REFERENCES

• SchumacherM.GuennounR.SteinDG.De NicolaAF.Progesterone: therapeutic opportunities for neuroprotection and myelin repair.Pharmacol Ther.20071167710617659348
   PubMed Web of Science ®Google Scholar
• DuvdevaniR.RoofRL.FulopZ.HoffmanSW.SteinDG.Blood-brain barrier breakdown and edema formation following frontal cortical contusion: does hormonal status playa role?J Neurotrauma.19951265757783233
   PubMed Web of Science ®Google Scholar
• RoofRL.DuvdevaniR.HeyburnJW.SteinDG.Progesterone rapidly decreases brain edema: treatment delayed up to 24 hours is still effective.Exp Neurol.19961382462518620923
   PubMed Web of Science ®Google Scholar
• RoofRL.FrittsME.CastroEA.PowellRA.SteinDG.Progesterone is more effective than methylprednisolone at reducing edema after cortical contusion in male rats. Paper presented at: Society for Neuroscience Annual Meeting; Washington, DC; 1996
   Google Scholar
• RoofRL.SteinDG.Progesterone treatment attenuates brain edema following contusion injury in male and female rats.Restor Neurol Neurosci.1992442542721551677
   PubMed Web of Science ®Google Scholar
• RoofRL.FrittsME.Progesterone metabolites may mediate its neuroprotective effects after traumatic brain injury.Neurotrauma.199714760
   Google Scholar
• DjebailiM.HoffmanSW.SteinDG.Allopregnanolone and progesterone decrease cell death and cognitive deficits after a contusion of the rat pre-frontal cortex. National Neurotrauma Society.J Neurotrauma.2004123349359
   Google Scholar
• PettusEH.WrightDW.SteinDG.HoffmanSW.Progesterone treatment inhibits the inflammatory agents that accompany traumatic brain injury.Brain Res.2005104911211915932748
   PubMed Web of Science ®Google Scholar
• VanLandinghamJW.CekicM.CutlerS.HoffmanSW.SteinDG.Neurosteroids reduce inflammation after TBI through CD55 induction.Neurosci Lett.2007425949817826908
   PubMed Web of Science ®Google Scholar
• CoughlanT.GibsonC.MurphyS.Progesterone, BDNF and neuroprotection in the injured CNS.Int J Neurosci.20091191718174019922383
   PubMed Web of Science ®Google Scholar
• JodhkaPK.KaurP.UnderwoodW.LydonJP.SinghM.The differences in neuroprotective efficacy of progesterone and medroxyprogesterone acetate correlate with their effects on brain-derived neurotrophic factor expression.Endocrinology.20091503162316819325006
   PubMed Web of Science ®Google Scholar
• KaurP.JodhkaPK.UnderwoodWA.et al.Progesterone increases brainderived neuroptrophic factor expression and protects against glutamate toxicity in a mitogen-actlvated protein kinase- and phosphoinositide-3 kinase-dependent manner in cerebral cortical explants.J Neurosci Res.2007852441244917549730
   PubMedGoogle Scholar
• DangJ.MitkarB.KippM.BeyerC.Gonadal steroids prevent cell damage and stimulate behavioral recovery after transient middle cerebral artery occlusion in male and female rats.Brain Behav Immun.20112571572621277368
   PubMed Web of Science ®Google Scholar
• GuoQ.SayeedI.BaronneLM.HoffmanSW.GuennounR.SteinDG.Progesterone administration modulates AQP4 expression and edema after traumatic brain injury in male rats.Exp Neurol.200619846947816445913
   PubMed Web of Science ®Google Scholar
• GhoumariAM.IbanezC.El-EtrM.et al.Progesterone and its metabolites increase myelin basic protein expression in organotypic slice cultures of rat cerebellum.J Neurochem.20038684885912887683
   PubMed Web of Science ®Google Scholar
• IbanezC.ShieldsSA.El-EtrM.et al.Steroids and the reversal of ageassociated changes in myelination and remyelination.Prog Neurobiol.200371495614611867
