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ARTICLE

An Evidence-Based Systematic Review of Yin Yang Huo (Epimedium spp.) by the Natural Standard Research Collaboration

, PharmD (& Natural Standard Research Collaboration) &
Pages 136-164 | Published online: 13 Aug 2015

REFERENCES

  • Chao SL, Huang LW, Yen HR. Pregnancy in premature ovarian failure after therapy using Chinese herbal medicine. Chang Gung Med J. 2003;26(6):449–452.
  • Chen C, Sha M, Yang S, Zhang Z. Quantitative study of magnoflorine in Epimedium koreanum Nakai.. Zhongguo Zhong Yao Za Zhi. 1996;21(11):681–2, 704.
  • Chen CC, Huang YL, Sun CM, Shen CC. New prenylflavones from the leaves of Epimedium saggitatum. J Nat Prod. 1996;59(4):412–414.
  • Chen HL, Wang JK, Zhang LL, Wu ZY. Contents of general flavonoides in Epimedium acuminatum Franch and its differently processed products. Zhongguo Zhong Yao Za Zhi. 2000;25(4):239–241.
  • Chen KM, Ge BF, Ma HP, Zheng RL. The serum of rats administered flavonoid extract from Epimedium sagittatum but not the extract itself enhances the development of rat calvarial osteoblast-like cells in vitro. Pharmazie. 2004;59(1):61–64.
  • Chen M, Kuang A, Chen J. Effect of monoamine neurotransmitters in the hypothalamus in a cortisol-induced rat model of yang deficiency. Zhong Xi Yi Jie He Za Zhi. 1990;10(5):262, 292–294.
  • Chen MD, Kuang AK, Chen JL. Influence of yang-restoring herb medicines upon metabolism of thyroid hormone in normal rats and a drug administration schedule. Zhong Xi Yi Jie He Za Zhi. 1989;9(2):70, 93–95.
  • Chen X, Zhou M, Wang J. Effect of epimedium sagittatum on soluble IL-2 receptor and IL-6 levels in patients undergoing hemodialysis. Zhonghua Nei Ke Za Zhi. 1995;34(2): 102–104.
  • Cheng QL, Chen XM, Shi SZ. Effects of Epimedium sagittatum on immunopathology and extracellular matrices in rats with chronic renal insufficiency. Zhonghua Nei Ke Za Zhi. 1994;33(2):83–86.
  • Chiba K, Yamazaki M, Umegaki E, Li MR, Xu ZW, Terada S, et al. Neuritogenesis of herbal (+)- and (-)-syringaresinols separated by chiral HPLC in PC12h and Neuro2a cells. Biol Pharm Bull. 2002;25(6):791–793.
  • Cirigliano, MD Szapary PO. Horny goat weed for erectile dysfunction. Altern Med Alert. 2001;4:19–22.
  • De Naeyer A, Pocock V, Milligan S, De Keukeleire D. Estrogenic activity of a polyphenolic extract of the leaves of Epimedium brevicornum. Fitoterapia. 2005;76(1):35–40.
  • Dong XP, Xiao CH, Zhang R, Li W. Chemical studies of Epimedium acuminatum Franch. Zhongguo Zhong Yao Za Zhi. 1994;19(10):614–615, 639.
  • Gao B, Yu J, Xiao P. Chemical constituents from the aerial part of Epimedium brevicornum maxim.. Zhongguo Zhong Yao Za Zhi. 1996;21(5):290–292, 319.
  • Guo B. Xiao P. Determination of flavonoids in different parts of five epimedium plants. Zhongguo Zhong Yao Za Zhi. 1996;21(9):523–525, 574.
  • Guo B, Yu J, Xiao P. Chemical constituents from the whole plant of Epimedium fargesii Franch.. Zhongguo Zhong Yao Za Zhi. 1996;21(6):353–355, 383.
  • Ho CC, Tan HM. Rise of herbal and traditional medicine in erectile dysfunction management. Curr Urol Rep. 2011;12(6):470–478.
  • Hsieh TC, Lu X, Guo J, Xiong W, Kunicki J, Darzynkiewicz Z, et al. Effects of herbal preparation Equiguard on hormone-responsive and hormone-refractory prostate carcinoma cells: mechanistic studies. Int J Oncol. 2002;20(4):681–689.
  • Hu BH, Zhou LD, Liu YL. Acuminatin from the aerial part of Epimedium acuminatum. Yao Xue Xue Bao. 1992;27(5):397–400.
  • Iinuma M, Tanaka T, Sakakibara N, Mizuno M, Matsuda H, Shiomoto H, et al. Phagocytic activity of leaves of Epimedium species on mouse reticuloendotherial system. Yakugaku Zasshi. 1990;110(3):179–185.
  • Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Controlled Clinical Trials. 1996;17(1):1–12.
  • Jia X, Wu J, Mao Q. Chemical constituents of the root of Epimedium acumiantum Franch. Zhongguo Zhong Yao Za Zhi. 1998;23(3):162–164, 192.
