1,715
Views
27
CrossRef citations to date
0
Altmetric
Pharmacological Aspects

The effectiveness of anticonvulsants in psychiatric disorders

La efectividad de los anticonvulsivantes en los trastornos psiquiátricos

Efficacité des anticonvulsivants dans les troubles psychiatriques

REFERENCES

  • TurnerWJ.The usefulness of diphenylhydantoin in treatment of non-epileptic emotional disorders.Int J Neuropsychiatry.19673(suppl 2)8205587569
  • OkumaT.KishimotoA.InoueK.MatsumotoH.OguraA.Anti-manic and prophylactic effects of carbamazepine (Tegretol) on manic depressive psychosis. A preliminary report.Folia Psychiatr Neurol Jpn.1973272832974801623
  • LambertPA.VenaudG.Utilisation de valpromide en thérapeutique psychiatrique.L'encephale.19668367373
  • DunnerDL.Safety and tolerability of emerging pharmacological treatments for bipolar disorder.Bipolar Disord.2005730732516026484
  • PatsalosPN.SanderJW.Newer antiepileptic drugs. Towards an improved risk-benefit ratio.Drug Saf.19941137677917080
  • OnatF.OzkaraC.Adverse effects of new antiepileptic drugs.DrugsToday. 200440325342
  • FerrendelliJA.Concerns with antiepileptic drug initiation: safety, tolerability, and efficacy.Epilepsia.200142(suppl 4) 283011564122
  • RogawskiMA.LoscherW.The neurobiology of antiepileptic drugs for the treatment of nonepileptic conditions.Nat Med.20041068569215229516
  • DubovskySL.FranksRD.Intracellular calcium ions in affective disorders: a review and an hypothesis.Biol Psychiatry.1983187817976311292
  • MunroG.ErichsenHK.MirzaNR.Pharmacological comparison of anticonvulsant drugs in animal models of persistent pain and anxiety.Neuropharmacology.20075360961817714743
  • LöscherW.HönackD.Valproate and its major metabolite E-2-en-valproate induce different effects on behaviour and brain monoamine metabolism in rats.Eur J Pharmacol.199629961678901008
  • BiggsCS.PearceBR.FowlerLJ.WhittonPS.Regional effects of sodium valproate on extracellular concentrations of 5-hydroxytryptamine, dopamine, and their metabolites in the rat brain: an in vivo microdialysis study.J Neurochern.19925917021708
  • von WegererJ.BergerM.WaldenJ.Changes of serotonin-induced field potentials by lamotrigine.Epilepsia.199738(suppl 3)175176. Abstract.9048669
  • KasterMP.RauppI.BinfareRW.AndreatiniR.RodriguesAL.Antidepressant-like effect of lamotrigine in the mouse forced swimming test: evidence for the involvement of the noradrenergic system.Eur J Pharmacol.200756511912417433291
  • TringaliG.AubryJM.NavarraP.PozzoliG.Lamotrigine inhibits basal and Na+-stimulated, but not Ca2+-stimulated, release of corticotropinreleasing hormone from the rat hypothalamus.Psychopharmacology.200618838639216947017
  • MulaM.PiniS.CassanoGB.The role of anticonvulsant drugs in anxiety disorders: a critical review of the evidence.J Clin Psychopharmacol.20072726327217502773
  • ChenG.ManjiHK.The extracellular signal-regulated kinase pathway: an emerging promising target for mood stabilizers.Curr Opin Psychiatry.20061931332316612219
  • BachmannRF.SchloesserRJ.GouldTD.ManjiHK.Mood stabilizers target cellular plasticity and resilience cascades: implications for the development of novel therapeutics.Mol Neurobiol.20053217320216215281
  • ChenG.HuangLD.ZengWZ.ManjiHK.Mood stabilizers regulate cytoprotective and mRNA-binding proteins in the brain: long-term effects on cell survival and transcript stability.Int J Neuropsychopharmacol.20014476411343630
  • WilliamsRS.ChengL.MudgeAW.HarwoodAJ.A common mechanism of action for three mood-stabilizing drugs.Nature.200241729229512015604
  • ChenPS.PengGS.LiG.et al.Valproate protects dopaminergic neurons in midbrain neuron/glia cultures by stimulating the release of neurotrophic factors from astrocytes.Mol Psychiatry.2006111116112516969367
  • ShaltielG.ShamirA.ShapiroJ.DingD.DaltonE.BialerM.et al.Valproate decreases inositol biosynthesis.Biol Psychiatry.20045686887415576064
  • RaoJS.BazinetRP.RapoportSI.LeeHJ.Chronic treatment of rats with sodium valproate downregulates frontal cortex NF-kappaB DMA binding activity and COX-2 mRNA.Bipolar Disord.2007951352017680922
  • DuJ.QuirozJA.GrayN.SzaboS.ZarateCA.ManjiHK.Regulation of cellular plasticity and resilience by mood stabilizers: the role of AMPA receptor trafficking.Dialogues Clin Neurosci.2004614315522034247
  • RainnieDG.AsprodiniEK.ShinnickGP.Kindling-induced long-lasting changes in synaptic transmission in the basolateral amygdala.J Neurophysiol.1992674434541349037
