- InselTRScolnickEMCure therapeutics and strategic prevention: raising the bar for mental health research.Mol Psychiatry.200611111716355250
- National Institutes of Mental Health. Facts about NIMH. Available at: http://www.nimh. nih.gov/about/nimh.cfm. Accessed August 8. 2006
- RothBLShefflerDJKroezeWKMagic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia. WatRev Drug Discov.20043353359
- SpeddingMJayTCosta eSilva JPerretLA pathophysiological paradigm for the therapy of psychiatric disease.Nat Rev Drug Discov.2005446747615931256
- KaneJHonigfieldGSingerJMeltzerHYGroup atCCSClozapine for the treatment-resistant schizophrenic.Arch Gen Psychiatry.1988457897963046553
- McEvoyJPLiebermanJAStroupTSDavisSMMeltzerHYRosenheckRAet al.Effectiveness of clozapine versus olanzapine, quetiapine, and risperidone in patients with chronic schizophrenia who did not respond to prior atypical antipsychotic treatment.Am J Psychiatry.200616360061016585434
- VenterJCAdamsMDMyersEWLiPWMuralRJSuttonGGet al.The sequence of the human genome.Science.20012911304135111181995
- HarrisonPJWeinbergerDRSchizophrenia genes, gene expression, and neuropathology: on the matter of their convergence.Mol Psychiatry.200510406815263907
- InselTRCollinsFSPsychiatry in the genomics era.Am J Psychiatry.200316061662012668345
- SawaASnyderSHSchizophrenia: neural mechanisms for novel therapies.Mol Med.200393912765334
- HymanSENestlerEJInitiation and adaptation: a paradigm for understanding psychotropic drug action.Am J Psychiatry.19961531511628561194
- CarlssonMCarlssonASystems within the basal ganglia: implications for schizophrenia and Parkinson's disease.Trends Neurosci.1990132722761695402
- CarlssonAThe current status of the dopamine hypothesis of schizophrenia.Neuropsychopharmacology.198811791863075131
- MeltzerHYClinical studies on the mechanism of action of clozapine: the dopamine-serotonin hypothesis of schizophrenia.Psychopharmacology.198999S18S272682729
- JavittDCZukinSRRecent advances in the phencyclidine model of schizophrenia.Am J Psychiatry.1991148130113081654746
- FreedmanRAdlerLEBickfordPet al.Schizophrenia and nicotinic receptors.Harv Rev Psychiatry.199421791929384901
- FreedmanRCoonHMyles-WorsleyMet al.Linkage of a neurophysiological deficit in schizophrenia to a chromosome 1 5 locus.Proc Natl Acad SciUSA.199794587592
- FreedmanRHallMAdlerLELeonardSEvidence in postmortem brain tissue for decreased numbers of hippocampal nicotinic receptors in schizophrenia.Biol Psychiatry.19953822337548469
- MartinLFKemWRFreedmanRAlpha-7 nicotinic receptor agonists: potential new candidates for the treatment of schizophrenia.Psychopharmacology (Bert).20041745464
- NeubigRRSpeddingMKenakinTChristopoulosAInternational Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on terms and symbols in quantitative pharmacology.Pharmacol Rev.20035559760614657418
- MorphyRKayCRankovicZFrom magic bullets to designed multiple ligands.Drug DiscovToday.20049641651
- RecanatiniMPoluzziEMasettiMCavalliADe PontiFQT prolongation through hERG K(+) channel blockade: current knowledge and strategies for the early prediction during drug development.Med Res Rev.20042513316615389727
- RothmanRBBaumannMHSavageJERauserLMcBrideAHufeisenSJet al.Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications.Circulation.20001022836284111104741
- LessardEYessineMAHamelinBAO'HaraGLeBlancJTurgeonJInfluence of CYP2D6 activity on the disposition and cardiovascular toxicity of the antidepressant agent venlafaxine in humans.Pharmacogenetics.1999943544310780263
- HopkinsALGroomCRThe druggable genome.Nat Rev Drug Discov.2002172773012209152
- RussAPLampelSThe druggable genome: an update.Drug Discov Today.2005101607161016376820
- StefanssonHSigurdssonESteinthorsdottirVet al.Neuregulin 1 and susceptibility to schizophrenia.Am J Hum Genet.20027187789212145742
- StraubREJiangYMacLeanCJet al.Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia.Ami J Hum Genet.200271337348
