19
Views
8
CrossRef citations to date
0
Altmetric
Miscellany

Gentamicin and Tobramycin Clinical Pharmacokinetics and Nephrotoxicity Aspects on Assay Techniques

Pages 1-40 | Published online: 02 Jan 2015

References

  • Alestig, K., Dornbusch, K., Ericson, C., Kallings, L.-O., Kamme, C., Nordbring, F., Norrby, R. & Wallmark, G. Resistensbestämning av bakterier: Ny indelning i känslighetsgrupper — S, I och R. Läkartidningen 75: 4346 (1978)
  • Alfthan, O., Renkonen, O. V. & Sivonen, A. Concentration of gentamicin in serum, urine and urogenital tissue in man. Acta Pathologica et Microbiologica Scandinavica. Section B. 81 ( Suppl. 241): 92 (1973)
  • Arvidsson, A., Borgå, O. & Alván, G. Renal excretion of cephapirin and cephaloridine: Evidence for saturable tubular reabsorption. Clinical Pharmacology and Therapeutics, In press.
  • Atterholm, I., Hedström, S.-Å., Kahlmeter, G. & Kamme, C. Tobramycin in patients with various infections: A clinical evaluation. Scandinavian Journal of Infectious Diseases 10: 229 (1978)
  • Banck, G., Belfrage, S., Juhlin, I., Nordström, L., Tjernström, Ö. & Toremalm, N. G. Retrospective study of the ototoxicity of gentamicin. Acta Pathologica et Microbiologica Scandinavica. Section B. 81 ( Suppl. 241): 54 (1973)
  • Barza, M., Brown, R. B., Shen, D., Gibaldi, M. & Weinstein, L. Predictability of blood levels of gentamicin in man. Journal of Infectious Diseases 132: 165 (1975)
  • Barza, M., Pinn, V., Tanguay, P. & Murray, T. Nephrotoxicity of newer cephalosporins and aminoglycosides alone and in combination in a rat model. Journal of Antimicrobial Agents and Chemotherapy 4 ( Suppl. A): 59 (1978)
  • Bendusch, C. L. & Weber, R. Tobramycin sulfate: A summary of world-wide experience from clinical trials. Journal of Infectious Diseases 134 ( Suppl.): 219 (1976)
  • Benveniste, R. & Davies, J. Mechanisms of antibiotic resistance in bacteria. Annual Review of Biochemistry 42: 471 (1973)
  • Bergan, T., Brodwall, E. K. & Öyri, A. Renal excretion of gentamicin in chronic pyelonephritis. Acta Medica Scandinavica 189: 1 (1971)
  • Bickel, H. Proximal tubular defects. In D. A. K. Black. Renal disease. Blackwell Scientific Publications, Oxford, p. 347 (1962)
  • Black, J., Calesnick, B., Williams, D. & Weinstein, M. J. Pharmacology of gentamicin, a new broad-spectrum antibiotic. Antimicrobial Agents and Chemotherapy 3: 138 (1963)
  • Brummet, R. E., Fox, K. E., Bendrick, T. W. & Himes, D. L. Ototoxicity of tobramycin, gentamicin, amikacin and sisomicin in the guinea pig. Journal of Antimicrobial Chemotherapy 4 ( Suppl. A): 73 (1978)
  • Brummet, R. E., Himes, D., Saine, B. & Vernon, J. A comparative study of the ototoxicity of tobramicin and gentamicin. Archives of Otolaryngology 96: 505 (1972)
  • Bryan, L. E. & Van den Elzen, H. M. Gentamicin accumulation by sensitive strains of E. coli and Ps. aeruginosa. Journal of Antibiotics 28: 696 (1975)
  • Bryant, R. E. & Hammond, D. Interaction of purulent material with antibiotics used to treat Pseudomonas infections. Antimicrobial Agents and Chemotherapy 6: 702 (1974)
  • Bygbjerg, I. C. & Möller, R. Gentamicin-induced nephropathy. Scandinavian Journal of Infectious Diseases 8: 203 (1976)
  • Bäck, S.-E., Nilsson-Ehle, I. & Nilsson-Ehle, P. Rapid chemical assay for aminoglycoside antibiotics. Clinical Chemistry, In press.
