REFERENCES

• Metal'nikovS.ChorineV.Rôle des réflexes conditionnels dans l'immunité.Ann inst Pasteur.192640893900
   Google Scholar
• AderR.CohenN.Behaviorally conditioned immunosuppression.Psychosom Med.1975373333401162023
   PubMed Web of Science ®Google Scholar
• RasmussenAF.MarshJT.BrillNQ.Increased susceptibility to herpes simplex in mice subjected to avoidance-learning stress or restraint.Proc Soc Exp Biol Med.19579618318913485051
   PubMed Web of Science ®Google Scholar
• BesedovskyH.SorkinE.Network of immune-neuroendocrine interactions.Clin Exp Immunol.197727112849642
   PubMed Web of Science ®Google Scholar
• WilliamsJM.PetersonRG.SheaPA.SchmedtjeJF.BauerDC.FeltenDL.Sympathetic innervation of murine thymus and spleen: evidence for a functional link between the nervous and immune systems.Brain Res Bull.1981683947193506
   PubMed Web of Science ®Google Scholar
• FeltenDL.FeltenSY.BellingerDL.et al.Noradrenergic sympathetic neural interactions with the immune system: structure and function.Immunol Rev.19871002252603326822
   PubMed Web of Science ®Google Scholar
• BerkenboschF.van OersJ.del ReyA.TildersF.BesedovskyH.Corticotropin-releasing factorproducing neurons in the rat activated by interleukin-1.Science19872385245262443979
   PubMed Web of Science ®Google Scholar
• BesedovskyH.del ReyA.Neuroendocrine and metabolic responses induced by inter leukin-1.J Neurosci Res.1987181721782824799
   PubMed Web of Science ®Google Scholar
• SapolskyR.RivierC.YamamotoG.PlotskyP.ValeW.Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor.Science.19872385225242821621
   PubMed Web of Science ®Google Scholar
• DuffGW.DurumSK.The pyrogenic and mitogenic actions of interleukin-1 are related.Nature.19833044494516603577
   PubMed Web of Science ®Google Scholar
• KruegerJM.WalterJ.DinarelloCA.WolffSM.ChedidL.Sleep-promoting effects of endogenous pyrogen (interleukin-1).Am J Physiol.1984246(6, pt 2)R994R9996611091
   PubMedGoogle Scholar
• McCarthyDO.KlugerMJ.VanderAJ.Effect of centrally administered interleukin-1 and endotoxin on food intake of fasted rats.Physiol Behav.1986367457493520613
   PubMed Web of Science ®Google Scholar
• ChanceWT.FischerJE.Aphagic and adipsic effects of interleukin-1.Brain Res.19915682612641814572
   PubMed Web of Science ®Google Scholar
• CrestaniF.SeguyF.DantzerR.Behavioural effects of peripherally injected interleukin-1: role of prostaglandins.Brain Res.19915423303352029641
   PubMed Web of Science ®Google Scholar
• SmedleyH.KatrakM.SikoraK.WheelerT.Neurological effects of recombinant human interferon.BMJ (Clin Res Ed).1983286262264
   PubMed Web of Science ®Google Scholar
• SpriggsDR.ShermanML.FreiE III.KufeDW.Clinical studies with tumour necrosis factor.Ciba Found Symp.19871312062273330011
   PubMedGoogle Scholar
• KapasL.KruegerJM.Tumor necrosis factor-beta induces sleep, fever, and anorexia.Am J Physiol.1992263(3, pt 2)R703R7071415661
   PubMedGoogle Scholar
• KapasL.HongL.CadyAB.et al.Somnogenic, pyrogenic, and anorectic activities of tumor necrosis factor-alpha and TNF-alpha fragments.Am J Physiol.1992263(3, pt 2)R708R7151357984
   PubMedGoogle Scholar
• DinarelloCA.BernheimHA.DuffGW.et al.Mechanisms of fever induced by recombinant human interferon.J Clin Invest.1984749069136590569
   PubMed Web of Science ®Google Scholar
• KimuraM.MajdeJA.TothLA.OppMR.KruegerJM.Somnogenic effects of rabbit and recombinant human interferons in rabbits.Am J Physiol.1994267(1, pt 2)R53R617519411
   PubMedGoogle Scholar
• RibeiroRC.RillD.RobersonPK.et al.Continuous infusion of interieukin-2 in children with refractory malignancies.Cancer.1993726236288319196
   PubMed Web of Science ®Google Scholar
• LeMayLG.VanderAJ.KlugerMJ.Role of interleukin 6 in fever in rats.Am J Physiol.1990258(3, pt 2)R798R8032316725
   PubMedGoogle Scholar
• AtkinsMB.RobertsonMJ.GordonM.et al.Phase I evaluation of intravenous recombinant human interleukin 12 in patients with advanced malignancies.Clin Cancer Res.199734094179815699
   PubMed Web of Science ®Google Scholar
• PflanzS.TimansJC.CheungJ.et al.IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells.Immunity.20021677979012121660
   PubMed Web of Science ®Google Scholar
• VilcekJ.The cytokines: an overview. In: Thomson A, ed.The Cytokine Handbook. London, UK: Academic Press;1998120
   Google Scholar
• KelsoA.Cytokines: principles and prospects.Immunol Cell Biol.1998763003179723771
   PubMed Web of Science ®Google Scholar
• BazanJF.Unraveling the structure of IL-2.Science.19922574104131631562
   PubMed Web of Science ®Google Scholar
• BoulayJL.PaulWE.The interleukin-4 family of lymphokines.Curr Opin Immunol.199242942981418708
   PubMed Web of Science ®Google Scholar
• RothwellNJ.LuheshiGN.Interleukin 1 in the brain: biology, pathology and therapeutic target.Trends Neurosci.20002361862511137152
   PubMed Web of Science ®Google Scholar
• FantuzziG.DinarelloCA.Interleukin-18 and interleukin-1 beta: two cytokine substrates for ICE (caspase-1).J Clin Immunol.19991911110080100
