158
Views
24
CrossRef citations to date
0
Altmetric
Research Article

The Dietary Supplementation of Nordihydroguaiaretic Acid (NDGA) Delayed the Loss of Climbing Ability in Drosophila Model of Parkinson's Disease

, , &
Pages 1-8 | Received 30 Aug 2011, Accepted 06 Oct 2011, Published online: 18 Nov 2011

REFERENCES

  • Abbott RA, Cox M, Markus H, Temkins A. Diet, body size and micronutrient status in Parkinson's disease. Eur J Clin Nutr. 1992;46:879–884.
  • Amer DA, Irvine GB, El-Agnaf OM. Inhibitors of alpha-synuclein oligomerization and toxicity: a future therapeutic strategy for Parkinson's disease and related disorders. Exp Brain Res. 2006;173:223–233.
  • Avanesian A, Semmani S, Jafri M. Can Drosophila melanogaster represent a model system the detection of reproductive adverse drug reactions?? Drug Dis Today. 2009;14:761–766.
  • Behl C, Davis JB, Lesley R, Schubert D. Hydrogen peroxide mediates amyloid beta protein toxicity. Cell 1994;77:817–827.
  • Benford DJ, Hanley AB, Bottrill K, Oehlschlager S, Balls M, Branca F, Castengnaro JJ, Descotes J, Hemminiki K, Lindsay D, Schitter B. Biomarkers as predictive tools in toxicity testing. The report and recommendations of EVCAM Workshop. Alt Lab Anim 2000;28:119–131.
  • Butterfield DA, Kanski J. Brain protein oxidation in age related neurodegenerative disorders that are associated with aggregated proteins. Mech Ageing Dev. 2001;15:1945–1962.
  • Caruana M, Hogen T, Levin J, Hillmer A, Giese A, Vassallo N. Inhibition and disaggregation of alpha Synuclein oligomers by natural polyphenolic compounds. FEBS Lett 2011;585:1113–1120.
  • Conway KA, Harper JD, Lansbury AT. Accelerated in vitro fibril formation by a mutant alpha synuclein linked to early onset Parkinson Disease. Nat Med. 1998;4:1318–1320.
  • Dauer W, Przedborski S. Parkinson's disease: mechanisms and models. Neuron 2003;39:889–909.
  • Duffy JB. GAL4 system in Drosophila: a fly geneticist's Swiss army knife. Genesis 2002;32:1–15.
  • Fahn S. The endogenous toxin hypothesis of the etiology of Parkinson's disease and a pilot trial of high dosage antioxidants in an attempt to slow the progression of the illness. Ann NY Acad Sci. 1989;570:186–196.
  • Feany MB, Bender WW. A drosophila model of parkinson's disease. Nature 2000;404:394–398.
  • Festing MFW, Baumans V, Combes DR, Halder M, Hendricsen FM, Howard BR, Lovell DP, Moore GJ, Overend P, Wilson MS. Reducing the use of laboratory animals in biomedical research: problems and possible solutions. Alt Lab Anim 1998;26:283–301.
  • Giasson BI, Ischiropoulos H, Lee VM, Trojanowski JQ. The relationship between oxidative/nitrative stress and pathological inclusions in Alzheimer's and Parkinson's diseases. Free Radic Biol Med. 2002;32:1264–1275.
  • Giasson BI, Ury UK, Trojanowski JQ, Lee MYE. Mutant and wild type human alpha synuclein assemble into elongated filaments with distinct morphologies in vitro. J. Biol Chem. 1999;274:7619–7622.
  • Goodman Y, Steiner MR, Steiner SM, Mattson MP. Nordihydroguaiaretic acid protects hippocampal neurons against amyloid beta- peptide toxicity and attenuates free radicals and calcium accumulation. Brain Res. 1994;654:171–176.
  • Lambert JD, Meyers RO, Timmermann BN, Dorr RT. Pharmacokinetic analysis by high performance liquid chromatography of intervenous nordihydroguaiaretic acid in the mouse. J Chromatogr B Biomed Sci App. 2001;754:85–90.
  • Lü JM, Nurko J, Weakley SM, Jiang J, Kouglas P, Lin PH, Yao Q, Chen C. Molecular mechanisms and clinical application of nordihydroguaiaretic acid (NDGA) and its derivatives: an update. Med Sci Monit. 2010;16: RA 93–R 100.
  • Masliah E, Rockenstein E, Veinbergs I, Mallory M, Hashimoto M, Takeda A, Sagara Y, Sisk A, Mucke L. Dopaminergic loss and inclusion body formation in alpha Synuclein mice: implication for neurogenerative disorders. Science 2000;287:1265–1269.