  • Kuroda M, Mimaki Y, Sashida Y, Umegaki E, Yamazaki M, Chiba K, et al. Flavonol glycosides from Epimedium sagittatum and their neurite outgrowth activity on PC12h cells. Planta Med. 2000;66(6):575–577.
  • Lee MK, Choi YJ, Sung SH, Shin DI, Kim JW, Kim YC. Antihepatotoxic activity of icariin, a major constituent of Epimedium koreanum. Planta Med. 1995;61(6):523–526.
  • Li J, Lee L, Gong Y, Shen P, Wong SP, Wise SD, et al. Bioassays for estrogenic activity: development and validation of estrogen receptor (ERalpha/ERbeta) and breast cancer proliferation bioassays to measure serum estrogenic activity in clinical studies. Assay Drug Dev Technol. 2009;7(1):80–89.
  • Li SY, Ping G, Geng L, Seow WK, Thong YH. Immunopharmacology and toxicology of the plant flavonoid baohuoside-1 in mice. Int J Immunopharmacol. 1994;16(3):227–231.
  • Li W, Guo B, Xiao P, Pan J, Lu M, Zhang R. Chemical constituents of Epimedium wanshanense S. Z. He et Guo. Zhongguo Zhong Yao Za Zhi. 1996;21(10):614–616, 640.
  • Li WK, Pan JQ, Lu MJ, Xiao PG, Zhang RY. Anhydroicaritin 3-O-rhamnosyl(1–>2)rhamnoside from epimedium koreanum and a reappraisal of other rhamnosyl(1–>2, 1–>3 and 1–>4)rhamnoside structures. Phytochemistry. 1996;42(1):213–216.
  • Li WK, Xiao PG, Tu GZ, Ma LB, Zhang RY. Flavonol glycosides from Epimedium koreanum. Phytochemistry. 1995;38(1):263–265.
  • Li WK, Zhang RY, Xiao PG. Flavonoids from Epimedium wanshanense. Phytochemistry. 1996;43(2):527–530.
  • Liang RN, Liu J, Lu J. Treatment of refractory polycystic ovary syndrome by bushen huoxue method combined with ultrasound-guided follicle aspiration. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2008;28(4):314–317.
  • Liao HJ, Chen XM, Li WG. Effect of Epimedium sagittatum on quality of life and cellular immunity in patients of hemodialysis maintenance. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1995;15(4):202–204.
  • Lin CC, Ng LT, Hsu FF, Shieh DE, Chiang LC. Cytotoxic effects of Coptis chinensis and Epimedium sagittatum extracts and their major constituents (berberine, coptisine, and icariin) on hepatoma and leukaemia cell growth. Clin Exp Pharmacol Physiol. 2004;31(1–2):65–69.
  • Liu TZ, Chen CY, Yiin SJ, Chen CH, Cheng JT, Shih MK, et al. Molecular mechanism of cell cycle blockage of hepatoma SK-Hep-1 cells by Epimedin C through suppression of mitogen-activated protein kinase activation and increased expression of CDK inhibitors p21(Cip1) and p27(Kip1). Food Chem Toxicol. 2006;44(2):227–235.
  • Ma H, He X, Yang Y, Li M, Hao D, Jia Z. The genus Epimedium: an ethnopharmacological and phytochemical review. J Ethnopharmacol. 2011;134(3):519–541.
  • Ma A, Qi S, Xu D, Zhang X, Daloze P, Chen H. Baohuoside-1, a novel immunosuppressive molecule, inhibits lymphocyte activation in vitro and in vivo. Transplantation. 2004(Sep 27);78(6):831–838.
  • Meng FH, Li YB, Xiong ZL, Jiang ZM, Li FM. Osteoblastic proliferative activity of Epimedium brevicornum Maxim. Phytomedicine. 2005;12(3):189–193.
  • Oh MH, Houghton PJ, Whang WK, Cho JH. Screening of Korean herbal medicines used to improve cognitive function for anti-cholinesterase activity. Phytomedicine. 2004;11(6):544–548.
  • Partin JF, Pushkin YR. Tachyarrhythmia and hypomania with horny goat weed. Psychosomatics. 2004;45(6):536–537.
  • Philips M, Sullivan B, Snyder B, Allegretti PJ, McBride BF. Effect of enzyte on QT and QTc intervals. Arch Intern Med. 2010;170(15):1402–1404.
  • Shen P, Guo BL, Gong Y, Hong DY, Hong Y, Yong EL. Taxonomic, genetic, chemical and estrogenic characteristics of Epimedium species. Phytochemistry. 2007;68(10):1448–1458.
  • Sun Y, Fung KP, Leung PC, Shi D, Shaw PC. Characterization of medicinal Epimedium species by 5S rRNA gene spacer sequencing. Planta Med 2004;70(3):287–288.
  • Tan X., Weng W. Efficacy of epimedium compound pills in the treatment of the aged patients with kidney deficiency syndrome of ischemic cardio-cerebral vascular diseases. Hunan Yi Ke Da Xue Xue Bao. 1998;23(5):450–452.
