Gene therapy for arthritis

References

• Alamanos Y, Drosos AA. Epidemiology of adult rheumatoid arthritis. Autoimmun Rev 2005;4(3):130–6.
   PubMed Web of Science ®Google Scholar
• Pollard L, Choy EH, Scott DL. The consequences of rheumatoid arthritis: quality of life measures in the individual patient. Clin Exp Rheumatol 2005;23 5 Suppl 39:S43–52.
   Google Scholar
• Fautrel B, Guillemin F. Cost of illness studies in rheumatic diseases. CUff Opin Rheumatol 2002;14(2):121–6.
   PubMedGoogle Scholar
• Firestein GS. Evolving concepts of rheumatoid arthritis. Nature 2003;423(6937):356–61.
   PubMed Web of Science ®Google Scholar
• Weyand CM. New insights into the pathogenesis of rheumatoid arthritis. Rheumatology (Oxford) 2000;39 Suppl 1:3–8.
   PubMed Web of Science ®Google Scholar
• Goldring SR. Pathogenesis of bone and cartilage destruction in rheumatoid arthritis. Rheumatology (Oxford) 2003;42 Suppl 2:ii11–6.
   Google Scholar
• Kay J, Calabrese L. The role of interleukin-1 in the pathogenesis of rheumatoid arthritis. Rheumatology (Oxford) 2004;43 Suppl 3:iii2–9.
   Google Scholar
• Dayer JM. The pivotal role of interleukin-1 in the clinical manifestations of rheumatoid arthritis. Rheumatology (Oxford) 2003;42 Suppl 2:ii3–10.
   Google Scholar
• Koch AE, Kunkel SL, Strieter RM. Cytokines in rheumatoid arthritis. J Investig Med 1995;43(1):28–38.
   PubMed Web of Science ®Google Scholar
• Smolen JS, Steiner G. Therapeutic strategies for rheumatoid arthritis. Nat Rev Drug Discov 2003;2(6):473–88.
   PubMed Web of Science ®Google Scholar
• Olsen NJ, Stein CM. New drugs for rheumatoid arthritis. N Engl J Med 2004;350(21):2167–79.
   PubMed Web of Science ®Google Scholar
• Bakker AC, Joosten LA, Arntz OJ, Helsen MM, Bendele AM, van de Loo FA, et al. Prevention of murine collagen-induced arthritis in the knee and ipsilateral paw by local expression of human interleukin-1 receptor antagonist protein in the knee. Arthritis Rheum 1997;40(5):893–900.
   Google Scholar
• Ghivizzani SC, Lechman ER, Kang R, Tio C, Kolls J, Evans CH, et al. Direct adenovirus-mediated gene transfer of inter-leukin 1 and tumor necrosis factor alpha soluble receptors to rabbit knees with experimental arthritis has local and distal anti-arthritic effects. Proc Natl Acad Sci USA 1998;95(8):4613–8.
   PubMed Web of Science ®Google Scholar
• Ma Y, Thornton S, Duwel LE, Boivin GP, Giannini EH, Leiden JM, et al. Inhibition of collagen-induced arthritis in mice by viral IL-10 gene transfer. J Immunol 1998;161(3):1516–24.
   PubMedGoogle Scholar
• Kim SH, Lechman ER, Kim S, Nash J, Oligino TJ, Robbins PD. Ex vivo gene delivery of IL-1Ra and soluble TNF receptor confers a distal synergistic therapeutic effect in antigen-induced arthritis. Mol 'Ther 2002;6(5):591–600.
   PubMedGoogle Scholar
• Lechman ER, Keravala A, Nash J, Kim SH, Mi Z, Robbins PD. The contralateral effect conferred by intra-articular adenovirus-mediated gene transfer of viral IL-10 is specific to the immu-nizing antigen. Gene Ther 2003;10(24):2029–35.
   PubMed Web of Science ®Google Scholar
• Evans CH, Robbins PD, Ghivizzani SC, Wasko MC, Tomaino MM, Kang R, et al. Gene transfer to human joints: progress toward a gene therapy of arthritis. Proc Natl Acad Sci USA 2005;102(24):8698–703.
   PubMed Web of Science ®Google Scholar
• Otani K, Nita I, Macaulay W, Georgescu HI, Robbins PD, Evans CH. Suppression of antigen-induced arthritis in rabbits by ex vivo gene therapy. J Immunol 1996;156(9):3558–62.
   PubMedGoogle Scholar
• Mor A, Abramson SB, Pillinger MH. The fibroblast-like syno-vial cell in rheumatoid arthritis: a key player in inflammation and joint destruction. Clin Immunol 2005;115(2):118–28.