  • PostRM.WeissSR.Kindling and stress sensitization. In: Young LT, Joffe RT, eds.Bipolar Disorder - Biological Models and their Clinical Application. New York, NY: Marcel Dekker199793126
  • PolycarpouA.PapanikolaouP.loannidisJP.Contopoulos-loannidisDG.Anticonvulsants for alcohol withdrawal.Cochrane Database Syst Rev.2005CD005064
  • ZullinoDF.KhazaalY.HattenschwilerJ.BorgeatF.BessonJ.Anticonvulsant drugs in the treatment of substance withdrawal.Drugs Today.20044060361915510234
  • KoetheD.JuelicherA.NoldenBM.et al.Oxcarbazepine - efficacy and tolerability during treatment of alcohol withdrawal: a double-blind, randomized, placebo-controlled multicenter pilot study.Alcohol Clin Exp Res.2007311188119417511748
  • LuchtM.KuehnKU.ArmbrusterJ.et al.Alcohol withdrawal treatment in intoxicated vs non-intoxicated patients: a controlled open-label study with tiapride/carbamazepine, clomethiazole and diazepam.Alcohol Alcohol.20033816817512634266
  • MartinottiG.DiNM.RomanelliR.et al.High and low dosage oxcarbazepine versus naltrexone for the prevention of relapse in alcohol-dependent patients.Hum Psychopharmacol.20072214915617397097
  • MyrickH.BradyKT.MalcolmR.Divalproex in the treatment of alcohol withdrawal.Am J Drug Alcohol Abuse.20002615516010718170
  • TressW.[Alcoholic withdrawal syndrome. Pathophysiological progress and therapeutic consequences].ZFA (Stuttgart).1980563633696768199
  • HillbomM.TokolaR.KuuselaV.et al.Prevention of alcohol withdrawal seizures with carbamazepine and valproic acid.Alcohol.198962232262500138
  • Mayo-SmithMF.Pharmacological management of alcohol withdrawal. A meta-analysis and evidence-based practice guideline. American Society of Addiction Medicine Working Group on Pharmacological Management of Alcohol Withdrawal.JAMA.19972781441519214531
  • MalcolmR.MyrickH.BradyKT.BallengerJC.Update on anticonvulsants for the treatment of alcohol withdrawal.Am J Addict.200110(suppl)162311268817
  • RubioG.PonceG.Jimenez-ArrieroMA.PalornoT.ManzanaresJ.FerreF.Effects of topiramate in the treatment of alcohol dependence.Pharmacopsychiatry.200437374014750047
  • MyrickH.AntonR.VoroninK.WangW.HendersonS.A double-blind evaluation of gabapentin on alcohol effects and drinking in a clinical laboratory paradigm.Alcohol Clin Exp Res.20073122122717250613
  • BonnetU.BangerM.LewekeFM.SpeckaM.MullerBW.HashemiT.et al.Treatment of acute alcohol withdrawal with gabapentin: results from a controlled two-center trial.J Clin Psychopharmacol.20032351451914520131
  • SalloumIM.CorneliusJR.DaleyDC.KirisciL.HimmelhochJM.ThaseME.Efficacy of valproate maintenance in patients with bipolar disorder and alcoholism: a double-blind placebo-controlled study.Arch Gen Psychiatry.200562374515630071
  • RubioG.Lopez-MunozF.AlamoC.Effects of lamotrigine in patients with bipolar disorder and alcohol dependence.Bipolar Disord.2006828929316696832
  • BallengerJC.PostRM.Carbamazepine in alcohol withdrawal syndromes and schizophrenic psychoses.Psychopharmacol Bull.1984205725846382378
  • KalyoncuA.MirsalH.PektasO.UnsalanN.TanD.BeyazyurekM.Use of lamotrigine to augment clozapine in patients with resistant schizophrenia and comorbid alcohol dependence: a potent anti-craving effect?J Psychopharmacol.20051930130515888516
  • SalloumIM.DouaihyA.CorneliusJR.KirisciL.KellyTM.HayesJ.Divalproex utility in bipolar disorder with co-occurring cocaine dependence: a pilot study.Addict Behav.20073241041516814474
  • BrownES.NejtekVA.PerantieDC.OrsulakPJ.BobadillaL.Lamotrigine in patients with bipolar disorder and cocaine dependence.J Clin Psychiatry.20036419720112633129
  • KampmanKM.PettinatiH.LynchKG.et al.A pilot trial of topiramate for the treatment of cocaine dependence.Drug Alcohol Depend.20047523324015283944
  • MalcolmRJ.GABA systems, benzodiazepines, and substance dependence.J Clin Psychiatry.200364(suppl 3)364012662132
  • ApeltS.EmrichHM.Sodium valproate in benzodiazepine withdrawal.Am J Psychiatry.19901479509512113360
  • RickelsK.SchweizerE.GarciaEF.CaseG.DeMartinisN.GreenblattD.Trazodone and valproate in patients discontinuing long-term benzodiazepine therapy: effects on withdrawal symptoms and taper outcome.Psychopharmacology.1999141159952057
  • DenisC.FatseasM.LavieE.AuriacombeM.Pharmacological interventions for benzodiazepine mono-dependence management in outpatient settings.Cochrane Database SystRev.20063:CD005194
  • Holtschmidt-TaschnerB.SoykaM.Hyponatremia-induced seizure during carbamazepine treatment.World J Biol Psychiatry.20078515317366352