   PubMed Web of Science ®Google Scholar
• SmithDE.RenshawBR.KetchemRR.KubinM.GarkaKE.SimsJE.Four new members expand the interleukin-1 superfamily.J Biol Chem.20002751169117510625660
   PubMed Web of Science ®Google Scholar
• BodmerJL.SchneiderP.TschoppJ.The molecular architecture of the TNF superfamily.Trends Biochem Sci.200227192611796220
   PubMed Web of Science ®Google Scholar
• JanewayCA.TraversP.WalportM.ShlomchikM.Immunobiology. 5th ed. New York, NY: Garland Publishing;2001
   Google Scholar
• FickenscherH.HorS.KupersH.KnappeA.WittmannS.StichtH.The interleukin-10 family of cytokines.Trends Immunol.200223899611929132
   PubMed Web of Science ®Google Scholar
• GurlingHM.KalsiG.BrynjolfsonJ.et al.Genomewide genetic linkage analysis confirms the presence of susceptibility loci for schizophrenia, on chromosomes 1q32.2, 5q33.2, and 8p21-22 and provides support for linkage to schizophrenia, on chromosomes 11q23.3-24 and 20q12.1-11.23.Am J Hum Genet20016866167311179014
   PubMed Web of Science ®Google Scholar
• RosaA.FananasL.CuestaMJ.PeraltaV.ShamP.1q21-q22 locus is associated with susceptibility to the reality-distortion syndrome of schizophrenia spectrum disorders.Am J Med Genet200211451651812116186
   PubMed Web of Science ®Google Scholar
• BrzustowiczLM.HodgkinsonKA.ChowEW.HonerWG.BassettAS.Location of a major susceptibility locus for familial schizophrenia on chromosome 1q21-q22.Science.200028867868210784452
   PubMed Web of Science ®Google Scholar
• ChiavettoLB.BoinF.ZanardiniR.et al.Association between promoter polymorphic haplotypes of interleukin-10 gene and schizophrenia.Biol Psychiatry.20025148048411922883
   PubMed Web of Science ®Google Scholar
• KatilaH.HanninenK.HurmeM.Polymorphisms of the interleukin-1 gene complex in schizophrenia.Mol Psychiatry.1999417918110208450
   PubMed Web of Science ®Google Scholar
• MeisenzahlEM.RujescuD.KirnerA.et al.Association of an interleukin-1beta genetic polymorphism with altered brain structure in patients with schizophrenia.Am J Psychiatry.20011581316131911481169
   PubMed Web of Science ®Google Scholar
• SchwabSG.HallmayerJ.AlbusM.et al.A genome-wide autosomal screen for schizophrenia susceptibility loci in 71 families with affected siblings: support for loci on chromosome 10p and 6.Mol Psychiatry.2000563864911126394
   PubMed Web of Science ®Google Scholar
• RiouxJD.DalyMJ.SilverbergMS.et al.Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease.Nat Genet.20012922322811586304
   PubMed Web of Science ®Google Scholar
• LindholmE.EkholmB.BalciunieneJ.et al.Linkage analysis of a large Swedish kindred provides further support for a susceptibility locus for schizophrenia on chromosome 6p23.Am J Med Genet19998836937710402504
   PubMed Web of Science ®Google Scholar
• BoinF.ZanardiniR.PioliR.AltamuraCA.MaesM.GennarelliM.Association between -G308A tumor necrosis factor alpha gene polymorphism and schizophrenia.Mol Psychiatry.20016798211244489
   PubMed Web of Science ®Google Scholar
• RiedelM.KronigH.SchwarzMJ.et al.No association between the G308A polymorphism of the tumor necrosis factor-alpha gene and schizophrenia.Eur Arch Psychiatry Clin Neurosci.200225223223412451465
   PubMed Web of Science ®Google Scholar
• KwiatkowskiDJ.DiazMO.Dinucleotide repeat polymorphism at the IFNA locus (9p22).Hum Mol Genet199216581301184
   PubMed Web of Science ®Google Scholar
• MatuseviciusD.NavikasV.PalasikW.PirskanenR.FredriksonS.LinkH.Tumor necrosis factor-alpha, lymphotoxin, interleukin (IL)-6, IL-10, IL-12 and perforin mRNA expression in mononuclear cells in response to acetylcholine receptor is augmented in myasthenia gravis.J Neuroimmunol.1996711911988982119
   PubMed Web of Science ®Google Scholar
• YsselH.de WaalMR.RoncaroloMG.et al.IL-10 is produced by subsets of human CD4+ T cell clones and peripheral blood T cells.J immunol.1992149237823841356125
   PubMed Web of Science ®Google Scholar
• HayakawaS.FujikawaT.FukuokaH.et al.Murine fetal resorption and experimental pre-eclampsia are induced by both excessive Th1 and Th2 activation.J Reprod immunol.20004712113810924746
   PubMed Web of Science ®Google Scholar
• SederRA.PaulWE.Acquisition of lymphokine-producing phenotype by CD4+ T cells.Annu Rev immunol.1994126356737912089
   PubMed Web of Science ®Google Scholar
• RomagnaniS.Biology of human TH1 and TH2 cells.J Clin immunol.1995151211297559914
   PubMed Web of Science ®Google Scholar
• PaludanSR.lnterleukin-4 and interferon-gamma: the quintessence of a mutual antagonistic relationship.Scand J immunol.1998484594689822252
   PubMed Web of Science ®Google Scholar
• AloisiF.RiaF.AdoriniL.Regulation of T-cell responses by CNS antigenpresenting cells: different roles for microglia and astrocytes.Immunol Today.20002114114710689302
   PubMedGoogle Scholar
• FordAL.FoulcherE.LemckertFA.SedgwickJD.Microglia induce CD4 T lymphocyte final effector function and death.J Exp Med.1996184173717458920862
   PubMed Web of Science ®Google Scholar