   Google Scholar
• Pap T, Gay RE, Muller-Ladner U, Gay S. Ex vivo gene transfer in the years to come. Arthritis Res 2002;4(1):10–2.
   Google Scholar
• Chan JM, Villarreal G, Jin WW, Stepan T, Burstein H, Wahl SM. Intraarticular gene transfer of TNFR:Fc suppresses exper-imental arthritis with reduced systemic distribution of the gene product. Mol Ther 2002;6(6):727–36.
   PubMedGoogle Scholar
• Ohashi S, Kubo T, Kishida T, Ikeda T, Takahashi K, Arai Y, et al. Successful genetic transduction in vivo into synovium by means of electroporation. Biochem Biophys Res Commun 2002;293(5):1530–5.
   PubMedGoogle Scholar
• Yovandich J, O'Malley B Jr, Sikes M, Ledley FD. Gene transfer to synovial cells by intra-articular administration of plasmid DNA. Hum Gene 'Ther 1995;6(5):603–10.
   Google Scholar
• Bloquel C, Bessis N, Boissier MC, Scherman D, Bigey P. Gene therapy of collagen-induced arthritis by electrotransfer of human tumor necrosis factor-alpha soluble receptor I variants. Hum Gene Ther 2004;15(2):189–201.
   Google Scholar
• Kim JM, Ho SH, Hahn W, Jeong JG, Park EJ, Lee HJ, et al. Electro-gene therapy of collagen-induced arthritis by using an expression plasmid for the soluble p75 tumor necrosis factor receptor-Fc fusion protein. Gene 'Ther 2003;10(15):1216–24.
   PubMedGoogle Scholar
• Kim JM, Jeong JG, Ho SH, Hahn W, Park RI, Kim S, et al. Protection against collagen-induced arthritis by intramuscular gene therapy with an expression plasmid for the interleukin-1 receptor antagonist. Gene Ther 2003;10(18):1543–50.
   PubMedGoogle Scholar
• Song XY, Gu M, Jin WW, Klinman DM, Wahl SM. Plasmid DNA encoding transforming growth factor-betal suppresses chronic disease in a streptococcal cell wall-induced arthritis model. J Clin Invest 1998;101(12):2615–21.
   Google Scholar
• Dreja H, Annenkov A, Chernajovsky Y. Soluble complement receptor 1 (CD35) delivered by retrovirally infected syngeneic cells or by naked DNA injection prevents the progression of collagen-induced arthritis. Arthritis Rheum 2000;43(8):1698–709.
   Google Scholar
• Ho SH, Hahn W, Lee HJ, Kim DS, Jeong JG, Kim S, et al. Protection against collagen-induced arthritis by electrotransfer of an expression plasmid for the interleukin-4. Biochem Biophys Res Commun 2004;321(4):759–66.
   PubMedGoogle Scholar
• Kuroda T, Maruyama H, Shimotori M, Higuchi N, Kameda S, Tahara H, et al. Effects of viral interleukin 10 introduced by in vivo electroporation on arthrogen-induced arthritis in mice. J Rheumatol 2006;33(3):455–62.
   PubMedGoogle Scholar
• Saidenberg-Kermanac'h N, Bessis N, Deleuze V, Bloquel C, Bureau M, Scherman D, et al. Efficacy of interleukin-10 gene electrotransfer into skeletal muscle in mice with collagen-induced arthritis. J Gene Med 2003;5(2):164–71.
   PubMedGoogle Scholar
• Celiker MY, Ramamurthy N, Xu JW, Wang M, Jiang Y, Greenwald R, et al. Inhibition of adjuvant-induced arthritis by systemic tissue inhibitor of metalloproteinases 4 gene delivery. Arthritis Rheum 2002;46(12):3361–8.
   PubMed Web of Science ®Google Scholar
• Imagawa T, Watanabe S, Katakura S, Boivin GP, Hirsch R. Gene transfer of a fibronectin peptide inhibits leukocyte recruitment and suppresses inflammation in mouse collagen-induced arthritis. Arthritis Rheum 2002;46(4):1102–8.
   Google Scholar
• Fellowes R, Etheridge CJ, Coade S, Cooper RG, Stewart L, Miller AD, et al. Amelioration of established collagen induced arthritis by systemic IL-10 gene delivery. Gene 'Ther 2000;7(11):967–77.
   PubMed Web of Science ®Google Scholar
• Miyata M, Sasajima T, Sato H, Saito A, Saito A, Iriswa A, et al. Suppression of collagen induced arthritis in mice utilizing plasmid DNA encoding interleukin 10. J Rheumatol 2000;27(7):1601–5.
   PubMedGoogle Scholar
• Zhang X, Yu C, Xushi,Zhang C, Tang T, Dai K. Direct chitosan-mediated gene delivery to the rabbit knee joints in vitro and in vivo. Biochem Biophys Res Commun 2006;341(1):202–8.
