Pharmacoeconomic aspects of poor adherence: can better adherence reduce healthcare costs?

References

• World Health Organization. Adherence to long-term therapies: evidence for action. Geneva: World Health Organization, 2003
   Google Scholar
• Cramer JA, Roy A, Burrell A, et al. Medication compliance and persistence: terminology and definitions. Value Health 2008;11:44-7
   PubMed Web of Science ®Google Scholar
• Aronson JK. Editors’ view: compliance, concordance, adherence. Br J Clin Pharmacol 2007;63:383-4
   PubMed Web of Science ®Google Scholar
• Haynes RB, Ackloo E, Sahota N, et al. Interventions for enhancing medication adherence. Cochrane Database Syst Rev 2008(2):CD000011
   PubMed Web of Science ®Google Scholar
• Heisler M, Faul JD, Hayward RA, et al. Mechanisms for racial and ethnic disparities in glycemic control in middle-aged and older Americans in the health and retirement study. Arch Intern Med 2007;167:1853-60
   PubMed Web of Science ®Google Scholar
• Schectman JM, Nadkarni MM, Voss JD. The association between diabetes metabolic control and drug adherence in an indigent population. Diabetes Care 2002;25:1015-21
   PubMed Web of Science ®Google Scholar
• Rhee MK, Slocum W, Ziemer DC, et al. Patient adherence improves glycemic control. Diabetes Educ 2005;31:240-50
   PubMed Web of Science ®Google Scholar
• Stratton IM, Adler AI, Neil HA, et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ 2000;321:405-12
   PubMed Web of Science ®Google Scholar
• The Diabetes Control and Complications Trial Research Group. The relationship of glycemic exposure (HbA1c) to the risk of development and progression of retinopathy in the diabetes control and complications trial. Diabetes 1995;44:968-83 retinopathy in the diabetes control and complications trial. Diabetes 1995;44:968-83
   Google Scholar
• Beckles GL, Engelgau MM, Narayan KM, et al. Population-based assessment of the level of care among adults with diabetes in the U.S. Diabetes Care 1998;21:1432-8
   PubMed Web of Science ®Google Scholar
• Diabetes and impaired glucose tolerance. In: Sicree R, Shaw J, Zimmet P (eds) IDF Diabetes Atlas, 4th Edn. 2009. Available at: http://www.diabetesatlas.org/content/background-papers-pdf [Last accessed 31 March 2011]
   Google Scholar
• Cramer JA, Benedict A, Muszbek N, et al. The significance of compliance and persistence in the treatment of diabetes, hypertension and dyslipidaemia: a review. Int J Clin Pract 2008;62:76-87
   PubMed Web of Science ®Google Scholar
• Yang Y, Thumula V, Pace PF, et al. Predictors of medication nonadherence among patients with diabetes in Medicare Part D programs: a retrospective cohort study. Clin Ther 2009;31:2178-88
   PubMed Web of Science ®Google Scholar
• Yeaw J, Benner JS, Walt JG, et al. Comparing adherence and persistence across 6 chronic medication classes. J Manag Care Pharm 2009;15:728-40
   PubMed Web of Science ®Google Scholar
• Bailey CJ, Kodack M. Patient adherence to medication requirements for therapy of type 2 diabetes. Int J Clin Pract 2011;65:314-22
   PubMed Web of Science ®Google Scholar
• Shetty S, Secnik K, Oglesby A. Relationship of glycemic control to total diabetes-related costs for managed care health plan members with type 2 diabetes. J Manag Care Pharm 2005;11:559-64
   PubMedGoogle Scholar
• Berger J. Economic and clinical impact of innovative pharmacy benefit designs in the management of diabetes pharmacotherapy. Am J Manag Care 2007;13(Suppl 2):S55-8
   PubMedGoogle Scholar
• Sokol MC, McGuigan KA, Verbrugge RR, et al. Impact of medication adherence on hospitalization risk and healthcare cost. Med Care 2005;43:521-30
   PubMed Web of Science ®Google Scholar