• KreutzbergGW.Microglia: a sensor for pathological events in the CNS.Trends Neurosci.1996193123188843599
   PubMed Web of Science ®Google Scholar
• KrakowskiML.OwensT.The central nervous system environment controls effector CD4+ T cell cytokine profile in experimental allergic encephalomyelitis.Eur J Immunol.199727284028479394808
   PubMed Web of Science ®Google Scholar
• StalderAK.PagenstecherA.YuNC.et al.Lipopolysaccharide-induced IL-12 expression in the central nervous system and cultured astrocytes and microglia.J immunol.1997159134413519233631
   PubMed Web of Science ®Google Scholar
• HailerNP.HeppnerFL.HaasD.NitschR.Astrocytic factors deactivate antigen presenting cells that invade the central nervous system.Brain Pathol.199884594749669697
   PubMed Web of Science ®Google Scholar
• BanksWA.KastinAJ.DurhamDA.Bidirectional transport of interleukin1 alpha across the blood-brain barrier.Brain Res Bull.1989234334372611685
   PubMed Web of Science ®Google Scholar
• BanksWA.OrtizL.PlotkinSR.KastinAJ.Human interleukin (IL) 1 alpha, murine IL-1 alpha and murine IL-1 beta are transported from blood to brain in the mouse by a shared saturable mechanism.J Pharmacol Exp Ther.19912599889961762091
   PubMed Web of Science ®Google Scholar
• BanksWA.KastinAJ.BroadwellRD.Passage of cytokines across the blood-brain barrier.Neuroimmunomodulation.199522412488963753
   PubMed Web of Science ®Google Scholar
• WaguespackPJ.BanksWA.KastinAJ.lnterleukin-2 does not cross the blood-brain barrier by a saturable transport system.Brain Res Bull.1994341031098044683
   PubMed Web of Science ®Google Scholar
• ManessLM.KastinAJ.BanksWA.Relative contributions of a CVO and the microvascular bed to delivery of blood-borne IL-1 alpha to the brain.Am J Physiol.1998275(2, pt 1)E207E2129688620
   PubMedGoogle Scholar
• HashimotoM.IshikawaY.YokotaS.et al.Action site of circulating interleukin-1 on the rabbit brain.Brain Res.19915402172232054614
   PubMed Web of Science ®Google Scholar
• DavsonH.SegalMB.Physiology of the CSF and Blood-Brain Barriers. Boca Raton, Fla: CRC Press;1996
   Google Scholar
• GanongWF.Circumventricular organs: definition and role in the regulation of endocrine and autonomic function.Clin Exp Pharmacol Physiol.20002742242710831247
   PubMed Web of Science ®Google Scholar
• BlatteisCM.HalesJR.McKinleyMJ.FawcettAA.Role of the anteroventral third ventricle region in fever in sheep.Can J Physiol Pharmacol.198765125512603497700
   PubMed Web of Science ®Google Scholar
• BlatteisCM.BealerSL.HunterWS.LlanosQ.AhokasRA.MashburnTA Jr.Suppression of fever after lesions of the anteroventral third ventricle in guinea pigs.Brain Res Bull.1983115195266365250
   PubMed Web of Science ®Google Scholar
• LeeSC.DicksonDW.BrosnanCF.Interleukin-1, nitric oxide and reactive astrocytes.Brain Behav Immunol.19959345354
   PubMed Web of Science ®Google Scholar
• StittJT.Evidence for the involvement of the organum vasculosum laminae terminalis in the febrile response of rabbits and rats.J Physiol.19853685015114078749
   PubMed Web of Science ®Google Scholar
• EricssonA.AriasC.SawchenkoPE.Evidence for an intramedullary prostaglandin-dependent mechanism in the activation of stress-related neuroendocrine circuitry by intravenous interleukin-1.J Neurosci.199717716671799278551
   PubMed Web of Science ®Google Scholar
• QuanN.HerkenhamM.Connecting cytokines and brain: a review of current issues.Histol Histopathol.20021727328811813877
   PubMed Web of Science ®Google Scholar
• WatkinsLR.WiertelakEP.GoehlerLE.SmithKP.MartinD.MaierSF.Characterization of cytokine-induced hyperalgesia.Brain Res.199465415267982088
   PubMed Web of Science ®Google Scholar
• SehicE.BlatteisCM.Blockade of lipopolysaccharide-induced fever by subdiaphragmatic vagotomy in guinea pigs.Brain Res.19967261601668836556
   PubMed Web of Science ®Google Scholar
• FleshnerM.GoehlerLE.HermannJ.ReltonJK.MaierSF.WatkinsLR.Interleukin-1 beta induced corticosterone elevation and hypothalamic NE depletion is vagally mediated.Brain Res Bull.1995376056107670884
   PubMed Web of Science ®Google Scholar
• OppMR.TothLA.Somnogenic and pyrogenic effects of interleukin1beta and lipopolysaccharide in intact and vagotomized rats.Life Sci.1998629239369496715
   PubMed Web of Science ®Google Scholar
• Bret-DibatJL.BlutheRM.KentS.KelleyKW.DantzerR.Lipopolysaccharide and interleukin-1 depress food-motivated behavior in mice by a vagal-mediated mechanism.Brain Behav Immunol.19959242246
   PubMed Web of Science ®Google Scholar
• KonsmanJP.ParnetP.DantzerR.Cytokine-induced sickness behaviour: mechanisms and implications.Trends Neurosci.20022515415911852148
   PubMed Web of Science ®Google Scholar
• QuanN.WhitesideM.HerkenhamM.Time course and localization patterns of interleukin-1beta messenger RNA expression in brain and pituitary after peripheral administration of lipopolysaccharide.Neuroscience.1998832812939466417
   PubMed Web of Science ®Google Scholar
