713
Views
26
CrossRef citations to date
0
Altmetric
Original Article

The ameliorated longevity and pharmacokinetics of valsartan released from a gel system of ultradeformable vesicles

, , , &
Pages 1457-1463 | Received 11 Mar 2015, Accepted 13 Apr 2015, Published online: 08 May 2015

References

  • Agarwal R, Katare OP, Vyas SP. 2001. Preparation and in vitro evaluation of liposomal/niosomal delivery systems for antipsoriatic drug dithranol. Int J Pharm. 228:43–52.
  • Ahad A, Al-Mohizea AM, Al-Jenoobi FI, Aqil M. 2014a. Transdermal delivery of angiotensin II receptor blockers (ARBs), angiotensin-converting enzyme inhibitors (ACEIs) and others for management of hypertension. Drug Deliv, Posted online on July. 28:1–12.
  • Ahad A, Aqil M, Ali A. 2014b. Investigation of antihypertensive activity of carbopol valsartan transdermal gel containing 1,8-cineole. Int J Biol Macromol. 64:144–149.
  • Ahad A, Aqil M, Kohli K, Chaudhary H, Sultana Y, Mujeeb M, Talegaonkar S. 2009. Chemical penetration enhancers: a patent review. Expert Opin Ther Pat. 19:969–988.
  • Ahad A, Aqil M, Kohli K, Sultana Y, Mujeeb M. 2013. Enhanced transdermal delivery of an anti-hypertensive agent via nanoethosomes: statistical optimization, characterization and pharmacokinetic assessment. Int J Pharm. 443:26–38.
  • Ahad A, Aqil M, Kohli K, Sultana Y, Mujeeb M. 2014c. Design, formulation and optimization of valsartan transdermal gel containing iso-eucalyptol as novel permeation enhancer: Preclinical assessment of pharmacokinetic in wistar albino rats. Expert Opin Drug Deliv. 11:1149–1162.
  • Ahad A, Aqil M, Kohli K, Sultana Y, Mujeeb M, Ali A. 2010. Transdermal drug delivery: the inherent challenges and technological advancements. Asian J Pharm Sci. 5:276–288.
  • Ahad A, Aqil M, Kohli K, Sultana Y, Mujeeb M, Ali A. 2011a. Interactions between novel terpenes and main components of rat and human skin: mechanistic view for transdermal delivery of propranolol hydrochloride. Curr Drug Deliv. 8:213–224.
  • Ahad A, Aqil M, Kohli K, Sultana Y, Mujeeb M, Ali A. 2011b. Role of novel terpenes in transcutaneous permeation of valsartan: effectiveness and mechanism of action. Drug Dev Ind Pharm. 37:583–596.
  • Ahad A, Aqil M, Kohli K, Sultana Y, Mujeeb M, Ali A. 2012. Formulation and optimization of nanotransfersomes using experimental design technique for accentuated transdermal delivery of valsartan. Nanomedicine. 8:237–249.
  • Ahad A, Raish M, Al-Mohizea AM, Al-Jenoobi FI, Alam MA. 2014d. Enhanced anti-inflammatory activity of carbopol loaded meloxicam nanoethosomes gel. Int J Biol Macromol. 67:99–104.
  • Alexander A, Dwivedi S, Ajazuddin, Giri TK, Saraf S, Tripathi DK. 2012. Approaches for breaking the barriers of drug permeation through transdermal drug delivery. J Control Release. 164:26–40.
  • Aqil M, Ahad A, Sultana Y, Ali A. 2007. Status of terpenes as skin penetration enhancers. Drug Discov Today. 12:1061–1067.
  • Aqil M, Ali A, Sultana Y, Parvez N. 2004. Communication: Matrix type transdermal drug delivery systems of metoprolol tartrate: skin toxicity and in vivo characterization. Ethiop Pharm J. 22:53–60.
  • Bachhav YG, Patravale VB. 2009. Microemulsion based vaginal gel of fluconazole: formulation, in vitro and in vivo evaluation. Int J Pharm. 365:175–179.
  • Bendas ER, Tadros MI. 2007. Enhanced transdermal delivery of salbutamol sulfate via ethosomes. AAPS PharmSciTech. 8:E107.
  • Cevc G, Blume G. 1992. Lipid vesicles penetrate into intact skin owing to the transdermal osmotic gradients and hydration force. Biochim Biophys Acta. 1104:226–232.
  • Cevc G, Gebauer D. 2003. Hydration-driven transport of deformable lipid vesicles through fine pores and the skin barrier. Biophys J. 84:1010–1024.
  • Cevc G, Gebauer D, Stieber J, Schatzlein A, Blume G. 1998. Ultraflexible vesicles, Transfersomes, have an extremely low pore penetration resistance and transport therapeutic amounts of insulin across the intact mammalian skin. Biochim Biophys Acta. 1368: 201–215.
  • Chaudhary H, Kohli K, Amin S, Rathee P, Kumar V. 2011. Optimization and formulation design of gels of Diclofenac and Curcumin for transdermal drug delivery by Box-Behnken statistical design. J Pharm Sci. 100:580–593.
  • Chaudhary H, Rohilla A, Rathee P, Kumar V. 2013. Optimization and formulation design of carbopol loaded Piroxicam gel using novel penetration enhancers. Int J Biol Macromol. 55:246–253.
  • Costa P, Sousa Lobo JM. 2001. Modeling and comparison of dissolution profiles. Eur J Pharm Sci. 13:123–133.
  • Dave V, Kumar D, Lewis S, Paliwal S. 2010. Ethosome for Enhanced Transdermal Drug Delivery of Aceclofenac. Int J Drug Deliv. 2: 81–92.
