REFERENCES

• LebowitzBDPearsonJL.CohenGD.Older Americans and their illnesses. In: Salzman C, ed.Clinical Geriatric Psychopharmacology. 3rd edition. Baltimore, Md: Williams and Wilkins;1998320
   Google Scholar
• MurrayCJL.LopezAD.edsThe Global Burden of Disease. Cambridge, Mass: Harvard University Press;1996
   Google Scholar
• DumanRS.HeningerGR.NestlerEJ.A molecular and cellular theory of depression.Arch Gen Psychiatry.1997545976069236543
   PubMed Web of Science ®Google Scholar
• KumarA.JinZ.BilkerW.UdupaJ.GottliebG.Late-onset minor and major depression: early evidence for common neuroanatomical substrates detected by using MRI.Proc Natl Acad Sci USA.199895765476589636205
   PubMed Web of Science ®Google Scholar
• MeltzerCC.SmithG.DeKoskyST.et al.Serotonin in aging, late-life depression, and Alzheimer's disease: the emerging role of functional imaging.Neuropsychopharmacology.1998184074309571651
   PubMed Web of Science ®Google Scholar
• MusselmanDL.EvansDL.NemeroffCB.The relationship of depression to cardiovascular disease: epidemiology, biology, and treatment.Arch Gen Psychiatry.1998555805929672048
   PubMed Web of Science ®Google Scholar
• ShelineYl.WangPW.GadoMH.CsernanskyJG.VannierMW.Hippocampal atrophy in recurrent major depression.Proc Natl Acad Sci USA.199693390839138632988
   PubMed Web of Science ®Google Scholar
• Diagnosis and Treatment of Depression in Late Life.NIH Consens DevConf Consens Statement19919(3)Nov 46
   Google Scholar
• GalloJJ.AnthonyJC.MuthenBG.Age differences in the symptoms of depression: a latent trait analysis.J Gerontol Psychol Sci.199449P251P264
   Google Scholar
• LebowitzBD.PearsonJL.SchneiderLS.et al.Diagnosis and treatment of depression in late life: consensus statement update.JAMA.1997278118611909326481
   PubMed Web of Science ®Google Scholar
• CoffeyCE.WilkinsonWE.WeinerRD.et al.Quantitative cerebral anatomy in depression: a controlled magnetic resonance imaging study.Arch Gen Psychiatry.1993507168422224
   PubMed Web of Science ®Google Scholar
• KetterTA.GeorgeMS.KimbrellTA.et al.Functional brain imaging, limbic function and affective disorders.Neuroscientist.199625565
   Web of Science ®Google Scholar
• DrevetsWC.PriceJL.SimpsonJR.et al.Subgenual prefrontal cortex abnormalities in mood disorders.Nature.19973868248279126739
   PubMed Web of Science ®Google Scholar
• KennedySH.JavanmardM.VaccarinoFJ.A review of functional neuroimaging in mood disorders: positron emission tomography and depression.Can J Psychiatry.1997424674759220109
   PubMed Web of Science ®Google Scholar
• KumarA.MillerD.EwbankD.et al.Quantitative anatomic measures and comorbid medical illness in late-life major depression.Am J Geriatr Psychiatry.1997515259169241
   PubMed Web of Science ®Google Scholar
• AlexopoulosGS.YoungRC.ShindecklerR.Brain computed tomography in geriatric depression and primary degenerative dementia.Biol Psychiatry.1992315915991581438
   PubMed Web of Science ®Google Scholar
• KrishnanKRR.GaddeKM.The pathophysiologic basis for late-life depression: imaging studies of the aging brain.Am J Geriatr Psychiatry.19964(suppl 1)S22S33
   Web of Science ®Google Scholar
• BassuckSS.BerkmanLF.WypijD.Depressive symptomatology and incident cognitive decline in an elderly community sample.Arch Gen Psychiatry.199855107310819862549
   PubMed Web of Science ®Google Scholar
• MeyersBS.BruceML.The depression-dementia conundrum: integrating clinical and epidemiological perspectives.Arch Gen Psychiatry.199855108210839862550
   PubMed Web of Science ®Google Scholar
• AlexopoulosGS.MeyersBS.YoungRC.et al.The course of geriatric depression with “reversible dementia.”Am J Psychiatry.1993150169316998105707
   PubMed Web of Science ®Google Scholar
• AlexopoulosGS.MeyersBS.YoungRC.CampbellS.SilbersweigD.CharlsonM.“Vascular depression” hypothesis.Arch Gen Psychiatry.1997549159229337771
   PubMed Web of Science ®Google Scholar