   PubMed Web of Science ®Google Scholar
• WrightDW.KellermannAL.HertzbergVS.et al.ProTECT: A randomized clinical trial of progesterone for acute traumatic brain injury.Ann Emerg Med.20074939140217011666
   PubMed Web of Science ®Google Scholar
• CutlerSM.CekicM.MillerDM.WaliB.VanLandinghamJW.SteinDG.Progesterone improves acute recovery after traumatic brain injury in the aged rat.J Neurotrauma.2007241475148617892409
   PubMed Web of Science ®Google Scholar
• McCulloughLD.HurnPD.Estrogen and ischemic neuroprotection: an integrated view.Trends Endocrinol Metab.20031422823512826329
   PubMed Web of Science ®Google Scholar
• SteinDG.WrightDW.KellermannAL.Does progesterone have neuroprotective properties?Ann Emerg Med.20085116417217588708
   PubMed Web of Science ®Google Scholar
• SteinDG.WrightDW.Progesterone in the clinical treatment of acute traumatic brain injury.Expert Opin investig Drugs.201019847857
   PubMed Web of Science ®Google Scholar
• SteinDG.HurnPD.Effects of sex steroids on damaged neural systems. In: Pfaff DW, Arnold AP, Etgen AM, Fahrbach SE, Rubin RT, eds.Hormones, Brain and Behavior. Vol 4. 2 ed. Oxford, UK: Elsevier;200922232258
   Google Scholar
• JunpengM.HuangS.QinS.Progesterone for acute traumatic brain injury.Cochrane Database Syst Rev.20111CD00840921249708
   PubMedGoogle Scholar
• LiuM.KelleyMH.HersonPS.HurnPD.Neuroprotection of sex steroids.Minerva Endocrinol.20103512714320595940
   PubMed Web of Science ®Google Scholar
• GibsonCL.GrayLJ.BathPM.MurphySP.Progesterone for the treatment of experimental brain injury; a systematic review.Brain.2008131(Pt 2)31832817715141
   PubMed Web of Science ®Google Scholar
• DjebailiM.GuoQ.PettusEH.HoffmanSW.SteinDG.The neurosteroids progesterone and allopregnanolone reduce cell death, gliosis, and functional deficits after traumatic brain injury in rats.J Neurotrauma.20052210611815665606
   PubMed Web of Science ®Google Scholar
• DjebailiM.HoffmanSW.SteinDG.Allopregnanolone and progesterone decrease cell death and cognitive deficits after a contusion of the rat pre-frontal cortex.Neuroscience.200412334935914698743
   PubMed Web of Science ®Google Scholar
• GossCW.HoffmanSW.SteinDG.Behavioral effects and anatomic correlates after brain injury: a progesterone dose-response study.Pharmacol Biochem Behav.20037623124214592674
   PubMed Web of Science ®Google Scholar
• SteinDG.The case for progesterone.Ann N Y Acad Sci.2005105215216916024758
   PubMed Web of Science ®Google Scholar
• ShearDA.GalaniR.HoffmanSW.SteinDG.Progesterone protects against necrotic damage and behavioral abnormalities caused by traumatic brain injury.Exp Neurol.2002178596712460608
   PubMed Web of Science ®Google Scholar
• AttellaMJ.NattinvilleA.SteinDG.Hormonal state affects recovery from frontal cortex lesions in adult female rats.Behav Neural Biol.1987483523673689284
   PubMedGoogle Scholar
• XiaoG.WeiJ.YanW.WangW.LuZ.Improved outcomes from the administration of progesterone for patients with acute severe traumatic brain injury: a randomized controlled trial.Crit Care.200812R6118447940
   PubMed Web of Science ®Google Scholar
• LoaneDJ.FadenAI.Neuroprotection for traumatic brain injury: translational challenges and emerging therapeutic strategies.Trends Pharmacol Sci.20103159660421035878
   PubMed Web of Science ®Google Scholar
• SaverJL.AlbersGW.DunnB.JohnstonKC.FisherM.Stroke Therapy Academic Industry Roundtable (STAIR) recommendations for extended window acute stroke therapy trials.Stroke.2009402594260019478212
   PubMed Web of Science ®Google Scholar
