Simplified intraoperative sentinel-node detection performed by the urologist accurately determines lymph-node stage in prostate cancer

References

• Heidenreich A, Bellmunt J, Bolla M, Joniau S, Mason M, Matveev V, et al. EAU guidelines on prostate cancer. Part 1: screening, diagnosis, and treatment of clinically localised disease. Eur Urol 2011;59:61–71.
   PubMed Web of Science ®Google Scholar
• Joniau S, Van den Bergh L, Lerut E, Deroose CM, Haustermans K, Oyen R, et al. Mapping of pelvic lymph node metastases in prostate cancer. Eur Urol 2013;63:450–8.
   PubMed Web of Science ®Google Scholar
• Mattei A, Fuechsel FG, Bhatta Dhar N, Warncke SH, Thalmann GN, Krause T, et al. The template of the primary lymphatic landing sites of the prostate should be revisited: results of a multimodality mapping study. Eur Urol 2008;53:118–25.
   PubMed Web of Science ®Google Scholar
• Van Hemelrijck M, Garmo H, Holmberg L, Bill-Axelson A, Carlsson S, Akre O, et al. Thromboembolic events following surgery for prostate cancer. Eur Urol 2013;63:354–63.
   PubMed Web of Science ®Google Scholar
• Sagalovich D, Calaway A, Srivastava A, Sooriakumaran P, Tewari AK. Assessment of required nodal yield in a high risk cohort undergoing extended pelvic lymphadenectomy in robotic-assisted radical prostatectomy and its impact on functional outcomes. BJU Int 2013;111:85–94.
   PubMed Web of Science ®Google Scholar
• Ji J, Yuan H, Wang L, Hou J. Is the impact of the extent of lymphadenectomy in radical prostatectomy related to the disease risk? A single center prospective study. J Surg Res 2012;178:779–84.
   Google Scholar
• Abdollah F, Karnes RJ, Suardi N, Cozzarini C, Gandaglia G, Fossati N, et al. Predicting survival of patients with node-positive prostate cancer following multimodal treatment. Eur Urol 2014;65:554–62.
   PubMed Web of Science ®Google Scholar
• Holl G, Dorn R, Wengenmair H, Weckermann D, Sciuk J. Validation of sentinel lymph node dissection in prostate cancer: experience in more than 2,000 patients. Eur J Nucl Med Mol Imaging 2009;36:1377–82.
   PubMed Web of Science ®Google Scholar
• Wawroschek F, Vogt H, Weckermann D, Wagner T, Hamm M, Harzmann R. Radioisotope guided pelvic lymph node dissection for prostate cancer. J Urol 2001;166:1715–19.
   PubMed Web of Science ®Google Scholar
• Weckermann D, Dorn R, Trefz M, Wagner T, Wawroschek F, Harzmann R. Sentinel lymph node dissection for prostate cancer: experience with more than 1,000 patients. J Urol 2007;177:916–20.
   PubMed Web of Science ®Google Scholar
• Corvin S, Schilling D, Eichhorn K, Hundt I, Hennenlotter J, Anastasiadis AG, et al. Laparoscopic sentinel lymph node dissection – a novel technique for the staging of prostate cancer. Eur Urol 2006;49:280–5.
   Google Scholar
• Häcker A, Jeschke S, Leeb K, Prammer K, Ziegerhofer J, Sega W, et al. Detection of pelvic lymph node metastases in patients with clinically localized prostate cancer: comparison of [18F]fluorocholine positron emission tomography–computerized tomography and laparoscopic radioisotope guided sentinel lymph node dissection. J Urol 2006;176:2014–18; discussion 2018–9.
   PubMed Web of Science ®Google Scholar
• Warncke SH, Mattei A, Fuechsel FG, Z’Brun S, Krause T, Studer UE. Detection rate and operating time required for gamma probe-guided sentinel lymph node resection after injection of technetium-99m nanocolloid into the prostate with and without preoperative imaging. Eur Urol 2007;52:126–32.
   PubMed Web of Science ®Google Scholar
• Rousseau C, Rousseau T, Bridji B, Pallardy A, Lacoste J, Campion L, et al. Laparoscopic sentinel lymph node (SLN) versus extensive pelvic dissection for clinically localized prostate carcinoma. Eur J Nucl Med Mol Imaging 2012;39:291–9.
   PubMed Web of Science ®Google Scholar
• Valdés-Olmos RA, Jansen L, Hoefnagel CA, Nieweg OE, Muller SH, Rutgers EJ, et al. Evaluation of mammary lymphoscintigraphy by a single intratumoral injection for sentinel node identification. J Nucl Med 2000;41:1500–6.
