Advanced search
Publication Cover
Journal of Dietary Supplements Volume 7, 2010 - Issue 4
Submit an article Journal homepage
88
Views
14
CrossRef citations to date
0
Altmetric
Research Article

The Anti-Inflammatory and Antinociceptive Properties of the Chloroform Fraction From Phyllanthus niruri Plant Is Mediated via the Peripheral Nervous System

Ifeoma Chinwude Obidike Ifeoma Chinwude Obidike, Oluwakanyinsola Adeola Salawu, and Mary Ndukuba are affiliated with the Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria.Correspondence[email protected]
, MPharm,
Oluwakanyinsola Adeola Salawu Ifeoma Chinwude Obidike, Oluwakanyinsola Adeola Salawu, and Mary Ndukuba are affiliated with the Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria.
,
Mary Ndukuba Ifeoma Chinwude Obidike, Oluwakanyinsola Adeola Salawu, and Mary Ndukuba are affiliated with the Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria.
,
Charles Ogbonnaya Okoli Charles Ogbonnaya Okoli is affiliated with the Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu, Nigeria.
&
Uche Alex Osunkwo Uche Alex Osunkwo is affiliated with the Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria.
Pages 341-350 | Published online: 11 Oct 2010

REFERENCES

  • Abbah J, Amos S, Chindo B, Ngazal I, Vongtau HO, Adzu B, Farida T, Odutola AA, Wambebe C, Gamaniel KS. Pharmacological evidence favouring the use of Nauclea latifolia in malaria ethnopharmacy: effects against nociception, inflammation and pyrexia in rats and mice. J Ethnopharmacol. 2010;127:85–90.
  • Akah P, Okogun JI, Ekpendu TO. Anti-oedema and analgesic activity of Diodia scandans extract in rats and mice. Phytother Res. 1993;7:317–319.
  • Al-Ghamdy MS. The anti-inflammatory, analgesic and antipyretic activity of Nigella sativa. J Ethnopharmacol. 2001;76:45–48.
  • Asprey GF, Thornton P. Medicinal plants of Jamaica. III. West Indian Med J. 1955;4:69–82.
  • Bagalkotkar G, Sagineedu SR, Saad MS, Stanslas J. Phytochemicals from Phyllanthus niruri Linn. and their pharmacological properties: a review. J Pharm Pharmacol. 2006;58:1559–1570.
  • Bavarva JH, Narasimhacharya AVRL. Comparative antidiabetic, hypolipidemic and antioxidant properties of Phyllanthus niruri in normal and diabetic rats. Pharm Biol. 2007;45:569–574.
  • Calixto JB, Beirith A, Ferrerra J, Santos ARS, Filho VC, Yunes RA. Naturally occuring antinociceptive substances from plants. Phytother Res. 2000;14:407–418.
  • Chandra R. Lipid lowering activity of Phyllanthus niruri. J Med Aromat Plant Sci. 2000;22:29–30.
  • Chin Y-W, Balunas MJ, Chai HB, Kinghorn AD. Drug discovery from natural sources. Am Ass Pharm Sci. 2006;8(2):E239–E253.
  • Collier HOJ, Dinneen LC, Johnson CA, Schneider C. The abdominal constriction response and its suppression by analgesic drugs in the mouse. Brit J Pharmacol. 1968;32:295–310.
  • Deraedt R, Jougney S, Delevalcee F, Falhout M. Release of prostaglandins E and F in an algogenic reaction and its inhibition. Eur J Pharmacol. 1980;51:17–24.
  • Dubinsky B, Gebre-Mariam S, Capetola RJ, Rosenthale ME. The analgesic drugs: human therapeutic correlates of their potency in laboratory animals of hyperalgesia. Agents Actions 1987;20:50–60.
  • Hamburger M, Hostettmann K. Bioactivity in plants: the link between phytochemistry and medicine. Phytochemistry 1991;30:3864–3874.
  • Koster R, Anderson M, De Beer EJ. Acetic acid for analgesic screening. Fed Proc. 1959;18:412.
  • Levini JD, Lau W, Kwait G, Goetzl EJ. Leukotriene B4 produces hyperalgesia that is dependent on the polymorphonuclear leucocytes. Science 1984;225:743–745.
  • MacPherson RD. The pharmacological basis of contemporary pain management. Pharmacol Therap. 2000;88(2):163–185.
  • Naik AD, Juvekar AR. Effects of alkaloidal extract of Phyllanthus niruri on HIV replication. Indian J Med Sci. 2003;57:387–393.
  • National Institute of Health. Guide for the care and use of laboratory animals. Bethesda, MD: Public Health Service, National Institutes of Health (NIH Publ. No. 86–23, Revised 1985), 1985.
  • Obidike IC. Pharmacological evaluation of the mechanisms of antidiabetic activity of extract of aerial parts of Phyllanthus niruri. M Pharm thesis. Au: University of Nigeria, Nsukka, 2010.
  • Shimizu M. Studies on aldose reductase inhibitors from natural products. II. Active components of a Paraguayan crude drug para-parai mi, Phyllanthus niruri. Chem Pharm Bull. 1989;37:2531–2532.
  • Tona L, Mesia K, Ngimbi NP, Chrimwami B, Okond’Ahoka A, Cimanga K, De Bruyne T, Apers S, Hermans N, Totté J, Pieters L, Vlietinck AJ. In vivo antimalarial activity of Cassia occidentalis, Morinda morindoides and Phyllanthus niruri. Ann Trop Med Parasitol. 2001;65:47–57.
  • Vilela FC, Bitencourt AD, Cabral LDM, Franqui LS. Anti-inflammatory and antipyretic effects of Sonchus oleraceus in rats. J Ethnopharmacol. 2010;127:737–741.
  • Vogel HG, Vogel WH (Eds.). Drug discovery and evaluation: pharmacological assays. Heidelberg, Berlin: Springer-Verlaag, 2002.
  • Vongtau HO, Abbah J, Mosugu O, Chindo BA, Ngazal IE, Salawu AO, Kwanashie HO, Gamaniel KS. Antinociceptive profile of the methanolic extract of Neorautanenia mitis root in rats and mice. J Ethnopharmacol. 2004;92:317–324.
  • Xu X-M, Sansores-Garcia L, Chen X-M, Matijevic-Aleksic N, Du M, Wu KK. Suppression of inducible cyclooxygenase 2 gene transcription by aspirin and sodium salicylate. Proc Natl Acad Sci USA 1999;96:5292–5297.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.