  • MichopoulosI.DouzenisA.ChristodoulouC.LykourasL.Topiramate use in alprazolam addiction.World J Biol Psychiatry.2006726526717071548
  • KhazaalY.CornuzJ.BilancioniR.ZullinoDF.Topiramate for smoking cessation.Psychiatry Clin Neurosci.20066038438816732758
  • ReidMS.PalamarJ.RaghavanS.FlamminoF.Effects of topiramate on cue-induced cigarette craving and the response to a smoked cigarette in briefly abstinent smokers.Psychopharmacology.200719214715817345064
  • LipperS.DavidsonJR.GradyTA.et al.Preliminary study of carbamazepine in post-traumatic stress disorder.Psychosomatics.1986278498543543990
  • LooffD.GrimleyP.KullerF.MartinA.ShonfieldL.Carbamazepine for PTSD.J Am Acad Child Adolesc Psychiatry.1995347037047608041
  • WolfME.AlaviA.MosnaimAD.Posttraumatic stress disorder in Vietnam veterans clinical and EEG findings; possible therapeutic effects of carbamazepine.Biol Psychiatry.1988 3 15 236426443355879
  • UhdeTW.SteinMB.PostRM.Lack of efficacy of carbamazepine in the treatment of panic disorder.Am J Psychiatry.1988145110411093046381
  • BaetzM.BowenRC.Efficacy of divalproex sodium in patients with panic disorder and mood instability who have not responded to conventional therapy.Can J Psychiatry.19984373779494751
  • LumM.FontaineR.ElieR.Divalproex sodium's antipanic effect in panic disorder. A placebo-controlled study.Biol Psychiatry.199027279
  • KeckPE.TaylorVE.TugrulKC.McElroySL.BennettJA.Valproate treatment of panic disorder and lactate-induced panic attacks.Biol Psychiatry.1993 4 1 335425468513040
  • ClarkRD.CaniveJM.CalaisLA.QuallsCR.TuasonVB.Divalproex in posttraumatic stress disorder: an open-label clinical trial.J Trauma Stress.19991239540110378177
  • HertzbergMA.ButterfieldMl.FeldmanME.et al.A preliminary study of lamotrigine for the treatment of posttraumatic stress disorder.Biol Psychiatry.1999451226122910331117
  • TuckerP.TrautmanRP.WyattDB.ThompsonJ.WuSC.CapeceJA.et al.Efficacy and safety of topiramate monotherapy in civilian posttraumatic stress disorder: a randomized, double-blind, placebo-controlled study.J Clin Psychiatry.20076820120617335317
  • ZwanzgerP.RupprechtR.Selective GABAergic treatment for panic? Investigations in experimental panic induction and panic disorder.J Psychiatry Neurosci.20053016717515944741
  • PollackMH.Roy-ByrnePP.VanAM.et al.The selective GABA reuptake inhibitor tiagabine for the treatment of generalized anxiety disorder: results of a placebo-controlled study.J Clin Psychiatry.2005661401140816420077
  • PandeAC.PollackMH.CrockattJ.et al.Placebo-controlled study of gabapentin treatment of panic disorder.J Clin Psychopharmacol.20002046747110917408
  • PandeAC.DavidsonJR.JeffersonJW.et al.Treatment of social phobia with gabapentin: a placebo-controlled study.J Clin Psychopharmacol.19991934134810440462
  • PandeAC.CrockattJG.FeltnerDE.et al.Pregabalin in generalized anxiety disorder: a placebo-controlled trial.Am J Psychiatry.200316053345012611835
  • FeltnerDE.CrockattJG.DubovskySJ.et al.A randomized, doubleblind, placebo-controlled, fixed-dose, multicenter study of pregabalin in patients with generalized anxiety disorder.J Clin Psychopharmacol.20032324024912826986
  • RickelsK.PollackMH.FeltnerDE.et al.Pregabalin for treatment of generalized anxiety disorder: a 4-week, multicenter, double-blind, placebocontrolled trial of pregabalin and alprazolam.Arch Gen Psychiatry.2005621022103016143734
  • PohlRB.FeltnerDE.FieveRR.PandeAC.Efficacy of pregabalin in the treatment of generalized anxiety disorder: double-blind, placebo-controlled comparison of BID versus TID dosing.J Clin Psychopharmacol.20052515115815738746
  • MontgomerySA.TobiasK.ZornbergGL.KasperS.PandeAC.Efficacy and safety of pregabalin in the treatment of generalized anxiety disorder: a 6-week, multicenter, randomized, double-blind, placebo-controlled comparison of pregabalin and venlafaxine.J Clin Psychiatry.20066777178216841627
  • PandeAC.FeltnerDE.JeffersonJW.et al.Efficacy of the novel anxiolytic pregabalin in social anxiety disorder: a placebo-controlled, multicenter study.J Clin Psychopharmacol.20042414114915206660
  • BechP.Dose-response relationship of pregabalin in patients with generalized anxiety disorder. A pooled analysis of four placebo-controlled trials.Pharmacopsychiatry.20074016316817694480
  • LindenmayerJP.KotsaftisA.Use of sodium valproate in violent and aggressive behaviors: a critical review.J Clin Psychiatry.20006112312810732659
