430
Views
21
CrossRef citations to date
0
Altmetric
Free Paper

Functional genomics in postmortem human brain: abnormalities in a DISC1 molecular pathway in schizophrenia

Genómics funcional en el cerebro humano postmortem: alteraciones de la vía molecular DISC1 en la esquizofrenia

Génomique fonctionnelle dans le cerveau humain postmortem: anomalies d'une voie moléculaire DISC1 dans la schizophrénie

, , , , , & show all
Pages 353-357 | Published online: 01 Apr 2022

REFERENCES

  • KendlerKS.Overview: a current perspective on twin studies of schizophrenia.Am J Psychiatry.1983140141314256353948
  • TsuangMT.GilbertsonMW.FaraoneSV.et alThe genetics of schizophrenia. Current knowledge and future directions.Schizophr Res.199141571712039759
  • KendlerKS.McGuireM.GruenbergAM.WalshD.An epidemiologic, clinical, and family study of simple schizophrenia in County Roscommon, Ireland.Am J Psychiatry.199415127348267130
  • RischN.Linkage strategies for genetically complex traits. II. The power of affected relative pairs.Am J Hum Genet.1990462292412301393
  • St ClairD.BlackwoodD.MuirW.et alAssociation within a family of a balanced autosomal translocation with major mental illness.Lancet.199033613161973210
  • BlackwoodDH.FordyceA.WalkerMT.et alSchizophrenia and affective disorders-cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family.Am J Hum Genet.20016942843311443544
  • DevonRS.AndersonS.TeaguePW.et alIdentification of polymorphisms within Disrupted in Schizophrenia 1 and Disrupted in Schizophrenia 2, and an investigation of their association with schizophrenia and bipolar affective disorder.Psychiatr Genet.200111717811525420
  • EkelundJ.HovattaI.ParkerA.et alChromosome 1 loci in Finnish schizophrenia families.Hum Mol Genet.2001101611161711468279
  • Ekelundj.HennahW.HiekkalinnaT.et alReplication of 1q42 linkage in Finnish schizophrenia pedigrees.Mol Psychiatry.200491037104115197400
  • HennahW.VariloT.KestilaM.et alHaplotype transmission analysis provides evidence of association for DISC1 to schizophrenia and suggests sex-dependent effects.Hum Mol Genet.2003123151315914532331
  • HodgkinsonCA.GoldmanD.JaegerJ.et alDisrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder.Am J Hum Genet.20047586287215386212
  • CallicottJH.StraubRE.PezawasL.et alVariation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia.Proc Natl Acad Sci USA.20051028627863215939883
  • SchurovIL.HandfordEJ.BrandonNJ.WhitingBJ.Expression of disrupted in schizophrenia 1 (DISC1) protein in the adult and developing mouse brain indicates its role in neurodevelopment.Mol Psychiatry.200491100111015381924
  • MaL.LiuY.KyB.ShughruePJ.AustinCP.MorrisJA.Cloning and characterization of Disci, the mouse ortholog of DISC1 (Disrupted-inSchizophrenia 1).Genomics.20028066267212504857
  • OzekiY.TomodaT.KleiderleinJ.et alDisrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth.Proc Natl Acad Sci U S A.200310028929412506198
  • TaylorMS.DevonRS.MillarJK.PorteousDJ.Evolutionary constraints on the Disrupted in Schizophrenia locus.Genomics.200381677712573262
  • MorrisJA.KandpalG.MaL.AustinCP.DISC1 (Disrupted-ln-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.Hum Mol Genet.2003121591160812812986
  • MillarJK.JamesR.BrandonNJ.ThomsonPA. DISC1 and DISC2: discovering and dissecting molecular mechanisms underlying psychiatric illness.Ann Med.20043636737815478311
  • BrandonNJ.HandfordEJ.SchurovI.et alDisrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders.Mol Ceil Neurosci.2004254255
  • NiethammerMD.SmithS.AyalaR.et alNUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein.Neuron.20032869771111163260
  • SasakiS.ShionoyaA.IshidaM.GambelloMJ.et alA LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system.Neuron.20002868169611163259
  • SweeneyKJ.ProkschaA.EicheleG.NudE-L, a novel Lis1-interacting protein, belongs to a family of vertebrate coiled-coil proteins.Mech Dev.2001101213311231056
  • FengY.WalshCA.Mitotic spindle regulation by Nde1 controls cerebral cortical size.Neuron.20044427929315473967
  • NguyenMD.ShuT.SanadaK.et alA NUDEL-dependent mechanism of neurofilament assembly regulates the integrity of CNS neurons. WatCell Biol.20046595608
  • ShuT.AyalaR.NguyenMD.XieZ.GleesonJG.TsaiLH.Ndel! operates in a common pathway with LIS1 and cytoplasmic dynein to regulate cortical neuronal positioning.Neuron.20044426327715473966
  • BrandonNJ.SchurovI.CamargoLM.et alSubcellular targeting of DISC1 is dependent on a domain independent from the Nudel binding site.Mol Cell Neurosci.20052861362415797709
  • HayashiMA.PortaroFC.BastosMF.et alInhibition of NUDEL (nuclear distribution element-like)-oligopeptidase activity by disrupted-in-schizophrenia 1.Proc Natl Acad Sci US A.200510238283833
  • CacedaR.KinkeadB.NemeroffCB.Do neurotensin receptor agonists represent a novel class of antipsychotic drugs?Semin Clin Neuropsychiatry.200389410812728409
  • KinkeadB.NemeroffCB.The effects of typical and atypical antipsychotic drugs on neurotensin-containing neurons in the central nervous system. JClin Psychiatry.199455(suppl B)3032
  • SawamuraN.Sawamura-YamamotoT.OzekiY.RossCA.SawaA.A form of DISC1 enriched in nucleus: altered subcellular distribution in orbitofrontal cortex in psychosis and substance/alcohol abuse.Proc Natl Acad Sci U S A.20051021187119215657124
  • MiyoshiK.HondaA.BabaK.et alDisrupted-ln-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth.Mol Psychiatry.2003868569412874605
  • LewisCM.LevinsonDF.WiseLH.DeLisiLE.StraubRE.Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: schizophrenia.Am J Hum Genet.200373344812802786
  • YamadaK.NakamuraK.MinabeY.et alAssociation analysis of FEZ1 variants with schizophrenia in Japanese cohorts.Biol Psychiatry.20045668369015522253
  • LipskaBK.PetersT.HalimN.et alExpression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs.Hum Mol Gen.200651245121216510495