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Research Article

Development of PEGylated solid lipid nanoparticles of pentoxifylline for their beneficial pharmacological potential in pathological cardiac hypertrophy

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Pages 1901-1908 | Received 31 Aug 2015, Accepted 07 Oct 2015, Published online: 02 Dec 2015

References

  • Alexis F, Pridgen E, Molnar LK, Farokhzad OC. 2008. Factors affecting the clearance and biodistribution of polymeric nanoparticles. Mol Pharm. 5:505–515.
  • Balakumar P, Singh M. 2005. The possible role of TNF-alpha in physiological and pathophysiological cardiac hypertrophy in rats. Iran J Pharmacol Ther. 4:138–142.
  • Champion S, Lapidus N, Cherié G, Spagnoli V, Oliary J, Solal AC. 2014. Pentoxifylline in heart failure: a meta‐analysis of clinical trials. Cardiovasc Ther. 32:159–162.
  • Chaudhari KR, Ukawala M, Manjappa AS, Kumar A, Mundada PK, Mishra AK, et al. 2012. Opsonization, biodistribution, cellular uptake and apoptosis study of PEGylated PBCA nanoparticle as potential drug delivery carrier. Pharm Res. 29:53–68.
  • Chmielewska A, Konieczna L, Plenis A, Lamparczyk H. 2006. Quantitative determination of pentoxifylline in human plasma. Acta Chromatogr. 16:70–79.
  • Kim KP, Cha JD, Jang EH, Klumpp J, Hagens S, Hardt WD, et al. 2008. PEGylation of bacteriophages increases blood circulation time and reduces T‐helper type 1 immune response. Microbial Biotechnol. 1:247–257.
  • Kuwahara F, Kai H, Tokuda K, Takeya M, Takeshita A, Egashira K, Imaizumi T. 2004. Hypertensive myocardial fibrosis and diastolic dysfunction another model of inflammation? Hypertension. 43:739–745.
  • Li J, Li P, Feng X, Li Z, Hou R, Han C, Zhang Y. 2003. Effects of losartan on pressure overload‐induced cardiac gene expression profiling in rats. Clin Exp Pharmacol Physiol. 30:827–832.
  • Lima V, Vidal FD, Rocha FAC, Brito GAC, Ribeiro RA. 2004. Effects of tumor necrosis factor-α inhibitors pentoxifylline and thalidomide on alveolar bone loss in short-term experimental periodontal disease in rats. J Periodontol. 75:162–168.
  • Lloyd-Jones D. 2010. Heart disease and stroke statistics—update: a report from the American Heart Association. Circulation. 121:e46–e215.
  • Lobovkina T, Jacobson GB, Gonzalez-Gonzalez E, Hickerson RP, Leake D, Kaspar RL, et al. 2011. In vivo sustained release of siRNA from solid lipid nanoparticles. ACS Nano. 5:9977–9983.
  • Mielniczuk LM, Lamas GA, Flaker GC, Mitchell G, Smith SC, Gersh BJ, et al. 2007. Left ventricular end‐diastolic pressure and risk of subsequent heart failure in patients following an acute myocardial infarction. Congest Heart Fail. 13:209–214.
  • Moller DR, Wysocka M, Greenlee BM, Ma X, Wahl L, Trinchieri G, Karp CL. 1997. Inhibition of human interleukin‐12 production by pentoxifylline. Immunology. 91:197–203.
  • Muller RH, Mader K, Gohla S. 2000. Solid lipid nanoparticles (SLN) for controlled drug delivery – a review of the state of the art. Eur J Pharm Biopharm. 50:161–177.
  • Nunes S, Barros A. 2015. The use of coating agents to enhance liposomes blood circulation time. J Mol Pharm Org Process Res. 3:e120.
  • Parhi R, Suresh P. 2010. Production of solid lipid nanoparticles—drug loading and release mechanism. J Chem Pharm Res. 2:211–227.
  • Simón-Yarza T, Formiga FR, Tamayo E, Pelacho B, Prosper F, Blanco-Prieto MJ. 2013. PEGylated-PLGA microparticles containing VEGF for long term drug delivery. Int J Pharm. 440:13–18.
  • Singh AP, Singh R, Krishan P. 2015. Ameliorative role of gemfibrozil against partial abdominal aortic constriction-induced cardiac hypertrophy in rats. Cardiol Young. 25:725–730.
  • Smith RV, Waller ES, Doluisio JT, Bauza MT, Puri SK, Ho I, Lassman HB. 1986. Pharmacokinetics of orally administered pentoxifylline in humans. J Pharm Sci. 75:47–52.
  • Sun M, Chen M, Dawood F, Zurawska U, Li JY, Parker T, et al. 2007. Tumor necrosis factor-α mediates cardiac remodeling and ventricular dysfunction after pressure overload state. Circulation. 115:1398–1407.
  • Varshosaz J, Minayian M, Moazen E. 2010. Enhancement of oral bioavailability of pentoxifylline by solid lipid nanoparticles. J Liposome Res. 20: 115–123.
  • Venkateswarlu V, Manjunath K. 2004. Preparation, characterization and in vitro release kinetics of clozapine solid lipid nanoparticles. J Control Release. 95: 627–638.
  • Wang Z, Li J, Cho J, Malik AB. 2014. Prevention of vascular inflammation by nanoparticle targeting of adherent neutrophils. Nat Nanotechnol. 9:204–210.
  • Waterborg JH. 2009. The Lowry Method for Protein Quantitation. The Protein Protocols Handbook. New York: Humana Press, pp. 7–10.
  • Zhai Y, Zhao Y, Lei J, Su Z, Ma G. 2009. Enhanced circulation half-life of site-specific PEGylated rhG-CSF: optimization of PEG molecular weight. J Biotechnol. 142:259–266.
  • Zhang C, Gu C, Peng F, Liu W, Wan J, Xu H, et al. 2013. Preparation and optimization of triptolide-loaded solid lipid nanoparticles for oral delivery with reduced gastric irritation. Molecules. 18:13340–13356.
  • Zhang M, Xu YJ, Saini HK, Turan B, Liu PP, Dhalla NS. 2005a. Pentoxifylline attenuates cardiac dysfunction and reduces TNF-∝ level in ischemic-reperfused heart. Am J Physiol Heart Circ Physiol. 289:H832–H839.
  • Zhang M, Xu YJ, Saini HK, Turan B, Liu PP, Dhalla NS. 2005b. TNF-α as a potential mediator of cardiac dysfunction due to intracellular Ca2+-overload. Biochem Biophys Res Commun. 327:57–63.
  • Zhao Y, Wang L, Yan M, Ma Y, Zang G, She Z, Deng Y. 2012. Repeated injection of PEGylated solid lipid nanoparticles induces accelerated blood clearance in mice and beagles. Int J Nanomed. 7:2891–2900.
  • Zou Y, Ding J, Zheng Z, Zhang L, Ma N. 2012. Preparation and in vitro–in vivo evaluation of long-circulating solid lipid nanoparticles loaded with praziquantel. Chin J Pharm. 43:438–442.

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