   PubMed Web of Science ®Google Scholar
• Adriaansen J, Vervoordeldonk MJ, Vanderbyl S, de Jong G, Tak PP. A novel approach for gene therapy: engraftment of fibro-blasts containing the artificial chromosome expression system at the site of inflammation. J Gene Med 2006;8(1):63–71.
   Google Scholar
• Barquinero J, Eixarch H, Perez-Melgosa M. Retroviral vectors: new applications for an old tool. Gene 'Ther 2004;11 Suppl 1:S3–9.
   Google Scholar
• Nita I, Ghivizzani SC, Galea-Lauri J, Bandara G, Georgescu HI, Robbins PD, et al. Direct gene delivery to synovium. An eval-uation of potential vectors in vitro and in vivo. Arthritis Rheum 1996;39(5):820–8.
   Google Scholar
• Goossens PH, Havenga MJ, Pieterman E, Lemckert AA, Breedveld FC, Bout A, et al. Infection efficiency of type 5 type 16 fiber. Arthritis Rheum 2001;44(3):570–7.
   PubMedGoogle Scholar
• Toh ML, Hong SS, van de Loo F, Franqueville L, Lindholm L,
   Google Scholar
• van de Loo FA, de Hooge AS, Smeets RL, Bakker AC, Bennink MB, Arntz OJ, et al. An inflammation-inducible adenoviral expression system for local treatment of the arthritic joint. Gene
   Google Scholar
• Anson DS. The use of retroviral vectors for gene therapy-what are the risks? A review of retroviral pathogenesis and its rele-vance to retroviral vector-mediated gene delivery. Genet
   Google Scholar
• Hacein-Bey-Abina S, Von Kalle C, Schmidt M, McCormack MP, Wulffraat N, Leboulch P, et al. LM02-associated clonal T cell proliferation in two patients after gene therapy for SCID-
   Google Scholar
• Kaiser J. Gene therapy. Panel urges limits on X-SCID trials. Science 2005;307(5715):1544–5.
   Google Scholar
• Sauter SL, Gasmi M. FIV vector systems. Somat Cell Mol Genet
   Google Scholar
• Lin YL, Noel D, Mettling C, Reant B, Clot J, Jorgensen C, et al. Feline immunodeficiency virus vectors for efficient transduction of primary human synoviocytes: application to an original
   Google Scholar
• Yin G, Liu W, An P, Li P, Ding I, Planelles V, et al. Endostatin gene transfer inhibits joint angiogenesis and pannus formation in
   Google Scholar
• Kato K, Miyake K, Igarashi T, Yoshino S, Shimada T. Human immunodeficiency virus vector-mediated intra-articular expres-
   Google Scholar
• Gouze E, Pawliuk R, Pilapil C, Gouze JN, Fleet C, Palmer GD, et al. In vivo gene delivery to synovium by lentiviral vectors.
   Google Scholar
• Lai CM, Lai YK, Rakoczy PE. Adenovirus and adeno-associ-ated virus vectors. DNA Cell Biol 2002;21(12):895–913.
   Google Scholar
• Bartlett JS, Wilcher R, Samulski RJ. Infectious entry pathway of
   Google Scholar
• Douar AM, Poulard K, Stockholm D, Danos 0. Intracellular trafficking of adeno-associated virus vectors: routing to the late
   Google Scholar
• Sanlioglu AD, Karacay B, Benson PK, Engelhardt JF, Sanlioglu S. Novel approaches to augment adeno-associated virus type-2 endocytosis and transduction. Virus Res 2004;104(1):
   Google Scholar
• Hansen J, Qing K, Srivastava A. Infection of purified nuclei by adeno-associated virus 2. Mol Ther 2001;4(4):289–96.
   Google Scholar
• Ferrari FK, Samulski T, Shenk T, Samulski RJ. Second-strand
   Google Scholar
• Fisher KJ, Gao GP, Weitzman MD, DeMatteo R, Burda JF, Wilson JM. Transduction with recombinant adeno-associated virus for gene therapy is limited by leading-strand synthesis. J Virol 1996;70(1):520�32
   Google Scholar
• Ponnazhagan S, Erikson D, Kearns WG, Thou SZ, Nahreini P, Wang XS, et al. Lack of site-specific integration of the recombinant adeno-associated virus 2 genomes in human cells. Hum Gene Ther 1997;8(3):275�84.
   Google Scholar
• Wang Z, Ma HI, Li J, Sun L, Zhang J, Xiao X. Rapid and highly efficient transduction by double-stranded adeno-associated virus vectors in vitro and in vivo. Gene Ther 2003;10(26):2105–11.
