Exploring the signalling pathways promoting T cell effector responses in chronic inflammation

References

• Mosmann TR, Coffman RL. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989;7:145–73.
   PubMed Web of Science ®Google Scholar
• Cope AP. Regulation of autoimmunity by proinflammatory cytokines. Curr Opin Immunol 1998;10:669–76.
   PubMedGoogle Scholar
• Pulendran B, Smith JL, Caspary G, Brasel K, Pettit D, Maraskovsky E, et al. Distinct dendritic cell subsets differentially regulate the class of immune response in vivo. Proc Natl Acad Sci 25. USA 1999;96:1036–41.
   PubMed Web of Science ®Google Scholar
• Winchester R. The molecular basis of susceptibility to rheumatoid arthritis. Adv Immunol 1994;56:389–466.
   PubMed Web of Science ®Google Scholar
• Avni 0, Rao A. T cell differentiation: a mechanistic view. Curr Opin Immunol 2000;12:654-9.26.
   Google Scholar
• Dustin ML, Cooper JA. The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling. Nat Immunol 2000;1:23–9.
   PubMed Web of Science ®Google Scholar
• Murphy KM, Ouyang W, Farrar JD, Yang J, Ranganath S, Asnagli 27. H, et al. Signaling and transcription in T helper development. Annu Rev Immunol 2000;18:451–94.
   PubMed Web of Science ®Google Scholar
• Blackwood EM, Kadonaga if. Going the distance: a current view 28. of enhancer action. Science 1998;281:61–3.
   Google Scholar
• Fitzpatrick DR, Shirley KM, McDonald LE, Bielefeldt-Ohmann H, Kay GF, Kelso A. Distinct methylation of the interferon gamma (IFN-gamma) and interleukin 3 (IL-3) genes in newly activated primary CD8+ T lymphocytes: regional IFN-gamma promoter 29. demethylation and mFtNA expression are heritable in CD44(high)CD8+ T cells. J Exp Med 1998;188: 103–17.
   Google Scholar
• Bird JJ, Brown DR, Mullen AC, Moskowitz NH, Mahowald MA, Sider JR, et al. Helper T cell differentiation is controlled by the cell 30. cycle. Immunity 1998;9:229–37.
   PubMed Web of Science ®Google Scholar
• Feldmann M, Brennan FM, Maini RN. Role of cytokines in rheu-matoid arthritis. Annu Rev Immunol 1996;14:397–440.
   PubMed Web of Science ®Google Scholar
• Emery P, Panayi GS, Welsh KI, Cole BC. Relationship of HLA- 31. DR4 to defective cellular immunity in rheumatoid arthritis using PPD, and mycoplasma and lectin mitogens. J Ftheumatol 1985; 12:859–64.
   Google Scholar
• Cush JJ, Lipsky PE. Phenotypic analysis of synovial tissue and peripheral blood lymphocytes isolated from patients with rheuma- 32. toid arthritis. Arthritis Rheum 1988;31:1230–8.
   PubMed Web of Science ®Google Scholar
• Malone DG, Wahl SM, Tsokos M, Catte11 H, Decker JL, Wilder RL. Immune function in severe, active rheumatoid arthritis. A relationship between peripheral blood mononuclear cell prolifera-tion to soluble antigens and synovial tissue immunohistologic 33. characteristics. J Clin Invest 1984;74: 1173–85.
   Google Scholar
• Emery P, Panayi GS, Noun i AM. Interleukin-2 reverses deficient cell-mediated immune responses in rheumatoid arthritis. Clin Exp Immunol 1984;57: 123–9.34.
   Google Scholar
• Weyand CM, Goronzy JJ, Takemura S, Kurtin PJ. Cell-cell inter-actions in synovitis. Interactions between T cells and B cells in rheumatoid arthritis. Arthritis Res 2000;2:457–63.
   Google Scholar
• Salmon M, Scheel-Toellner D, Huissoon AP, Pilling D, Shamsadeen N, Hyde H, et al. Inhibition of T cell apoptosis in the 35. rheumatoid synovium. J Clin Invest 1997;99:439–46.