- St ClairDBlackwoodDMuirWet al.Association within a family of a balanced autosomal translocation with major mental illness.Lancet.199033613161973210
- HarrisonPJOwenMJGenes for schizophrenia? Recent findings and their pathophysiological implications.Lancet.200336141741912573388
- VorthermsTARothBLReceptorome screening for CNS drug discovery.Drugs.20058491496
- ArmbrusterBNRothBLMining the receptorome.J Biol Chem.20052805129513215590622
- FliriAFLogingWTThadeioPFVolkmannRABiological spectra analysis: Linking biological activity profiles to molecular structure.Proc Natl Acad SciUSA.2005102261266
- KroezeWKHufeisenSJPopadakBAet al.H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs.Neuropsychopharmacology.20032851952612629531
- WirshingDAWirshingWCKysarLet al.Novel antipsychotics: comparison of weight gain liabilities.J Clin Psychiatry.1999603586310401912
- MorphyRRankovicZDesigned multiple ligands. An emerging drug discovery paradigm.J Med Chem.2005486523654316220969
- GeyerMAEllenbroekBAnimal behavior models of the mechanisms underlying antipsychotic atypicality.Prog Neuropsychopharmacol Biol Psychiatry.2003271071107914642967
- VartyGBBakshiVPGeyerMAM100907, a serotonin 5-HT2A receptor antagonist and putative antipsychotic, blocks dizocilpine-induced prepulse inhibition deficits in Sprague-Dawley and Wistar rats.Neuropsychopharmacology.19992031132110088132
- PotkinSGShipleyJBeraRet al.Clinical and PET Effects of M100907, a selective 5HT-2A receptor antagonist.Schizophr Res.200149242
- MeltzerHYArvanitisLBauerDReinWPlacebo-controlled evaluation of four novel compounds for the treatment of schizophrenia and schizoaffective disorder.Am J Psychiatry.200416197598415169685
- EllenbroekBAAnimal models in the genomic era: possibilities and limitations with special emphasis on schizophrenia.Behav Pharmacol.20031440941714501254
- CostaEChenYDavisJet al.REELIN and schizophrenia: a disease at the interface of the genome and the epigenome.Moi Interv.20022475714993361
- TremolizzoLCarboniGRuzickaWBet al.An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability.Proc Natl Acad Sci U S A.200299170951710012481028
- AbdolmalekyHMChengKHRussoAet al.Hypermethylation of the reelin (RELN) promoter in the brain of schizophrenic patients: a preliminary report.Am J Med Genet B Neuropsychiatr Genet.2005134606615717292
- GraysonDRJiaXChenYet al.Reelin promoter hypermethylation in schizophrenia.Proc Natl Acad Sci U S A.20051029341934615961543
- BergerGEWoodSMcGorryPDIncipient neurovulnerability and neuroprotection in early psychosis.Psychopharmacol Bull.2003377910114566217
- de HaanLBakkerJMOverview of neuropathological theories of schizophrenia: from degeneration to progressive developmental disorder.Psychopathology.2004371714988644
- McGlashanTHZipurskyRBPerkinsDet al.Randomized, double-blind trial of olanzapine versus placebo in patients prodromally symptomatic for psychosis.Am J Psychiatry.200616379079916648318
Open access
356
Views
12
CrossRef citations to date
0
Altmetric
Pharmacological Aspects
Contributions of molecular biology to antipsychotic drug discovery: promises fulfilled or unfulfilled?
Contribuciones de la biología molecular al descubrimiento de fármacos antipsicóticos: ¿promesas cumplidas o incumpiidas?
Apports de la biologie moléculaire à la dêcouwetle des médicaments antipsychotiques: promesses tenues ou non?
Bryan L. RothDepartments of Biochemistry, Psychiatry, Neurosciences, and Oncology, National Institute of Mental Health Psychoactive Drug Screening Program, Case Western Reserve University Medical School, Cleveland, Ohio, USA (Current affiliation: Departments of Pharmacology, Medicinal Chemistry and Natural Products, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA)Correspondence[email protected]
Pages 303-309
|
Published online: 01 Apr 2022
Related research
People also read lists articles that other readers of this article have read.
Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.
Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.