An Evidence-Based Systematic Review of Gymnema (Gymnema sylvestre R. Br.) by the Natural Standard Research Collaboration

REFERENCES

• Ananthan R, Baskar C, NarmathaBai V, Pari L, Latha M, Ramkumar KM. Antidiabetic effect of Gymnema montanum leaves: effect on lipid peroxidation induced oxidative stress in experimental diabetes. Pharmacol Res. 2003;48:551–556.
   PubMed Web of Science ®Google Scholar
• Ananthan R, Latha M, Pari L, Ramkumar KM, Baskar CG, Bai VN. Effect of Gymnema montanum on blood glucose, plasma insulin, and carbohydrate metabolic enzymes in alloxan-induced diabetic rats. J Med Food. 2003;6:43–49.
   PubMedGoogle Scholar
• Baskaran Kizar, Ahamath B, Shanmugasundaram K, Shanmugasundaram ER. Antidiabetic effect of a leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients. J Ethnopharm. 1990;30:295–300.
   PubMed Web of Science ®Google Scholar
• Bishayee A, Chatterjee M. Hypolipidaemic and antiatherosclerotic effects of oral Gymnema sylvestre R. Br. leaf extract in albino rats fed a high fat diet. Phytother Res. 1994;8:118–120.
   Web of Science ®Google Scholar
• Brala P, Hagen R. Effects of sweetness perception and caloric value of a preload on short term intake. Physiol Behav. 1983;30:1–9.
   PubMedGoogle Scholar
• Chattopadhyay RR. Possible mechanism of antihyperglycemic effect of Gymnema sylvestre leaf extract, part I. Gen Pharm. 1998;31:495–496.
   PubMedGoogle Scholar
• Cicero AF, Derosa G, Gaddi A. What do herbalists suggest to diabetic patients in order to improve glycemic control? Evaluation of scientific evidence and potential risks. Acta Diabetol. 2004;41:91–98.
   PubMed Web of Science ®Google Scholar
• Gholap S, Kar A. Effects of Inula racemosa root and Gymnema sylvestre leaf extracts in the regulation of corticosteroid induced diabetes mellitus: involvement of thyroid hormones. Pharmazie. 2003;58:413–415.
   PubMed Web of Science ®Google Scholar
• Grover JK, Yadav S, Vats V. Medicinal plants of India with anti-diabetic potential. J Ethnopharmacol. 2002;81:81–100.
   PubMed Web of Science ®Google Scholar
• Gupta SS, Variyar MC. Experimental studies on pituitary diabetes IV. Effect of Gymnema sylvestre and Coccinia indica against the hyperglycemia response of somatotrophin and corticotrophin hormones. Indian J Med Res. 1964;52:200–207.
   PubMed Web of Science ®Google Scholar
• Imoto T, Miyasaka A, Ishima R, Akasaka K. A novel peptide isolated from the leaves of Gymnema sylvestre—I. Characterization and its suppressive effect on the neural responses to sweet taste stimuli in the rat. Comp Biochem Physiol A. 1991;100:309–314.
   PubMedGoogle Scholar
• Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, McQuay HJ. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials. 1996;17(1):1–12.
   PubMedGoogle Scholar
• Jiang H. Advances in the study on hypoglycemic constituents of Gymnema sylvestre (Retz.) Schult. Zhong Yao Cai. 2003;26:305–307.
   PubMedGoogle Scholar
• Kamei K, Takano R, Miyasaka A, Imoto T, Hara S. Amino acid sequence of sweet-taste-suppressing peptide (gurmarin) from the leaves of Gymnema sylvestre. J Biochem. 1992;111:109–112.
   PubMedGoogle Scholar
• Khare AK, Tondon RN, Tewari JP. Hypoglycaemic activity of an indigenous drug (Gymnema sylvestre, “Gurmar”) in normal and diabetic persons. Indian J Physiol Pharm. 1983;27:257–258.
   PubMedGoogle Scholar
• Koch RB, Desaiah D, Cutkomp LK. Inhibition of ATPases by gymnemic acid. Chem Biol Interact. 1973;7:121–125.