• SayeedI.GuoQ.HoffmanSW.SteinDG.Allopregnanolone, a progesterone metabolite, is more effective than progesterone in reducing cortical infarct volume after transient middle cerebral artery occlusion.Ann Emerg Med.20064738138916546625
   PubMed Web of Science ®Google Scholar
• SayeedI.WaliB.SteinDG.Progesterone inhibits ischemic brain injury in a rat model of permanent middle cerebral artery occlusion.Restor Neurol Neurosci.20072515115917726274
   PubMed Web of Science ®Google Scholar
• JiangN.ChoppM.SteinD.FeitH.Progesterone is neuroprotective after transient middle cerebral artery occlusion in male rats.Brain Res.19967351011078905174
   PubMed Web of Science ®Google Scholar
• CervantesM.Gonzalez-VidalMD.RuelasR.EscobarA.MoraliG.Neuroprotective effects of progesterone on damage elicited by acute global cerebral ischemia in neurons of the caudate nucleus.Arch Med Res.20023361411825624
   PubMed Web of Science ®Google Scholar
• Gonzalez-VidalMD.Cervera-GaviriaM.RuelasR.EscobarA.MoraliG.CervantesM.Progesterone: protective effects on the cat hippocampal neuronal damage due to acute global cerebral ischemia.Arch Med Res.1998291171249650325
   PubMed Web of Science ®Google Scholar
• ChenJ.ChoppM.LiY.Neuroprotective effects of progesterone after transient middle cerebral artery occlusion in rat.J Neurol Sci.1999171243010567046
   PubMed Web of Science ®Google Scholar
• IshratT.SayeedI.AtifF.HuaF.SteinDG.Progesterone and allopregnanolone attenuate blood-brain barrier dysfunction following permanent focal ischemia by regulating the expression of matrix metalloproteinases.Exp Neurol.201022618319020816826
   PubMed Web of Science ®Google Scholar
• WangJ.JiangC.LiuC.LiX.ChenN.HaoY.Neuroprotective effects of progesterone following stroke in aged rats.Behav Brain Res.201020911912220109497
   PubMed Web of Science ®Google Scholar
• SayeedI.SteinDG.Progesterone as a neuroprotective factor in traumatic and ischemic brain injury. In: Verhaagen J, Hol EM, Huitinga I, et al, eds.Neurotherapy. Vol 175. New York, NY: Elsevier;2009219237
   Google Scholar
• JiangC.WangJ.LiX.LiuC.ChenN.HaoY.Progesterone exerts neuroprotective effects by inhibiting inflammatory response after stroke.inflamm Res.20095861962419333725
   PubMed Web of Science ®Google Scholar
• IshratT.SayeedI.AtifF.SteinDG.Effects of progesterone administration on infarct volume and functional deficits following permanent focal cerebral ischemia in rats.Brain Res.200912579410119135987
   PubMed Web of Science ®Google Scholar
• LabombardaF.GonzalezSL.LimaA.et al.Effects of progesterone on oligodendrocyte progenitors, oligodendrocyte transcription factors, and myelin proteins following spinal cord injury.Glia.20095788489719053058
   PubMed Web of Science ®Google Scholar
• BaulieuEE.Neurosteroids: of the nervous system, by the nervous system, for the nervous system.Recent Prog Horm Res.1997521329238846
   PubMedGoogle Scholar
• Jung-TestasI.BaulieuEE.Steroid hormone receptors and steroid action in rat glial cells of the central and peripheral nervous system.J Steroid Biochem Mol Biol.1998652432519699879
   PubMed Web of Science ®Google Scholar
• Jung-TestasI.SchumacherM.RobelP.BaulieuEE.Actions of steroid hormones- and growth factors on glial cells of the central and peripheral nervous system.J Steroid Biochem Mol Biol.1994481451548136300
   PubMed Web of Science ®Google Scholar
• SchumacherM.RobelP.BaulieuEE.Development and regeneration of the nervous system: a role for neurosteroids.Dev Neurosci.1996186218840083
   PubMed Web of Science ®Google Scholar