  • Chiu, P. J. S., Brown, A., Miller, G. & Long, J. F. Renal extraction of gentamicin in anesthetized dogs. Antimicrobial Agents and Chemotherapy 10: 211 (1976)
  • Chiu, P. J. S., Miller, G. H., Brown, A. D., Long, J. F. & Waitz, J. A. Renal pharmacology of netilmicin. Antimicrobial Agents and Chemotherapy 11: 821 (1977)
  • Colburn, W. A., Schentag, J. J., Jusko, W. J. & Gibaldi, M. A model for the prospective identification of the prenephrotoxic state during gentamicin therapy. Journal of Pharmacokinetics and Biopharmaceutics 6: 179 (1978)
  • Cox, C. E. Gentamicin, a new aminoglycoside antibiotic: Clinical and laboratory studies in urinary tract infection. Journal of Infectious Diseases 119: 486 (1969)
  • Cox, C. E. & Harrison, L. H. Comparison of gentamicin and polymixin B—kanamycin in bacteremia due to gramnegative bacilli. Journal of Infectious Diseases 124 ( Suppl.): 156 (1971)
  • Cronberg, S., Ericson, C. & Skånsberg, P. Drug sensitivity of bacteria isolated by blood culture. Scandinavian Journal of Infectious Diseases 6: 247 (1974)
  • Dahlgren, J. A., Anderson, E. T. & Hewitt, W. L. Gentamicin blood levels: A guide to nephrotoxicity. Antimicrobial Agents and Chemotherapy 8: 58 (1975)
  • Davis, W. W. & Stout, T. R. Disc plate method of microbiological antibiotic assay. I. Factors inluencing variability and error. Applied Microbiology 22: 659 (1971)
  • Davis, W. W. & Stout, T. R. Disc plate method of microbiological antibiotic assay. II. Novel procedure offering improved accuracy. Applied Microbiology 22: 666 (1971)
  • Dellinger, P., Murphy, T., Barza, M., Pinn, V. & Weinstein, L. Effects of cephalothin on renal cortical concentrations of gentamicin in rats. Antimicrobial Agents and Chemotherapy 9: 587 (1976)
  • Dellinger, P., Murphy, T., Pinn, V., Barza, M. & Weinstein, L. Protective effect of cephalothin against gentamicin-induced nephrotoxicity in rats. Antimicrobial Agents and Chemotherapy 9: 172 (1976)
  • deRosa, F., Buoncristiani, U., Capitanucci, P. & Frongillo, R. F. Tobramycin: Toxicological and pharmacological studies in animals and pharmacokinetic research in patients with varying degrees of renal impairment. Journal of International Medical Research 2: 100 (1974)
  • Dobbs, S. M. & Mawer, G. E. Intravenous injection of gentamicin and tobramycin without impairment of hearing. Journal of Infectious Diseases 134 ( Suppl.): 114 (1976)
  • Edwards, C. Q., Smith, C. R., Baughman, K. L., Rogers, J. F. & Lietman, P. S. Concentrations of gentamicin and amikacin in human kidneys. Antimicrobial Agents and Chemotherapy 9: 925 (1976)
  • Elfving, J. W. & Pettay, O. Some sources of error in monitoring antibiotic treatment. In Proceedings of the 8th International Congress of Chemotherapy, Athens, 1974: 211 (1974)
  • Enger, E. & Blegen, E. M. The relationship between endogenous creatinine clearance and serum creatinine in renal failure. Scandinavian Journal of Clinical and Laboratory Investigation 16: 273 (1964)
  • Ericsson, H. M. & Sherris, J. C. Antibiotic sensitivity testing. Report of an international collaborative study. Acta Pathologica et Microbiologica Scandinavica, Section B. ( Suppl. 217) (1971)
  • Erlanson, P. Determination of the sensitivity in vitro of bacteria to chemotherapeutic agents. Acta Pathologica et Microbiologica Scandinavica ( Suppl. 85) (1951)
