Multicompartmental, multilayered probucol microcapsules for diabetes mellitus: Formulation characterization and effects on production of insulin and inflammation in a pancreatic β-cell line

References

• Ajun W, Yan S, Li G, Huili L. 2009. Preparation of aspirin and probucol in combination loaded chitosan nanoparticles and in vitro release study. Carbohydr Polym. 75:566–574.
   Web of Science ®Google Scholar
• Al-Kassas RS, Al-Gohary O, Al-Faadhel MM. 2007. Controlling of systemic absorption of gliclazide through incorporation into alginate beads. Int J Pharma. 341:230–237.
   PubMed Web of Science ®Google Scholar
• Al-Salami H, Butt G, Tucker I, Fawcett PJ, Golocorbin-Kon S, Mikov I, Mikov M. 2009. Gliclazide reduces MKC intestinal transport in healthy but not diabetic rats. Eur J Drug Metab Pharmacokinet. 34:43–50.
   PubMed Web of Science ®Google Scholar
• Al-Salami H, Butt G, Tucker I, Golocorbin-Kon S, Mikov M. 2012. Probiotics decreased the bioavailability of the bile acid analog, monoketocholic acid, when coadministered with gliclazide, in healthy but not diabetic rats. Eur J Drug Metab Pharmacokinet. 37:99–108.
   PubMed Web of Science ®Google Scholar
• Al-Salami H, Butt G, Tucker I, Mikov M. 2008a. Influence of the semisynthetic bile acid MKC on the ileal permeation of gliclazide in vitro in healthy and diabetic rats treated with probiotics. Methods Find Exp Clin Pharmacol. 30:107–113.
   PubMed Web of Science ®Google Scholar
• Al-Salami H, Butt G, Tucker I, Skrbic R, Golocorbin-Kon S, Mikov M. 2008b. Probiotic Pre-treatment Reduces Gliclazide Permeation (ex vivo) in Healthy Rats but Increases It in Diabetic Rats to the Level Seen in Untreated Healthy Rats. Arch Drug Inf. 1:35–41.
   PubMedGoogle Scholar
• Al-Salami H, Butt G, Tucker IG, Mikov M. 2008c. The Influence of Pre-Treatment with Probiotics on the in Vitro Ileal Permeation of the Antidiabetic Drug Gliclazide, in Healthy and Diabetic Rats. Drug Metabol Rev. 40:81–82.
   Web of Science ®Google Scholar
• Al-Salami H, Grant B, Ian T, Mikov M. 2008d. The influence of probiotics pre-treatment, on the ileal permeation of gliclazide, in healthy and diabetic rats. Arch Drug Inf. 1:35–41.
   PubMedGoogle Scholar
• Altaf M. 2008. Ionic gelation controlled drug delivery systems for gastric-mucoadhesive microcapsules of captopril. Indian J Pharm Sci. 70:655.
   PubMed Web of Science ®Google Scholar
• Andersen E, Karlaganis G, Sjovall J. 1988. Altered bile acid profiles in duodenal bile and urine in diabetic subjects. Eur J Clin Invest. 18:166–172.
   PubMed Web of Science ®Google Scholar
• Arifin DR, Long CM, Gilad AA, Alric C, Roux S, Tillement O, et al. 2011. Trimodal gadolinium-gold microcapsules containing pancreatic islet cells restore normoglycemia in diabetic mice and can be tracked by using US, CT, and positive-contrast MR imaging. Radiology. 260:790–798.
   PubMed Web of Science ®Google Scholar
• Arifin DR, Manek S, Call E, Arepally A, Bulte JW. 2012. Microcapsules with intrinsic barium radiopacity for immunoprotection and X-ray/CT imaging of pancreatic islet cells. Biomaterials. 33:4681–4689.
   PubMed Web of Science ®Google Scholar
• Awasthi R, Kulkarni GT. 2012. Development of novel gastroretentive floating particulate drug delivery system of gliclazide. Curr Drug Deliv. 9:437–451.