• AlexopoulosGS.MeyersBS.YoungRC.KakumaT.SilbersweigD.CharlsonM.Clinically defined vascular depression.Am J Psychiatry.19971545625659090349
   PubMed Web of Science ®Google Scholar
• LeuchterAF.DunkinJJ.LufkinRB.et al.Effect of white matter disease on functional connections in the aging brain.J Neurol Neurosurg Psychiatry.199457134713547964810
   PubMed Web of Science ®Google Scholar
• LeuchterAF.SimonSL.DalyKA.et al.Quantitative EEG correlates of outcome in older psychiatric patients. Part II: Two-year follow-up of patients with depression.Am J Geriatr Psychiatry.19942290299
   PubMed Web of Science ®Google Scholar
• KatzIR.On the inseparability of medical and physical health in aged persons: lessons from depression and medical comorbidity.Am J Geriatr Psychiatry.19964116
   PubMed Web of Science ®Google Scholar
• WhooleyMA.BrownerWS.Association between depressive symptoms and mortality in older women: study of osteoporotic fractures research group.Arch intern Med.1998158212921359801180
   PubMed Web of Science ®Google Scholar
• BruceML.HoffRA.Social and physical health risk factors for first onset major depressive disorder in a community sample.Soc Psychiatry Psychiatr Epidemiol.1994291651717939965
   PubMed Web of Science ®Google Scholar
• BruceML.SeemanTE.MerrillSS.et al.The impact of depressive symptomatology on physical disability: MacArthur studies of successful aging.Am J Pub Health.199484179617997977920
   PubMed Web of Science ®Google Scholar
• BruceML.The association between depression and disability.Am J Geriatr Psychiatry.199978119919315
   PubMed Web of Science ®Google Scholar
• SteffensDC.HaysJC.KrishnanRRK.Disability in geriatric depression.Am J Geriatr Psychiatry.1999734409919318
   PubMed Web of Science ®Google Scholar
• BorsonS.McDonaldGJ.GayleT.et al.Improvement in mood, physical symptoms, and function with nortriptyline for depression in patients with chronic obstructive pulmonary disease.Psychosomatics.1992331902011557484
   PubMed Web of Science ®Google Scholar
• JohnsonJ.WeissmanMM.KlermanGL.Service utilization and social morbidity associated with depressive symptoms in the community.JAMA.1992267147814831538538
   PubMed Web of Science ®Google Scholar
• JuddLL.RapaportMH.PaulusMP.et al.Subsyndromal symptomatic depression: a new mood disorder.J Clin Psychiatry199455518288077164
   PubMedGoogle Scholar
• American Psychiatric Association.Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, DSM-IV.^TM Washington, DC: American Psychiatric Press;1994
   Google Scholar
• KoenigHG.BlazerDG.Minor depression in late tife.Am J Geriatr Psychiatry.19964(suppl 1)S14S21
   Web of Science ®Google Scholar
• MosseyJM.KnottKA.CraikR.The effects of persistent depressive symptoms on hip fracture recovery.J Gerontol Med Sci.199045M163M168
   Google Scholar
• MosseyJM.KnottKA.HigginsM.et al.Effectiveness of a psychosocial intervention. Interpersonal Counseling, for subdysthymic depression in medically ill elderly.J Gerontol Med Sci.199651AM172M178
   Google Scholar
• StoneA.PearlsteinT.Evaluation and treatment of changes in mood, sleep, and sexual functioning associated with menopause.Obstet Gynecol Clin North Am.1994213914037936551
   PubMed Web of Science ®Google Scholar
• SchmidtP.RubinowD.Neuroregulatory role of gonadal steroids in human.Psychopharmacol Bull.1997332192209230633
   PubMedGoogle Scholar
• SeidmanSN.WalshBT.Testosterone and depression in aging men.Am J Geriatr Psychiatry.1999718339919317
   PubMed Web of Science ®Google Scholar
• TrussM.BeatoM.Steroid hormone receptors: interaction with deoxyribonucleic acid and transcription factors.Endocr Rev.1993144594798223341
   PubMed Web of Science ®Google Scholar
• SchneiderLS.Pharmacological considerations in the treatment of late life depression.Am J Geriatr Psychiatry.19964(suppl 1)S51S65
   Web of Science ®Google Scholar
• SalzmanC.SchneiderL.AlexopoulosG.Pharmacological treatment of depression in late life. In: Bloom F, Kupfer D, eds.Psychopharmacology: Fourth Generation of Progress. New York, NY: Raven Press;199514711477