• VallieresL.RivestS.Regulation of the genes encoding interleukin-6, its receptor, and gp130 in the rat brain in response to the immune activator lipopolysaccharide and the proinflammatory cytokine interleukin-1 beta.J Neurochem.199769166816839326296
   PubMed Web of Science ®Google Scholar
• NadeauS.RivestS.Regulation of the gene encoding tumor necrosis factor alpha (TNF-alpha) in the rat brain and pituitary in response in different models of systemic immune challenge.J Neuropathol Exp Neurol.199958617710068315
   PubMed Web of Science ®Google Scholar
• QuanN.SundarSK.WeissJM.Induction of interleukin-1 in various brain regions after peripheral and central injections of lipopolysaccharide.J Neuroimmunol.1994491251348294551
   PubMed Web of Science ®Google Scholar
• EkM.EngblomD.SahaS.BlomqvistA.JakobssonPJ.Ericsson-DahlstrandA.Inflammatory response: pathway across the blood-brain barrier.Nature.200141043043111260702
   PubMed Web of Science ®Google Scholar
• MarkKS.TrickierWJ.MillerDW.Tumor necrosis factor-alpha induces cyclooxygenase-2 expression and prostaglandin release in brain microvessel endothelial cells.J Pharmacol Exp Ther.20012971051105811356928
   PubMed Web of Science ®Google Scholar
• JohnsonRW.von BorellE.Lipopolysaccharide-induced sickness behavior in pigs is inhibited by pretreatment with indomethacin.J Anim Sci.1994723093148157515
   PubMed Web of Science ®Google Scholar
• DunnAJ.SwiergielAH.The role of cyclooxygenases in endotoxin- and interleukin-1-induced hypophagia.Brain Behav immunol.200014141152
   PubMed Web of Science ®Google Scholar
• OehmichenM.DomaschD.WietholterH.Origin, proliferation, and fate of cerebrospinal fluid cells. A review on cerebrospinal fluid cell kinetics.J Neurol.19822271451506181221
   PubMed Web of Science ®Google Scholar
• HickeyWF.Migration of hematogenous cells through the blood-brain barrier and the initiation of CNS inflammation.Brain Pathol.19911971051669702
   PubMed Web of Science ®Google Scholar
• FreiK.PianiD.PfisterHW.FontanaA.Immune-mediated injury in bacterial meningitis.Int Rev Exp Pathol.199334(Pt B)1831928458712
   PubMedGoogle Scholar
• Del MaschioA.De LuigiA.Martin-PaduraI.et al.Leukocyte recruitment in the cerebrospinal fluid of mice with experimental meningitis is inhibited by an antibody to junctional adhesion molecule (JAM).J Exp Med.19991901351135610544206
   PubMed Web of Science ®Google Scholar
• BienvenuJ.MonneretG.FabienN.RevillardJP.The clinical usefulness of the measurement of cytokines.Clin Chem Lab Med.20003826728510928646
   PubMed Web of Science ®Google Scholar
• BakhietM.TjernlundA.MousaA.et al.RANTES promotes growth and survival of human first-trimester forebrain astrocytes.Nat Cell Biol.2001315015711175747
   PubMed Web of Science ®Google Scholar
• VankelecomH.MatthysP.DenefC.Involvement of nitric oxide in the interferon-gamma-induced inhibition of growth hormone and prolactin secretion in anterior pituitary cell cultures.Mol Cell Endocrinol.19971291571679202399
   PubMed Web of Science ®Google Scholar
• KamataM.HiguchiH.YoshimotoM.YoshidaK.ShimizuT.Effect of single intracerebroventricular injection of alpha-interferon on monoamine concentrations in the rat brain.Eur Neuropsychopharmacol.20001012913210706995
   PubMed Web of Science ®Google Scholar
• MorikawaO.SakaiN.ObaraH.SaitoN.Effects of interferon-alpha, interferon-gamma and cAMP on the transcriptional regulation of the serotonin transporter.Eur J Pharmacol.19983493173249671113
   PubMed Web of Science ®Google Scholar
• ShutoH.KataokaY.HorikawaT.FujiharaN.OishiR.Repeated interferon-alpha administration inhibits dopaminergic neural activity in the mouse brain.Brain Res.19977473483519046014
   PubMed Web of Science ®Google Scholar
• KatafuchiT.TakeS.HoriT.Roles of cytokines in the neural-immune interactions: modulation of NMDA responses by IFN-alpha.Neurobiology (Bp).199533193278696300
   PubMedGoogle Scholar
• NickolaTJ.IgnatowskiTA.ReynoldsJL.SpenglerRN.Antidepressant drug-induced alterations in neuron-localized tumor necrosis factor-alpha mRNA and alpha(2)-adrenergic receptor sensitivity.J Pharmacol Exp Ther.200129768068711303058
   PubMed Web of Science ®Google Scholar
• AndoT.DunnAJ.Mouse tumor necrosis factor-alpha increases brain tryptophan concentrations and norepinephrine metabolism while activating the HPA axis in mice.Neuroimmunomodulation.1999631932910474050
   PubMed Web of Science ®Google Scholar
• HayleyS.WallP.AnismanH.Sensitization to the neuroendocrine, central monoamine and behavioural effects of murine tumor necrosis factoralpha: peripheral and central mechanisms.Eur J Neurosci.2002151061107611918665
   PubMed Web of Science ®Google Scholar
• RamamoorthyS.RamamoorthyJD.PrasadPD.et al.Regulation of the human serotonin transporter by interleukin-1 beta.Biochem Biophys Res Commun.19952165605677488148
   PubMed Web of Science ®Google Scholar
• GemmaC.ImeriL.De SimoniMG.MandaM.Interleukin-1 induces changes in sleep, brain temperature, and serotonergic metabolism.Am J Physiol.1997272(2, Pt 2)R601R6069124484