  • PorsteinssonAP.Divalproex sodium for the treatment of behavioural problems associated with dementia in the elderly.Drugs Aging.20062387788617109566
  • DevarajanS.DursunSM.Aggression in dementia with lamotrigine treatment.Am J Psychiatry.2000157117810873935
  • RoaneDM.FeinbergTE.MecklerL.MinerCR.ScicutellaA.RosenthalRN.Treatment of dementia-associated agitation with gabapentin.J Neuropsychiatry Clin Neurosci.200012404310678511
  • KyomenHH.WhitfieldTH.BaldessariniRJ.Levetiracetam for manic behavior in hospitalized geriatric patients with dementia of the Alzheimer's type.J Clin Psychopharmacol.20072740841017632234
  • EttingerAB.ArgoffCE.Use of antiepileptic drugs for nonepileptic conditions: psychiatric disorders and chronic pain.Neurotherapeutics.20074758317199018
  • OlpeHR.JonesRS.The action of anticonvulsant drugs on the firing of locus coeruleus neurons: selective, activating effect of carbamazepine.Eur J Pharmacol.1983911071106617734
  • BourinM.MasseF.HascoetM.Evidence for the activity of lamotrigine at 5-HT1 A receptors in the mouse forced swimming test.J Psychiatry Neurosci.20053027528216049571
  • ShiahIS.YathamLN.LamRW.ZisAP.Effects of divalproex sodium on 5-HT1 A receptor function in healthy human males: hypothermic, hormonal, and behavioral responses to ipsapirone.Neuropsychopharmacology.1997173823909397426
  • JobePC.DaileyJW.WernickeJF.A noradrenergic and serotonergic hypothesis of the linkage between epilepsy and affective disorders.Crit Rev Neurobiol.19991331735611028680
  • FinnerupNB.OttoM.JensenTS.SindrupSH.An evidence-based algorithm for the treatment of neuropathic pain.Med Gen Med.2007936
  • DworkinRH.O'ConnorAB.BackonjaM.et al.Pharmacologic management of neuropathic pain: Evidence-based recommendations.Pain.200713223725117920770
  • TassoneDM.BoyceE.GuyerJ.NuzumD.Pregabalin: a novel gamrnaaminobutyricacid analogue in the treatment of neuropathic pain, partialonset seizures, and anxiety disorders.Clin Ther.200729264817379045
  • BackonjaM.BeydounA.EdwardsKR.et al.Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus:a randomized controlled trial.JAMA.1998280183118169846777
  • BoneM.CritchleyP.BuggyDJ.Gabapentin in postamputation phantom limb pain: a randomized, double-blind, placebo-controlled, cross-over study.Reg Anesth Pain Med.20022748148612373695
  • CaraceniA.ZeccaE.BonezziC.et al.Gabapentin for neuropathic cancer pain: a randomized controlled trial from the Gabapentin Cancer Pain Study Group.J Clin Oncol.2004222909291715254060
  • GorsonKC.SchottC.HermanR.RopperAH.RandWM.Gabapentin in the treatment of painful diabetic neuropathy: a placebo controlled, double blind, crossover trial.J Neurol Neurosurg Psychiatry.19996625125210071116
  • LevendogluF.OgunCO.OzerbilO.OgunTC.UgurluH.Gabapentin is a first line drug for the treatment of neuropathic pain in spinal cord injury.Spine.20042974357115087796
  • PandeyCK.BoseN.GargG.SinghN.BaroniaA.AgarwalA.et al.Gabapentin for the treatment of pain in Guillain-barre syndrome: a double-blinded, placebo-controlled, crossover study.Anesth Analg.2002951719172312456446
  • RiceAS.MatonS.Gabapentin in postherpetic neuralgia: a randomised, double blind, placebo controlled study.Pain.20019421522411690735
  • RowbothamM.HardenN.StaceyB.BernsteinP.Magnus-MillerL.Gabapentin for the treatment of postherpetic neuralgia: a randomized controlled trial.JAMA.1998280183718429846778
  • SerpellMG.Gabapentin in neuropathic pain syndromes: a randomised, double-blind, placebo-controlled trial.Pain.20029955756612406532
  • TaiQ.KirshblumS.ChenB.MillisS.JohnstonM.DeLisaJA.Gabapentin in the treatment of neuropathic pain after spinal cord injury: a prospective, randomized, double-blind, crossover trial.J Spinal Cord Med.20022510010512137213
  • DworkinRH.CorbinAE.YoungJP.et al..Pregabalin for the treatment of postherpetic neuralgia: a randomized, placebo-controlled trial.Neurology.2003601274128312707429
  • SabatowskiR.GalvezR.CherryDA.et al.Pregabalin reduces pain and improves sleep and mood disturbances in patients with postherpetic neuralgia: results of a randomised, placebo-controlled clinical trial.Pain.2004109263515082123
  • vanSR.FeisterHA.YoungJP.Jr.Stoker M, Versavel M, Rigaudy L. Efficacy and tolerability of twice-daily pregabalin for treating pain and related sleep interference in postherpetic neuralgia: a 13-week, randomized trial.Curr Med Res Opin.20062237538416466610