   PubMed Web of Science ®Google Scholar
• Awasthi R, Kulkarni GT. 2013. Development of novel gastroretentive drug delivery system of gliclazide: hollow beads. Drug Dev Ind Pharm. 1–11.
   Web of Science ®Google Scholar
• Barnett R. 2010. Historical keyword: diabetes. Lancet. 375:191.
   PubMed Web of Science ®Google Scholar
• Batta AK, Aggarwal SK, Salen G, Shefer S. 1991. Selective reduction of oxo bile acids: synthesis of 3 beta-, 7 beta-, and 12 beta-hydroxy bile acids. J Lipid Res. 32:977–983.
   PubMed Web of Science ®Google Scholar
• Bonino CA, Samorezov JE, Jeon O, Alsberg E, Khan SA. 2011. Real-time in situ rheology of alginate hydrogel photocrosslinking. Soft Matter. 7:11510–11517.
   Web of Science ®Google Scholar
• Buckley MM, Goa KL, Price AH, Brogden RN. 1989. Probucol. A reappraisal of its pharmacological properties and therapeutic use in hypercholesterolaemia. Drugs. 37:761–800.
   PubMed Web of Science ®Google Scholar
• Cook MT, Tzortzis G, Charalampopoulos D, Khutoryanskiy VV. 2012. Microencapsulation of probiotics for gastrointestinal delivery. J Control Release. 162:56–67.
   PubMed Web of Science ®Google Scholar
• Davignon J. 1990. Probucol revisited. In: Descovich G, Gaddi A, Magri G & Lenzi S (eds.) Atherosclerosis and Cardiovascular Disease. Springer Netherlands.
   Google Scholar
• Davignon J. 1994. Probucol. Principles and Treatment of Lipoprotein Disorders. Springer.
   Google Scholar
• De Celis Alonso B, Rayment P, Ciampi E, Ablett S, Marciani L, Spiller RC, et al. 2010. NMR relaxometry and rheology of ionic and acid alginate gels. Carbohydr Polym. 82:663–669.
   Web of Science ®Google Scholar
• Draget KI, Taylor C. 2011. Chemical, physical and biological properties of alginates and their biomedical implications. Food Hydrocolloids. 25:251–256.
   Web of Science ®Google Scholar
• Düfer M, Hörth K, Wagner R, Schittenhelm B, Prowald S, Wagner TF, et al. 2012. Bile Acids Acutely Stimulate Insulin Secretion of Mouse β-Cells via Farnesoid X Receptor Activation and KATP Channel Inhibition. Diabetes. 61:1479–1489.
   PubMed Web of Science ®Google Scholar
• Fakhoury M, Coussa-Charley M, Al-Salami H, Kahouli I, Prakash S. 2014a. Use of artificial cell microcapsule containing thalidomide for treating TNBS-induced Crohn's disease in mice. Curr Drug Deliv. 11:146–153.
   PubMed Web of Science ®Google Scholar
• Fakhoury M, Negrulj R, Mooranian A, Al-Salami H. 2014b. Inflammatory bowel disease: clinical aspects and treatments. J Inflamm Res. 7:113–120.
   PubMedGoogle Scholar
• Festi D, Schiumerini R, Birtolo C, Marzi L, Montrone L, Scaioli E, et al. 2011. Gut microbiota and its pathophysiology in disease paradigms. Dig Dis. 29:518–524.
   PubMed Web of Science ®Google Scholar
• Fukuda M, Ikegami H, Kawaguchi Y, Sano T, Ogihara T. 1995. Antioxidant, probucol, can inhibit the generation of hydrogen peroxide in islet cells induced by macrophages and prevent islet cell destruction in NOD mice. Biochem Biophys Res Commun. 209:953–958.
   PubMed Web of Science ®Google Scholar
• George M, Abraham TE. 2006. Polyionic hydrocolloids for the intestinal delivery of protein drugs: alginate and chitosan–a review. J Control Release. 114:1–14.