   Google Scholar
• Laghrissi-ThodeF.PollockBG.MillerMC.et al.Double-blind comparison of paroxetine and nortriptyline on the postural stability of late-life depressed patients.Psychopharm Bull.199531659663
   PubMed Web of Science ®Google Scholar
• NemeroffCB.DeVaneCL.PollockBG.Newer antidepressants and the cytochrome P450 system.Am J Psychiatry.19961533113208610817
   PubMed Web of Science ®Google Scholar
• Von MoltkeLL.AbernethyDR.GreenblattDJ.Kinetics and dynamics of psychotropic drugs in the elderly. In: Salzman C, ed.Clinical Geriatric Psychopharmacology. 3rd edition. Baltimore, Md: Williams and Wilkins;19987093
   Google Scholar
• ReynoldsCF.FrankE.PerelJM.et al.Nortriptyline and interpersonal psychotherapy as maintenance therapies for recurrent major depression: a randomized controlled trial in patients older than 59 years.JAMA.199928139459892449
   PubMed Web of Science ®Google Scholar
• NiedereheG.Psychosocial treatments with depressed older adults: a research update.Am J Geriatr Psychiatry.1996(suppl 1)4S66S78
   Web of Science ®Google Scholar
• NiedereheG.SchneiderLS.Treatments for anxiety and depression in the aged. In: Nathan PE, Gorman JM, eds.A Guide to Treatments that Work. New York, NY: Oxford University Press;1998270287
   Google Scholar
• AreanPA.PerriMG.NezuAM.et al.Comparative effectiveness of social problem-solving therapy and reminiscence therapy as treatments for depression in older adults.J Consult Clin Psychol.199361100310108113478
   PubMed Web of Science ®Google Scholar
• PrudicJ.HaskettRF.MulsantB.et al.Resistance to antidepressant medications and short-term clinical response to ECT.Am J Psychiatry.19961539859928678194
   PubMed Web of Science ®Google Scholar
• SackeimHA.The use of electroconvulsive therapy in late-life depression. In: Schneider LS, Reynolds CF, Lebowitz BD, Friedhoff AJ, eds.Diagnosis and Treatment of Depression in Late Life. Washington DC: American Psychiatric Press;1994259278
   Google Scholar
• SackeimHA.Continuation therapy following ECT: directions for further research.Psychopharm Bull.199430501521
   PubMedGoogle Scholar
• AlexopoulosGS.MeyersBS.YoungRC.et al.Recovery in geriatric depression.Arch Gen Psychiatry.1996533053128634008
   PubMed Web of Science ®Google Scholar
• ReynoldsCF.FrankE.KupferDJ.et al.Treatment outcomes in recurrent major depression: a post hoc comparison of elderly (“young old”) and midlife patients.Ami J Psychiatry.19965312881292
   Google Scholar
• ReynoldsCF.FrankE.DewMA.et al.Treatment of 70+ year-olds with recurrent major depression: excellent short-term but brittle long-term results.Am J Geriatr Psychiatry.1999764699919322
   PubMed Web of Science ®Google Scholar
• FriesBE.MehrDR.SchneiderD.et al.Mental dysfunction and resource use in nursing homes.Medical Care.1993318989208412392
   PubMed Web of Science ®Google Scholar
• SimonGE.Von KorffM.BarlowW.Health care costs of primary care patients with recognized depression.Arch Gen Psychiatry1995528508567575105
   PubMed Web of Science ®Google Scholar
• HenkHJ.KatzelnickDJ.KobakKA.et al.Medical costs attributed to depression among patients with a history of high medical expenses in a health maintenance organization.Arch Gen Psychiatry.1996538999048857866
   PubMed Web of Science ®Google Scholar
• Von KorffM.OrmelH.KatonW.et al.Disability and depression among high utilizers of health care.Arch Gen Psychiatry.199219911001550468
   PubMedGoogle Scholar
• Cooper-PatrickL.CrumRM.FordDE.Characteristics of patients with major depression who received care in general medical and specialty health settings.Medical Care.19943215248277799
   PubMed Web of Science ®Google Scholar
• CallahanCM.HuiSL.NienaberNA.et al.Longitudinal study of depression and health services use among elderly primary care patients. J AmGeriatr Soc.199442833838
   PubMed Web of Science ®Google Scholar
• Williams-RussoP.Barriers to diagnosis and treatment of depression in primary care settings.Am J Geriatr Psychiatry.19964(suppl 1)S84S90
