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Modern Rheumatology Volume 20, 2010 - Issue 2
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Original Article

Minimal influence of tocilizumab on IFN-γ synthesis by tuberculosis antigens

Atsushi OgataDepartment of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, JapanCorrespondence[email protected]
,
Masahide MoriDepartment of Respiratory Medicine, National Hospital Organization Toneyama National Hospital, Osaka, Japan
,
Shoji HashimotoDivision of Infection Control and Prevention, Osaka University Hospital, Osaka, Japan
,
Yukihiro YanoDepartment of Respiratory Medicine, National Hospital Organization Toneyama National Hospital, Osaka, Japan
,
Takeya FujikawaDepartment of Respiratory Medicine, National Hospital Organization Toneyama National Hospital, Osaka, Japan
,
Mari KawaiDepartment of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan
,
Yusuke KuwaharaDepartment of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan
,
Toru HiranoDepartment of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan
,
Junsuke ArimitsuDepartment of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan
,
Keisuke HagiharaDepartment of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan
,
Yoshihito ShimaDepartment of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan
,
Masashi NarazakiDepartment of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan
,
Souichirou YokotaDepartment of Respiratory Medicine, National Hospital Organization Toneyama National Hospital, Osaka, Japan
,
Tadamitsu KishimotoLaboratory of Immune Regulation, Osaka University Graduate School of Frontier Biosciences, Osaka, Japan
,
Ichiro KawaseDepartment of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan
&
Toshio TanakaDepartment of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan
 show all
Pages 130-133 | Received 01 Sep 2009, Accepted 01 Oct 2009, Published online: 02 Jan 2014

References

  • Gardam MA, Keystone EC, Menzies R, Manners S, Skamene E, Long R, et al. Anti-tumour necrosis factor agents and tuberculosis risk: mechanisms of action and clinical management. Lancet Infect Dis. 2003;3:148–55.
  • Jacobs M, Togbe D, Fremond C, Samarina A, Allie N, Botha T, et al. Tumor necrosis factor is critical to control tuberculosis infection. Microbes Infect. 2007;9:623–8.
  • Lalvani A. Diagnostic tuberculosis infection in the 21st century. Chest. 2007;131:1898–906.
  • Hamdi H, Mariette X, Godot V, Weldingh K, Hamid AM, Prejean MV, Baron G, Lemann M, Puechal X, Breban M, Berenbaum F, Delchier JC, Flipo RM, Dautzenberg B, Salmon D, Humbert M, Emilie D; RATIO (Recherche sur Anti-TNF et Infections Opportunistes) Study Group. Inhibition of anti-tuber-culosis T-lymphocyte function with tumour necrosis factor antagonists. Arthritis Res Ther. 2006;8:R114.
  • Saliu OY, Sofer C, Stein DS, Schwander SK, Wallis RS. Tumor-necrosis-factor blockers: differential effects on mycobacterial immunity. J Infect Dis. 2006;194:486–92.
  • Nishimoto N, Hashimoto J, Miyasaka N, Yamamoto K, Kawai S, Takeuchi T, et al. Study of active controlled monotherapy used for rheumatoid arthritis, an IL-6 inhibitor (SAMURAI): evidence of clinical and radiographic benefit from an x ray reader-blinded randomised controlled trial of tocilizumab. Ann Rheum Dis. 2007;66:1162–7.
  • Smolen JS, Beaulieu A, Rubbert-Roth A, Ramos-Remus C, Rovensky J, Alecock E, et al. Alten R; OPTION Investigators. Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study). A double-blind, placebo-controlled, randomised trial. Lancet. 2008;371: 987–97.
  • Furst DE, Wallis R, Broder M, Beenhouwer DO. Tumor necrosis factor antagonists: different kinetics and/or mechanisms of action may explain differences in the risk for developing granulomatous infection. Semin Arthritis Rheum. 2006;36:159–67.
  • Diehl S, Rincón M. The two faces of IL-6 on Th 1/Th2 differ-entiation. Mol Immunol. 2002;39:531–6.
  • Salvana EM, Cooper GS, Salata RA. Mycobacterium other than tuberculosis (MOTT) infection: An emerging disease in inflix-imab-treated patients. J Infect. 2007;55:484–7.
  • Korn T, Oukka M, Kuchroo V, Bettelli E. Th17 cells: effector T cells with inflammatory properties. Semin Immunol. 2007;19:362–71.

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