   PubMed Web of Science ®Google Scholar
• Pan RY, Chen SL, Xiao X, Liu DW, Peng HJ, Tsao YP. Therapy and prevention of arthritis by recombinant adeno-associated virus vector with delivery of interleukin-1 receptor antagonist. Arthritis Rheum 2000;43(2):289–97.
   PubMedGoogle Scholar
• Jennings K, Miyamae T, Traister R, Marinov A, Katakura S, Sowders D, et al. Proteasome inhibition enhances AAV-medi-ated transgene expression in human synoviocytes in vitro and in vivo. Mol Ther 2005;11(4):600–7.
   PubMed Web of Science ®Google Scholar
• Zhang HG, Xie J, Yang P, Wang Y, Xu L, Liu D, et al. Adeno-associated virus production of soluble tumor necrosis factor receptor neutralizes tumor necrosis factor alpha and reduces arthritis. Hum Gene Ther 2000;11(17):2431–42.
   PubMed Web of Science ®Google Scholar
• Cottard V, Mulleman D, Bouille P, Mezzina M, Boissier MC, Bessis N. Adeno-associated virus-mediated delivery of IL-4 prevents collagen-induced arthritis. Gene Ther 2000;7(22): 1930–9.
   PubMed Web of Science ®Google Scholar
• Watanabe S, Imagawa T, Boivin GP, Gao G, Wilson JM, Hirsch R. Adeno-associated virus mediates long-term gene transfer and delivery of chondroprotective IL-4 to murine synovium. Mol Ther 2000;2(2):147–52.
   PubMed Web of Science ®Google Scholar
• Apparailly F, Millet V, Noel D, Jacquet C, Sony J, Jorgensen C. Tetracycline-inducible interleukin-10 gene transfer mediated by an adeno-associated virus: application to experimental arthritis. Hum Gene Ther 2002;13(10):1179–88.
   PubMed Web of Science ®Google Scholar
• Takahashi H, Kato K, Miyake K, Hirai Y, Yoshino S, Shimada T. Adeno-associated virus vector-mediated anti-angiogenic gene therapy for collagen-induced arthritis in mice. Clin Exp Rheu-matol 2005;23(4):455–61.
   PubMedGoogle Scholar
• Conlon TJ, Flotte TR. Recombinant adeno-associated virus vectors for gene therapy. Expert Opin Biol Ther 2004;4(7): 1093–101.
   PubMed Web of Science ®Google Scholar
• Jeong JG, Kim JM, Ho SH, Hahn W, Yu SS,Kim S. Electro-transfer of human IL-1Ra into skeletal muscles reduces the incidence of murine collagen-induced arthritis. J Gene Med 2004;6(l0):1125–33.
   Google Scholar
• Makarov SS, Olsen JC, Johnston WN, Anderle SK, Brown RR, Baldwin AS Jr, et al. Suppression of experimental arthritis by gene transfer of interleukin 1 receptor antagonist cDNA. Proc Natl Acad Sci USA 1996;93(1):402–6.
   Google Scholar
• Muller-Ladner U, Roberts CR, Franklin BN, Gay RE, Robbins PD, Evans CH, et al. Human IL-1Ra gene transfer into human synovial fibroblasts is chondroprotective. J Immunol 1997;158(7): 3492–8.
   Google Scholar
• Smeets RL, van de Loo FA, Joosten LA, Arntz OJ, Bennink MB, Loesberg WA, et al. Effectiveness of the soluble form of the interleukin-1 receptor accessory protein as an inhibitor of interleukin-1 in collagen-induced arthritis. Arthritis Rheum 2003;48(10):2949–58.
   PubMedGoogle Scholar
• Mukherjee P, Wu B, Mayton L, Kim SH, Robbins PD, Wooley PH. TNF receptor gene therapy results in suppression of IgG2a anticollagen antibody in collagen induced arthritis. Ann Rheum Dis 2003;62(8):707–14.
   PubMedGoogle Scholar
• Gould DJ, Bright C, Chernajovsky Y. Inhibition of established collagen-induced arthritis with a tumour necrosis factor-alpha inhibitor expressed from a self-contained doxycycline-regulated plasmid. Arthritis Res Ther 2004;6(2):R103–13.
   Google Scholar
• Gould D, Yousaf N, Fatah R, Subang MC, Chernajovsky Y. Gene therapy with an improved doxycycline-regulated plasmid encoding a tumour necrosis factor-alpha inhibitor in experi-mental arthritis. Arthritis Res Ther 2007;9(1):R7.
   Google Scholar
• Adriaansen J, Khoury M, de Cortie CJ, Fallaux FJ, Bigey P, Scherman D, et al. Reduction of arthritis following intra-artic-ular administration of an adeno-associated virus serotype 5 expressing a disease-inducible TNF-blocking agent. Ann Rheum Dis 2007.