   PubMed Web of Science ®Google Scholar
• Koetz K, Bryl E, Spickschen K, O'Fallon WM, Goronzy JJ, Weyand CM. T cell homeostasis in patients with rheumatoid arthritis. Proc Natl Acad Sci USA 2000;97:9203–8.
   PubMed Web of Science ®Google Scholar
• Morita Y, Yamamura M, Kawashima M, Harada S, Tsuji K, 36. Shibuya K, et al. Flow cytometric single-cell analysis of cytokine production by CD4+ T cells in synovial tissue and peripheral blood from patients with rheumatoid arthritis. Arthritis Rheum 1998;41: 1669–76.37.
   Google Scholar
• Ronnelid J, Berg L, Rogberg S, Nilsson A, Albertsson K, Klareskog L. Production of T-cell cytokines at the single-cell level in patients with inflammatory arthritides: enhanced activity in 38. synovial fluid compared to blood. Br J Rheumatol 1998;37:7–14.
   PubMedGoogle Scholar
• Davis LS, Cush JJ, Schulze-Koops H, Lipsky PE. Rheumatoid synovial CD4+ T cells exhibit a reduced capacity to differentiate into IL-4-producing T-helper-2 effector cells. Arthritis Res 39. 2001;3: 54–64.
   Google Scholar
• Warrington KJ, Takemura S, Goronzy JJ, Weyand CM. CD4+, CD28- T cells in rheumatoid arthritis patients combine features of 40. the innate and adaptive immune systems. Arthritis Rheum 2001;44:13–20.
   PubMedGoogle Scholar
• Brennan FM, Chantry D, Jackson A, Maini R, Feldmann M. 41. Inhibitory effect of TNF alpha antibodies on synovial cell interleukin-1 production in rheumatoid arthritis. Lancet 1989;2: 244–7.42.
   Google Scholar
• Brennan FM, Gibbons DL, Mitchell T, Cope AP, Maini RN, Feldmann M. Enhanced expression of tumor necrosis factor 43. receptor mRNA and protein in mononuclear cells isolated from rheumatoid arthritis synovial joints. Eur J Immunol 1992;22:1907-44. 12.
   Google Scholar
• Deleuran BW, Chu CQ, Field M, Brennan FM, Mitchell T, Feldmann M, et al. Localization of tumor necrosis factor receptors in the synovial tissue and cartilage-pannus junction in patients with rheumatoid arthritis. Implications for local actions of tumor necro-sis factor alpha. Arthritis Rheum 1992;35:1170–8.
   Google Scholar
• Cope AP, Aderka D, Doherty M, Engelmann H, Gibbons D, Jones AC, et al. Increased levels of soluble tumor necrosis factor re-ceptors in the sera and synovial fluid of patients with rheumatic diseases. Arthritis Rheum 1992;35:1160–9.
   PubMed Web of Science ®Google Scholar
• Yokota S, Geppert TD, Lipsky PE. Enhancement of antigen- and mitogen-induced human T lymphocyte proliferation by tumor ne-crosis factor-alpha. J Immunol 1988;140:531–6.
   Google Scholar
• Cope AP, Londei M, Chu NR, Cohen SB, Elliott MJ, Brennan FM, et al. Chronic exposure to tumor necrosis factor (TNF) in vitro impairs the activation of T cells through the T cell receptor/CD3 complex: reversal in vivo by anti-TNF antibodies in patients with rheumatoid arthritis. J Clin Invest 1994;94:749–60.
   PubMed Web of Science ®Google Scholar
• Cope AP, Liblau RS, Yang XD, Congia M, Laudanna C, Schreiber RD, et al. Chronic tumor necrosis factor alters T cell responses by attenuating T cell receptor signaling. J Exp Med 1997;185:1573–84.
   PubMed Web of Science ®Google Scholar
• Isomäki P, Panesar M, Annenkov A, Clark JM, Foxwell BM, Chernajovsky Y, et al. Prolonged exposure of T cells to TNF down-regulates TCR-zeta and expression of the TCR/CD3 complex at the cell surface. J Immunol 2001;166: 5495–507.
   Google Scholar
• Lorenz HM, Antoni C, Valerius T, Repp R, Grunke M, Schwerdtner N, et al. In vivo blockade of TNF-alpha by intrave-nous infusion of a chimeric monoclonal TNF-alpha antibody in patients with rheumatoid arthritis. Short-term cellular and mole-cular effects. J Immunol 1996;156:1646–53.
