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Research Article

Gene therapy with IL-12 induced enhanced anti-tumor activity in fibrosarcoma mouse model

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Pages 1988-1993 | Received 09 Sep 2015, Accepted 11 Nov 2015, Published online: 13 Jan 2016

References

  • Bathula SR, Huang L. 2010. Gene Therapy with Plasmid DNA. Burger's Medicinal Chemistry and Drug Discovery. New York: Wiley.
  • Beh CW, Seow WY, Wang Y, Zhang Y, Ong ZY, Ee PLR, Yang YY. 2008. Efficient delivery of Bcl-2-targeted siRNA using cationic polymer nanoparticles: downregulating mRNA expression level and sensitizing cancer cells to anticancer drug. Biomacromolecules. 10:41–48.
  • Bhatia S, Menezes ME, Das SK, Emdad L, Dasgupta S, Wang XY, Sarkar D, Fisher PB. 2013. Innovative approaches for enhancing cancer gene therapy. Discov Med. 15:309–317.
  • Bramante S, Koski A, Kipar A, Diaconu I, Liikanen I, Hemminki O, et al. 2014. Serotype chimeric oncolytic adenovirus coding for GM‐CSF for treatment of sarcoma in rodents and humans. Int J Cancer. 135:720–730.
  • Brunda MJ, Luistro L, Warrier RR, Wright RB, Hubbard BR, Murphy M, Wolf SF, Gately M. 1993. Antitumor and antimetastatic activity of interleukin 12 against murine tumors. J Exp Med. 178:1223–1230.
  • Cohen J. 1995. IL-12 deaths: explanation and a puzzle. Science. 270:908.
  • Conwell CC, Huang L. 2005. Recent advances in non‐viral gene delivery. Adv Genetics. 53:1–18.
  • Folini M, Pennati M, Zaffaroni N. 2009. RNA interference-mediated validation of genes involved in telomere maintenance and evasion of apoptosis as cancer therapeutic targets. siRNA and miRNA Gene Silencing. Berlin: Springer.
  • Gajewski TF. 2012. Cancer immunotherapy. Mol Oncol. 6:242–250.
  • Gately MK, Wolitzky AG, Quinn PM, Chizzonite R. 1992. Regulation of human cytolytic lymphocyte responses by interleukin-12. Cell Immunol. 143:127–142.
  • Gutiérrez-Ortega A, Sandoval-Montes C, De Olivera-Flores TJ, Santos-Argumedo L, Gómez-Lim MÁ. 2005. Expression of functional interleukin-12 from mouse in transgenic tomato plants. Transgenic Res. 14:877–885.
  • Hallaj-Nezhadi S, Valizadeh H, Baradaran B, Dobakhti F, Lotfipour F. 2013. Preparation and characterization of gelatin nanoparticles containing pDNA encoding IL-12 and their expression in CT-26 carcinoma cells. Future Oncol. 9:1195–1206.
  • Hara I, Nagai H, Miyake H, Yamanaka K, Hara S, Micallef MJ, et al. 2000. Effectiveness of cancer vaccine therapy using cells transduced with the interleukin-12 gene combined with systemic interleukin-18 administration. Cancer Gene Ther. 7:83–90.
  • Helmy KY, Patel SA, Nahas GR, Rameshwar P. 2013. Cancer immunotherapy: accomplishments to date and future promise. Ther Deliv. 4:1307–1320.
  • Kobayashi M, Fitz L, Ryan M, Hewick RM, Clark SC, Chan S, et al. 1989. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J Exp Med. 170:827–845.
  • Konsti J, Lundin M, Joensuu H, Lehtimäki T, Sihto H, Holli K, et al. 2011. Development and evaluation of a virtual microscopy application for automated assessment of Ki-67 expression in breast cancer. BMC Clin Pathol. 11:3.
  • Kowalczyk DW, Wysocki PJ, Mackiewicz A. 2003. Cancer immunotherapy using cells modified with cytokine genes. Acta Biochim Pol. 50:613–624.
  • Kresina TF. 2001. An Introduction to Molecular Medicine and Gene Therapy. New York: Wiley Online Library.
  • Lehrman S. 1999. Virus treatment questioned after gene therapy death. Nature. 401:517–518.
  • Leonard JP, Sherman ML, Fisher GL, Buchanan LJ, Larsen G, Atkins MB, et al. 1997. Effects of single-dose interleukin-12 exposure on interleukin-12–associated toxicity and interferon-γ production. Blood. 90:2541–2548.
  • Li S, Xia X, Mellieon FM, Liu J, Steele S. 2004. Candidate genes associated with tumor regression mediated by intratumoral IL-12 electroporation gene therapy. Mol Ther. 9:347–354.
  • Lode HN, Dreier T, Xiang R, Varki NM, Kang AS, Reisfeld RA. 1998. Gene therapy with a single chain interleukin 12 fusion protein induces T cell-dependent protective immunity in a syngeneic model of murine neuroblastoma. Proc Natl Acad Sci USA. 95:2475–2480.