• Freedberg KA, Hirschhorn LR, Schackman BR, et al. Cost-effectiveness of an intervention to improve adherence to antiretroviral therapy in HIV-infected patients. J Acquir Immune Defic Syndr 2006;43(Suppl 1):S113-18
   PubMedGoogle Scholar
• Norgren S. Adherence remains a challenge for patients receiving growth hormone therapy. Pediatr Endocrinol Rev 2009;6(Suppl 4):545-8
   PubMedGoogle Scholar
• Osterberg L, Blaschke T. Adherence to medication. N Engl J Med 2005;353:487-97
   PubMed Web of Science ®Google Scholar
• Electronic monitoring of adherence. AARDEX. Sion, Switzerland. Available at: http://www.aardexgroup.com/aardex_index.php?group=aardex&id=83 [Last accessed 31 March 2011]
   Google Scholar
• Peer reviewed publications. AARDEX. Sion, Switzerland. Available at: http://www.iadherence.org/publication.action [Last accessed 31 March 2011]
   Google Scholar
• Smartinhalers. Nexus6. Franklin, OH, USA. Available at: http://www.smartinhaler.com/Researcher_SI.aspx [Last accessed 31 March 2011]
   Google Scholar
• What is the Doser? Meditrack. Easton, MA, USA. Available at: http://www.doser.com/dWhat.html [Last accessed 31 March 2011]
   Google Scholar
• Dahlgren J, Veimo D, Johansson L, et al. Patient acceptance of a novel electronic auto-injector device to administer recombinant human growth hormone: results from an open-label, user survey of everyday use. Curr Med Res Opin 2007;23:1649-55
   PubMed Web of Science ®Google Scholar
• Devonshire V, Arbizu T, Borre B, et al. Patient-rated suitability of a novel electronic device for self-injection of subcutaneous interferon beta-1a in relapsing multiple sclerosis: an international, single-arm, multicentre, Phase IIIb study. BMC Neurology 2010;10:28
   PubMed Web of Science ®Google Scholar
• Hanaire H, Lassman-Vague V, Jeandidier N, et al. Treatment of diabetes mellitus using an external insulin pump: the state of the art. Diab Metab 2008;34:401-23
   PubMedGoogle Scholar
• Product information. Medtronic. Northridge, CA, USA. Available at: http://www.minimed.com/products/index.html [Last accessed 31 March 2011]
   Google Scholar
• DANA Diabecare R. SOOIL. Seoul, Korea. Available at: http://www.sooil.com/NEW/eng/m3_r_01.html [Last accessed 31 March 2011]
   Google Scholar
• Accu-Chek Combo System. Roche. Basel, Switzerland. Available at: http://www.accu-chek.co.uk/gb/products/insulinpumps/combo.html [Last accessed 31 March 2011]
   Google Scholar
• See how we match up to competition. Animas. West Chester, PA, USA. Available at: http://www.animas.com/animas-insulin-pumps/onetouch-ping [Last accessed 31 March 2011]
   Google Scholar
• Omnipod system overview. Insulet. Bedford, MA, USA. Available at: http://www.myomnipod.com/about-omnipod/system-overview/ [Last accessed 31 March 2011]
   Google Scholar
• George J, Kong DC, Stewart K. Adherence to disease management programs in patients with COPD. Int J Chron Obstruct Pulmon Dis 2007;2:253-62
   PubMedGoogle Scholar
• Jentzsch NS, Camargos PA, Colosimo EA, et al. Monitoring adherence to beclomethasone in asthmatic children and adolescents through four different methods. Allergy 2009;64:1458-62
   PubMed Web of Science ®Google Scholar
• Cramer JA. A systematic review of adherence with medications for diabetes. Diabetes Care 2004;27:1218-24
   PubMed Web of Science ®Google Scholar
• Costello K, Kennedy P, Scanzillo J. Recognizing nonadherence in patients with multiple sclerosis and maintaining treatment adherence in the long term. Medscape J Med 2008;10:225
   PubMedGoogle Scholar
• Patti F. Optimizing the benefit of multiple sclerosis therapy: the importance of treatment adherence. Patient Prefer Adherence 2010;4:1-9
   PubMed Web of Science ®Google Scholar