   PubMed Web of Science ®Google Scholar
• Gill P, Moghadam TT, Ranjbar B. 2010. Differential scanning calorimetry techniques: applications in biology and nanoscience. J Biomol Tech. 21:167–193.
   PubMedGoogle Scholar
• Goh CH, Heng PWS, Chan LW. 2012. Alginates as a useful natural polymer for microencapsulation and therapeutic applications. Carbohydr Polym. 88:1–12.
   Web of Science ®Google Scholar
• Gorogawa S, Kajimoto Y, Umayahara Y, Kaneto H, Watada H, Kuroda A, et al. 2002. Probucol preserves pancreatic beta-cell function through reduction of oxidative stress in type 2 diabetes. Diabetes Res Clin Pract. 57:1–10.
   PubMed Web of Science ®Google Scholar
• Hamaguchi K, Gaskins HR, Leiter EH. 1991. NIT-1, a pancreatic beta-cell line established from a transgenic NOD/Lt mouse. Diabetes. 40:842–849.
   PubMed Web of Science ®Google Scholar
• Heeg JF, Hiser MF, Satonin DK, Rose JQ. 1984. Pharmacokinetics of probucol in male rats. J Pharm Sci. 73:1758–1763.
   PubMed Web of Science ®Google Scholar
• Heel RC, Brogden RN, Speight TM, Avery GS. 1978. Probucol: a review of its pharmacological properties and therapeutic use in patients with hypercholesterolaemia. Drugs. 15:409–428.
   PubMed Web of Science ®Google Scholar
• Kandrac J, Kevresan S, Gu JK, Mikov M, Fawcett JP, Kuhajda K. 2006. Isolation and determination of bile acids. Eur J Drug Metab Pharmacokinet. 31:157–177.
   PubMed Web of Science ®Google Scholar
• Karunakaran U, Park KG. 2013. A systematic review of oxidative stress and safety of antioxidants in diabetes: focus on islets and their defense. Diabetes Metab J. 37:106–112.
   PubMedGoogle Scholar
• Kulkarni AR, Soppimath KS, Aminabhavi TM, Rudzinski WE. 2001. In-vitro release kinetics of cefadroxil-loaded sodium alginate interpenetrating network beads. Eur J Pharm Biopharm. 51:127–133.
   PubMed Web of Science ®Google Scholar
• Legrand J, Dumont E, Comiti J, Fayolle F. 2000. Diffusion coefficients of ferricyanide ions in polymeric solutions—comparison of different experimental methods. Electrochimica acta. 45:1791–1803.
   Web of Science ®Google Scholar
• Lin SY, Wang SL. 2012. Advances in simultaneous DSC-FTIR microspectroscopy for rapid solid-state chemical stability studies: some dipeptide drugs as examples. Adv Drug Deliv Rev. 64:461–478.
   PubMed Web of Science ®Google Scholar
• Liu JH, Liu DF, Wang NN, Lin HL, Mei X. 2011. Possible role for the thioredoxin system in the protective effects of probucol in the pancreatic islets of diabetic rats. Clin Exp Pharmacol Physiol. 38:528–533.
   PubMed Web of Science ®Google Scholar
• Maritim AC, Sanders RA, Watkins JB, 3rd. 2003. Diabetes, oxidative stress, and antioxidants: a review. J Biochem Mol Toxicol. 17:24–38.
   PubMed Web of Science ®Google Scholar
• Mooranian A, Negrulj R, Al-Sallami HS, Fang Z, Mikov M, Golocorbin-Kon S, et al. 2014a. Release and swelling studies of an innovative antidiabetic-bile acid microencapsulated formulation, as a novel targeted therapy for diabetes treatment. J Microencapsul. 1–6.
   Web of Science ®Google Scholar
• Mooranian A, Negrulj R, Arfuso F, Al-Salami H. 2014b. Characterization of a novel bile acid-based delivery platform for microencapsulated pancreatic β-cells. Artificial Cells Nanomed Biotechnol. 1–7.