   PubMedGoogle Scholar
• Kothe A, Uppal R. Antidiabetic effects of Gymnema sylvestre in NIDDM—a short study. Indian J Homeopath Med. 1997;32:61–62, 66.
   Google Scholar
• Lawless HT. Evidence for neural inhibition in bittersweet taste mixtures [abstract]. J Comp Physiol Psychol. 1979;93(3):538–547.
   PubMedGoogle Scholar
• Meiselman HL, Halperin BP. Human judgments of Gymnema sylvestre and sucrose mixtures. Physiol Behav. 1970;5:945–948.
   PubMedGoogle Scholar
• Meiselman HL, Halpern, BP. Effects of Gymnema sylvestre on complex tastes elicited by amino acids and sucrose. Physiol Behav. 1970;5:1379–1384.
   PubMedGoogle Scholar
• Min BC, Sakamoto K. Influence of sweet suppressing agent on gustatory brain evoked potentials generated by taste stimuli. Appl Human Sci. 1998;17:9–17.
   PubMedGoogle Scholar
• Murakami N, Murakami T, Kadoya M, Matsuda H, Yamahara J, Yoshikawa M. New hypoglycemic constituents in “gymnemic acid” from Gymnema sylvestre. Chem Pharm Bull. 1996;44:469–471.
   PubMed Web of Science ®Google Scholar
• Okabayashi Y, Tani S, Fujisawa T, Koide M, Hasegawa H, Nakamura T, Fujii M, Otsuki M. Effect of Gymnema sylvestre, R.Br. on glucose homeostasis in rats. Diabetes Res Clin Pract. 1990;9:143–148.
   PubMed Web of Science ®Google Scholar
• Persaud SJ, Al Majed H, Raman A, Jones PM. Gymnema sylvestre stimulates insulin release in vitro by increased membrane permeability. J Endocrinol. 1999;163:207–212.
   PubMed Web of Science ®Google Scholar
• Porchezhian E, Dobriyal RM. An overview on the advances of Gymnema sylvestre: chemistry, pharmacology and patents. Pharmazie. 2003;58:5–12.
   PubMed Web of Science ®Google Scholar
• Preuss HG, Gondal JA, Bustos E, Bushehri N, Lieberman S, Bryden NA, Polansky MM, Anderson RA. Effect of chromium and guar on sugar-induced hypertension in rats. Clin Neph. 1995;44:170–177.
   PubMed Web of Science ®Google Scholar
• Preuss HG, Jarrell ST, Scheckenbach R, Lieberman S, Anderson RA. Comparative effects of chromium, vanadium and gymnema sylvestre on sugar-induced blood pressure elevations in SHR. J Amer Coll Nutrit. 1998;17:116–123.
   PubMed Web of Science ®Google Scholar
• Preuss HG, Garis RI, Bramble JD, Bagchi D, Bagchi M, Rao CV, Satyanarayana S. Efficacy of a novel calcium/potassium salt of (-)-hydroxycitric acid in weight control. Int J Clin Pharmacol Res. 2005;25:133–144.
   PubMedGoogle Scholar
• Rathi AN, Visvanathan A, Shanmugasundaram KR. Studies on protein-bound polysaccharide components & glycosaminoglycans in experimental diabetes—effect of Gymnema sylvestre, R. Br. Indian J Exper Biol. 1981;19:715–721.
   Google Scholar
• Satdive RK, Abhilash P, Fulzele DP. Antimicrobial activity of Gymnema sylvestre leaf extract. Fitoterapia. 2003;74:699–701.
   PubMed Web of Science ®Google Scholar
• Shanmugasundaram ERB, Gopinath KL, Radha Shanmugasundaram K, Rajendran VM. Possible regeneration of the islets of Langerhans in streptozotocin-diabetic rats given Gymnema sylvestre leaf extracts. J Ethnopharm. 1990;30:265–279.