  • Ervin, F. R. & Bullock, W. E. Jr. Simple assay for clindamycin in the presence of aminglycosides. Antimicrobial Agents and Chemotherapy 6: 831 (1974)
  • Ewald, U. & Jernelius, H. Njurinsufficiens vid behandling med antibiotikakombinationen cefalotin-gentamycin. Läkartidningen 71: 2595 (1974)
  • Fabre, J., Rudhart, M., Blanchard, P. & Regamey, C. Persistence of sisomicin and gentamicin in renal cortex and medulla compared with other organs and serum of rats. Kidney International 10: 444 (1976)
  • Falco, F. G., Smith, H. M. & Arcieri, G. M. Nephrotoxicity of aminoglycosides and gentamicin. Journal of Infectious Diseases 119: 406 (1969)
  • Fee, W. E. Jr., Vierra, V. & Lathrop, G. R. Clinical evaluation of aminoglycoside toxicity: Tobramycin versus gentamicin, a preliminary report. Journal of Antimicrobial Chemotherapy 4 ( Suppl. A): 31 (1978)
  • Feld, R., Valdivieso, M., Bodey, G. P. & Rodriguez, V. Comparison of amikacin and tobramycin in the treatment of infection in patients with cancer. Journal of Infectious Dieases 135: 61 (1977)
  • Flandre, O. & Damon, M. Experimental study of the nephrotoxicity of gentamicin in rats. Gentamicin, First International Symposium. Basel, Schwabe and Co., p. 47 (1967)
  • Follath, F., Spring, P., Wenk, M., Benet, L. Z. & Dettli, L. Comparative pharmacokinetics of sisomicin and netilmicin in healthy volunteers. In Proceedings of the 10th International Congress of Chemotherapy, Zürich, 1977. Current Chemotherapy 2: 979 (1978)
  • Garrod, L. P. & Waterworth, P. M. Effect of medium composition on the apparent sensitivity of Pseudomonas aeruginosa. Journal of Clinical Pathology 22: 534 (1969)
  • Gary, N. E., Buzzeo, L., Salaki, J. & Eisinger, R. P. Gentamicin-associated acute renal failure. Archives of Internal Medicine 136: 1101 (1976)
  • Gibaldi, M. & Perrier, D. Pharmacokinetics. Marcel Dekker, Inc., New York (1975)
  • Gilbert, D. N., Plamp, C., Starr, P., Bennett, W. M., Houghton, D. C. & Porter, G. Comparative nephrotoxicity of gentamicin and tobramycin in rats. Antimicrobial Agents and Chemotherapy 13: 34 (1978)
  • Gingell, J. C. & Waterworth, P. M. Dose of gentamicin in patients with normal renal function and renal impairment. British Medical Journal 2: 19 (1968)
  • Ginsburg, D. S., Quintanilla, A. P. & Levin, M. Renal glucosuria due to gentamicin in rabbits. Journal of Infectious Diseases 134: 119 (1976)
  • Gordon, R. C., Regamey, C. & Kirby, W. M. M. Serum protein binding of the aminoglycoside antibiotics. Antimicrobial Agents and Chemotherapy 2: 214 (1972)
  • Gyselynck, A.-M., Forrey, A. & Cutler, R. Pharmacokinetics of gentamicin: Distribution and plasma and renal clearance. Journal of Infectious Diseases 124 ( Suppl.): 70 (1971)
  • Hewitt, W. L. Gentamicin: Toxicity in perspective. Postgraduate Medical Journal 50 ( Suppl. 7): 55 (1974)
  • Hoffman, R. P. & Mood, D. W. Impaired renal function secondary to gentamicin. Drug Intelligence and Clinical Pharmacy 11: 134 (1977)
  • Hollenberg, N. K., Adams, D. F., Oken, D. E., Abrams, H. L. & Merril, J. P. Acute renal failure due to nephrotoxins. New England Journal of Medicine 282: 1329 (1970)
  • Houghton, D. C., Hartnett, M., Campbell-Boswell, M., Porter, G. & Bennett, W. A light and electron microscopic analysis of gentamicin nephrotoxicity in rats. American Journal of Pathology 82: 589 (1976)