   Web of Science ®Google Scholar
• Mooranian A, Negrulj R, Chen-Tan N, Al-Sallami HS, Fang Z, Mukkur T, et al. 2014c. Novel artificial cell microencapsulation of a complex gliclazide-deoxycholic bile acid formulation: a characterization study. Drug Des Dev Ther. 8:1003.
   PubMed Web of Science ®Google Scholar
• Mooranian A, Negrulj R, Chen-Tan N, Al-Sallami HS, Fang Z, Mukkur TK, et al. 2014d. Microencapsulation as a novel delivery method for the potential antidiabetic drug, Probucol. Drug Des Devel Ther. 8:1221–1230.
   PubMed Web of Science ®Google Scholar
• Mooranian A, Negrulj R, Chen-Tan N, Watts GF, Arfuso F, Al-Salami H. 2014e. An optimized probucol microencapsulated formulation integrating a secondary bile acid (deoxycholic acid) as a permeation enhancer. Drug Des Devel Ther. 8:1673–1683.
   PubMed Web of Science ®Google Scholar
• Mooranian A, Negrulj R, Mathavan S, Martinez J, Sciarretta J, Chen-Tan N, et al. 2014f. Stability and Release Kinetics of an Advanced Gliclazide-Cholic Acid Formulation: The Use of Artificial-Cell Microencapsulation in Slow Release Targeted Oral Delivery of Antidiabetics. J Pharm Innov. 9:150–157.
   PubMed Web of Science ®Google Scholar
• Mooranian A, Negrulj R, Mathavan S, Martinez J, Sciarretta J, Chen-Tan N, et al. 2014g. An advanced microencapsulated system: a platform for optimized oral delivery of antidiabetic drug-bile acid formulations. Pharm Dev Technol. 1–8.
   PubMed Web of Science ®Google Scholar
• Mooranian A, Negrulj R, Al-Sallami HS, Fang Z, Mikov M, Golocorbin-Kon S, et al. 2015a. Probucol Release from Novel Multicompartmental Microcapsules for the Oral Targeted Delivery in Type 2 Diabetes. AAPS PharmSciTech. 16:45–52.
   PubMed Web of Science ®Google Scholar
• Mooranian A, Negrulj R, Mikov M, Golocorbin-Kon S, Arfuso F, Al-Salami H. 2015b. Novel chenodeoxycholic acid-sodium alginate matrix in the microencapsulation of the potential antidiabetic drug, probucol. An in vitro study. J Microencapsul (in press).
   Google Scholar
• Negrulj R, Mooranian A, Al-Salami H. 2013. Potentials and Limitations of Bile Acids in Type 2 Diabetes Mellitus: Applications of Microencapsulation as a Novel Oral Delivery System. J Endocrinol Diab Mellitus. 1:49–59.
   Google Scholar
• Negrulj R, Mooranian A, Chen-Tan N, Al-Sallami HS, Mikov M, Golocorbin-Kon S, et al. 2015. Swelling, mechanical strength, and release properties of probucol microcapsules with and without a bile acid, and their potential oral delivery in diabetes. Artif Cells Nanomed Biotechnol. 1–8.
   PubMed Web of Science ®Google Scholar
• Pamies R, Schmidt RR, Martínez MDCL, Torre JGDL. 2010. The influence of mono and divalent cations on dilute and non-dilute aqueous solutions of sodium alginates. Carbohydrate Polymers. 80:248–253.
   Web of Science ®Google Scholar
• Perez MJ, Briz O. 2009. Bile-acid-induced cell injury and protection. World J Gastroenterol. 15:1677–1689.
   PubMed Web of Science ®Google Scholar
• Prajapati S, Tripathi P, Ubaidulla U, Anand V. 2008. Design and development of gliclazide mucoadhesive microcapsules: in vitro and in vivo evaluation. AAPS PharmSciTech. 9:224–230.
   PubMed Web of Science ®Google Scholar
• Prawitt J, Caron S, Staels B. 2011. Bile acid metabolism and the pathogenesis of type 2 diabetes. Curr Diab Rep. 11:160–166.