  • FreynhagenR.StrojekK.GriesingT.WhalenE.BalkenohlM.Efficacy of pregabalin in neuropathic pain evaluated in a 12-week, randomised, double-blind, multicentre, placebo-controlled trial of flexible- and fixeddose regimens.Pain.200511525426315911152
  • LesserH.SharmaU.LaMoreauxL.PooleRM.Pregabalin relieves symptoms of painful diabetic neuropathy: a randomized controlled trial.Neurology.2004632104211015596757
  • RichterRW.PortenoyR.SharmaU.LaMoreauxL.BockbraderH.KnappLE.Relief of painful diabetic peripheral neuropathy with pregabalin: a randomized, placebo-controlled trial.J Pain.2005625326015820913
  • RosenstockJ.TuchmanM.LaMoreauxL.SharmaU.Pregabalin for the treatment of painful diabetic peripheral neuropathy: a double-blind, placebo-controlled trial.Pain.200411062863815288403
  • SiddallPJ.CousinsMJ.OtteA.GriesingT.ChambersR.MurphyTK.Pregabalin in central neuropathic pain associated with spinal cord injury: a placebo-controlled trial.Neurology.2006671792180017130411
  • GrantSM.FauldsD.Oxcarbazepine. A review of its pharmacology and therapeutic potential in epilepsy, trigeminal neuralgia and affective disorders.Drugs.1992438738881379159
  • WiffenPJ.McQuayHJ.MooreRA.Carbamazepine for acute and chronic pain.Cochrane Database Syst Rev.2005CD005451
  • FinnerupNB.OttoM.McQuayHJ.JensenTS.SindrupSH.Algorithm for neuropathic pain treatment: an evidence based proposal.Pain.200511828930516213659
  • ChronicleE.MullenersW.Anticonvulsant drugs for migraine prophylaxis.Cochrane Database Syst Rev.2004CD003226
  • VinikAI.TuchmanM.SafirsteinB.et al.Lamotrigine for treatment of pain associated with diabetic neuropathy: results of two randomized, double-blind, placebo-controlled studies.Pain.200712816917917161535
  • SilverM.BlumD.GraingerJ.HammerAE.QuessyS.Double-blind, placebo-controlled trial of lamotrigine in combination with other medications for neuropathic pain.J Pain Symptom Manage.20073444645417662571
  • BrandesJL.SaperJR.DiamondM.et al.Topiramate for migraine prevention: a randomized controlled trial.JAMA.200429196597314982912
  • SilbersteinSD.LiptonRB.DodickDW.et al.Efficacy and safety of topiramate for the treatment of chronic migraine: a randomized, double-blind, placebo-controlled trial.Headache.20074717018017300356
  • DienerHC.BussoneG.Van OeneJC.LahayeM.SchwalenS.GoadsbyPJ.Topiramate reduces headache days in chronic migraine: a randomized, double-blind, placebo-controlled study.Cephalalgia.20072781482317441971
  • SilbersteinSD.NetoW.SchmittJ.JacobsD.Topiramate in migraine prevention: results of a large controlled trial.Arch Neurol.20046149049515096395
  • WinnerP.PearlmanEM.LinderSL.JordanDM.FisherAC.HulihanJ.Topiramate for migraine prevention in children: a randomized, doubleblind, placebo-controlled trial.Headache2005451304131216324162
  • MorinigoA.MartinJ.GonzalezS.MateoI.Treatment of resistant schizophrenia with valproate and neuroleptic drugs.Hillside J Clin Psychiatry.1989111992072577309
  • SimhandlC.MeszarosK.DenkE.ThauK.TopitzA.Adjunctive carbamazepine or lithium carbonate in therapy-resistant chronic schizophrenia.Can J Psychiatry.1996413178793154
  • HesslingerB.NormannC.LangoschJM.KloseP.BergerM.WaldenJ.Effects of carbamazepine and valproate on haloperidol plasma levels and on psychopathologic outcome in schizophrenic patients.J Clin Psychopharmacol.19991931031510440457
  • LeuchtS.KisslingW.McGrathJ.WhiteP.Carbamazepine for schizophrenia.Cochrane Database Syst Rev.2007CD001258
  • SajatovicM.CoconceaN.IgnacioRV.et al.Adjunct extended-release valproate semisodium in late life schizophrenia.Int J Geriatr Psychiatry.20082314214717582828
  • WassefAA.DottSG.HarrisA.BrownA.O'BoyleM.MeyerWJ.IIIet al.Randomized, placebo-controlled pilot study of divalproex sodium in the treatment of acute exacerbations of chronic schizophrenia.J Clin Psychopharmacol.200020357361 10831024
  • CaseyDE.DanielDG.WassefAA.TracyKA.WozniakP.SommervilleKW.Effect of divalproex combined with olanzapine or risperidone in patients with an acute exacerbation of schizophrenia.Neuropsychopharmacology.20032818219212496955
  • BasanA.KisslingW.LeuchtS.Valproate as an adjunct to antipsychotics for schizophrenia: a systematic review of randomized trials.Schizophr Res.200470333715246461
  • GrunzeHC.RainnieDG.HasselmoME.et al.NMDA-dependent modulation of CA1 local circuit inhibition.J Neurosci.199616203420438604048
  • AnandA.CharneyDS.OrenDA.et al.Attenuation of the neuropsychiatrie effects of ketamine with lamotrigine: support for hyperglutamatergic effects of N-methyl-D-aspartate receptor antagonists.Arch Gen Psychiatry.20005727027610711913