   PubMed Web of Science ®Google Scholar
• Shanmugasundaram ERB, Rajeswari G, Baskaran K, Rajesh Kumar BR, Radha Shanmugasundaram K, Kizar Ahmath B. Use of Gymnema sylvestre leaf extract in the control of blood glucose in insulin-dependent diabetes mellitus. J Ethnopharm. 1990;30:281–294.
   PubMed Web of Science ®Google Scholar
• Shanmugasundaram KR, Panneerselvam C, Samudram P, Shanmugasundaram ER. Enzyme changes and glucose utilisation in diabetic rabbits: the effect of Gymnema sylvestre, R. Br. J Ethnopharm. 1983;7:205–234.
   PubMed Web of Science ®Google Scholar
• Shapiro K, Gong WC. Natural products used for diabetes. J Am Pharm Assoc (Wash). 2002;42:217–226.
   PubMedGoogle Scholar
• Shimizu K, Ozeki M, Tanaka K, Itoh K, Nakajyo S, Urakawa N, Atsuchi M. Suppression of glucose absorption by extracts from the leaves of Gymnema inodorum [abstract]. J Vet Med Sci. 1997;59:753–757.
   PubMed Web of Science ®Google Scholar
• Simons CT, O'Mahony M, Carstens E. Taste suppression following lingual capsaicin pre-treatment in humans. Chem Senses. 2002;27:353–365.
   PubMed Web of Science ®Google Scholar
• Sinsheimer JE, Rao GS, McIlhenny HM. Constituents from Gymnema sylvestre leaves V. Isolation and preliminary characterization of the gymnemic acids. J Pharm Sci. 1970;59:622–628.
   PubMed Web of Science ®Google Scholar
• Srivastava Y, Nigam SK, Bhatt HV, Verma Y, Prem AS. Hypoglycemic and life-prolonging properties of Gymnema sylvestre leaf extract in diabetic rats. Israel J Med Sci. 1985;21:540–542.
   PubMedGoogle Scholar
• Terasawa H, Miyoshi M, Imoto T. Effects of long-term administration of Gymnema sylvestre watery-extract on variations of body weight, plasma glucose, serum triglyceride, total cholesterol and insulin in Wistar fatty rats. Yonago Acta Med. 1994;37:117–127.
   Google Scholar
• Tominaga M, Kimura M, Sugiyama K, Abe T, Igarashi K, Igarashi M, Eguchi H, Sekikawa A, Ogawa A, Manaka H, Effects of seishin-renshi-in and Gymnema sylvestre on insulin resistance in streptozotocin-induced diabetic rats. Diabet Res Clin Pract. 1995;29:11–17.
   PubMed Web of Science ®Google Scholar
• Wang LF, Luo H, Miyoshi M, Imoto T, Hiji Y, Sasaki T. Inhibitory effect of gymnemic acid on intestinal absorption of oleic acid in rats. Can J Physiol Pharmacol. 1998;76:1017–1023.
   PubMedGoogle Scholar
• Warren RP, Warren RM, Weninger MG. Inhibition of the sweet taste by Gymnema sylvestre. Nature. 1969;223:94–95.
   PubMed Web of Science ®Google Scholar
• Xie JT, Wang A, Mehendale S, Wu J, Aung HH, Dey L, Qiu S, Yuan CS. Anti-diabetic effects of Gymnema yunnanense extract. Pharmacol Res. 2003;47:323–329.
   PubMed Web of Science ®Google Scholar
• Ye W, Liu X, Zhang Q, Che CT, Zhao S. Antisweet saponins from Gymnema sylvestre. J Nat. Prod. 2001;64:232–235.
   PubMed Web of Science ®Google Scholar
• Yoshikawa M, Murakami T, Kadoya M, Li Y, Murakami N, Yamahara J, Matsuda H. Medicinal foodstuffs. IX. The inhibitors of glucose absorption from the leaves of Gymnema sylvestre R. BR. (Asclepiadaceae): structures of gymnemosides a and b. Chem Pharm Bull (Tokyo). 1997;45:1671–1676.
   PubMed Web of Science ®Google Scholar