   PubMedGoogle Scholar
• Liedberg F, Chebil G, Davidsson T, Gudjonsson S, Månsson W. Intraoperative sentinel node detection improves nodal staging in invasive bladder cancer. J Urol 2006;175:84–8; discussion 88–9.
   PubMed Web of Science ®Google Scholar
• Heidenreich A, Ohlmann CH, Polyakov S. Anatomical extent of pelvic lymphadenectomy in patients undergoing radical prostatectomy. Eur Urol 2007;52:29–37.
   PubMed Web of Science ®Google Scholar
• Mattei A, Di Pierro GB, Grande P, Beutler J, Danuser H. Standardized and simplified extended pelvic lymph node dissection during robot-assisted radical prostatectomy: the monoblock technique. Urology 2013;81:446–50.
   Google Scholar
• Meinhardt W, Valdés Olmos RA, van der Poel HG, Bex A, Horenblas S. Laparoscopic sentinel node dissection for prostate carcinoma: technical and anatomical observations. BJU Int 2008;102:714–17.
   PubMed Web of Science ®Google Scholar
• Wawroschek F, Wagner T, Hamm M, Weckermann D, Vogt H, Märkl B, et al. The influence of serial sections, immunohistochemistry, and extension of pelvic lymph node dissection on the lymph node status in clinically localized prostate cancer. Eur Urol 2003;43:132–6; discussion 137.
   PubMed Web of Science ®Google Scholar
• Fukuda M, Egawa M, Imao T, Takashima H, Yokoyama K, Namiki M. Detection of sentinel node micrometastasis by step section and immunohistochemistry in patients with prostate cancer. J Urol 2007;177:1313–17; discussion 1317.
   Google Scholar
• Farshid G, Pradhan M, Kollias J, Gill PG. Computer simulations of lymph node metastasis for optimizing the pathologic examination of sentinel lymph nodes in patients with breast carcinoma. Cancer 2000;89:2527–37.
   Google Scholar
• Grabau D, Ryden L, Fernö M, Ingvar C. Analysis of sentinel node biopsy – a single-institution experience supporting the use of serial sectioning and immunohistochemistry for detection of micrometastases by comparing four different histopathological laboratory protocols. Histopathology 2011;59:129–38.
   PubMed Web of Science ®Google Scholar
• Heck MM, Retz M, Bandur M, Souchay M, Vitzthum E, Weirich G, et al. Topography of lymph node metastases in prostate cancer patients undergoing radical prostatectomy and extended lymphadenectomy: results of a combined molecular and histopathologic mapping study. Eur Urol 2014;66:222–9.
   Google Scholar
• Miyake H, Kurahashi T, Hara I, Takenaka A, Fujisawa M. Significance of micrometastases in pelvic lymph nodes detected by real-time reverse transcriptase polymerase chain reaction in patients with clinically localized prostate cancer undergoing radical prostatectomy after neoadjuvant hormonal therapy. BJU Int 2007;99:315–20.
   Google Scholar
• Ferrari AC, Stone NN, Kurek R, Mulligan E, McGregor R, Stock R, et al. Molecular load of pathologically occult metastases in pelvic lymph nodes is an independent prognostic marker of biochemical failure after localized prostate cancer treatment. J Clin Oncol 2006;24:3081–8.
   Google Scholar
• Kennecke HF, Keyes M. Surgical management of node-positive prostate cancer: perspectives from breast oncology. Eur Urol 2014;66:202–3.
   Google Scholar
• van der Poel HG, Buckle T, Brouwer OR, Valdés Olmos RA, van Leeuwen FWB. Intraoperative laparoscopic fluorescence guidance to the sentinel lymph node in prostate cancer patients: clinical proof of concept of an integrated functional imaging approach using a multimodal tracer. Eur Urol 2011;60:826–33.
   PubMed Web of Science ®Google Scholar
• Jeschke S, Lusuardi L, Myatt A, Hruby S, Pirich C, Janetschek G. Visualisation of the lymph node pathway in real time by laparoscopic radioisotope- and fluorescence-guided sentinel lymph node dissection in prostate cancer staging. Urology 2012;80:1080–6.
   PubMed Web of Science ®Google Scholar
• Weckermann D, Dorn R, Holl G, Wagner T, Harzmann R. Limitations of radioguided surgery in high-risk prostate cancer. Eur Urol 2007;51:1549–56; discussion 1556–8.
   PubMed Web of Science ®Google Scholar