  • TiihonenJ.HallikainenT.RyynanenOP.et al.Lamotrigine in treatmentresistant schizophrenia: a randomized placebo-controlled crossover trial.Biol Psychiatry.2003541241124814643092
  • ZoccaliR.MuscatelloMR.BrunoA.et al.The effect of lamotrigine augmentation of clozapine in a sample of treatment-resistant schizophrenic patients: a double-blind, placebo-controlled studySchizophr Res.20079310911617383857
  • KremerI.VassA.GorelikI.et al.Placebo-controlled trial of lamotrigine added to conventional and atypical antipsychotics in schizophrenia.Biol Psychiatry.20045644144615364042
  • PremkumarTS.PickJ.Lamotrigine for schizophrenia.Cochrane Database Syst Rev.2006CD005962
  • TiihonenJ.HalonenP.WahlbeckK.et al.Topiramate add-on in treatment-resistant schizophrenia: a randomized, double-blind, placebo-controlled, crossover trial.J Clin Psychiatry.2005661012102516086616
  • HurleySC.Lamotrigine update and its use in mood disorders.Ann Pharmacother.20023686087311978166
  • GutierrezRL.McKercherRM.GaleaJ.JamisonKL.Lamotrigine augmentation strategy for patients with treatment-resistant depression.CNS Spectr.20051080080516400242
  • GabrielA.Lamotrigine adjunctive treatment in resistant unipolar depression: an open, descriptive study.Depress Anxiety.20062348548816845646
  • SchindlerF.AnghelescuIG.Lithium versus lamotrigine augmentation in treatment resistant unipolar depression: a randomized, open-label studyInt Clin Psychopharmacol.20072217918217414745
  • NormannC.HummelB.ScharerLO.HornM.GrunzeH.WaldenJ.Lamotrigine as adjunct to paroxetine in acute depression: a placebo-controlled, double-blind study.J Clin Psychiatry.20026333734412000208
  • BarbosaL.BerkM.VorsterM.A double-blind, randomized, placebocontrolled trial of augmentation with lamotrigine or placebo in patients concomitantly treated with fluoxetine for resistant major depressive episodes.J Clin Psychiatry.20036440340712716240
  • NickelC.LahmannC.TrittK.et al.Topiramate in treatment of depressive and anger symptoms in female depressive patients: a randomized, double-blind, placebo-controlled study.J Affect Disord.20058724325215985295
  • De la FuenteJM.MendlewiczJ.Carbamazepine addition in tricyclic antidepressant-resistant unipolar depression.Biol Psychiatry.1992323693741420651
  • OtaniK.YasuiN.KanekoS.OhkuboT.OsanaiT.SugawaraK.Carbamazepine augmentation therapy in three patients with trazodoneresistant unipolar depression.Int Clin Psychopharmacol.19961155758732315
  • SteinacherL.VandelP.ZullinoDF.EapCB.Brawand-AmeyM.BaumannP.Carbamazepine augmentation in depressive patients non-responding to citalopram: a pharmacokinetic and clinical pilot study.Eur Neuropsychopharmacology:200212255260
  • PostRM.UhdeTW.Roy-ByrnePP.JoffeRT.Antidepressant effects of carbamazepine.Am J Psychiatry.198614329343510572
  • StuppaeckCH.BarnasC.SchwitzerJ.FleischhackerWW.Carbamazepine in the prophylaxis of major depression: a 5-year follow-up.J Clin Psychiatry.1994551461508071258
  • DavisLL.KabelD.PatelD.et al.Valproate as an antidepressant in major depressive disorder.Psychopharmacol Bull.1996326476528993086
  • DebattistaC.SolomonA.ArnowB.KendrickE.TilstonJ.SchatzbergAF.The efficacy of divalproex sodium in the treatment of agitation associated with major depression.J Clin Psychopharmacol.20052547647916160625
  • NemetsB.BersudskyY.BelmakerRH.Controlled double-blind trial of phenytoin vs. fluoxetine in major depressive disorder.J Clin Psychiatry.20056658659015889944
  • KachkovskiiMA.KriukovNN.[Treatment of depression in patients with myocardial infarction with tianeptine].Kardiologiia.200646212616858350
  • WeislerRH.HirschfeldR.CutlerAJ.et al.Extended-release carbamazepine capsules as monotherapy in bipolar disorder: pooled results from two randomised, double-blind, placebo-controlled trials.CNS Drugs.20062021923116529527
  • SmithLA.CorneliusV.WarnockA.BellA.YoungAH.Effectiveness of mood stabilizers and antipsychotics in the maintenance phase of bipolar disorder: a systematic review of randomized controlled trials.Bipolar Disord.2007939441217547586
  • GreilW.Ludwig-MayerhoferW.ErazoN.et al.Lithium versus carbamazepine in the maintenance treatment of bipolar disorders - a randomised study.J Affect Disord.1997431511619165384
  • HartongEG.MolemanP.HoogduinCA.BroekmanTG.NolenWA.Prophylactic efficacy of lithium versus carbamazepine in treatment-naive bipolar patients.J Clin Psychiatry.200364144151 12633122