  • Hruban, Z., Slesers, A. & Hopkins, E. Drug-induced and naturally occurring myeloid bodies. Laboratory Investigation 27: 62 (1972)
  • Jackson, G. G. Gentamicin. Current therapeutics. Practitioner 198: 855 (1967)
  • Jackson, G. G. Present status of aminoglycoside antibiotics and their safe effective use. Clinical Therapeutics 1: 200 (1977)
  • Jalling, B., Malmborg, A.-S., Lindman, A. & Boréus, L. O. Evaluation of a micromethod for determination of antibiotic concentrations in plasma. European Journal of Clinical Pharmacology 4: 150 (1972)
  • Jao, R. L. & Jackson, G. G. Clinical experience with gentamicin in Gram-negative infections. Antimicrobial Agents and Chemotherapy 1963: 148 (1964)
  • Jarvis, J. D. & Leung, T. W. C. Some factors influencing the assay of gentamicin. In Proceedings of the 9th International Congress of Chemotherapy, London, 1975. Chemotherapy 2: 143 (1976)
  • Jonsson, S., Kahlmeter, G., Hallberg, T. & Kronvall, G. Characteristics of a new radioimmunoassay for gentamicin using 125I-labelled gentamicin-HSA as a tracer and protein A-containing Staph. aureus as a separation reagent. In Proceedings of the VIth International Congress of Infectious and Parasitic Diseases, Warsaw, 3: 160 (1974)
  • Juhlin, I. The determination of gentamicin concentrations. Acta Pathologica et Microbiologica Scandinavica. Section B. 81 ( Suppl. 241): 48 (1973)
  • Jusko, J. W. & Levy, G. Pharmacokinetic evidence for saturable renal tubular reabsorption of riboflavin. Journal of Pharmaceutical Science 59: 767 (1970)
  • Kahlmeter, G. & Dornbusch, K. Quality control surveys of gentamicin assays. To be published.
  • Kahlmeter, G., Hallberg, T., Jonsson, S., Kamme, C. & Ursing, B. Prolonged excretion of gentamicin in patients with normal renal function. In Proceedings of the 9th International Congress of Chemotherapy, London, 1975. Chemotherapy 4: 115 (1976)
  • Kahlmeter, G. & Kamme, C. Prolonged excretion of gentamicin in a patient with unimpaired renal function. Lancet i: 286 (1975)
  • Kahlmeter, G. & Kamme, C. Behandling med aminoglycosider. Läkartidningen, In press.
  • Kahn, T. & Stein, R. M. Gentamicin and renal failure. Lancet i: 498 (1972)
  • Kavanagh, F. Analytical Microbiology. Academic Press, New York (1967)
  • Kaye, D., Levison, M. E. & Labovitz, E. D. The unpredictability of serum concentrations of gentamicin in patients with normal and abnormal renal function. Journal of Infectious Diseases 130: 150 (1974)
  • Klein, P. Bakteriologische Grundlagen der Chemotherapeutischen Laboratoriumspraxis. Springer-Verlag, Berlin (1957)
  • Kornguth, M. L. & Kunin, C. M. Distribution of gentamicin and amikacin in rabbit tissues. Antimicrobial Agents and Chemotherapy 11: 974 (1977)
  • Kosek, J. C., Mazze, R. I. & Cousins, M. Nephrotoxicity of gentamicin. Laboratory Investigation 30: 48 (1974)
  • Kovnat, P., Labovitz, E. & Levison, S. P. Antibiotics and the kidney. Medical Clinics of North America 57: 1045 (1973)
  • Labovitz, E., Levison, M. E. & Kaye, D. Single-dose daily gentamicin therapy in urinary tract infection. Antimicrobial Agents and Chemotherapy 6: 465 (1974)
