24
Views
37
CrossRef citations to date
0
Altmetric
ORIGINAL ARTICLE

Effects of low-dosage simvastatin on rheumatoid arthritis through reduction of Th1/Th2 and CD4/CD8 ratios

, , , , , , , , & show all
Pages 364-368 | Received 09 Jan 2007, Accepted 07 May 2007, Published online: 02 Jan 2014

References

  • Kobashigawa JA, Katznelson S, Laks H, Johnson JA, Yeatman L, Wang KM, et al. Effect of pravastatin on outcomes after cardiac transplantation. N Eng J Med 1995;333:621–7.
  • Shovman 0, Levy Y, Gilburd B, Shoenfeld Y Anti-inflammatory and immunomodulatory properties of statins. Immunol Res 2002; 25/3:271–85.
  • Weitz-Schmidt G, Welzenbach K, Brinkmann V, Kamata T, Kanen J, Brims C, et al. Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site. Nat Med 2001;7: 687–92.
  • Kwak B, Mulhaupt F, Myit S, Mach F. Statins as newly recognized type of immunomodulator. Nat Med 2000;6:1399–402.
  • Kanda H, Hamasaki K, Kubo K, Tateishi S, Yonezumi A, Kanda Y, et al. Antiinflammatory effect of simvastatin in patients with rheu-matoid arthritis. J Ftheumatol 2002;19:2024–6.
  • Pincus T, Summey JA, Soraci SA Jr, Wallston KA, Hummon NP. Assessment of patient satisfaction in activities of daily living using a modified Stanford health assessment questionnaire. Arthritis Rheum 1983;26:1346–53.
  • Felson DT, Anderson JJ, Boers M, Bombardier C, Furst D, Goldsmith C, et al. American College of Ftheumatology: prelimi-nary definition of improvement in rheumatoid arthritis. Arthritis Rheum 1995;38:727–35.
  • Abud-Mendoza C, de la Fuente H, Cuevas-Orta E, Baranda L, Cruz-Ftizo J, González-Amaro R. Therapy with statins in patients with refractory rheumatic diseases: a preliminary study. Lupus 2003;12:607–11.
  • McCarey DW, McInnes IB, Madhok R, Hampson R, Scherbakova 0, Ford I, et al. Trial of atorvastatin in rheumatoid arthritis (TAFtA): double-blind, randomized placebo-controlled trial. Lancet 2004;363: 2015–21.
  • Hochberg MC, Tracy JK, Hawkins-Holt M, Flores RH. Compari-son of the efficacy of the tumor necrosis factor a blocking agents adalimumab, etanercept, and infliximab when added to methotrex-ate in patients with active rheumatoid arthritis. Ann Rheum Dis 2003;62 Suppl II:ii13–6.
  • Youssef S, Stuve 0, Patarrayo JC, Ruiz PJ, Radosevich JL, Hur EM, et al. The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverse paralysis in central nervous system autoimmune disease. Nature 2002;420: 78–84.
  • Leung BP, Sattar N, Crilly A, Prach M, McCarey DW, Payne H, et al. A novel anti-inflammatory role for simvastatin in inflamma-tory arthritis. J Immunol 2003;170:1524–30.
  • Mckay A, Leung BP, McInnes IB, Thomson NC, Liew FY. A novel anti-inflammatory role of simvastatin in a murine model of allergic asthma. J Immunol 2004;172:2903–8.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.