   Google Scholar
• Maurice MM, van der Graaff WL, Leow A, Breedveld FC, van Lier RA, Verweij CL. Treatment with monoclonal anti-tumor necrosis factor alpha antibody results in an accumulation of Thl CD4+ T cells in the peripheral blood of patients with rheumatoid arthritis. Arthritis Rheum 1999;42:2166–73.
   PubMed Web of Science ®Google Scholar
• Berg L, Lampa J, Rogberg S, van Vollenhoven R, Klareskog L. Increased peripheral T cell reactivity to microbial antigens and collagen type II in rheumatoid arthritis after treatment with soluble TNF-alpha receptors. Ann Rheum Dis 2001;60:133–9.
   Google Scholar
• Kassiotis G, Kollias G. Uncoupling the proinflammatory from the immunosuppressive properties of tumor necrosis factor (TNF) at the p55 TNF receptor level. Implications for pathogenesis and therapy of autoimmune demyelination. J Exp Med 2001;193:427–34.
   Google Scholar
• van Oosten BW, Barkhof F, Truyen L, Boringa JB, Bertelsmann FW, von Blomberg BM, et al. Increased MRI activity and immune activation in two multiple sclerosis patients treated with the mono-clonal anti-tumor necrosis factor antibody cA2. Neurology 1996;47: 1531–4.
   Google Scholar
• Minami Y, Weissman AM, Samelson LE, Klausner RD. Building a multichain receptor: synthesis, degradation, and assembly of the T-cell antigen receptor. Proc Natl Acad Sci USA 1987;84:2688–92.
   PubMed Web of Science ®Google Scholar
• Maurice MM, Lankester AC, Bezemer AC, Geertsma MF, Tak PP, Breedveld FC, et al. Defective TCR-mediated signaling in synovial T cells in rheumatoid arthritis. J Immunol 1997;159:2973–8.
   PubMedGoogle Scholar
• Berg L, Ronnelid J, Klareskog L, Bucht A. Down-regulation of the T cell receptor CD3-zeta chain in rheumatoid arthritis (RA) and its influence on T cell responsiveness. Clin Exp Immunol 2000;120: 174–82.
   PubMed Web of Science ®Google Scholar
• Irving BA, Weiss A. The cytoplasmic domain of the T cell receptor zeta chain is sufficient to couple to receptor-associated signal trans-duction pathways. Cell 1991;64:891–901.
   PubMed Web of Science ®Google Scholar
• Letourneur F, Klausner RD. Activation of T cells by a tyrosine kinase activation domain in the cytoplasmic tail of CD3-epsilon. Science 1992;255:79–82.
   PubMedGoogle Scholar
• Sloan-Lancaster J, Shaw AS, Rothbard JB, Allen PM. Partial T cell signaling: altered phospho-zeta and lack of zap70 recruitment in APL-induced T cell anergy. Cell 1994;79: 913–22.
   Google Scholar
• Tsokos GC, Liossis SN. Immune cell signaling defects in lupus: activation, anergy and death. Immunol Today 1999;20:119–24.
   PubMedGoogle Scholar
• Tsokos GC, Wong HK, Enyedy EJ, Nambiar MP. Immune cell signaling in lupus. Curr Opin Ftheumatol 2000;12:355–63.
   PubMedGoogle Scholar
• Liossis SN, Ding XZ, Dennis GJ, Tsokos GC. Altered pattern of TCR/CD3-mediated protein-tyrosyl phosphorylation in T cells from patients with systemic lupus erythematosus. Deficient ex-pression of the T cell receptor zeta chain. J Clin Invest 1998;101:1448–57.
   PubMed Web of Science ®Google Scholar
• Takeuchi T, Tsuzaka K, Pang M, Amano K, Koide J, Abe T. TCR-zeta chain lacking exon 7 in two patients with systemic lupus erythematosus. Int Immunol 1998;10:911–21.
   PubMed Web of Science ®Google Scholar
• Brundula V, Rivas LJ, Blasini AM, Paris M, Salazar S, Stekman IL, et al. Diminished levels of T cell receptor zeta chains in peripheral blood T lymphocytes from patients with systemic lupus erythema-tosus. Arthritis Rheum 1999;42:1908–16.