  • Lamb, J. W., Mann, J. M. & Simmons, R. J. Factors influencing the microbiological assay of tobramycin. Antimicrobial Agents and Chemotherapy 1: 323 (1972)
  • Lerner, S. A., Seligsohn, R., Rudd, R. & Matz, G. Comparative clinical studies of ototoxicity and nephrotoxicity of amikacin and gentamicin. In Proceedings of the 10th International Congress of Chemotherapy, Zürich, 1977. Current Chemotherapy 2: 945 (1978)
  • Lewis, J. E., Nelson, J. C. & Elder, H. A. Radioimmunoassay of an antibiotic: Gentamicin. Nature New Biology 239: 214 (1972)
  • Lietman, P. S. Aminoglycoside nephrotoxicity: Transport and subcellular aspects. Symposium on “Therapeutic and Toxicologic Implications of Aminoglycoside Use“, Paris, March (1978)
  • Lode, G., Kemmerich, B. & Koeppe, P. Comparative clinical pharmacology of gentamicin, sisomicin and tobramycin. Antimicrobial Agents and Chemotherapy 8: 396 (1975)
  • Luft, F. C., Bloch, R., Sloan, R. S., Nahm Yum, M., Costello, R. & Maxwell, D. R. Comparative nephrotoxicity of aminoglycoside antibiotics in rats. Journal of Infectious Diseases 138: 541 (1978)
  • Luft, F. C. & Kleit, S. A. Renal parenchymal accumulation of aminoglycoside antibiotics in rats. Journal of Infectious Diseases 130: 656 (1974)
  • Luft, F. C., Nahm Yum, M. & Kleit, S. A. Comparative nephrotoxicities of netilmicin and gentamicin in rats. Antimicrobial Agents and Chemotherapy 10: 845 (1976)
  • Madsen, P. O., Kjaer, T. B. & Mosegaard, A. Comparison of tobramycin and gentamicin in the treatment of complicated urinary tract infections. Journal of Infectious Diseases 134 ( Suppl.): 150 (1976)
  • Mahon, W. A., Ezer, J. I. & Inaba, T. Renal binding of aminoglycosides. Assessment of Aminoglyoside Toxicity. Bürgenstock, Switzerland, 1977, p. 14 (1978)
  • Maitra, S. K., Yoshikawa, T. T., Steyn, C. M., Guze, L. B. & Schotz, M. C. Amikacin assay in serum by high-performance liquid chromatography. Antimicrobial Agents and Chemotherapy 14: 880 (1978)
  • Maliwan, N., Grieble, H. G. & Bird, T. J. Hospital Ps. aeruginosa: Surveillance of resistance to gentamicin and transfer of aminoglycoside R-factor. Antimicrobial Agents and Chemotherapy 8: 415 (1975)
  • Manuel, C., Witchitz, J., Veyssier, P. & Bouvet, E. Application of radioenzymatic assay of netilmicin to the monitoring of plasma concentrations in severe sepsis. In Proceedings of the 10th International Congress of Chemotherapy, Zürich, 1977. Current Chemotherapy 2: 910 (1978)
  • Marre, R., Beck, H., Züllich, B., Husstedt, W. & Freiesleben, H. Animal studies on accumulation of 11 aminoglycosides in renal tissue. In Proceedings of the 10th International Congress of Chemotherapy, Zürich, 1977. Current Chemotherapy 2: 955 (1978)
  • Mawer, G. E., Ahmad, R., Dobbs, S. M., McGough, J. G., Lucas, S. B. & Tooth, J. A. Prescribing aids for gentamicin. British Journal of Clinical Pharmacology 1: 45 (1974)
  • Medeiros, A. A., O'Brien, T. F., Wacker, W. E. C. & Yulug, N. F. Effect of salt concentration on the apparent in vitro susceptibility of Pseudomonas and other Gram-negative bacilli to gentamicin. Journal of Infectious Diseases 124 ( Suppl.): 59 (1971)
  • Mendelson, J., Portnoy, J. & Black, M. Safety of the bolus administration of gentamicin. Antimicrobial Agents and Chemotherapy 9: 633 (1976)