• Haverkamp F, Johansson L, Dumas H, et al. Observations of nonadherence to recombinant human growth hormone therapy in clinical practice. Clin Ther 2008;30:307-16
   PubMed Web of Science ®Google Scholar
• Cazzoletti L, Marcon A, Janson C, et al. Asthma control in Europe: a real-world evaluation based on an international population-based study. J Allergy Clin Immunol 2007;120:1360-7
   PubMed Web of Science ®Google Scholar
• Ware NC, Idoko J, Kaaya S, et al. Explaining adherence success in sub-Saharan Africa: an ethnographic study. PLoS Med 2009;6:e11
   PubMed Web of Science ®Google Scholar
• Vanelli M, Pedan A, Liu N, et al. The role of patient inexperience in medication discontinuation: a retrospective analysis of medication nonpersistence in seven chronic illnesses. Clin Ther 2009;31:2628-52
   PubMed Web of Science ®Google Scholar
• Schectman JM, Schorling JB, Voss JD. Appointment adherence and disparities in outcomes among patients with diabetes. J Gen Intern Med 2008;23:1685-7
   PubMed Web of Science ®Google Scholar
• Gold DT, McClung B. Approaches to patient education: emphasizing the long-term value of compliance and persistence. Am J Med 2006;119(4 Suppl 1):S32-7
   PubMed Web of Science ®Google Scholar
• Delamater AM. Improving patient adherence. Clinical Diabetes 2006:24;71-7
   Google Scholar
• Saini SD, Schoenfeld P, Kaulback K, et al. Effect of medication dosing frequency on adherence in chronic diseases. Am J Manag Care 2009;15:e22-e33
   PubMed Web of Science ®Google Scholar
• Gregg JA, Callaghan GM, Hayes SC, et al. Improving diabetes self-management through acceptance, mindfulness, and values: a randomized controlled trial. J Consult Clin Psychol 2007;75:336-43
   PubMed Web of Science ®Google Scholar
• Clatworthy J, Price D, Ryan D, et al. The value of self-report assessment of adherence, rhinitis and smoking in relation to asthma control. Prim Care Respir J 2009;18:300-5
   PubMedGoogle Scholar
• Bozek A, Jarzab J. Adherence to asthma therapy in elderly patients. J Asthma 2010;47:162-5
   PubMed Web of Science ®Google Scholar
• Chapman RH, Ferrufino CP, Kowal SL, et al. The cost and effectiveness of adherence-improving interventions for antihypertensive and lipid-lowering drugs. Int J Clin Pract 2010;64:169-81
   PubMed Web of Science ®Google Scholar
• Mohr DC, Boudewyn AC, Likosky W, et al. Injectable medication for the treatment of multiple sclerosis: the influence of self-efficacy expectations and injection anxiety on adherence and ability to self-inject. Ann Behav Med 2001;23:125-32
   PubMed Web of Science ®Google Scholar
• Gaziano TA. Reducing the growing burden of cardiovascular disease in the developing world. Health Aff (Millwood) 2007;26:13-24
   PubMed Web of Science ®Google Scholar
• Bhat VG, Ramburuth M, Singh M, et al. Factors associated with poor adherence to anti-retroviral therapy in patients attending a rural health centre in South Africa. Eur J Clin Microbiol Infect Dis 2010;29:947-53
   PubMed Web of Science ®Google Scholar
• Blau N, van Spronsen FJ, Levy HL. Phenylketonuria. Lancet 2010;376:1417-27
   PubMed Web of Science ®Google Scholar
• National Institutes of Health Consensus Development Panel. National Institutes of Health Consensus Development Conference Statement: phenylketonuria: screening and management, October 16–18, 2000. Pediatrics 2000;108:972-82
   Google Scholar
• Management of PKU. April 2004. The National Society for Phenylketonuria (United Kingdom) Limited. Available at: http://www.nspku.org/Documents/Management%20of%20PKU.pdf [Last accessed 31 March 2011]
   Google Scholar
• Ris MD, Williams SE, Hunt MM, et al. Early-treated phenylketonuria: adult neuropsychologic outcome. J Pediatr 1994;124:388-92