   PubMedGoogle Scholar
• ImeriL.GemmaC.De SimoniMG.OppMR.MandaM.Hypothalamic serotonergic activity correlates better with brain temperature than with sleep-wake cycle and muscle tone in rats.Neuroscience.1999891241124610362311
   PubMed Web of Science ®Google Scholar
• OppMR.SmithEM.HughesTK Jr.Interleukin-10 (cytokine synthesis inhibitory factor) acts in the central nervous system of rats to reduce sleep.J Neuroimmunol.1995601651687642744
   PubMed Web of Science ®Google Scholar
• PetittoJM.McCarthyDB.RinkerCM.HuangZ.GettyT.Modulation of behavioral and neurochemical measures of forebrain dopamine function in mice by species-specific interleukin-2.J Neuroimmunol.1997731831909058775
   PubMed Web of Science ®Google Scholar
• HanischUK.QuirionR.Interleukin-2 as a neuroregulatory cytokine.Brain Res Brain Res Rev.1995212462848806016
   PubMedGoogle Scholar
• Van WagonerNJ.BenvenisteEN.Interleukin-6 expression and regulation in astrocytes.J Neuroimmunol.199910012413910695723
   PubMed Web of Science ®Google Scholar
• GadientRA.OttenUH.Interieukin-6 (IL-6)- a molecule with both beneficial and destructive potentials.Prog Neurobiol.1997523793909304698
   PubMed Web of Science ®Google Scholar
• SongC.MeraliZ.AnismanH.Variations of nucleus accumbens dopamine and serotonin following systemic interleukin-1, interleukin-2 or interleukin-6 treatment.Neuroscience.19998882383610363820
   PubMed Web of Science ®Google Scholar
• QiuZ.ParsonsKL.GruolDL.Interleukin-6 selectively enhances the intracellular calcium response to NMDA in developing CNS neurons.J Neurosci.199515668866997472429
   PubMed Web of Science ®Google Scholar
• QiuZ.SweeneyDD.NetzebandJG.GruolDL.Chronic interleukin-6 alters NMDA receptor-mediated membrane responses and enhances neurotoxicity in developing CNS neurons.J Neurosci.19981810445104569852582
   PubMed Web of Science ®Google Scholar
• WangJ.DunnAJ.The role of interleukin-6 in the activation of the hypothalamo-pituitary-adrenocortical axis and brain indoleamines by endotoxin and interleukin-1 beta.Brain Res.19998153373489878816
   PubMed Web of Science ®Google Scholar
• WangJ.DunnAJ.Mouse interleukin-6 stimulates the HPA axis and increases brain tryptophan and serotonin metabolism.Neurochem int.1998331431549761458
   PubMed Web of Science ®Google Scholar
• ZalcmanS.Green-JohnsonJM.MurrayL.et al.Cytokine-specific central monoamine alterations induced by interleukin-1, -2 and -6.Brain Res.199464340497518332
   PubMed Web of Science ®Google Scholar
• BarkhudaryanN.DunnAJ.Molecular mechanisms of actions of interieukin-6 on the brain, with special reference to serotonin and the hypothalamo-pituitary-adrenocortical axis.Neurochem Res.1999241169118010485589
   PubMed Web of Science ®Google Scholar
• KatsukiH.NakaiS.HiraiY.AkajiK.KisoY.SatohM.Interleukin-1 beta inhibits long-term potentiation in the CA3 region of mouse hippocampal slices.Eur J Pharmacol.19901813233262166677
   PubMed Web of Science ®Google Scholar
• BellingerFP.MadambaS.SigginsGR.Interleukin 1 beta inhibits synaptic strength and long-term potentiation in the rat CA1 hippocampus.Brain Res.19936282272348313151
   PubMed Web of Science ®Google Scholar
• BeattieEC.StellwagenD.MorishitaW.et al.Control of synaptic strength by glial TNFalpha.Science.20022952282228511910117
   PubMed Web of Science ®Google Scholar
• GibertiniM.Cytokines and cognitive behavior.Neuroimmunomodulation.199851601659730681
   PubMed Web of Science ®Google Scholar
• GibertiniM.NewtonC.FriedmanH.KleinTW.Spatial learning impairment in mice infected with Legionella pneumophila or administered exogenous interieukin-1-beta.Brain Behav immunol.19959113128
   PubMed Web of Science ®Google Scholar
• MellorAL.MunnDH.Tryptophan catabolism and T-cell tolerance: immunosuppression by starvation?Immunol Today.19992046947310500295
   PubMedGoogle Scholar
• MunnDH.ShafizadehE.AttwoodJT.BondarevI.PashineA.MellorAL.Inhibition of T cell proliferation by macrophage tryptophan catabolism.J Exp Med.19991891363137210224276
   PubMed Web of Science ®Google Scholar
• WeissG.MurrC.ZollerH.et al.Modulation of neopterin formation and tryptophan degradation by Th1- and Th2-derived cytokines in human monocytic cells.Clin Exp Immunol.199911643544010361231
   PubMed Web of Science ®Google Scholar
• AlberatiGD.RicciardiCP.KohlerC.CesuraAM.Regulation of the kynurenine metabolic pathway by interferon-gamma in murine cloned macrophages and microglial cells.J Neurochem.19966699610048769859
   PubMed Web of Science ®Google Scholar
• FarrarWL.KilianPL.RuffMR.HillJM.PertCB.Visualization and characterization of interleukin 1 receptors in brain.J Immunol.19871394594632955042
   PubMed Web of Science ®Google Scholar
• BrederCD.DinarelloCA.SaperCB.Interleukin-1 immunoreactive innervation of the human hypothalamus.Science.19882403213243258444
   PubMed Web of Science ®Google Scholar
• TaziA.DantzerR.CrestaniF.Le MoalM.Interleukin-1 induces conditioned taste aversion in rats: a possible explanation for its pituitary-adrenal stimulating activity.Brain Res.19884733693713266091