   PubMed Web of Science ®Google Scholar
• Renga B, Mencarelli A, Vavassori P, Brancaleone V, Fiorucci S. 2010. The bile acid sensor FXR regulates insulin transcription and secretion. Biochim Biophys Acta Mol Basis Dis. 1802:363–372.
   PubMed Web of Science ®Google Scholar
• Rodes L, Paul A, Coussa-Charley M, Al-Salami H, Tomaro-Duchesneau C, Fakhoury M, Prakash S. 2011. Transit time affects the community stability of lactobacillus and bifidobacterium species in an in vitro model of human colonic microbiotia. Artif Cells Blood Substit Immobil Biotechnol. 39:351–356.
   PubMed Web of Science ®Google Scholar
• Sarmento B, Ferreira D, Veiga F, Ribeiro A. 2006. Characterization of insulin-loaded alginate nanoparticles produced by ionotropic pre-gelation through DSC and FTIR studies. Carbohydr Polym. 66:1–7.
   Web of Science ®Google Scholar
• Sherman I, Fisher M. 1986. Hepatic transport of fluorescent molecules: in vivo studies using intravital TV microscopy. Hepatology. 6:444–449.
   PubMed Web of Science ®Google Scholar
• Soares J, Santos J, Chierice G, Cavalheiro E. 2004. Thermal behavior of alginic acid and its sodium salt. Eclética Química. 29:57–64.
   Google Scholar
• Stojancevic M, Bojic G, Salami HA, Mikov M. 2013. The Influence of Intestinal Tract and Probiotics on the Fate of Orally Administered Drugs. Curr Issues Mol Biol. 16:55–68.
   PubMed Web of Science ®Google Scholar
• Takka S, Cali AG. 2012. Bile salt-reinforced alginate-chitosan beads. Pharm Dev Technol. 17:23–29.
   PubMed Web of Science ®Google Scholar
• Tanous D, Hime N, Stocker R. 2008. Anti-atherosclerotic and anti- diabetic properties of probucol and related compounds. Redox Rep. 13:48–59.
   PubMed Web of Science ®Google Scholar
• Thomas C, Gioiello A, Noriega L, Strehle A, Oury J, Rizzo G, et al. 2009. TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis. Cell Metabolism. 10:167–177.
   PubMed Web of Science ®Google Scholar
• Thybo P, Pedersen BL, Hovgaard L, Holm R, Müllertz A. 2008. Characterization and Physical Stability of Spray Dried Solid Dispersions of Probucol and PVP-K30*. Pharm Dev Technol. 13:375–386.
   PubMed Web of Science ®Google Scholar
• Torpy JM, Lynm C, Glass RM. 2009. DIabetes. JAMA. 301:1620–1620.
   PubMedGoogle Scholar
• Xie HG, Li XX, Lv GJ, Xie WY, Zhu J, Luxbacher T, et al. 2010. Effect of surface wettability and charge on protein adsorption onto implantable alginate‐chitosan‐alginate microcapsule surfaces. J Biomed Mat Res Part A. 92:1357–1365.
   PubMed Web of Science ®Google Scholar
• Yamashita S, Matsuzawa Y. 2009. Where are we with probucol: a new life for an old drug? Atherosclerosis. 207:16–23.
   PubMed Web of Science ®Google Scholar
• Yang L, Xu Y, Su Y, Wu J, Zhao K, Chen J, Wang M. 2005. FT-IR spectroscopic study on the variations of molecular structures of some carboxyl acids induced by free electron laser. Spectrochim Acta Part A, Mol Biomol Spectrosc. 62:1209–1215.
   PubMed Web of Science ®Google Scholar
• Yang Y, Campanella OH, Hamaker BR, Zhang G, Gu Z. 2013. Rheological investigation of alginate chain interactions induced by concentrating calcium cations. Food Hydrocoll. 30:26–32.
   Web of Science ®Google Scholar