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Modern Rheumatology Volume 18, 2008 - Issue 5
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Review Article

Proposals for leflunomide use to avoid lung injury in patients with rheumatoid arthritis

Shigeko InokumaStudy Committee for Leflunomide-Induced Lung Injury, Japan College of Rheumatology, 1-1-24 Toranomon, Minato-ku, Tokyo 105-0011, Japan;Department of Allergy and Immunological Diseases, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan
,
Takeo SatoStudy Committee for Leflunomide-Induced Lung Injury, Japan College of Rheumatology, 1-1-24 Toranomon, Minato-ku, Tokyo 105-0011, Japan;Department of Allergy and Rheumatology, Japanese Red Cross Medical Center, 4-1-22 Hiroo, Shibuya-ku, Tokyo 150-8935, JapanCorrespondence[email protected]
,
Akira SagawaStudy Committee for Leflunomide-Induced Lung Injury, Japan College of Rheumatology, 1-1-24 Toranomon, Minato-ku, Tokyo 105-0011, Japan;Sagawa Akira Rheumatology Clinic, Sapporo, Japan
,
Takemasa MatsudaStudy Committee for Leflunomide-Induced Lung Injury, Japan College of Rheumatology, 1-1-24 Toranomon, Minato-ku, Tokyo 105-0011, Japan;The Center for Rheumatic Diseases, Kagoshima Red Cross Hospital, Kagoshima, Japan
,
Tamiko TakemuraStudy Committee for Leflunomide-Induced Lung Injury, Japan College of Rheumatology, 1-1-24 Toranomon, Minato-ku, Tokyo 105-0011, Japan;Department of Pathology, Japanese Red Cross Medical Center, Tokyo, Japan
,
Takeshi OhtsukaStudy Committee for Leflunomide-Induced Lung Injury, Japan College of Rheumatology, 1-1-24 Toranomon, Minato-ku, Tokyo 105-0011, Japan;Department of Internal Medicine, Munakata Medical Association Hospital, Fukuoka, Japan
,
Yukihiko SaekiStudy Committee for Leflunomide-Induced Lung Injury, Japan College of Rheumatology, 1-1-24 Toranomon, Minato-ku, Tokyo 105-0011, Japan;Division of Allergy and Clinical Immunology, National Hospital Organization, Osaka-Minami Medical Center, Osaka, Japan
,
Tsutomu TakeuchiStudy Committee for Leflunomide-Induced Lung Injury, Japan College of Rheumatology, 1-1-24 Toranomon, Minato-ku, Tokyo 105-0011, Japan;Division of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Saitama, Japan
&
Tetsuji SawadaStudy Committee for Leflunomide-Induced Lung Injury, Japan College of Rheumatology, 1-1-24 Toranomon, Minato-ku, Tokyo 105-0011, Japan;Department of Allergy and Rheumatology, University of Tokyo School of Medicine, Tokyo, Japan
 show all
Pages 442-446 | Received 07 Dec 2007, Accepted 11 Mar 2008, Published online: 02 Jan 2014

References

  • McCurry J. Japan deaths spark concerns over arthritis drug. Lancet. 2004;363:461.
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  • Sato T, Inokuma S, Sagawa A, Matsuda T, Ohtsuka T, Saeki Y, et al. Analysis of rheumatoid arthritis patients of died of and recovered from leflunomide-induced interstitial pneumonia. Mod Rheumatol. 2007;17(Suppl):100.
  • Hirabayashi Y, Shimizu H, Kobayashi N, Kudo K. Leflunomide-induced pneumonitis in a patient with rheumatoid arthritis. Intern Med. 2006;45:689–91.
  • Study Group of the Ministry of Health, Labour and Welfare. Therapeutic manual of rheumatoid arthritis (revised). Diagnostic manual and evidence-based treatment guidelines. Jpn Rheum Found; 2004.
  • Inokuma S, Kono H, Kohno Y, Hiramatsu K, Ito K, Shiratori K, et al. Methotrexate-induced lung injury in patients with rheu-matoid arthritis occurs with peripheral blood lymphocyte count decrease. Ann Rheum Dis. 2006;65:1113–4.

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