A1330V polymorphism of low-density lipoprotein receptor-related protein 5 gene and self-reported incident fractures in Japanese female patients with rheumatoid arthritis

References

• Haugeberg G, Uhlig T, Falch JA, Halse JI, Kvien TK. Bone mineral density and frequency of osteoporosis in female patients with rheumatoid arthritis: results from 394 patients in the Oslo County Rheumatoid Arthritis register. Arthritis Rheum. 2000;43: 522–30.
   Google Scholar
• Orstavik RE, Haugeberg G, Mowinckel P, Hoiseth A, Uhlig T, Falch JA, et al. Vertebral deformities in rheumatoid arthritis: a comparison with population-based controls. Arch Intern Med. 2004;164:420–5.
   PubMedGoogle Scholar
• Huusko TM, Korpela M, Karppi P, Avikainen V, Kautiainen H, Sulkava R. Threefold increased risk of hip fractures with rheu-matoid arthritis in central Finland. Ann Rheum Dis. 2001;60:521–2.
   PubMed Web of Science ®Google Scholar
• Arai K, Hanyu T, Sugitani H, Murai T, Fujisawa J, Nakazono K, et al. Risk factors for vertebral fracture in menopausal or postmenopausal Japanese women with rheumatoid arthritis: a cross-sectional and longitudinal study. J Bone Miner Metab. 2006;24:118–24.
   PubMed Web of Science ®Google Scholar
• Furuya T, Kotake S, Inoue E, Nanke Y, Yago T, Hara M, et al. Risk factors associated with incident fractures in Japanese men with rheumatoid arthritis: a prospective observational cohort study. J Bone Miner Metab. 2008;26:499–505.
   PubMed Web of Science ®Google Scholar
• Furuya T, Kotake S, Inoue E, Nanke Y, Yago T, Kobashigawa T, et al. Risk factors associated with incident clinical vertebral and nonvertebral fractures in Japanese women with rheumatoid arthritis: a prospective 54-month observational study. J Rheu-matol. 2007;34:303–10.
   PubMed Web of Science ®Google Scholar
• Hooyman JR, Melton LJ 3rd, Nelson AM, O'Fallon WM, Riggs BL. Fractures after rheumatoid arthritis. A population-based study. Arthritis Rheum. 1984;27:1353–61.
   PubMed Web of Science ®Google Scholar
• Nampei A, Hashimoto J, Koyanagi J, Ono T, Hashimoto H, Tsumaki N, et al. Characteristics of fracture and related factors in patients with rheumatoid arthritis. Mod Rheumatol. 2008;18:170–6.
   PubMed Web of Science ®Google Scholar
• van Staa TP, Geusens P, Bijlsma JW, Leufkens HG, Cooper C. Clinical assessment of the long-term risk of fracture in patients with rheumatoid arthritis. Arthritis Rheum. 2006;54:3104–12.
   Google Scholar
• Gough A, Sambrook P, Devlin J, Lilley J, Huisoon A, Betteridge J, et al. Effect of vitamin D receptor gene alleles on bone loss in early rheumatoid arthritis. J Rheumatol. 1998;25:864–8.
   PubMedGoogle Scholar
• Ho YV, Briganti EM, Duan Y, Buchanan R, Hall S, Seeman E. Polymorphism of the vitamin D receptor gene and corticosteroid-related osteoporosis. Osteoporos Int. 1999;9:134–8.
   PubMed Web of Science ®Google Scholar
• Adachi JD, Saag KG, Delmas PD, Liberman UA, Emkey RD, Seeman E, et al. Two-year effects of alendronate on bone mineral density and vertebral fracture in patients receiving glucocorti-coids: a randomized, double-blind, placebo-controlled extension trial. Arthritis Rheum. 2001;44:202–11.
   PubMed Web of Science ®Google Scholar
• Katayama K, Matsuno T. Effects of bisphosphonates on fracture incidence and bone metabolism in rheumatoid arthritis patients in general practice taking long-term corticosteroid therapy: a ret-rospective study. Clin Drug Investig. 2008;28:149–58.
   PubMed Web of Science ®Google Scholar
• Lange U, Illgner U, Teichmann J, Schleenbecker H. Skeletal benefit after one year of risedronate therapy in patients with rheumatoid arthritis and glucocorticoid-induced osteoporosis: a prospective study. Int J Clin Pharmacol Res. 2004;24:33–8.
   PubMedGoogle Scholar
• Buckley LM, Leib ES, Cartularo KS, Vacek PM, Cooper SM. Calcium and vitamin D3 supplementation prevents bone loss in the spine secondary to low-dose corticosteroids in patients with rheumatoid arthritis. A randomized, double-blind, placebo-con-trolled trial. Ann Intern Med. 1996;125: 961–8.
   Google Scholar
• Hey PJ, Twells RC, Phillips MS, Yusuke N, Brown SD, Kaw-aguchi Y, et al. Cloning of a novel member of the low-density lipoprotein receptor family. Gene. 1998;216:103–11.