  • Naoi M, Maruyama W. Future of neuroprotection in Parkinson's disease. Parkinson Relat Disord 2001;8:139–145.
  • Noor R, Mittal S, Iqbal J. Superoxide dismutase: applications and relevance to human diseases. Med Sci Monit 2002;8: R A 210–5.
  • Ono K, Hasegaua K, Yoshiike Y, Takashima A, Yamada M, Naiki H. Nordihydroguaiaretic acid potentially breaks down preformed Alzheimer's beta amyloid fibrils in vitro. J Neurochem. 2002;81:434–440.
  • Ono K, Yamada M. Antioxidant compounds have potent anti-fibrillogenic and fibril- destabilizing effects for alpha synuclein fibrils in vitro. J Neurochem 2006;97:105–115.
  • Pal R, Miranda M, Narayan M. Nitrosative stress-induced Parkinsonian lewy like aggregates prevented through polyphenolic phytochemical analog intervention. Biochem Biophys Res Commun 2011;404:324–329.
  • Pendleton RG, Parvez F, Sayed M, Hillman R. Effects of pharmacological agents upon a transgenic model of Parkinson's disease in Drosophila melanogaster. J Pharmacol Exp Therap. 2002;300:91–96.
  • Prasad KN, Cole WC, Kumar B. Multiple antioxidants in the prevention and treatment of Parkinson's Disease. J Am Coll Nutr. 1999;18:413–423.
  • Richie JP, Mills BJ, Lang CA. Dietary nordihydroguaiaretic acid increases the life span of the mosquitoes. Pro Soc Exp Biol Med. 1986;183:81–85.
  • Scherzer CR, Jensen RV, Gullans SR, Feany MB. Gene expression changes presage neurodegeneration in a Drosophila model of Perkinson's disease. Hum Mol Genet. 2003;12:2457– 2466.
  • Shishido Y, Furushiro M, Hashimoto S, Yokokura T. Effect of nordihydroguaiaretic acid on behavioral impairment and neuronal cell death after forebrain ischemia. Pharmacol Biochem Behav. 2001;69:469–474.
  • Siddique YH, Ara G, Beg T, Afzal M, Faisal M. Protective role of Plumbago zeylanica extract against toxic effects of ethinylestradiol in the third instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ)Bg9 and cultured human peripheral blood lymphocytes. Alt Med Studies. 2011;1e7:26–29.
  • Siddique YH, Ara G, Beg T, Afzal M. Protective role of nordihydroguaiaretic acid (NDGA) against the genotoxic damage induced by ethynodiol diacetate in human lymphocytes in vitro. J Environ Biol 2007;28:279–282.
  • Siddique YH, Beg T, Afzal M. Protective effect of nordihydroguaiaretic acid (NDGA) against norgestrel induced genotoxic damage. Toxicol in vitro. 2006;20:227–233.
  • Singh M, Arseneault M, Sanderson T, Murthy V, Ramassamy C. Challenges for research on polyphenols from foods in Alzheimer's disease: bioavailability, metabolism and cellular and molecular mechanisms. J Agric Food Chem. 2008;56:4855–4873.
  • Simonian NA, Coyle JT. Oxidative stress in neurodegenerative diseases. Annu Rev Pharmacol Toxicol 1996;36:83–106.
  • Strong R, Miller RA, Astle CM, Floyd RA, Flurkey K, Hensley KL, Javors MA, Leeuwenburgh C, Nelson JF, Ongini E, Nadon NL, Warner HR, Harrison DE. Nordihydroguaiaretic acid and aspirin increase life- span of genetically heterogeneous mice. Aging Cell. 2008;7:641– 650.
  • Van der Putten H, Wiederhold KH, Probst A, Barbieri S, Mistl C, Danner S, Kauffmann S, Hofele K, Spooren WP, Ruegg MA, Lin S, Caroni P, Sommer B, Tolnay M, Bilbe G. Neuropathology in mice expressing human alpha-synuclein. J Neurosci. 2000;15:6021–9.
  • Xun Z, Kaufman TC, Clemmer DE. Proteome response to the panneural expression of human wild type alpha synuclein: a drosophila model of Parkinson's Disease. J Proteome Res 2008;7 3911–3921.
  • Youdim KA, Qaiser MZ, Begley DJ, Rice-Evans CA, Abott NJ. Flavonoid permeability across an insitu model of the blood brain barrier. Free Radic Biol. Med. 2004;36:592–604.
  • Zhang Y, Dawson VL, Dawson TM. Oxidative stress and genetics in the pathogenesis of Parkinson's disease. Neurobiol Dis. 2000;7:240–250.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.