  • GreilW.KleindienstN.ErazoN.Müller-OerlinghausenB.Differential response to lithium and carbamazepine in the prophylaxis of bipolar disorder.J Clin Psychopharmacol.1998184554609864077
  • DenicoffKD.Smith-JacksonEE.DisneyER.AliSO.LeverichGS.PostRM.Comparative prophylactic efficacy of lithium, carbamazepine, and the combination in bipolar disorder.J Clin Psychiatry.1997584704789413412
  • PopeHG.McElroySL.KeckPE.HudsonJl.Valproate in the treatment of acute mania. A placebo-controlled study.Arch Gen Psychiatry.19914862681984763
  • BowdenCL.BruggerAM.SwannAC.et al.Efficacy of divalproex vs lithium and placebo in the treatment of mania. The Depakote Mania Study Group.JAMA.19942719189248120960
  • Müller-OerlinghausenB.RetzowA.HennF.GiedkeH.WaldenJ.Valproate as an adjunct to neuroleptic medication for the treatment of acute episodes of mania. A prospective, randomized, double- blind, placebo-controlled multicenter studyJ Clin Psychopharmacol.20002019520310770458
  • BowdenCL.SwannAC.CalabreseJR.RubenfaerLM.WozniakPJ.CollinsMA.et al.A randomized, placebo-controlled, multicenter study of divalproex sodium extended release in the treatment of acute mania.J Clin Psychiatry.2006671501151017107240
  • SwannAC.BowdenCL.MorrisD.et al.Depression during mania. Treatment response to lithium or divalproex.Arch Gen Psychiatry.19975437429006398
  • DavisLL.BartolucciA.PettyF.Divalproex in the treatment of bipolar depression: a placebo-controlled study.J Affect Disord.20058525966615780695
  • MishoryA.YaroslavskyY.BersudskyY.BelmakerRH.Phenytoin as an antimanic anticonvulsant: a controlled study.Am J Psychiatry.200015746346510698828
  • MishoryA.WinokurM.BersudskyY.Prophylactic effect of phenytoin in bipolar disorder: a controlled study.Bipolar Disord.2003546446714636372
  • BersudskyY.Phenytoin: an anti-bipolar anticonvulsant?Int J Neuropsychopharmacol.20069479478416202184
  • GallagherP.ReidKS.WatsonS.Phenytoin, an anti-bipolar anticonvulsant: a potential anti-glucocorticoid mechanism?Int J Neuropsychopharmacol.2006962762816426479
  • CalabreseJR.BowdenCL.SachsGS.et al.A double-blind placebo-controlled study of lamotrigine monotherapy in outpatients with bipolar I depression.J Clin Psychiatry.199960798810084633
  • SchafferA.ZukerP.LevittA.Randomized, double-blind pilot trial comparing lamotrigine versus citalopram for the treatment of bipolar depression.J Affect Disord.200696959916820213
  • BrownEB.McElroySL.KeckPE.Jr.et al.A 7-week, randomized, double-blind trial of olanzapine/fluoxetine combination versus lamotrigine in the treatment of bipolar l depression.J Clin Psychiatry.2006671025103316889444
  • NolenWA.KupkaRW.HellemannG.et al.Tranylcypromine vs. lamotrigine in the treatment of refractory bipolar depression: a failed but clinically useful study. ArraPsychiatr Scand.2007115360365
  • BowdenCL.CalabreseJR.SachsG.et al.A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently manic or hypomanic patients with bipolar I disorder.Arch Gen Psychiatry.20036039240012695317
  • CalabreseJ.BowdenCL.SachsG.et al.A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently depressed patients with bipolar I disorder.J Clin Psychiatry.2003641024
  • GoodwinGM.BowdenCL.CalabreseJR.et al.A pooled analysis of two placebo-controlled 18-month trials of lamotrigine and lithium maintenance in Bipolar I disorder.J Clin Psychiatry.2004 6543244115096085
  • EmrichHM.Studies with Oxcarbazepine (Trileptal) in acute maniaInt Clin Psychopharmacol.19905(suppl 1)83881696292
  • HummelB.WaldenJ.StampferR.et al.Acute antimanic efficacy and safety of oxcarbazepine in an open trial with an oOn-off-on design.Bipolar Disord.2002441241712519102
  • SuppesT.KellyDl.HynanLS.et al.Comparison of two anticonvulsants in a randomized, single-blind treatment of hypomanic symptoms in patients with bipolar disorder.Aust N Z J Psychiatry.20074139740217464731
  • WagnerKD.KowatchRA.EmslieGJ.et al.A double-blind, randomized, placebo-controlled trial of oxcarbazepine in the treatment of bipolar disorder in children and adolescents.Am J Psychiatry.20061631179118616816222
  • PandeAC.CrockattJG.JanneyCA.WerthJL.TsarouchaG.Gabapentin in bipolar disorder: a placebo-controlled trial of adjunctive therapy. Gabapentin Bipolar Disorder Study Group.Bipolar Disord.2000224925511249802
  • FryeM.KetterT.KimbrellTA.et al.A placebo controlled study of lamotrigine and gabapentin monotherapy in refractory mood disorders.J Clin Psychopharmacol.20002060761411106131