  • Meyers, B. R. & Hirschman, S. Z. Pharmacologic studies on tobramycin and comparison with gentamicin. Journal of Clinical Pharmacology and New Drugs 12: 321 (1972)
  • Milman, N. Gentamycinnefropati. Ugeskrift for Lœger 135: 1861 (1973)
  • Milner, R. D. G., Ross, J., Froud, D. J. R. & Davies, J. A. Clinical pharmacology of gentamicin in the newborn infant. Archives of Disease in Childhood 47: 927 (1972)
  • Minuth, J. N., Musher, D. M. & Thorsteinsson, S. B. Inhibition of antibacterial activity of gentamicin in urine. Journal of Infectious Dieases 133: 14 (1976)
  • Mondorf, A. W., Zegelman, M., Klose, J., Hendus, J. & Breier, J. Comparative studies on the action of aminoglycosides and cephalosporins on the proximal tubule of the human kidney. Journal of Antimicrobial Chemotherapy 4 ( Suppl. A): 53 (1978)
  • Mortensen, I. & Bang, J. Quality control of serum gentamicin assays in Denmark. In Proceedings of the 10th International Congress of Chemotherapy, Zürich, 1977. Current Chemotherapy 2: 905 (1978)
  • Neu, H. C. Tobramycin: An overview. Journal of Infectious Diseases 134 ( Suppl.): 3 (1976)
  • Neu, H. C. & Bendusch, C. L. Ototoxicity of tobramycin: A clinical overview. The Journal of Infectious Diseases 134 ( Suppl.): 206 (1976)
  • Nilsson-Ehle, I. High-pressure liquid chromatography as a tool for determination of antibiotics in biological fluids. Acta Pathologica et Microbiologica Scandinavica, Section B. ( Suppl. 259): 61 (1977)
  • Nordström, L., Banck, G., Belfrage, S., Juhlin, I., Tjernström, Ö. & Toremalm, N. G. Prospective study of the ototoxicity of gentamicin. Acta Pathologica et Microbiologica Scandinavica, Section B. 81 ( Suppl. 241): 58 (1973)
  • Opitz, A., Herrmann, I., Herrath, D. & Schaefer, K. Akute niereninsuffizienz nach gentamycin-chepalosporin-kombinationstherapie. Medizinischer Welt 22: 434 (1971)
  • Patel, V., Luft, F. C., Nahm Yum, M., Patel, B., Zeman, W. & Kleit, S. A. Enzymuria in gentamicin-induced kidney damage. Antimicrobial Agents and Chemotherapy 7: 364 (1975)
  • Pestka, S. Inhibitors of ribosome functions. Annual Review of Microbiology 25: 487 (1971)
  • Phillips, I. P., Warren, C. & Smith, S. E. Serum gentamicin assay: A comparison and assessment of different methods. Journal of Clinical Pathology 27: 447 (1974)
  • Ramirez-Ronda, C. H., Holmes, R. K., Sandford, J. P. Effects of divalent cations on binding of aminoglycoside antibiotics to human serum-proteins and to bacteria. Antimicrobial Agents and Chemotherapy 7: 239 (1975)
  • Reeves, D. S. & Bywater, M. J. Quality control of serum gentamicin assays—experience of national surveys. Journal of Antimicrobial Chemotherapy 1: 103 (1975)
  • Reeves, D. S. & Bywater, M. J. Assay of antimicrobial agents. In Selected topics in Clinical Bacteriology. De Louvois, J. (Ed.) Ballière Tindall, London (1976)
  • Regamey, C., Gordon, R. C. & Kirby, W. M. M. Comparative pharmacokinetics of tobramycin and gentamicin. Clinical Pharmacology and Therapeutics 14: 396 (1973)
  • Reiner, N. E., Bloxham, D. D., Thompson, W. L. Nephrotoxicity of gentamicin and tobramycin given once daily or continuously in dogs. Journal of Antimicrobial Chemotherapy 4 ( Suppl. A): 85 (1978)
  • Riff, L. J. & Jackson, G. G. Pharmacology of gentamicin in man. Journal of Infectious Diseases 124 ( Suppl.): 98 (1971)