   PubMedGoogle Scholar
• Charman WN, Porter CJH, Mithani S, et al. Physicochemical and physiological mechanisms for the effects of food on drug absorption: the role of lipids and pH. J Pharmaceut Sci 1997;86(3):269-82
   PubMed Web of Science ®Google Scholar
• Yuen KCJ, Amin R. Developments in administration of growth hormone treatment: focus on Norditropin® Flexpro®. Patient Pref Adhere 2011;5:117-24
   PubMed Web of Science ®Google Scholar
• Ziance R, Chandler C, Bishara RH. Integration of temperature-controlled requirement into pharmacy practice. J Am Pharm Assoc 2009;49:e61-e69
   Google Scholar
• Morgan M. The doctor–patient relationship. In: Sociology as Applied to Medicine, 6th Edn. WB Saunders Company Limited, Philadelphia, USA, 2008
   Google Scholar
• Global Parkinson’s Disease Survey Steering Committee. Factors impacting on quality of life in Parkinson’s disease: results from an international survey. Mov Disord 2002;17:60-7
   PubMed Web of Science ®Google Scholar
• Arbuthnott A, Sharpe D. The effect of physician–patient collaboration on patient adherence in non-psychiatric medicine. Patient Educ Couns 2009;77:60-7
   PubMed Web of Science ®Google Scholar
• Kulkarni AS, Balkrishnan R, Anderson RT, et al. Medication adherence and associated outcomes in Medicare health maintenance organization-enrolled older adults with Parkinson’s disease. Mov Disord 2008;23:359-65
   PubMed Web of Science ®Google Scholar
• Wills CJ, Scott A, Swift PG, et al. Retrospective review of care and outcomes in young adults with type 1 diabetes. BMJ 2003;327:260-1
   PubMedGoogle Scholar
• Aubert RE, Herman WH, Waters J, et al. Nurse case management to improve glycemic control in diabetic patients in a health maintenance organization: a randomized, controlled trial. Ann Intern Med 1998;129:605-12
   PubMed Web of Science ®Google Scholar
• Raynor DK, Nicolson M, Nunney J, et al. The development and evaluation of an extended adherence support programme by community pharmacists for elderly patients at home. Int J Pharmacy Pract 2000;8:157-64
   Google Scholar
• Blenkinsopp A, Phelan M, Bourne J, Dakhil N. Extended adherence support by community pharmacists for patients with hypertension: a randomised controlled trial. Int J Pharmacy Pract 2000;8:165-75
   Google Scholar
• Hirsch JD, Gonzales M, Rosenquist A, et al. Antiretroviral therapy adherence, medication use, and health care costs during 3 years of a community pharmacy medication therapy management program for Medi-Cal beneficiaries with HIV/AIDS. J Manag Care Pharm 2011;17:213-23
   PubMed Web of Science ®Google Scholar
• Rosenquist A, Best BM, Miller TA, et al. Medication therapy management services in community pharmacy: a pilot programme in HIV specialty pharmacies. J Eval Clin Pract 2010;16:1142-6
   PubMedGoogle Scholar
• Chernew ME, Shah MR, Wegh A, et al. Impact of decreasing copayments on medication adherence within a disease management environment. Health Affairs 2008;27:103-12
   PubMed Web of Science ®Google Scholar
• Alikhan A, Sockolov M, Brodell RT, et al. Drug samples in dermatology: special considerations and recommendations for the future. J Am Acad Dermatol 2010;62:1053-61
   PubMedGoogle Scholar
• Johri M, David Paltiel A, Goldie SJ, et al. State AIDS Drug Assistance Programs: equity and efficiency in an era of rapidly changing treatment standards. Med Care 2002;40:429-41
   PubMedGoogle Scholar
• Walensky RP, Paltiel AD, Freedberg KA. AIDS Drug Assistance Programs: highlighting inequities in human immunodeficiency virus-infection health care in the United States. Clin Infect Dis 2002;35:606-10
   PubMedGoogle Scholar
• Morgan TM. The economic impact of wasted prescription medication in an outpatient population of older adults. J Fam Pract 2001;50:779-81