  • WangPW.SantosaC.SchumacherM.WinsbergME.StrongC.KetterTA.Gabapentin augmentation therapy in bipolar depression.Bipolar Disord.2002429630112479661
  • AltshulerLL.KeckPE.McElroySL.et al.Gabapentin in the acute treatment of refractory bipolar disorder.Bipolar Disord.19991616511256659
  • VietaE.ManuelGJ.Martinez-AranA.et al.A double-blind, randomized, placebo-controlled, prophylaxis study of adjunctive gabapentin for bipolar disorder.J Clin Psychiatry.20066747347716649836
  • GoldbergJF.BurdickKE.Levetiracetam for acute mania.Am J Psychiatry.200215914811772709
  • GrunzeH.LangoschJ.BornC.SchaubG.WaldenJ.Levetiracetam in the treatment of acute mania: an open add-on study with an on-off-on design.J Clin Psychiatry.20036478178412934978
  • MuralidharanA.BhagwagarZ.Potential of levetiracetam in mood disorders: a preliminary review.CNS Drugs.20062096997917140277
  • SuppesT.ChisholmK.DhavaleD.et al.Tiagabine in treatment refractory bipolar disorder: a clinical case series.Bipolar Disord.2002428328912479659
  • GrunzeH.ErfurthA.MarcuseA.AmannB.NormannC.WaldenJ.Tiagabine appears not to be efficacious in the treatment of acute mania.J Clin Psychiatry.19996075976210584764
  • AmannB.SterrA.VietaE.StampferR.WaldenJ.GrunzeH.An exploratory open trial on safety and efficacy of the anticonvulsant retigabine in acute manic patients.J Clin Psychopharmacol.20062653453616974202
  • CartaMG.HardoyMC.GrunzeH.CarpinielloB.The use of tiagabine in affective disorders.Pharmacopsychiatry.200235333411819159
  • YoungAH.GeddesJR.MacritchieK.RaoSN.VasudevA.Tiagabine in the maintenance treatment of bipolar disorders.Cochrane Database Syst Rev.20063:CD005173
  • YoungAH.GeddesJR.MacritchieK.RaoSN.WatsonS.VasudevA.Tiagabine in the treatment of acute affective episodes in bipolar disorder: efficacy and acceptability.Cochrane Database Syst Rev.20063:CD004694
  • KushnerSF.KhanA.LaneR.OlsonWH.Topiramate monotherapy in the management of acute mania: results of four double-blind placebo-controlled trials.Bipolar Disord.20068152716411977
  • Roy ChengappaKN.SchwarzmanLK.HulihanJF.XiangJ.RosenthalNR.Adjunctive topiramate therapy in patients receiving a mood stabilizer for bipolar I disorder: a randomized, placebo-controlled trial.J Clin Psychiatry.2006671698170617196048
  • AnandA.BukhariL.JenningsSA.et al.A preliminary open-label study of zonisamide treatment for bipolar depression in 10 patients.J Clin Psychiatry.20056619519815705004
  • GhaemiSN.ZablotskyB.FilkowskiMM.et al.An open prospective study of zonisamide in acute bipolar depression.J Clin Psychopharmacol.20062638538816855456
  • KanbaS.YagiG.KamijimaK.et al.The first open study of zonisamide, a novel anticonvulsant, shows efficacy in mania.Prog Neuropsychopharmacol Biol Psychiatry.1994187077157938561
  • McElroySL.SuppesT.KeckPE.Jr.et al.Open-label adjunctive zonisamide in the treatment of bipolar disorders: a prospective trial.J Clin Psychiatry.20056661762415889949
  • WilsonMS.FindlingRL.Zonisamide for bipolar depression.Exp Opin Pharmacother.20078111113
  • GardnerDL.CowdryRW.Positive effects of carbamazepine on behavioral dyscontrol in borderline personality disorder.Am J Psychiatry.19861435195223513634
  • HollanderE.AllenA.LopezRP.et al.A preliminary double-blind, placebo-controlled trial of divalproex sodium in borderline personality disorder.J Clin Psychiatry.20016219920311305707
  • SteinDJ.SimeonD.FrenkelM.IslamMN.HollanderE.An open trial of valproate in borderline personality disorder.J Clin Psychiatry.1995565065107592502
  • PintoOC.AkiskalHS.Lamotrigine as a promising approach to borderline personality: an open case series without concurrent DSM-IV major mood disorder.J Affect Disord.19985133334310333987
  • BellinoS.ParadisoE.BogettoF.Oxcarbazepine in the treatment of borderline personality disorder: a pilot study.J Clin Psychiatry.2005661111111516187767
  • NickelMK.NickelC.MitterlehnerFO.et al.Topiramate treatment of aggression in female borderline personality disorder patients: a doubleblind, placebo-controlled study.J Clin Psychiatry.2004651515151915554765
  • NickelMK.NickelC.KaplanP.et al.Treatment of aggression with topiramate in male borderline patients: a double-blind, placebo-controlled study.Biol Psychiatry.20055749549915737664
  • LoewTH.NickelMK.MuehlbacherM.KaplanP.NickelC.KettlerC.et al.Topiramate treatment for women with borderline personality disorder: a double-blind, placebo-controlled study.J Clin Psychopharmacol.200626616616415708