  • Rodriguez, V., Stewart, D. & Bodey, G. P. Gentamicin sulfate distribution in body fluids. Clinical Pharmacology and Therapeutics 11: 275 (1970)
  • Sabath, L. D. & Toftegaard, I. Rapid microassays for clindamycin and gentamicin when present together and the effect of pH and of ecah on the antibacterial activity of the other. Antimicrobial Agents and Chemotherapy 6: 54 (1974)
  • Sack, K. & Freiesleben, H. Experimentelle untersuchungen zur potentiellen nephrotoxizität von tobramycin, gentamicin und sisomicin. Infection 3 ( Suppl. 1): 40 (1975)
  • Schentag, J. J., Cumbo, T. J., Jusko, W. J. & Plaut, M. E. Gentamicin tissue accumulation and nephrotoxic reactions. JAMA 240: 2067 (1978)
  • Schentag, J. J. & Jusko, W. J. Renal clearance and tissue accumulation of gentamicin. Clinical Pharmacology and Therapeutics 22: 364 (1977)
  • Schentag, J. J., Jusko, W. J., Vance, J. W., Cumbo, T. J., Abrutyn, E., DeLattre, M. & Gerbracht, L. M. Gentamicin disposition and tissue accumulation on multiple dosing. Journal of Pharmacokinetics and Biopharmaceutics 5: 559 (1977)
  • Schentag, J. J., Lasezkay, G., Plaut, M. E., Jusko, W. J. & Cumbo, T. J. Comparative tissue accumulation of gentamicin and tobramycin in patients. Journal of Antimicrobial Chemotherapy 4 ( Suppl. A.): 23 (1978)
  • Schering File. Schering Corporation, Bloomfield, U.S.A.
  • Shanson, D. C. & Daniels, J. V. Factors affecting plate assay of gentamicin. I. Diluents. Journal of Antimicrobial Chemotherapy 1: 219 (1975)
  • Shanson, D. C. & Hince, C. J. Factors affecting plate assay of gentamicin. II. Media. Journal of Antimicrobial Chemotherapy 3: 17 (1977)
  • Siber, G. R., Echeverria, P., Smith, A. L., Paisley, J. W. & Smith, D. H. Pharmacokinetics of gentamicin in children and adults. Journal of Infectious Diseases 132: 637 (1975)
  • Siersbaek-Nielsen, K., Mölholm-Hansen, J., Kampmann, J. & Kristensen, M. Rapid evaluation of creatinine clearance. Lancet i: 1133 (1971)
  • Smith, C. R., Baughman, K. L., Edwards, C. Q., Rogers, J. F. & Lietman, P. S. Controlled comparison of amikacin and gentamicin. New England Journal of Medicine 296: 349 (1977)
  • Smith, D. H., Van Otto, B. & Smith, A. L. A rapid chemical assay for gentamicin. New England Journal of Medicine 286: 583 (1972)
  • Stark, W. M., Hoehn, M. M. & Knox, N. G. Nebramycin, a new broad-spectrum antibiotic complex. I. Detection and biosynthesis. Antimicrobial Agents and Chemotherapy 1967: 314 (1968)
  • Stevens, P., Young, L. S. & Hewitt, W. L. Improved rapid radioenzymatic assay of amikacin, tobramycin and sisomicin in serum. Antimicrobial Agents and Chemotherapy 7: 374 (1975)
  • Szwed, J., Luft, F. C., Black, H. R., Elliott, R. A. & Kleit, S. A. Comparison of the distribution of tobramycin and gentamicin in body fluids of dogs. Antimicrobial Agents and Chemotherapy 5: 444 (1974)
  • Trottier, S., Bergeron, M.-G. & Gauvreau, L. Intrarenal concentration of netilmicin and gentamicin. In Proceedings of the 10th International Congress of Chemotherapy, Zürich, 1977. Current Chemotherapy 2: 953 (1978)
  • Valdivieso, M., Horikoshi, N., Rodriguez, V. & Bodey, G. P. Therapeutic trials with tobramycin. American Journal of Medical Sciences 268: 149 (1974)
  • Wagman, G. H., Bailey, J. V. & Weinstein, M. J. Binding of aminglycosides to feces. Antimicrobial Agents and Chemotherapy 6: 415 (1974)