  • Wang T, Zhang JC, Chen Y, Huang F, Yang MS, Xiao PG. Comparison of antioxidative and antitumor activities of six flavonoids from Epimedium koreanum. Zhongguo Zhong Yao Za Zhi. 2007;32(8):715–718.
  • Wang T, Zhang JC, Yang MS, Xiao PG. Progress in anti-osteoporosis activity of traditional Chinese medicine and medicinal plants. Zhongguo Zhong Yao Za Zhi. 2006;31(9):718–722.
  • Wang YK Huang ZQ. Protective effects of icariin on human umbilical vein endothelial cell injury induced by H2O2 in vitro. Pharmacol Res. 2005;52(2):174–182.
  • Wang ZQ Lou YJ. Proliferation-stimulating effects of icaritin and desmethylicaritin in MCF-7 cells. Eur J Pharmacol. 2004(Nov 19);504(3):147–153.
  • Wei SY, Zhang PX, Yang DM, Zhang HB, Jiang BG. Traditional Chinese medicine and formulas of improving peripheral nerve regeneration. Zhongguo Zhong Yao Za Zhi. 2008;33(17):2069–2072.
  • Wu H, Lu Y Du S Chen W Wang Y. Comparative study on absorption kinetics in intestines of rats of epimedii foliunm of Xianlinggubao capsules prepared by different processes. Zhongguo Zhong Yao Za Zhi. 2011;36(19):2648–2652 [in Chinese].
  • Wu BY, Zou JH, Meng SC. Effect of wolfberry fruit and epimedium on DNA synthesis of the aging-youth 2BS fusion cells. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2003;23(12):926–928.
  • Wu H, Lien EJ, Lien LL. Chemical and pharmacological investigations of Epimedium species: a survey. Prog Drug Res. 2003;60:1–57.
  • Yamamoto H, Ieda K, Tsuchiya S, Yan K, Tanaka T, Iinuma M, et al. Flavonol glycoside production in callus cultures of Epimedium diphyllum. Phytochemistry. 1992;31(3):837–840.
  • Yan FF, Liu Y, Liu YF, Zhao YX. Herba Epimedii water extract elevates estrogen level and improves lipid metabolism in post-menopausal women. Phytother Res. 2008;22(9):1224–1228.
  • Yap SP, Shen P, Butler MS, Gong Y, Loy CJ, Yong EL. New estrogenic prenylflavone from Epimedium brevicornum inhibits the growth of breast cancer cells. Planta Med. 2005;71(2):114–119.
  • Yin XX, Chen ZQ, Dang GT, Ma QJ, Liu ZJ. Effects of Epimedium pubescens icariine on proliferation and differentiation of human osteoblasts. Zhongguo Zhong Yao Za Zhi. 2005;30(4):289–291.
  • Yong EL, Wong SP, Shen P, Gong YH, Li J, Hong Y. Standardization and evaluation of botanical mixtures: lessons from a traditional Chinese herb, Epimedium, with oestrogenic properties. Novartis Found Symp. 2007;282:173–188.
  • Yu YJ. Effect of tian-huang-ling granule in the treatment of allergic rhinitis. Zhong Xi Yi Jie He Za Zhi. 1989;9(12): 708, 720–721.
  • Zhang CZ, Wang SX, Zhang Y, Chen JP, Liang XM. In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. J Ethnopharmacol. 2005(Apr 26);98(3):295–300.
  • Zhang G, Qin L, Shi Y. Epimedium-derived phytoestrogen flavonoids exert beneficial effect on preventing bone loss in late post-menopausal women: a 24-month randomized, double-blind and placebo-controlled trial. J.Bone Miner Res. 2007;22(7):1072–1079.
  • Zhang X, Li Y, Yang X, Wang K, Ni J, Qu X. Inhibitory effect of Epimedium extract on S-adenosyl-L-homocysteine hydrolase and biomethylation. Life Sci. 2005(Nov 26);78(2):180–186.
  • Zhao YL, Song HR, Fei JX, Liang Y, Zhang BH, Liu QP, et al. The effects of Chinese yam-epimedium mixture on respiratory function and quality of life in patients with chronic obstructive pulmonary disease. J Tradit Chin Med. 2012;32(2):203–207.
  • Zhao L, Lan LG, Min XL, Lu AH, Zhu LQ, He XH, et al. Integrated treatment of traditional Chinese medicine and western medicine for early- and intermediate-stage diabetic nephropathy. Nan Fang Yi Ke Da Xue Xue Bao. 2007;27(7):1052–1055.
  • Zhao Y, Cui Z, Zhang L. Effects of icariin on the differentiation of HL-60 cells. Zhonghua Zhong Liu Za Zhi. 1997;19(1):53–55.
  • Zheng MS. An experimental study of the anti-HSV-II action of 500 herbal drugs. J Tradit Chin Med 1989;9(2):113–116.
  • Zhou L, Mei X. Review of study on peripheral nerve regeneration promoted by traditional Chinese medicines. Zhongguo Zhong Yao Za Zhi. 2011;36(1):77–80 [in Chinese].

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