   Google Scholar
• Chemajovsky Y, Adams G, Podhajcer OL, Mueller GM, Rob-bins PD, Feldmann M. Inhibition of transfer of collagen-induced arthritis into SCID mice by ex vivo infection of spleen cells with retroviruses expressing soluble tumor necrosis factor receptor. Gene Ther 1995;2(10):731–5.
   Google Scholar
• Mageed RA, Adams G, Woodrow D, Podhajcer OL, Cher-najovsky Y. Prevention of collagen-induced arthritis by gene delivery of soluble p75 tumour necrosis factor receptor. Gene Ther 1998;5(12):1584–92.
   Google Scholar
• Smeets RL, van de Loo FA, Arntz OJ, Bennink MB, Joosten LA, van den Berg WB. Adenoviral delivery of IL-18-binding protein C ameliorates collagen-induced arthritis in mice. Gene Ther 2003; 10(12): 1004–11.
   PubMed Web of Science ®Google Scholar
• Harrington LE, Hatton RD, Mangan PR, Turner H, Murphy TL, Murphy KM, et al. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 2005;6(11):1123–32.
   PubMed Web of Science ®Google Scholar
• Lubberts E, Koenders MI, Oppers-Walgreen B, van den Bers-selaar L, Coenen-de Roo CJ, Joosten LA, et al. Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, carti-lage destruction, and bone erosion. Arthritis Rheum 2004;50(2):650–9.
   Google Scholar
• Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006;441(7090):235–8.
   PubMed Web of Science ®Google Scholar
• Woods JM, Katschke KJ Jr, Tokuhira M, Kurata H, Arai KI, Campbell PL, et al. Reduction of inflammatory cytokines and prostaglandin E2 by IL-13 gene therapy in rheumatoid arthritis synovium. J Immunol 2000;165(5):2755–63.
   PubMed Web of Science ®Google Scholar
• Woods JM, Amin MA, Katschke KJ Jr, Volin MV, Ruth JH, Connors MA, et al. Interleukin-13 gene therapy reduces inflammation, vascularization, and bony destruction in rat adjuvant-induced arthritis. Hum Gene Ther 2002;13(3):381–93.
   PubMedGoogle Scholar
• Nabbe KC, van Lent PL, Holthuysen AE, Sloetjes AW, Koch AE, Radstake TR, et al. Local IL-13 gene transfer prior to immune-complex arthritis inhibits chondrocyte death and matrix-metalloproteinase-mediated cartilage matrix degradation despite enhanced joint inflammation. Arthritis Res Ther 2005;7(2):R392–401.
   PubMed Web of Science ®Google Scholar
• Woods JM, Tokuhira M, Berry JC, Katschke KJ Jr, Kurata H, Damergis JA Jr, et al. Interleukin-4 adenoviral gene therapy reduces production of inflammatory cytokines and prostaglandin E2 by rheumatoid arthritis synovium ex vivo. J Investig Med 1999;47(6):285–92.
   Google Scholar
• Lubberts E, Joosten LA, van Den Bersselaar L, Helsen MM, Bakker AC, van Meurs JB, et al. Adenoviral vector-mediated overexpression of IL-4 in the knee joint of mice with collagen-induced arthritis prevents cartilage destruction. J Immunol 1999; 163(8):4546–56.
   Google Scholar
• Lubberts E, Joosten LA, Chabaud M, van Den Bersselaar L, Op-pers B, Coenen-De Roo CJ, et al. IL-4 gene therapy for collagen arthritis suppresses synovial IL-17 and osteoprotegerin ligand and prevents bone erosion. J Clin Invest 2000;105(12):1697–710.
   Google Scholar
• Kim SH, Evans CH, Kim S, Oligino T, Ghivizzani SC, Robbins PD. Gene therapy for established murine collagen-induced arthritis by local and systemic adenovirus-mediated delivery of interleukin-4. Arthritis Res 2000;2(4):293–302.
   PubMedGoogle Scholar
• Kageyama Y, Koide Y, Uchijima M, Nagata T, Yoshida A, Taiki A, et al. Plasmid encoding interleukin-4 in the ameliora-tion of murine collagen-induced arthritis. Arthritis Rheum 2004;50(3):968–75.
   PubMed Web of Science ®Google Scholar
• Boyle DL, Nguyen KH, Zhuang S, Shi Y, McCormack JE, Chada S, et al. Intra-articular IL-4 gene therapy in arthritis: anti-inflammatory effect and enhanced th2activity. Gene Ther 1999;6(12): 1911–8.