   Google Scholar
• Koay MA, Brown MA. Genetic disorders of the LRP5-Wnt sig-nalling pathway affecting the skeleton. Trends Mol Med. 2005;11:129–37.
   PubMed Web of Science ®Google Scholar
• Okubo M, Horinishi A, Kim DH, Yamamoto TT, Murase T. Seven novel sequence variants in the human low-density lipo-protein receptor related protein 5 (LRP5) gene. Hum Mutat. 2002;19: 186.
   Google Scholar
• Ezura Y, Nakajima T, Urano T, Sudo Y, Kajita M, Yoshida H, et al. Association of a single-nucleotide variation (A1330V) in the low-density lipoprotein receptor-related protein 5 gene (LRP5) with bone mineral density in adult Japanese women. Bone. 2007;40:997–1005.
   PubMed Web of Science ®Google Scholar
• Mizuguchi T, Furuta I, Watanabe Y, Tsukamoto K, Tomita H, Tsujihata M, et al. LRP5, low-density-lipoprotein-receptor-rela-ted protein 5, is a determinant for bone mineral density. J Hum Genet. 2004;49:80–6.
   PubMed Web of Science ®Google Scholar
• Urano T, Shiraki M, Ezura Y, Fujita M, Sekine E, Hoshino S, et al. Association of a single-nucleotide polymorphism in low-density lipoprotein receptor-related protein 5 gene with bone mineral density. J Bone Miner Metab. 2004;22:341–5.
   PubMed Web of Science ®Google Scholar
• Ferrari SL, Deutsch S, Baudoin C, Cohen-Solal M, Ostertag A, Antonarakis SE, et al. LRP5 gene polymorphisms and idiopathic osteoporosis in men. Bone. 2005;37: 770–5.
   Google Scholar
• Kiel DP, Ferrari SL, Cupples LA, Karasik D, Manen D, Imamovic A, et al. Genetic variation at the low-density lipopro-tein receptor-related protein 5 (LRP5) locus modulates Wnt signaling and the relationship of physical activity with bone mineral density in men. Bone. 2007;40:587–96.
   PubMed Web of Science ®Google Scholar
• Saarinen A, Valimaki VV, Valimaki MJ, Loyttyniemi E, Auro K, Uusen P, et al. The A1330V polymorphism of the low-density lipoprotein receptor-related protein 5 gene (LRP5) associates with low peak bone mass in young healthy men. Bone. 2007;40:1006–12.
   PubMed Web of Science ®Google Scholar
• van Meurs JB, Rivadeneira F, Jhamai M, Hugens W, Hofman A, van Leeuwen JP, et al. Common genetic variation of the low-density lipoprotein receptor-related protein 5 and 6 genes deter-mines fracture risk in elderly white men. J Bone Miner Res. 2006;21: 141–50.
   Google Scholar
• van Meurs JB, Trikalinos TA, Ralston SH, Balcells S, Brandi ML, Brixen K, et al. Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis. Jama. 2008;299: 1277–90.
   PubMed Web of Science ®Google Scholar
• Fujino T, Asaba H, Kang MJ, Ikeda Y, Sone H, Takada S, et al. Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion. Proc Natl Acad Sci USA. 2003;100:229–34.
   PubMed Web of Science ®Google Scholar
• Magoori K, Kang MJ, Ito MR, Kakuuchi H, Ioka RX, Kamataki A, et al. Severe hypercholesterolemia, impaired fat tolerance, and advanced atherosclerosis in mice lacking both low-density lipo-protein receptor-related protein 5 and apolipoprotein E. J Biol Chem. 2003;278:11331–6.
   PubMed Web of Science ®Google Scholar
• Suwazono Y, Kobayashi E, Dochi M, Miura K, Morikawa Y, Ishizaki M, et al. Combination of the C1429T polymorphism in the G-protein beta-3 subunit gene and the A1330V polymor-phism in the low-density lipoprotein receptor-related protein 5 gene is a risk factor for hypercholesterolaemia. Clin Exp Med. 2007;7:108–14.
   PubMed Web of Science ®Google Scholar
• Suwazono Y, Kobayashi E, Uetani M, Miura K, Morikawa Y, Ishizaki M, et al. G-protein beta 3 subunit polymorphism C1429T and low-density lipoprotein receptor-related protein 5 polymor-phism A1330V are risk factors for hypercholesterolemia in Japanese males-a prospective study over 5 years. Metabolism. 2006;55:751–7.
   PubMed Web of Science ®Google Scholar
• Yamanaka H. Tohma S: potential impact of observational cohort studies in Japan on rheumatoid arthritis research and practice. Mod Rheumatol. 2006;16:75–6.
   PubMedGoogle Scholar
• Matsuda Y, Singh G, Yamanaka H, Tanaka E, Urano W, Tan-iguchi A, et al. Validation of a Japanese version of the Stanford Health Assessment Questionnaire in 3,763 patients with rheu-matoid arthritis. Arthritis Rheum. 2003;49: 784–8.