  • Wagman, G. H., Bailey, J. V. & Weinstein, M. J. Binding of aminoglycoside antibiotics to filtration materials. Antimicrobial Agents and Chemotherapy 7: 316 (1975)
  • Wahlig, H., Metallinos, A., Hameister, W. & Bergman, R. Gentamicin-konzentrationen in geweben und körperflussigkeiten von versuchstieren. International Journal of Clinical Pharmacology, Therapy and Toxicology 10: 212 (1974)
  • Walker, B. D. & Gentry, L. O. A randomized, comparative study of tobramycin and gentamicin in treatment of acute urinary tract infections. Journal of Infectious Diseases 134 ( Suppl.): 146 (1976)
  • Washington II, J. A., Snyder, R. J., Kohner, P. C., Wiltse, C. G., Ilstrup, D. M. & McCall, J. T. Effect of cation content of agar on the activity of gentamicin, tobramycin and amikacin against Pseudomonas aeruginosa. Journal of Infectious Diseases 137: 103 (1978)
  • Watson, R. A. A. & Wenk, M. New 125I tracers in netilmicin and sisomicin radioimmunoassay. In Proceedings of the 10th International Congress of Chemotherapy, Zürich, 1977. Current Chemotherapy 2: 906 (1978)
  • Weinstein, M. J., Luedemann, G. M., Oden, E. M. & Wagman, G. H. Gentamicin, a new broad-spectrum antibiotic complex. Antimicrobial Agents and Chemotherapy 1963: 1 (1964)
  • Welles, J. S., Emmerson, J. L., Gibson, W. R., Nickander, R., Owen, N. V. & Anderson, R. C. Preclinical toxicology studies with tobramycin. Toxicology and Applied Pharmacology 25: 398 (1973)
  • Wellwood, J. M., Simpson, P. M., Tighe, J. R. & Thompson, A. E. Evidence of gentamicin nephrotoxicity in patients with renal allografts. British Medical Journal 3: 278 (1975)
  • Wersäll, J., Björkroth, B., Flock, Å. & Lundquist, P. G. Sensory hair fusion in vestibular sensory cells after gentamicin exposure. Archiv für Klinische und Experimentelle Ohren-, Nasen-und Kehlkopfheilkunde 200: 1 (1971)
  • Whelton, A., Carter, G. G., Bryant, H. H., Fox, L. & Walker, W. G. Therapeutic implications of gentamicin accumulation in severely diseased kidneys. Archives of Internal Medicine 136: 172 (1976)
  • Whelton, A., Carter, G.G., Craig, T. J., Bryant, H. H., Herbst, D. V. & Walker, W. G. Comparison of the intrarenal disposition of tobramycin and gentamicin: Therapeutic and toxicologic answers. Journal of Antimicrobial Chemotherapy 4 ( Suppl. A): 13 (1978)
  • Whelton, A. & Walker, W. G. Intrarenal antibiotic distribution in health and disease. Kidney International 6: 131 (1974)
  • Wilfert, J. N., Burke, J. P., Bloomer, H. A. & Smith, C. B. Renal insufficiency associated with gentamicin therapy. Journal of Infectious Diseases 124 ( Suppl.): 148 (1971)
  • Wilson, T. W., Mahon, W. A., Inaba, T., Johnson, G. E. & Kadar, D. Elimination of tritiated gentamicin in normal human subjects and in patients with severely impaired renal function. Clinical Pharmacology and Therapeutics 14: 815 (1973)
  • Wood, M. J. & Farrell, W. Comparison of urinary excretion of tobramycin and gentamicin in adults. Journal of Infectious Diseases 134 ( Suppl.): 133 (1976)
  • Wretlind, B., Nord, C.-E. & Wadström, T. In vitro sensitivity of isolates of Pseudomonas aeruginosa to carbenicillin, gentamicin, tobramycin and some other antibiotics. Scandinavian Journal of Infectious Diseases 6: 49 (1974)

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.