   PubMedGoogle Scholar
• Woods JM, Katschke KJ, Volin MV, Ruth JH, Woodruff DC, Amin MA, et al. IL-4 adenoviral gene therapy reduces inflam-mation, proinflammatory cytokines, vascularization, and bony destruction in rat adjuvant-induced arthritis. J Immunol 2001;166(2): 1214–22.
   PubMed Web of Science ®Google Scholar
• Haas CS, Amin MA, Allen BB, Ruth JH, Haines GK III, Woods JM, et al. Inhibition of angiogenesis by interleukin-4 gene therapy in rat adjuvant-induced arthritis. Arthritis Rheum 2006;54(8):2402–14.
   PubMedGoogle Scholar
• Bessis N, Cottard V, Saidenberg-Kermanac'h N, Lemeiter D, Fournier C, Boissier MC. Syngeneic fibroblasts transfected with a plasmid encoding interleukin-4 as non-viral vectors for anti-inflammatory gene therapy in collagen-induced arthritis. J Gene Med 2002;4(3):300–7.
   Google Scholar
• Saidenberg-Kermanac'h N, Bessis N, Lemeiter D, de Vemejoul MC, Boissier MC, Cohen-Solal M. Interleukin-4 cellular gene therapy and osteoprotegerin decrease inflammation-associated bone resorption in collagen-induced arthritis. J Clin Immunol 2004;24(4):370–8.
   PubMedGoogle Scholar
• Guery L, Chiocchia G, Batteux F, Boissier MC, Fournier C. Collagen II-pulsed antigen-presenting cells genetically modified to secrete IL-4 down-regulate collagen-induced arthritis. Gene Ther 2001;8(24):1855–62.
   Google Scholar
• Apparailly F, Verwaerde C, Jacquet C, Auriault C, Sony J, Jorgensen C. Adenovirus-mediated transfer of viral IL-10 gene inhibits murine collagen-induced arthritis. J Immunol 1998;160(11):5213–20.
   PubMedGoogle Scholar
• Whalen JD, Lechman EL, Carlos CA, Weiss K, Kovesdi I, Glorioso JC, et al. Adenoviral transfer of the viral IL-10 gene periarticularly to mouse paws suppresses development of col-lagen-induced arthritis in both injected and uninjected paws. J Immunol 1999;162(6):3625–32.
   PubMed Web of Science ®Google Scholar
• Chemajovsky Y, Adams G, Triantaphyllopoulos K, Ledda MF, Podhajcer OL. Pathogenic lymphoid cells engineered to express TGF beta 1 ameliorate disease in a collagen-induced arthritis model. Gene Ther 1997;4(6):553–9.
   Google Scholar
• Mi Z, Ghivizzani SC, Lechman E, Glorioso JC, Evans CH, Robbins PD. Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees. Arthritis Res Ther 2003;5(3):R132–9.
   PubMed Web of Science ®Google Scholar
• Quattrocchi E, Dallman MJ, Feldmann M. Adenovirus-mediated gene transfer of CTLA-41g fusion protein in the suppression of experimental autoimmune arthritis. Arthritis Rheum 2000;43(8): 1688–97.
   Google Scholar
• Ijima K, Murakami M, Okamoto H, Inobe M, Chikuma S, Saito I, et al. Successful gene therapy via intraarticular injection of adenovirus vector containing CTLA4IgG in a murine model of type II collagen-induced arthritis. Hum Gene Ther 2001;12(9): 1063–77.
   PubMedGoogle Scholar
• Yao Q, Wang S, Gambotto A, Glorioso JC, Evans CH, Robbins PD, et al. Intra-articular adenoviral-mediated gene transfer of trail induces apoptosis of arthritic rabbit synovium. Gene Ther 2003;10(12): 1055–60.
   PubMedGoogle Scholar
• Liu Z, Xu X, Hsu HC, Tousson A, Yang PA, Wu Q, et al. CH-DC-AdTRAIL cell gene therapy inhibits infiltration of CII-reactive T cells and CH-induced arthritis. J Clin Invest 2003;112(9): 1332–41.
   PubMedGoogle Scholar
• Terzioglu E, Bisgin A, Sanlioglu AD, Ulker M, Yazisiz V, Tuzuner S, et al. Concurrent gene therapy strategies effectively destroy synoviocytes of patients with rheumatoid arthritis. Rheumatology (Oxford) 2007;46(5):783–9.
   PubMedGoogle Scholar
• Zhang H, Yang Y, Horton JL, Samoilova EB, Judge TA, Turka LA, etal. Amelioration of collagen-induced arthritis by CD95 (Apo-1/ Fas)-ligand gene transfer. J Clin Invest 1997;100(8):1951–7.
   Google Scholar
• Okamoto K, Asahara H, Kobayashi T, Matsuno H, Hasunuma T, Kobata T, et al. Induction of apoptosis in the rheumatoid syn-ovium by Fas ligand gene transfer. Gene Ther 1998;5(3):331–8.
