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Research Article

VEGF promotes cardiac stem cells differentiation into vascular endothelial cells via the PI3K/Akt signaling pathway

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Pages 400-405 | Received 12 Jul 2013, Accepted 20 Aug 2013, Published online: 23 Sep 2013

References

  • Bai C, Hou L, Zhang M, Wang L, Guan W, Ma Y. 2013. Identification and biological characterization of chicken embryonic cardiac progenitor cells. Cell Prolif. 46:232–242. Epub 2013/03/21.
  • Boo YC. 2006. Shear stress stimulates phosphorylation of protein kinase A substrate proteins including endothelial nitric oxide synthase in endothelial cells. Exp Mol Med. 38:453. Epub 2006/ 09/20.
  • Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM. 1999. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature. 399:601–605. Epub 1999/06/22.
  • Ferrara N. 2001. Role of vascular endothelial growth factor in regulation of physiological angiogenesis. Am J Physiol Cell Physiol. 280:C1358–1366. Epub 2001/05/15.
  • Freedman SB, Isner JM. 2001. Therapeutic angiogenesis for ischemic cardiovascular disease. J Mol Cell Cardiol. 33:379–393. Epub 2001/02/22.
  • Fujio Y, Walsh K. 1999. Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner. J Biol Chem. 274:16349–16354. Epub 1999/05/29.
  • Fulton D, Gratton JP, McCabe TJ, Fontana J, Fujio Y, Walsh K, et al. 1999. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature. 399:597–601. Epub 1999/06/22.
  • Gerber HP, McMurtrey A, Kowalski J, Yan M, Keyt BA, Dixit V, Ferrara N. 1998. Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3’-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation. J Biol Chem. 273:30336–30343. Epub 1998/11/07.
  • Houck KA, Leung DW, Rowland AM, Winer J, Ferrara N. 1992. Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms. J Biol Chem. 267:26031–26037. Epub 1992/12/25.
  • Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N. 1989. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science. 246:1306–1309. Epub 1989/12/08.
  • Ma J, Sawai H, Ochi N, Matsuo Y, Xu D, Yasuda A, et al. 2009. PTEN regulates angiogenesis through PI3K/Akt/VEGF signaling pathway in human pancreatic cancer cells. Mol Cell Biochem. 331:161–171. Epub 2009/05/14.
  • Millauer B, Wizigmann-Voos S, Schnurch H, Martinez R, Moller NP, Risau W, Ullrich A. 1993. High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell. 72:835–846. Epub 1993/03/26.
  • Mishra R, Vijayan K, Colletti EJ, Harrington DA, Matthiesen TS, Simpson D, et al. 2011. Characterization and functionality of cardiac progenitor cells in congenital heart patients. Circulation. 123:364–373. Epub 2011/01/19.
  • Otsuru S, Gordon PL, Shimono K, Jethva R, Marino R, Phillips CL, et al. 2012. Transplanted bone marrow mononuclear cells and MSCs impart clinical benefit to children with osteogenesis imperfecta through different mechanisms. Blood. 120:1933–1941. Epub 2012/07/26.
  • Papapetropoulos A, Garcia-Cardena G, Madri JA, Sessa WC. 1997. Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells. J Clin Invest. 100:3131–3139. Epub 1998/01/31.
  • Perez-Simon JA, Lopez-Villar O, Andreu EJ, Rifon J, Muntion S, Campelo MD, et al. 2011. Mesenchymal stem cells expanded in vitro with human serum for the treatment of acute and chronic graft- versus-host disease: results of a phase I/II clinical trial. Haematologica. 96:1072–1076. Epub 2011/03/12.
  • Plate KH, Warnke PC. 1997. Vascular endothelial growth factor. J Neurooncol. 35:365–372. Epub 1998/01/24.
  • Trounson A, Thakar RG, Lomax G, Gibbons D. 2011. Clinical trials for stem cell therapies. BMC Med. 9:52. Epub 2011/05/17.
  • Verdu J, Buratovich MA, Wilder EL, Birnbaum MJ. 1999. Cell- autonomous regulation of cell and organ growth in Drosophila by Akt/PKB. Nat Cell Biol. 1:500–506. Epub 1999/12/10.
  • Weinkove D, Leevers SJ. 2000. The genetic control of organ growth: insights from Drosophila. Curr Opin Genet Dev. 10:75–80. Epub 2000/02/19.
  • Yi BA, Wernet O, Chien KR. 2010. Pregenerative medicine: developmental paradigms in the biology of cardiovascular regeneration. J Clin Invest. 120:20–28. Epub 2010/01/07.
  • Zachary I, Morgan RD. 2011. Therapeutic angiogenesis for cardiovascular disease: biological context, challenges, prospects. Heart. 97:181–189. Epub 2010/10/05.

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