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Original Article

A meta-analysis of the association of STAT4 polymorphism with systemic lupus erythematosus

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Pages 257-262 | Received 17 Nov 2009, Accepted 15 Jan 2010, Published online: 02 Jan 2014

References

  • Moser KL, Kelly JA, Lessard CJ, Harley JB. Recent insights into the genetic basis of systemic lupus erythematosus. Genes Immun. 2009;10:373–9.
  • Graham RR, Hom G, Ortmann W, Behrens TW. Review of recent genome-wide association scans in lupus. J Intern Med. 2009; 265:680–8.
  • Remmers EF, Plenge RM, Lee AT, Graham RR, Hom G, Behrens TW, et al. STAT4 and the risk of rheumatoid arthritis and sys-temic lupus erythematosus. N Engl J Med. 2007;357:977–86.
  • Watford WT, Hissong BD, Bream JH, Kanno Y, Muul L, O'Shea JJ. Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4. Immunol Rev. 2004;202: 139–56.
  • Thierfelder WE, van Deursen JM, Yamamoto K, Tripp RA, Sarawar SR, Carson RT, et al. Requirement for STAT4 in interleukin-12-mediated responses of natural killer and T cells. Nature. 1996;382:171–4.
  • Mathur AN, Chang HC, Zisoulis DG, Stritesky GL, Yu Q, O'Malley JT, et al. Stat3 and STAT4 direct development of IL-17-secreting Th cells. J Immunol. 2007;178: 4901–7.
  • DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177–88.
  • Cochran WG. The combination of estimates from different experiments. Biometrics. 1954;10:101–29.
  • Tobias A. Assessing the influence of a single study in the meta-analysis estimate. Stata Tech Bull. 1999;8:15–7.
  • Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta analysis detected by a simple, graphical test. BMJ. 1997;315: 629–34.
  • Harly JB, Alarcon-Riquelme ME, Criswell LA, Jacob CO, Kimberly RP, Moser KL, et al. Genome-wide association scan in women with systemic lupus erythematosus identifies suscepti-bility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet. 2008;40:204–10.
  • Palomino-Morales RJ, Rojas-Villarraga A, Gonzalez CI, Ramirez G, Anaya JM, Martin J. STAT4 but not TRAF1/C5 variants influence the risk of developing rheumatoid arthritis and systemic lupus erythematosus in Colombians. Genes Immun. 2008;9:379–82.
  • Kobayashi S, Ikari K, Kaneko H, Kochi Y, Yamamoto K, Shimane K, et al. Association of STAT4 with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in the Japanese population. Arthritis Rheum. 2008;58:1940–6.
  • Kawasaki A, Ito I, Hikami K, Ohashi J, Hayashi T, Goto D, et al. Role of STAT4 polymorphisms in systemic lupus erythematosus in a Japanese population: a case-control association study of the STAT1-STAT4 region. Arthritis Res Ther. 2008;10:R113.
  • Abelson AK, Delgado-Vega AM, Kozyrev SV, Sanchez E, Vel-azquez-Cruz R, Eriksson N, et al. STAT4 associates with SLE through two independent effects that correlate with gene expression and act additively with IRF5 to increase risk. Ann Rheum Dis. 2008 [Epub ahead of print].
  • Yang W, Ng P, Zhao M, Hirankarn N, Lau CS, Mok CC, et al. Population differences in SLE susceptibility genes: STAT4 and BLK, but not PXK, are associated with systemic lupus erythe-matosus in Hong Kong Chinese. Genes Immun. 2009;10:219–26.
  • Suarez-Gestal M, Calaza M, Endreffy E, Pullmann R, Ordi-Ros J, Domenico Sebastiani G, et al. Replication of recently identified systemic lupus erythematosus genetic associations: a case-con-trol study. Arthritis Res Ther. 2009;11:R69.
  • Sigurdsson S, Nordmark G, Gamier S, Grundberg E, Kwan T, Nilsson O, et al. A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5. Hum Mol Genet. 2008;17:2868–76.
  • Taylor KE, Remmers EF, Lee AT, Ortmann WA, Plenge RM, Tian C, et al. Specificity of the STAT4 genetic association for severe disease manifestations of systemic lupus erythematosus. PLoS Genet. 2008;4:e1000084.
  • Hom G, Graham RR, Modrek B, Taylor KE, Ortmann W, Gamier S, et al. Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. N Engl J Med. 2008; 358:900–9.
  • Deapen D, Escalante A, Weinrib L, Horwitz D, Bachman B, Roy-Burman P, et al. A revised estimate of twin concordance in systemic lupus erythematosus. Arthritis Rheum. 1992;35:311–8.
  • Alarcon-Segovia D, Alarcon-Riquelme ME, Cardiel MH, Caeiro F, Massardo L, Villa AR, et al. Familial aggregation of systemic lupus erythematosus, rheumatoid arthritis, and other autoimmune diseases in 1,177 lupus patients from the GLADEL cohort. Arthritis Rheum. 2005;52:1138–47.
  • Ji JD, Lee WJ, Kong KA, Woo JH, Choi SJ, Lee YH, et al. Association of STAT4 polymorphism with rheumatoid arthritis and systemic lupus erythematosus: a meta-analysis. Mol Biol Rep. 2009 [Epub ahead of print].
  • Lee HS, Remmers EF, Le JM, Kastner DL, Bae SC, Gregersen PK. Association of STAT4 with rheumatoid arthritis in the Korean population. Mol Med. 2007;13:455–60.
  • Lee HS, Park H, Yang S, Kim D, Park Y. STAT4 polymorphism is associated with early-onset type 1 diabetes, but not with late-onset type 1 diabetes. Ann N Y Acad Sci. 2008;1150:93–8.
  • Korman BD, Alba MI, Le JM, Alevizos I, Smith JA, Nikolov NP, et al. Variant form of STAT4 is associated with primary Sjogren's syndrome. Genes Immun. 2008;9:267–70.
  • Martinez A, Varadé J, Marquez A, Cénit MC, Espino L, Perdi-gones N, et al. Association of the STAT4 gene with increased susceptibility for some immune mediated diseases. Arthritis Rheum. 2008;58:2598–602.
  • Chitnis T, Najafian N, Benou C, Salama AD, Grusby MJ, Sayegh MH, et al. Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis. J Clin Invest. 2001;108:739–47.
  • Boyton RJ, Davies S, Marden C, Fantino C, Reynolds C, Portugal K, et al. STAT4-null non-obese diabetic mice: protection from diabetes and experimental allergic encephalomyelitis, but with concomitant epitope spread. Int Immunol. 2005;17:1157–65.

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