   PubMedGoogle Scholar
• Zhang H, Gao G, Clayburne G, Schumacher HR. Elimination of rheumatoid synovium in situ using a Fas ligand 'gene scalpel'. Arthritis Res Ther 2005;7(6):R1235–43.
   PubMed Web of Science ®Google Scholar
• Kim SH, Kim S, Oligino TJ, Robbins PD. Effective treatment of established mouse collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express FasL. Mol Ther 2002;6(5):584–90.
   PubMedGoogle Scholar
• Kobayashi T, Okamoto K, Kobata T, Hasunuma T, Kato T, Ha-mada H, et al. Novel gene therapy for rheumatoid arthritis by FADD gene transfer: induction of apoptosis of rheumatoid synoviocytes but not chondrocytes. Gene Ther 2000;7(6):527–33.
   Google Scholar
• Colville-Nash PR, Scott DL. Angiogenesis and rheumatoid arthritis: pathogenic and therapeutic implications. Ann Rheum Dis 1992;51(7):919–25.
   Google Scholar
• Kimball ES, Gross JL. Angiogenesis in pannus formation. Agents Actions 1991;34(3-4):329–31.
   PubMedGoogle Scholar
• Gerlag DM, Borges E, Tak PP, Ellerby HM, Bredesen DE, Pasqualini R, et al. Suppression of murine collagen-induced arthritis by targeted apoptosis of synovial neovasculature. Arthritis Res 2001;3(6):357–61.
   PubMedGoogle Scholar
• Kim JM, Ho SH, Park RI, Hahn W, Cho H, Jeong JG, et al. Angiostatin gene transfer as an effective treatment strategy in murine collagen-induced arthritis. Arthritis Rheum 2002;46(3):793–801.
   PubMed Web of Science ®Google Scholar
• Chen Y, Donnelly E, Kobayashi H, Debusk LM, Lin PC. Gene therapy targeting the Tie2 function ameliorates collagen-induced arthritis and protects against bone destruction. Arthritis Rheum 2005;52(5):1585–94.
   Google Scholar
• Afuwape AO, Feldmann M, Paleolog EM. Adenoviral delivery of soluble VEGF receptor 1 (sFlt-1) abrogates disease activity in murine collagen-induced arthritis. Gene Ther 2003;10(23): 1950–60.
   Google Scholar
• Jou IM, Shiau AL, Chen SY, Wang CR, Shieh DB, Tsai CS, et al. Thrombospondin 1 as an effective gene therapeutic strat-egy in collagen-induced arthritis. Arthritis Rheum 2005;52(1): 339–44.
   PubMedGoogle Scholar
• Park YW, Kong YM, Butterfield J, Detmar M, Goronzy JJ, Weyand CM. Thrombospondin 2 functions as an endogenous regulator of angiogenesis and inflammation in rheumatoid arthritis. Am J Pathol 2004;165(6):2087–98.
   PubMedGoogle Scholar
• Apparailly F, Bouquet C, Millet V, Noel D, Jacquet C, Opolon P, et al. Adenovirus-mediated gene transfer of urokinase plas-minogen inhibitor inhibits angiogenesis in experimental arthritis. Gene Ther 2002;9(3):192–200.
   PubMedGoogle Scholar
• Rutkauskaite E, Vollmer D, Shigeyama Y, Schedel J, Pap G, Muller-Ladner U, et al. Retroviral gene transfer of an antisense construct against membrane type 1 matrix metalloproteinase reduces the invasiveness of rheumatoid arthritis synovial fibro-blasts. Arthritis Rheum 2005;52(7):2010–4.
   Google Scholar
• Rutkauskaite E, Zacharias W, Schedel J, Muller-Ladner U, Mawrin C, Seemayer CA, et al. Ribozymes that inhibit the production of matrix metalloproteinase 1 reduce the invasive-ness of rheumatoid arthritis synovial fibroblasts. Arthritis Rheum 2004;50(5):1448–56.
   Google Scholar
• van der Laan WH, Quax PH, Seemayer CA, Huisman LG, Pieterman EJ, Grimbergen JM, et al. Cartilage degradation and invasion by rheumatoid synovial fibroblasts is inhibited by gene transfer of TIMP-1 and TIMP-3. Gene Ther 2003;10(3):234–42.
   PubMedGoogle Scholar
• Tomita T, Takeuchi E, Tomita N, Morishita R, Kaneko M, Yamamoto K, et al. Suppressed severity of collagen-induced arthritis by in vivo transfection of nuclear factor kappaB decoy oligodeoxynucleotides as a gene therapy. Arthritis Rheum 1999;42(12) : 2532–42.