   PubMed Web of Science ®Google Scholar
• Peyrot M, Rubin RR, Lauritzen T, et al. Psychosocial problems and barriers to improved diabetes management: results of the Cross-National Diabetes Attitudes, Wishes and Needs (DAWN) Study. Diabet Med 2005;22:1379-85
   PubMed Web of Science ®Google Scholar
• Lugaresi A. Addressing the need for increased adherence to multiple sclerosis therapy: can delivery technology enhance patient motivation? Expert Opin Drug Deliv 2009;6:995-1002
   PubMed Web of Science ®Google Scholar
• Dumas H, Panayiotopoulos P, Parker D, et al. Understanding and meeting the needs of those using growth hormone injection devices. BMC Endocr Disord 2006;6:5
   PubMedGoogle Scholar
• Main KM, Jørgensen JT, Hertel NT, et al. Automatic needle insertion diminishes pain during growth hormone injection. Acta Paediatr 1995;84:331-4
   PubMed Web of Science ®Google Scholar
• Chatelain P, Latour S, Maetzel A. The economic value of the easypod® electronic auto injector in improving the response to growth hormone (GH) in children with idiopathic growth hormone deficiency (IGHD): a cost-consequence analysis. Poster presentation at ISPOR 13th European Congress, 6–9 November 2010, Prague, Czech Republic. Abstract available at: http://www.ispor.org/RESEARCH_STUDY_DIGEST/details.asp [Last accessed 1 April 2011]
   Google Scholar
• Ruger JP, Weinstein MC, Hammond SK, et al. Cost-effectiveness of motivational interviewing for smoking cessation and relapse prevention among low-income pregnant women: a randomized controlled trial. Value Health 2008;11:191-8
   PubMedGoogle Scholar
• Gordon L, Graves N, Hawkes A, et al. A review of the cost-effectiveness of face-to-face behavioural interventions for smoking, physical activity, diet and alcohol. Chronic Illn 2007;3:101-29
   PubMedGoogle Scholar
• Chesney A. The elusive gold standard. Future perspectives for HIV adherence assessment and intervention. J Acquir Immune Defic Syndr 2006;43(Suppl 1):S149-55
   Google Scholar
• Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Department of Health and Human Services. January 10, 2011; 1-166. Available at: http://www.aidsinfo.nih.gov/ContentFiles/AdultandAdolescentGL.pdf [Last accessed 31 March 2011]
   Google Scholar
• Altice FL, Maru DS, Bruce RD, et al. Superiority of directly administered antiretroviral therapy over self-administered therapy among HIV-infected drug users: a prospective, randomized, controlled trial. Clin Infect Dis 2007;45:770-8
   PubMed Web of Science ®Google Scholar
• Goggin K, Liston RJ, Mitty JA. Modified directly observed therapy for antiretroviral therapy: a primer from the field. Public Health Reports 2007;122:472-81
   PubMed Web of Science ®Google Scholar
• Lord J, Thomason MJ, Littlejohns P, et al. Secondary analysis of economic data: a review of cost-benefit studies of neonatal screening for phenylketonuria. J Epidemiol Community Health 1999;53:179-86
   PubMed Web of Science ®Google Scholar
• Santos LL, Magalhães MC, Januário JN, et al. The time has come: a new scene for PKU treatment. Genet Mol Res 2006;5:33-44
   PubMedGoogle Scholar
• Blau N, Bélanger-Quintana A, Demirkol M, et al. Management of phenylketonuria in Europe: survey results from 19 countries. Mol Genet Metab 2010;99:109-15
   PubMed Web of Science ®Google Scholar
• Somaraju UR, Merrin M. Sapropterin dihydrochloride for phenylketonuria. Cochrane Database Syst Rev 2010;6:CD008005
   Google Scholar
• Tarlov AR, Ware JE Jr, Greenfield S, et al. The medical outcomes study. An application of methods for monitoring the results of medical care. J Am Med Assoc 1989;262:925-30
   PubMedGoogle Scholar