   PubMed Web of Science ®Google Scholar
• Plata-SalamanCR.OomuraY.KaiY.Tumor necrosis factor and interleukin-1 beta: suppression of food intake by direct action in the central nervous system.Brain Res.19884481061143260533
   PubMed Web of Science ®Google Scholar
• Van DamAM.BrounsM.LouisseS.BerkenboschF.Appearance of interleukin-1 in macrophages and in ramified microglia in the brain of endotoxin-treated rats: a pathway for the induction of non-specific symptoms of sickness?Brain Res.19925882912961393581
   PubMed Web of Science ®Google Scholar
• GattiS.BartfaiT.Induction of tumor necrosis factor-alpha mRNA in the brain after peripheral endotoxin treatment: comparison with interleukin-1 family and interleukin-6.Brain Res.19936242912948252403
   PubMed Web of Science ®Google Scholar
• LayeS.ParnetP.GoujonE.DantzerR.Peripheral administration of lipopolysaccharide induces the expression of cytokine transcripts in the brain and pituitary of mice.Brain Res Mol Brain Res.1994271571627877446
   PubMedGoogle Scholar
• DantzerR.Cytokine-induced sickness behavior: where do we stand?Brain Behav immunol.200115724
   PubMed Web of Science ®Google Scholar
• PapanicolaouDA.WilderRL.ManolagasSC.ChrousosGP.The pathophysiologic roles of interleukin-6 in human disease.Ann Intern Med.19981281271379441573
   PubMed Web of Science ®Google Scholar
• SchaeferM.EngelbrechtMA.GutO.et al.Interferon alpha (IFNalpha) and psychiatric syndromes: a review.Prog Neuropsychopharmacol Biol Psychiatry.20022673174612188106
   PubMed Web of Science ®Google Scholar
• CapuronL.RavaudA.NeveuPJ.MillerAH.MaesM.DantzerR.Association between decreased serum tryptophan concentrations and depressive symptoms in cancer patients undergoing cytokine therapy.Mol Psychiatry.2002746847312082564
   PubMed Web of Science ®Google Scholar
• LernerDM.StoudemireA.RosensteinDL.Neuropsychiatrie toxicity associated with cytokine therapies.Psychosomatics.19994042843510479948
   PubMed Web of Science ®Google Scholar
• FattovichG.GiustinaG.FavaratoS.RuolA.A survey of adverse events in 11 241 patients with chronic viral hepatitis treated with alfa interferon.J Hepatol.19962438478834023
   PubMed Web of Science ®Google Scholar
• DenicoffKD.RubinowDR.PapaMZ.et al.The neuropsychiatrie effects of treatment with interleukin-2 and lymphokine-activated killer cells.Ann Intern Med.19871072933003497595
   PubMed Web of Science ®Google Scholar
• ReichenbergA.YirmiyaR.SchuldA.et al.Cytokine-associated emotional and cognitive disturbances in humans.Arch Gen Psychiatry.20015844545211343523
   PubMed Web of Science ®Google Scholar
• SeidelA.AroltV.HunstigerM.RinkL.BehnischA.KirchnerH.Increased CD56+ natural killer cells and related cytokines in major depression.Clin Immunol Immunopathol.19967883858599889
   PubMedGoogle Scholar
• MaesM.ScharpeS.MeltzerHY.et al.Increased neopterin and interferon-gamma secretion and lower availability of L-tryptophan in major depression: further evidence for an immune response.Psychiatry Res.1994541431607761549
   PubMed Web of Science ®Google Scholar
• MaesM.VerkerkR.VandoolaegheE.et al.Serotonin-immune interactions in major depression: lower serum tryptophan as a marker of an immune-inflammatory response.Eur Arch Psychiatry Clin Neurosci.19972471541619224908
   PubMed Web of Science ®Google Scholar
• MaesM.SongC.LinAH.et al.Negative immunoregulatory effects of antidepressants: inhibition of interferon-gamma and stimulation of interieukin-10 secretion.Neuropsychopharmacology.19992037037910088138
   PubMed Web of Science ®Google Scholar
• MohrDC.GoodkinDE.IslarJ.HauserSL.GenainCP.Treatment of depression is associated with suppression of nonspecific and antigen-specific T(H)1 responses in multiple sclerosis.Arch Neurol.2001581081108611448297
   PubMed Web of Science ®Google Scholar
• MaesM.ScharpeS.MeltzerHY.et al.Relationships between interieukin-6 activity, acute phase proteins, and function of the hypothalamicpituitary-adrenal axis in severe depression.Psychiatry Res.19934911277511248
   PubMed Web of Science ®Google Scholar
• MaesM.MeltzerHY.BosmansE.et al.Increased plasma concentrations of interleukin-6, soluble interleukin-6, soluble interleukin-2 and transferrin receptor in major depression.J Affect Disord.1995343013098550956
   PubMed Web of Science ®Google Scholar
• SluzewskaA.RybakowskiJ.BosmansE.et al.Indicators of immune activation in major depression.Psychiatry Res.1996641611678944394
   PubMed Web of Science ®Google Scholar
• BerkM.WadeeAA.KuschkeRH.O'NeillKA.Acute phase proteins in major depression.J Psychosom Res.1997435295349394269
   PubMed Web of Science ®Google Scholar
• MaesM.BosmansE.De JonghR.KenisG.VandoolaegheE.NeelsH.Increased serum IL-6 and IL-1 receptor antagonist concentrations in major depression and treatment-resistant depression.Cytokine.199798538589367546
   PubMed Web of Science ®Google Scholar