   PubMed Web of Science ®Google Scholar
• Maurice MM, Nakamura H, van der Voort EA, van Vliet Al, Staal FJ, Tak PP, et al. Evidence for the role of an altered redox state in hyporesponsiveness of synovial T cells in rheumatoid arthritis. J Immunol 1997;158:1458–65.
   Google Scholar
• Vassilopoulos D, Kovacs B, Tsokos GC. TCR/CD3 complex-mediated signal transduction pathway in T cells and T cell lines from patients with systemic lupus erythematosus. J Immunol 1995;155: 2269–81.
   Google Scholar
• Tsuzaka K, Takeuchi T, Onoda N, Pang M, Abe T. Mutations in T cell receptor zeta chain mFtNA of peripheral T cells from systemic lupus erythematosus patients. J Autoimmun 1998;11:381–85.
   Google Scholar
• Nambiar MP, Enyedy EJ, Warke VG, Krishnan S, Dennis G, Wong HK, et al. T cell signaling abnormalities in systemic lupus erythematosus are associated with increased mutations/polymor-phisms and splice variants of T cell receptor zeta chain messenger RNA. Arthritis Rheum 2001;44:1336–50.
   PubMed Web of Science ®Google Scholar
• Nambiar MP, Enyedy EJ, Warke VG, Krishnan S, Dennis G, Kammer GM, et al. Polymorphisms/mutations of TCR-zeta-chain promoter and 3' untranslated region and selective expression of TCR zeta-chain with an alternatively spliced 3' untranslated region in patients with systemic lupus erythematosus. J Autoimmun 2001;16:133–42.
   PubMed Web of Science ®Google Scholar
• Yamazaki T, Arase H, Ono S, Ohno H, Watanabe H, Saito T. A shift from negative to positive selection of autoreactive T cells by the reduced level of TCR signal in TCR-transgenic CD3-zeta-deficient mice. J Immunol 1997;158:1634–40.
   PubMedGoogle Scholar
• Schett G, Tohidast-Akrad M, Smolen JS, Schmid BJ, Steiner CW, Bitzan P, et al. Activation, differential localization, and regulation of the stress-activated protein kinases, extracellular signal-regulated kinase, c-JUN N-terminal kinase, and p38 mitogen-activated protein kinase in synovial tissue and cells in rheumatoid arthritis. Arthritis Rheum 2000;43:2501–12.
   PubMed Web of Science ®Google Scholar
• Collantes E, Valle Blazquez M, Mazorra V, Macho A, Aranda E, Munoz E. Nuclear factor-kappa B activity in T cells from patients with rheumatic diseases: a preliminary report. Ann Rheum Dis 1998;57:738–41.
   PubMedGoogle Scholar
• Gerlag DM, Ransone L, Tak PP, Han Z, Palanki M, Barbosa MS, et al. The effect of a T cell-specific NF-kappa B inhibitor on in vitro cytokine production and collagen-induced arthritis. J Immunol 2000;165:1652–8.
   PubMed Web of Science ®Google Scholar
• Feldmann M, Maini RN. Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned? Annu Rev Immunol 2001;19:163–96.
   PubMed Web of Science ®Google Scholar
• van Deventer SJ. Anti-TNF antibody treatment of Crohn's disease. Ann Rheum Dis 1999;58 Suppl 1:1114–20.
   Google Scholar
• Chizzolini C, Chicheportiche R, Burger D, Dayer JM. Human Thl cells preferentially induce interleukin (IL)-lbeta while Th2 cells induce IL-1 receptor antagonist production upon cell/cell contact with monocytes. Eur J Immunol 1997;27:171–7.
   PubMed Web of Science ®Google Scholar
• Dayer JM, Burger D. Cytokines and direct cell contact in synovitis: relevance to therapeutic intervention. Arthritis Res 1999;1:17–20.
   PubMedGoogle Scholar
• McInnes IB, Leung BP, Sturrock RD, Field M, Liew FY. Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-alpha production in rheumatoid arthritis. Nat Med 1997;3: 189–95.
   Google Scholar