhibit the proliferative phenotype of oral squamous cell carcinomas. Evid Based Complement Alternat. Med 2008, Jul 23 (epub ahead of print) http://ecam.oxfordjournals.org/ cgi/content/full/nen047v1?iew=long&pmid=18955355.
  • Choi SW, Mason JB. Folate status: effects on pathways of colorectal carcinogenesis. J Nutr. 2002;132:2413S–2418S.
  • Choumenkovitch SF, Selhub J, Wilson PW, Rader JI, Rosenberg IH, Jacques PF. Folic acid intake from fortification in United States exceeds predictions. J Nutr. 2002;132:2792–2798.
  • Cole BF, Baron JA, Sandler RS, Haile RW, Ahnen DJ, Bresalier RS, McKeown-Eyssen G, Summers RW, Rothstein RI, Burke CA, Snover DC, Church TR, Allen JI, Robertson DJ, Beck GJ, Bond JH, Byers T, Mandel JS, Mott LA, Pearson LH, Barry EL, Rees JR, Marcon N, Saibil F, Ueland PM, Greenberg ER; Polyp Prevention Study Group. Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. JAMA 2007;297:2351–2359.
  • Dietrich M, Brown CJ, Block G. The effect of folate fortification of cereal-grain products on blood folate status, dietary folate intake, and dietary folate sources among adult non-supplement users in the United States. J Am Coll Nutr. 2005;24:266–274.
  • Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJ, den Heijer M, Kluijtmans LA, van Den Heuvel LP, Rozen R. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet. 1995;10:111–113.
  • Hays WL. Inferences about population means. In: Statistics (5th ed.), pp. 311–342. International Thomson, Fort Worth, Texas, 1994.
  • Hubner RA, Houlston RS. Folate and colorectal cancer prevention. Br J Cancer 2009;100(2):233–239.
  • Kim YI. Folic acid fortification and supplementation—good for some but not so good for others. Nutr Rev. 2007;65(11):504–511.
  • Kim YI. Nutritional epigenetics: impact of folate deficiency on DNA methylation and colon cancer susceptibility. J Nutr. 2005;135:2703–2709.
  • King M, Chatelain K, Farris D, Jensen D, Pickup J, Swapp A, O’Malley S, Kingsley K. Oral squamous cell carcinoma proliferative phenotype is modulated by proanthocyanidins: a potential prevention and treatment alternative for oral cancer. BMC Complement Altern Med. 2007;7:22.
  • Kingsley K. Potential effects of dietary folate supplementation on oral carcinogenesis, development and progression. J Diet Suppl. 2010;7(1):51–59.
  • Kingsley K, O'Malley S, Ditmyer M, Chino M. Analysis of oral cancer epidemiology in the US reveals state-specific trends: implications for oral cancer prevention. BMC Public Health 2008;8:87.
  • Lucock M, Yates Z. Folic acid fortification: a double-edged sword. Curr Opin Clin Nutr Metab Care 2009;12(6):555–564.
  • Matsue H, Rothberg KG, Takashima A, Kamen BA, Anderson RG, Lacey SW. Folate receptor allows cells to grow in low concentrations of 5-methyltetrahydrofolate. Proc Natl Acad Sci U S A 1992;89:6006–6009.
  • McCully KS. Homocysteine, vitamins, and vascular disease prevention. Am J Clin Nutr. 2007;86(5):1563S–1568S.
  • Mills JL, Signore C. Neural tube defect rates before and after food fortification with folic acid. Birth Defects Res A Clin Mol Teratol. 2004;70:844–845.
  • Mu LN, Cao W, Zhang ZF, Yu SZ, Jiang QW, You NC, Lu QY, Zhou XF, Ding BG, Chang J, Chen CW, Wei GR, Cai L. Polymorphisms of 5,10-methylenetetralydrofolate reductase (MTHFR), fruit and vegetable intake, and the risk of stomach cancer. Biomarkers 2007;12(1):61–75.
  • National Research Council. Folate. Recommended dietary allowances. Washington, DC: National Academy Press, 1989:150–158.
  • Oakley GP, Jr. The scientific basis for eliminating folic acid-preventable spina bifida: a modern miracle from epidemiology. Ann Epidemiol. 2009;19(4):226–230.
  • Quinlivan EP, Gregory JF. Effect of food fortification on folic acid intake in the United States. Am J Clin Nutr. 2003;77:221–225.
  • Rader JI, Schneeman BO. Prevalence of neural tube defects, folate status, and folate fortification of enriched cereal-grain products in the United States. Pediatrics 2006;117:1394–1399.
  • Schernhammer ES, Ogino S, Fuchs CS. Folate and vitamin B6 intake and risk of colon cancer in relation to p53 expression. Gastroenterology 2008;135:770–780.
  • Solomons NW. Food fortification with folic acid: has the other shoe dropped? Nutr Rev. 2007;65(11):512–515.
  • Sugerman PB, Joseph BK, Savage NW. The role of oncogenes, tumour suppressor genes and growth factors in oral squamous cell carcinoma: a case of apoptosis versus proliferation. Oral Dis. 1995;1:172–188.
  • Ulrich CM. Folate and cancer prevention: a closer look at the complex picture. Am J Clin Nutr. 2007;86:271–273.
  • Vairaktaris E, Yapijakis C, Kessler P, Vylliotis A, Ries J, Wiltfang J, Vassiliou S, Derka S, Neukam FW. Methylenetetrahydrofolate reductase polymorphism and minor increase of risk for oral cancer. J Cancer Res Clin Oncol. 2006;132:219–222.
  • Van Der Put NM, Gabreëls F, Stevens EM, Smeitink JA, Trijbels FJ, Eskes TK, Van Den Heuvel LP, Blom HJ. A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects? Am J Hum Genet. 1998;62:1044–1051.
  • Wang X, Qin X, Demirtas H, Li J, Mao G, Huo Y, Sun N, Liu L, Xu X. Efficacy of folic acid supplementation in stroke prevention: a meta-analysis. Lancet 2007;369(9576):1876–1882.
  • Weinstein SJ, Gridley G, Harty LC, Diehl SR, Brown LM, Winn DM, Bravo-Otero E, Hayes RB. Folate intake, serum homocysteine and methylenetetrahydrofolate reductase (MTHFR) C677T genotype are not associated with oral cancer risk in Puerto Rico. J Nutr. 2002;132:762–767.
  • Williams HK. Molecular pathogenesis of oral squamous carcinoma. Mol Pathol. 2000;53:165–172.
  • Wolff T, Witkop CT, Miller T, Syed SB, US Preventive Services Task Force. Folic acid supplementation for the prevention of neural tube defects: an update of the evidence for the US Preventive Services Task Force. Ann Intern Med. 2009;150(9):632–639.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.