  • Lotfipour F, Hallaj-Nezhadi S, Valizadeh H, Dastmalchi S, Baradaran B, Jalali MB, Dobakhti F. 2011. Preparation of chitosan-plasmid DNA nanoparticles encoding interleukin-12 and their expression in CT-26 colon carcinoma cells. J Pharm Pharm Sci. 14:181–195.
  • Mazzolini G, Qian C, Xie X, Sun Y, Lasarte JJ, Drozdzik M, Prieto J. 1999. Regression of colon cancer and induction of antitumor immunity by intratumoral injection of adenovirus expressing interleukin-12. Cancer Gene Ther. 6:514–522.
  • Nasu Y, Bangma C, Hull G, Lee H, Hu J, Wang J, et al. 1999. Adenovirus-mediated interleukin-12 gene therapy for prostate cancer: suppression of orthotopic tumor growth and pre-established lung metastases in an orthotopic model. Gene Ther. 6:338–349.
  • Newman C, Bettinger T. 2007. Gene therapy progress and prospects: ultrasound for gene transfer. Gene Ther. 14:465–475.
  • Nogawa M, Yuasa T, Kimura S, Tanaka M, Kuroda J, Sato K, et al. 2005. Intravesical administration of small interfering RNA targeting PLK-1 successfully prevents the growth of bladder cancer. J Clin Investig. 115:978–985.
  • Pertl U, Luster AD, Varki NM, Homann D, Gaedicke G, Reisfeld RA, Lode HN. 2001. IFN-γ-inducible protein-10 is essential for the generation of a protective tumor-specific CD8 T cell response induced by single-chain IL-12 gene therapy. J Immunol. 166:6944–6951.
  • Qin Z, Schwartzkopff J, Pradera F, Kammertœns T, Seliger B, Pircher H, Blankenstein T. 2003. A critical requirement of interferon γ-mediated angiostasis for tumor rejection by CD8 + T cells. Cancer Res. 63:4095–4100.
  • Shen Z, Brayman A, Chen L, Miao C. 2008. Ultrasound with microbubbles enhances gene expression of plasmid DNA in the liver via intraportal delivery. Gene Ther. 15:1147–1155.
  • Shi X, Liang Z, Ren X, Liu T. 2008. Combined silencing of K-ras and Akt2 oncogenes achieves synergistic effects in inhibiting pancreatic cancer cell growth in vitro and in vivo. Cancer Gene Ther. 16:227–236.
  • Suzuki R, Namai E, Oda Y, Nishiie N, Otake S, Koshima R, et al. 2010. Cancer gene therapy by IL-12 gene delivery using liposomal bubbles and tumoral ultrasound exposure. J Control Release. 142:245–250.
  • Taniyama Y, Tachibana K, Hiraoka K, Namba T, Yamasaki K, Hashiya N, et al. 2002. Local delivery of plasmid DNA into rat carotid artery using ultrasound. Circulation. 105:1233–1239.
  • Tare NS, Bowen S, Warrier RR, Carvajal DM, Benjamin WR, Riley JH, Anderson TD, Gately MK. 1995. Administration of recombinant interleukin-12 to mice suppresses hematopoiesis in the bone marrow but enhances hematopoiesis in the spleen. J Interferon Cytokine Res. 15:377–383.
  • Toda M, Martuza R, Rabkin S. 2001. Combination suicide/cytokine gene therapy as adjuvants to a defective herpes simplex virus-based cancer vaccine. Gene Ther. 8:332–339.
  • Voest EE, Kenyon BM, O'Reilly MS, Truitt G, D'Amato RJ, Folkman J. 1995. Inhibition of angiogenesis in vivo by interleukin 12. J Natl Cancer Inst. 87:581–586.
  • Walser TC, Ma X, Kundu N, Dorsey R, Goloubeva O, Fulton AM. 2007. Immune-mediated modulation of breast cancer growth and metastasis by the chemokine Mig (CXCL9) in a murine model. J Immunother. 30:490–498.
  • Wang JH, Liu XY. 2003. Targeting strategies in cancer gene therapy. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao. 35:311–316.
  • Wold SM, Toth K. 2013. Adenovirus vectors for gene therapy, vaccination and cancer gene therapy. Curr Gene Ther. 13:421–433.
  • Xu D, Gu P, Pan PY, Li Q, Sato AI, Chen SH. 2004. NK and CD8 + T cell‐mediated eradication of poorly immunogenic B16‐F10 melanoma by the combined action of IL‐12 gene therapy and 4‐1BB costimulation. Int J Cancer. 109:499–506.
  • Yoshimoto T, Morishima N, Okumura M, Chiba Y, Xu M, Mizuguchi J. 2009. Interleukins and cancer immunotherapy. Immunotherapy. 1:825–844.
  • Zarour HM, Ferrone S. 2011. Cancer immunotherapy: progress and challenges in the clinical setting. Eur J Immunol. 41:1510.

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