   PubMed Web of Science ®Google Scholar
• Zhang HG, Huang N, Liu D, Bilbao L, Zhang X, Yang P, et al. Gene therapy that inhibits nuclear translocation of nuclear factor kappaB results in tumor necrosis factor alpha-induced apoptosis of human synovial fibroblasts. Arthritis Rheum 2000;43(5): 1094–105.
   PubMedGoogle Scholar
• Tas SW, Adriaansen J, Hajji N, Bakker AC, Firestein GS, Vervoordeldonk MJ, et al. Amelioration of arthritis by intraar-ticular dominant negative Eck beta gene therapy using adeno-associated virus type 5. Hum Gene Ther 2006;17(8):821–32.
   PubMedGoogle Scholar
• Shouda T, Yoshida T, Hanada T, Wakioka T, Oishi M, Miyoshi K, et al. Induction of the cytokine signal regulator 50053/CI53 as a therapeutic strategy for treating inflammatory arthritis. J Clin Invest 2001;108(12):1781–8.
   PubMed Web of Science ®Google Scholar
• Takayanagi H, Juji T, Miyazaki T, Iizuka H, Takahashi T, Is-shiki M, et al. Suppression of arthritic bone destruction by adenovirus-mediated csk gene transfer to synoviocytes and osteoclasts. J Clin Invest 1999;104(2):137–46.
   Google Scholar
• Yamamoto A, Fukuda A, Seto H, Miyazaki T, Kadono Y, Sawada Y, et al. Suppression of arthritic bone destruction by adenovirus-mediated dominant-negative Ras gene transfer to synoviocytes and osteoclasts. Arthritis Rheum 2003;48(9): 2682–92.
   PubMedGoogle Scholar
• Rabinovich GA, Daly G, Dreja H, Tailor H, Riera CM, Hira-bayashi J, et al. Recombinant galectin-1 and its genetic delivery suppress collagen-induced arthritis via T cell apoptosis. J Exp Med 1999;190(3):385–98.
   Google Scholar
• Schedel J, Seemayer CA, Pap T, Neidhart M, Kuchen S, Michel BA, et al. Targeting cathepsin L (CL) by specific ribozymes decreases CL protein synthesis and cartilage destruction in rheumatoid arthritis. Gene Ther 2004;11(13):1040–7.
   PubMedGoogle Scholar
• Nonomura Y, Kohsaka H, Nasu K, Terada Y, Ikeda M, Miya-saka N. Suppression of arthritis by forced expression of cyclin-dependent kinase inhibitor p21(Cip 1) gene into the joints. Int Immunol 2001;13(6):723–31.
   Google Scholar
• Taniguchi K, Kohsaka H, Inoue N, Terada Y, Ito H, Hirokawa K, et al. Induction of the p 16INK4a senescence gene as a new therapeutic strategy for the treatment of rheumatoid arthritis. Nat Med 1999;5(7):760–7.
   PubMedGoogle Scholar
• Triantaphyllopoulos KA, Williams RO, Tailor H, Chernajovsky Y. Amelioration of collagen-induced arthritis and suppression of interferon-gamma, interleukin-12, and tumor necrosis factor alpha production by interferon-beta gene therapy. Arthritis Rheum 1999;42(1):90–9.
   PubMedGoogle Scholar
• Dai L, Claxson A, Marklund SL, Feakins R, Yousaf N, Cher-najovsky Y, et al. Amelioration of antigen-induced arthritis in rats by transfer of extracellular superoxide dismutase and cata-lase genes. Gene Ther 2003;10(7):550–8.
   Google Scholar
• Iyama S, Okamoto T, Sato T, Yamauchi N, Sato Y, Sasaki K, et al. Treatment of murine collagen-induced arthritis by ex vivo extracellular superoxide dismutase gene transfer. Arthritis Rheum 2001 ;44(9):2160–7.
   PubMedGoogle Scholar
• Adriaansen J, Fallaux FJ, de Cortie CJ, Vervoordeldonk MJ, Tak PP. Local delivery of beta interferon using an adeno-associated virus type 5 effectively inhibits adjuvant arthritis in rats. J Gen Virol 2007;88\(Pt 6):1717–21.
   Google Scholar
• Shiau AL, Chen SY, Chang MY, Su CH, Chung SY, Yo YT, et al. Prothymosin alpha lacking the nuclear localization signal as an effective gene therapeutic strategy in collagen-induced arthritis. J Immunol 2007;178(7):4688–94.
   PubMedGoogle Scholar
• Raper SE, Chirmule N, Lee FS, Wive! NA, Bagg A, Gao GP, et al. Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenovi-ral gene transfer. Mol Genet Metab 2003;80(1-2):148–58.
   Google Scholar