  • Draize JH, Woodard G, Calvery HO. 1944. Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes. J Pharmacol Exp Ther. 82:377–390.
  • Duangjit S, Opanasopit P, Rojanarata T, Ngawhirunpat T. 2013. Evaluation of meloxicam-loaded cationic transfersomes as transdermal drug delivery carriers. AAPS PharmSciTech. 14:133–140.
  • El Zaafarany GM, Awad GA, Holayel SM, Mortada ND. 2010. Role of edge activators and surface charge in developing ultradeformable vesicles with enhanced skin delivery. Int J Pharm. 397: 164–172.
  • Elsabahy M, Foldvari M. 2013. Needle-free gene delivery through the skin: an overview of recent strategies. Curr Pharm Des. 19:7301–7315.
  • Elsayed MM, Abdallah OY, Naggar VF, Khalafallah NM. 2006. Deformable liposomes and ethosomes: mechanism of enhanced skin delivery. Int J Pharm. 322:60–66.
  • Garg AK, Mohan NL, Meenakshi C. 2010. Gel containing ethosomal vesicles for transdermal delivery of aceclofenac. Int J Pharmacy Pharm Sci. 2:102–108.
  • Glavas-dodov M, Fredro-kumbaradzi E, Goracinova K, Calis S, Simonoska M, Hincal AA. 2003. 5-Fluorouracil in topical liposome gels for anticancer treatment -Formulation and evaluation. Acta Pharmacol Sin. 53:241–245.
  • Gupta A, Aggarwal G, Singla S, Arora R. 2012. Transfersomes: a novel vesicular carrier for enhanced transdermal delivery of sertraline: development, characterization, and performance evaluation. Sci Pharm. 80:1061–1080.
  • Higuchi T. 1963. Mechanism of sustained-action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J Pharm Sci. 52:1145–1149.
  • Hiruta Y, Hattori Y, Kawano K, Obata Y, Maitani Y. 2006. Novel ultra-deformable vesicles entrapped with bleomycin and enhanced to penetrate rat skin. J Control Release. 113:146–154.
  • Jain R, Aqil M, Ahad A, Ali A, Khar RK. 2008. Basil oil is a promising skin penetration enhancer for transdermal delivery of labetolol hydrochloride. Drug Dev Ind Pharm. 34:384–389.
  • Kim MS, Baek IH. 2014. Fabrication and evaluation of valsartan-polymer- surfactant composite nanoparticles by using the supercritical antisolvent process. Int J Nanomedicine. 9:5167–5176.
  • Korsmeyer RW, Gurny R, Doelker EM, Buri P, Peppas NA. 1983. Mechanism of solute release from porous hydrophilic polymers. Int J Pharm. 15:25–35.
  • Moghimi HR, Makhmalzadeh BS, Manafi A. 2009. Enhancement effect of terpenes on silver sulphadiazine permeation through third-degree burn eschar. Burns. 35:1165–1170.
  • Mura S, Manconi M, Fadda AM, Sala MC, Perricci J, Pini E, Sinico C. 2013. Penetration enhancer-containing vesicles (PEVs) as carriers for cutaneous delivery of minoxidil: in vitro evaluation of drug permeation by infrared spectroscopy. Pharm Dev Technol. 18:1339–1345.
  • Mura S, Manconi M, Sinico C, Valenti D, Fadda AM. 2009. Penetration enhancer-containing vesicles (PEVs) as carriers for cutaneous delivery of minoxidil. Int J Pharm. 380:72–79.
  • Nishida N, Taniyama K, Sawabe T, Manome Y. 2010. Development and evaluation of a monolithic drug-in-adhesive patch for valsartan. Int J Pharm. 402:103–109.
  • Paget GM, Barnes JM. 1964. Interspecies dosage conversion scheme in evaluation of results and quantitative application in different species. In: Laurence DR, Bacharach AL, Eds. Evaluation of Drug Activities: Pharmacometrics. London and New York: Academic press. pp. 160–162.
  • Patel SS, Patel MS, Salampure S, Vishwanath B, Patel NM. 2010. Development and evaluation of liposomes for topical delivery of tacrolimus (Fk-506). J Sci Res. 2:585–596.
  • Peppas NA. 1985. Analysis of Fickian and non-Fickian drug release from polymers. Pharm Acta Helv. 60:110–111.
  • Piao ZZ, Lee ES, Tran HT, Lee BJ. 2008. Improved analytical validation and pharmacokinetics of valsartan using HPLC with UV detection. Arch Pharm Res. 31:1055–1059.
  • Ritger PL, Peppas NA. 1987. A simple equation for description of solute release I. Fickian and non-fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discs. J Control Release. 5:23–36.
  • Rizwan M, Aqil M, Ahad A, Sultana Y, Ali MM. 2008. Transdermal delivery of valsartan: I. Effect of various terpenes. Drug Dev Ind Pharm. 34:618–626.
  • Tatar S, Saglik S. 2002. Comparison of UV- and second derivative-spectrophotometric and LC methods for the determination of valsartan in pharmaceutical formulation. J Pharm Biomed Anal. 30:371–375.
  • Ubaidulla U, Reddy MV, Ruckmani K, Ahmad FJ, Khar RK. 2007. Transdermal therapeutic system of carvedilol: effect of hydrophilic and hydrophobic matrix on in vitro and in vivo characteristics. AAPS PharmSciTech. 8:2.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.