• FrommbergerUH.BauerJ.HaselbauerP.FraulinA.RiemannD.BergerM.Interleukin-6 (IL-6) plasma levels in depression and schizophrenia: comparison between the acute state and after remission.Eur Arch Psychiatry Clin Neurosci.19972472282339332905
   PubMed Web of Science ®Google Scholar
• SongC.LinA.BonaccorsoS.et al.The inflammatory response system and the availability of plasma tryptophan in patients with primary sleep disorders and major depression.J Affect Disord.1998492112199629951
   PubMed Web of Science ®Google Scholar
• SmithRS.MaesM.The macrophage-T-lymphocyte theory of schizophrenia: additional evidence.Med Hypotheses.1995451351418531836
   PubMed Web of Science ®Google Scholar
• Plata-SalamanCR.Immunoregulators in the nervous system.Neurosci Biobehav Rev.1991151852151852312
   PubMed Web of Science ®Google Scholar
• RoyA.PickarD.PaulS.DoranA.ChrousosGP.GoldPW.CSF corticotropin-releasing hormone in depressed patients and normal control subjects.Am J Psychiatry.19871446416453495188
   PubMed Web of Science ®Google Scholar
• SalasMA.EvansSW.LevellMJ.WhicherJT.Interleukin-6 and ACTH act synergistically to stimulate the release of corticosterone from adrenal gland cells.Clin Exp immunol.1990794704732156641
   PubMed Web of Science ®Google Scholar
• LeMayLG.VanderAJ.KlugerMJ.The effects of psychological stress on plasma interleukin-6 activity in rats.Physiol Behav.1990479579612388952
   PubMed Web of Science ®Google Scholar
• ZhouD.KusnecovAW.ShurinMR.DePaoliM.RabinBS.Exposure to physical and psychological stressors elevates plasma interleukin 6: relationship to the activation of hypothalamic-pituitary-adrenal axis.Endocrinology.1993133252325308243274
   PubMed Web of Science ®Google Scholar
• MiyaharaS.KomoriT.FujiwaraR.et al.Effects of repeated stress on expression of interleukin-6 (IL-6) and IL-6 receptor mRNAs in rat hypothalamus and midbrain.Life Sci.200066L93L98
   Web of Science ®Google Scholar
• RothermundtM.AroltV.FenkerJ.GutbrodtH.PetersM.KirchnerH.Different immune patterns in melancholic and non-melancholic major depression.Eur Arch Psychiatry Clin Neurosci.2001251909711407444
   PubMed Web of Science ®Google Scholar
• LicinioJ.SeibyiJP.AltemusM.CharneyDS.KrystaiJH.Elevated CSF levels of interleukin-2 in neuroleptic-free schizophrenic patients.Am J Psychiatry.1993150140814108102512
   PubMed Web of Science ®Google Scholar
• McAllisterCG.van KammenDP.RehnTJ.et al.Increases in CSF levels of interleukin-2 in schizophrenia: effects of recurrence of psychosis and medication status.Am J Psychiatry.1995152129112977653683
   PubMed Web of Science ®Google Scholar
• RapaportMH.McAllisterCG.PickarD.TamarkinL.KirchDG.PaulSM.CSF IL-1 and IL-2 in medicated schizophrenic patients and normal volunteers.Schizophr Res.1997251231299187011
   PubMed Web of Science ®Google Scholar
• BarakV.BarakY.LevineJ.NismanB.RoismanI.Changes in interleukin-1 beta and soluble interleukin-2 receptor levels in CSF and serum of schizophrenic patients.J Basic Clin Physiol Pharmacol.1995661698562579
   PubMedGoogle Scholar
• el MallakhRS.SuddathRL.WyattRJ.Interieukin-1 alpha and interieukin-2 in cerebrospinal fluid of schizophrenic subjects.Prog Neuropsychopharmacol Biol Psychiatry.1993173833918475320
   PubMed Web of Science ®Google Scholar
• MittlemanBB.CastellanosFX.JacobsenLK.RapoportJL.SwedoSE.ShearerGM.Cerebrospinal fluid cytokines in pediatric neuropsychiatrie disease.J Immunol.1997159299429999300724
   PubMed Web of Science ®Google Scholar
• KimYK.KimL.LeeMS.Relationships between interleukins, neurotransmitters and psychopathology in drug-free male schizophrenics.Schizophr Res.20004416517510962218
   PubMed Web of Science ®Google Scholar
• TheodoropoulouSt.SpanakosG.BaxevanisCN.et al.Cytokine serum levels, autologous mixed lymphocyte reaction and surface marker analysis in never medicated and chronically medicated schizophrenic patients.Schizophr Res.2001471225
   Web of Science ®Google Scholar
• AroltV.RothermundtM.WandingerKP.KirchnerH.Decreased in vitro production of interferon-gamma and interleukin-2 in whole blood of patients with schizophrenia during treatment.Mol Psychiatry.2000515015810822342
   PubMed Web of Science ®Google Scholar
• KimYK.LeeMS.SuhKY.Decreased interleukin-2 production in Korean schizophrenic patients.Biol Psychiatry.1998437017049583005
   PubMed Web of Science ®Google Scholar
• GanguliR.BrarJS.SolomonW.ChengappaKN.RabinBS.Altered interleukin-2 production in schizophrenia: association between clinical state and autoantibody production.Psychiatry Res.1992441131231480677
   PubMed Web of Science ®Google Scholar
• YangZW.ChengappaKN.ShurinG.et al.An association between anti-hippocampal antibody concentration and lymphocyte production of IL-2 in patients with schizophrenia.Psychol Med.1994244494558084939
   PubMed Web of Science ®Google Scholar
• GanguliR.BrarJS.ChengappaKR.et al.Mitogen-stimulated interleukin-2 production in never-medicated, first-episode schizophrenic patients. The influence of age at onset and negative symptoms [see comments].Arch Gen Psychiatry.1995526686727632120