   Web of Science ®Google Scholar
• Williams-RussoP.PetersenJ.CharlsonME.et al.Longitudinal course of depressive symptoms after bypass surgery. Presented at NIMH Primary Care Conference, Rockville, Md; July 1996
   Google Scholar
• CallahanCM.WolinskyFD.Hospitalization for major depression among older Americans.J Gerontol Med Sci.199550AM196M202
   Web of Science ®Google Scholar
• KoenigHG.KuchibhatlaM.Use of health services by medically ill depressed elderly patients after hospital discharge.Am J Geriatr Psychiatry.1999748569919320
   PubMed Web of Science ®Google Scholar
• OlfsonM.PincusHA.Outpatient mental health care in nonhospital settings: distribution of patients across provider groups.Am J Psychiatry1996153135313568831450
   PubMed Web of Science ®Google Scholar
• CallahanCM.HendrieHC.DittusRS.et al.Improving treatment of late life depression in primary care: a randomized clinical trial.J Am Geriatr Soc.1994428398468046193
   PubMed Web of Science ®Google Scholar
• KlinkmanMS.OkkesI.Mental health problems in primary care: a research agenda.J Fam Pract.1998473793849834775
   PubMed Web of Science ®Google Scholar
• LebowitzBD.Priorities for agenda building: mental health and primary care.J Fam Pract.1998473419834767
   PubMed Web of Science ®Google Scholar
• HenrikssonMM.MarttunenMJ.IsometsaET.et al.Mental disorders in elderly suicide.Int Psychogeriatr.199572752868829433
   PubMedGoogle Scholar
• ConwellY.DubersteinPR.CoxC.et al.Relationships of age and axis I diagnoses in victims of completed suicide: a psychological autopsy study.Am J Psychiatry.1996153100110088678167
   PubMed Web of Science ®Google Scholar
• ConwellY.Management of suicidal behavior in the elderly.Psychiatr Clin North Am.1997206676839323319
   PubMed Web of Science ®Google Scholar
• LebowitzBD.HarrisHW.Treatment research in geriatric psychiatry: from regulatory to public health considerations.Am J Geriatr Psychiatry.199861011039581205
   PubMed Web of Science ®Google Scholar
• LeberPD.DavisCS.Threats to the validity of clinical trials employing enrichment strategies for sample selection.Control Clin Trials.1998191781879551282
   PubMedGoogle Scholar
• SalzmanC.SchneiderLS.LebowitzBD.Antidepressant treatment of very old patients.Am J Geriatr Psychiatry199312129
   PubMedGoogle Scholar
• HorowitzMJ.SiegelB.HolenA.et al.Diagnostic criteria for complicated grief disorder.Am J Psychiatry.19971549049109210739
   PubMed Web of Science ®Google Scholar
• PrigersonHG.FrankE.KaslSV.et al.Complicated grief and bereavement-related depression as distinct disorders: preliminary empirical validation in elderly bereaved spouses.Am J Psychiatry.199515222307802116
   PubMed Web of Science ®Google Scholar
• PrigersonHG.BierhalsAJ.KaslSV.et al.Traumatic grief as a risk factor for mental and physical morbidity.Am J Psychiatry.19971546166239137115
   PubMed Web of Science ®Google Scholar
• AstinJA.Why patients use alternative medicine: results of a national study.JAMA1998279154815539605899
   PubMed Web of Science ®Google Scholar
• EisenbergDM.DavisRB.EttnerSL.et al.Trends in alternative medicine use in the United States, 1990-1997: results of a follow-up national survey.JAMA.1998280156915759820257
   PubMed Web of Science ®Google Scholar
• EmmanuelNP.CosbyC.CrawfordM.et al.Prevalence of herbal products use by subjects evaluated for pharmacological clinical trials. Poster Presentation, 38th annual New Clinical Drug Evaluation Unit (NCDEU) Meeting, Boca Raton, Fl; 1998
   Google Scholar
• LehmanAF.SteinwachsDM.Patterns of usual care for schizophrenia: initial results from the schizophrenia patient outcomes research team (PORT) client survey.Schizophr Bull.19982411209502543
   PubMed Web of Science ®Google Scholar
• Geriatric Psychiatry Alliance.Depression in Late Life: Not a Natural Part of Aging. Bethesda, Md: American Association for Geriatric Psychiatry;1997
   Google Scholar