   Google Scholar
• Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988;31:315–24.
   PubMed Web of Science ®Google Scholar
• Prevoo ML, van 't Hof MA, Kuper HH, van Leeuwen MA, van de Putte LB, van Riel PL. Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum. 1995;38:44–8.
   Google Scholar
• Hata Y, Mabuchi H, Saito Y, Itakura H, Egusa G, Ito H, et al. Report of the Japan Atherosclerosis Society (JAS) Guideline for Diagnosis and Treatment of Hyperlipidemia in Japanese adults. J Atheroscler Thromb. 2002;9:1–27.
   PubMedGoogle Scholar
• Suwazono Y, Kobayashi E, Uetani M, Miura K, Morikawa Y, Ishizaki M, et al. G-protein beta3 subunit gene variant (C825T) is unlikely to have a significant influence on serum total cholesterol level in Japanese workers. Clin Exp Hypertens. 2006;28:47–56.
   PubMed Web of Science ®Google Scholar
• Chen Z, Maricic M, Bassford TL, Pettinger M, Ritenbaugh C, Lopez AM, et al. Fracture risk among breast cancer survivors: results from the Women's Health Initiative Observational Study. Arch Intern Med. 2005;165:552–8.
   PubMed Web of Science ®Google Scholar
• Kanis JA, Borgstrom F, De Laet C, Johansson H, Johnell 0, Jonsson B, et al. Assessment of fracture risk. Osteoporos Int. 2005;16:581–9.
   PubMed Web of Science ®Google Scholar
• Melton LJ 3rd, Atkinson EJ, O'Fallon WM, Wahner HW, Riggs BL. Long-term fracture prediction by bone mineral assessed at different skeletal sites. J Bone Miner Res. 1993;8:1227–33.
   PubMed Web of Science ®Google Scholar
• Boers M, Nurmohamed MT, Doelman CJ, Lard LR, Verhoeven AC, Voskuyl AE, et al. Influence of glucocorticoids and disease activity on total and high-density lipoprotein cholesterol in patients with rheumatoid arthritis. Ann Rheum Dis. 2003;62:842–5.
   PubMed Web of Science ®Google Scholar
• Okamoto H, Koizumi K, Kamitsuji S, Inoue E, Hara M, Tomatsu T, et al. Beneficial action of statins in patients with rheumatoid arthritis in a large observational cohort. J Rheumatol. 2007;34:964–8.
   PubMed Web of Science ®Google Scholar
• Mormando RM. Lipid levels. Applying the second National Cholesterol Education Program report to geriatric medicine. Geriatrics. 2000;55:48-53. quiz 54.
   Google Scholar
• McNamara DJ, Howell WH. Epidemiologic data linking diet to hyperlipidemia and arteriosclerosis. Semin Liver Dis. 1992;12:347–55.
   PubMed Web of Science ®Google Scholar
• Chen Z, Kooperberg C, Pettinger MB, Bassford T, Cauley JA, LaCroix AZ, et al. Validity of self-report for fractures among a multiethnic cohort of postmenopausal women: results from the Women's Health Initiative observational study and clinical trials. Menopause. 2004;11:264–74.
   PubMed Web of Science ®Google Scholar
• Ismail AA, O'Neill 'TW, Cockerill W, Finn JD, Cannata JB, Hoszowski K, et al. Validity of self-report of fractures: results from a prospective study in men and women across Europe. EPOS Study Group. European Prospective Osteoporosis Study Group. Osteoporos Int. 2000;11:248–54.
   Google Scholar
• Michel BA, Bloch DA, Wolfe F, Fries JF. Fractures in rheuma-toid arthritis: an evaluation of associated risk factors. J Rheumatol. 1993;20:1666–9.
   PubMed Web of Science ®Google Scholar
• Orstavik RE, Haugeberg G, Uhlig T, Mowinckel P, Falch JA, Halse JI, et al. Self-reported non-vertebral fractures in rheumatoid arthritis and population based controls: incidence and relationship with bone mineral density and clinical variables. Ann Rheum Dis. 2004;63:177–82.
   PubMed Web of Science ®Google Scholar
• Sins ES, Chen YT, Abbott TA, Barrett-Connor E, Miller PD, Wehren LE, et al. Bone mineral density thresholds for pharma-cological intervention to prevent fractures. Arch Intern Med. 2004;164:1108–12.
   Google Scholar
• Kiel D. Assessing vertebral fractures. National Osteoporosis Foundation Working Group on Vertebral Fractures. J Bone Miner Res. 1995;10:518–23.
   PubMed Web of Science ®Google Scholar
• Angeli A, Guglielmi G, Dovio A, Capelli G, de Feo D, Giannini S, et al. High prevalence of asymptomatic vertebral fractures in post-menopausal women receiving chronic glucocorticoid ther-apy: a cross-sectional outpatient study. Bone. 2006;39:253–9.
   PubMed Web of Science ®Google Scholar