   PubMed Web of Science ®Google Scholar
• O'DonnellMC.CattsSV.WardPB.et al.Increased production of interieukin-2 (IL-2) but not soluble interleukin-2 receptors (slL-2R) in unmedicated patients with schizophrenia and schizophreniform disorder.Psychiatry Res.1996651711789029665
   PubMed Web of Science ®Google Scholar
• CazzulloCL.SacchettiE.GalluzzoA.et al.Cytokine profiles in drugnaive schizophrenic patients.Schizophr Res.20014729329811278147
   PubMed Web of Science ®Google Scholar
• HornbergM.AroltV.WilkeI.KruseA.KirchnerH.Production of interferons and lymphokines in leukocyte cultures of patients with schizophrenia.Schizophr Res.1995152372427543276
   PubMed Web of Science ®Google Scholar
• WilkeI.AroltV.RothermundtM.WeitzschC.HornbergM.KirchnerH.Investigations of cytokine production in whole blood cultures of paranoid and residual schizophrenic patients.Eur Arch Psychiatry Clin Neurosci.19962462792848863007
   PubMed Web of Science ®Google Scholar
• SongC.LinA.KenisG.BosmansE.MaesM.Immunosuppressive effects of clozapine and haloperidol: enhanced production of the interleukin-1 receptor antagonist.Schizophr Res.20004215716410742653
   PubMed Web of Science ®Google Scholar
• MaesM.BocchioCL.BignottiS.et al.Increased serum interleukin-8 and interleukin-10 in schizophrenic patients resistant to treatment with neuroleptics and the stimulatory effects of clozapine on serum leukemia inhibitory factor receptor.Schizophr Res.20025428129111950553
   PubMed Web of Science ®Google Scholar
• RothermundtM.AroltV.WeitzschC.EckhoffD.KirchnerH.Immunological dysfunction in schizophrenia: a systematic approach.Neuropsychobiology.1998371861939648126
   PubMed Web of Science ®Google Scholar
• CazzulloCL.ScaroneS.GrassiB.et al.Cytokine production in chronic schizophrenia patients with or without paranoid behaviour.Prog Neuropsychopharmacol Biol Psychiatry.1998229479579789879
   PubMed Web of Science ®Google Scholar
• RingheimGE.BurgherKL.HerouxJA.Interleukin-6 mRNA expression by cortical neurons in culture: evidence for neuronal sources of interleukin-6 production in the brain.J Neuroimmunol.1995631131238550808
   PubMed Web of Science ®Google Scholar
• GanguliR.YangZ.ShurinG.et al.Serum interleukin-6 concentration in schizophrenia: elevation associated with duration of illness.Psychiatry Res.1994511107910974
   PubMed Web of Science ®Google Scholar
• MaesM.BosmansE.CalabreseJ.SmithR.MeltzerHY.Interleukin-2 and interleukin-6 in schizophrenia and mania: effects of neuroleptics and mood stabilizers.J Psychiatr Res.1995291411527666381
   PubMed Web of Science ®Google Scholar
• NaudinJ.MegeJL.AzorinJM.DassaD.Elevated circulating levels of IL-6 in schizophrenia.Schizophr Res.1996202692738827853
   PubMed Web of Science ®Google Scholar
• LinA.KenisG.BignottiS.et al.The inflammatory response system in treatment-resistant schizophrenia: increased serum interleukin-6.Schizophr Res.1998329159690329
   PubMed Web of Science ®Google Scholar
• AkiyamaK.Serum levels of soluble IL-2 receptor alpha, IL-6 and IL-1 receptor antagonist in schizophrenia before and during neuroleptic administration.Schizophr Res.1999379710610227112
   PubMed Web of Science ®Google Scholar
• MaesM.BocchioCL.BignottiS.et al.Effects of atypical antipsychotics on the inflammatory response system in schizophrenic patients resistant to treatment with typical neuroleptics.Eur Neuropsychopharmacol.20001011912410706993
   PubMed Web of Science ®Google Scholar
• HaackM.HinzeSD.FenzelT.et al.Plasma levels of cytokines and soluble cytokine receptors in psychiatric patients upon hospital admission: effects of confounding factors and diagnosis.J Psych iatr Res.199933407418
   PubMed Web of Science ®Google Scholar
• MaesM.BosmansE.KenisG.De JongR.SmithRS.MeltzerHY.In vivo immunomodulatory effects of clozapine in schizophrenia.Schizophr Res.1997262212259323354
   PubMed Web of Science ®Google Scholar
• SchwarzMJ.ChiangS.MüllerN.AckenheilM.T-heiper-1 and T-heiper-2 responses in psychiatric disorders.Brain Behav Immunol.200115340370
   PubMed Web of Science ®Google Scholar
• SchwarzMJ.MullerN.RiedelM.AckenheilM.The Th2-hypothesis of schizophrenia: a strategy to identify a subgroup of schizophrenia caused by immune mechanisms.Med Hypotheses.20015648348611339852
   PubMed Web of Science ®Google Scholar
• NawaH.TakahashiM.PattersonPH.Cytokine and growth factor involvement in schizophrenia - support for the developmental model.Mol Psychiatry.2000559460311126390
   PubMed Web of Science ®Google Scholar
• The American College of Rheumatology nomenclature and case definitions for neuropsychiatrie lupus syndromes.Arthritis Rheum.19994259960810211873
   PubMed Web of Science ®Google Scholar
• MüllerN.RiedelM.ScheppachC.et al.Beneficial antipsychotic effects of celecoxib add-on therapy compared to risperidone alone in schizophrenia.Am J Psychiatry.20021591029103412042193
   PubMed Web of Science ®Google Scholar