• LeonelliE.BlanchiR.CavalettiG.et al.Progesterone and its derivatives are neuroprotective agents in experimental diabetic neuropathy: a multimodal analysis.Neuroscience.20071441293130417187935
   PubMed Web of Science ®Google Scholar
• AhmadI.Lope-PiedrafitaS.BiX.et al.Allopregnanolone treatment, both as a single injection or repetitively, delays demyelination and enhances survival of Niemann-Pick C mice.J Neurosci Res.20058281182116273542
   PubMed Web of Science ®Google Scholar
• LangmadeSJ.GaleSE.FrolovA.et al.Pregnane X receptor (PXR) activation: a mechanism for neuroprotection in a mouse model of NiemannPick C disease.Proc Natl Acad Sci U S A.2006103138071381216940355
   PubMed Web of Science ®Google Scholar
• MellonSH.GongW.SchonemannMD.Endogenous and synthetic neurosteroids in treatment of Niemann-Pick Type C disease.Brain Res Rev.20085741042017629950
   PubMedGoogle Scholar
• GarayL.DeniselleMC.LimaA.RoigP.De NicolaAF.Effects of progesterone in the spinal cord of a mouse model of multiple sclerosis.J Steroid Biochem Mol Biol.200710722823717692515
   PubMed Web of Science ®Google Scholar
• ReddyDS.RogawskiMA.Neurosteroid replacement therapy for catamenial epilepsy.Neurotherapeutics.2009639240119332335
   PubMed Web of Science ®Google Scholar
• FryeCA.Hormonal influences on seizures: basic neurobiology.Int Rev Neurobiol.200883277718929075
   PubMed Web of Science ®Google Scholar
• ReevesR.PanguluriR.Neuropsychiatrie complications of traumatic brain injury.J Psychosoc Nurs Ment Health Serv.201119
   Web of Science ®Google Scholar
• HudakA.WarnerM.Marquez de la PlataC.MooreC.HarperC.Diaz-ArrastiaR.Brain morphometry changes and depressive symptoms after traumatic brain injury.Psychiatry Res.201119116016521310594
   PubMed Web of Science ®Google Scholar
• KernpfJ.WerthE.KaiserPR.BassettiCL.BaumannCR.Sleep-wake disturbances 3 years after traumatic brain injury.J Neurol Neurosurg Psychiatry.2010811402140520884672
   PubMed Web of Science ®Google Scholar
• BombardierCH.FannJR.TemkinNR.EsselmanPC.BarberJ.DikmenSS.Rates of major depressive disorder and clinical outcomes following traumatic brain injury.JAMA.20103031938194520483970
   PubMed Web of Science ®Google Scholar
• FryeCA.Progesterone reduces depressive behaviour of young ovariectomized, aged progestin receptor knockout, and aged wild type mice in the tail suspension test.J Psychopharmacol.20112542142819965943
   PubMed Web of Science ®Google Scholar
• BeckleyEH.ScibelliAC.FinnDA.Progesterone receptor antagonist CDB-4124 increases depression-like behavior in mice without affecting locomotor ability.Psychoneuroendocrinology.20103682483321163582
   PubMed Web of Science ®Google Scholar
• PinnaG.In a mouse model relevant for post-traumatic stress disorder, selective brain steroidogenic stimulants (SBSS) improve behavioral deficits by normalizing allopregnanolone biosynthesis.Behav Pharmacol.20102143845020716970
   PubMed Web of Science ®Google Scholar
• ReddyDS.Neurosteroids: endogenous role in the human brain and therapeutic potentials.Prog Brain Res.201018611313721094889
   PubMed Web of Science ®Google Scholar
• KiltsJD.TuplerLA.KeefeFJ.et al.Neurosteroids and self-reported pain in veterans who served in the U.S. Military after September 11, 2001.Pain Med.2010111469147620735755
   PubMed Web of Science ®Google Scholar
• TurkmenS.BackstromT.WahlstromG.AndreenL.JohanssonIM.Tolerance to allopregnanolone with focus on the GABA-A receptor.Br J Pharmacol.201116231132720883478
   PubMed Web of Science ®Google Scholar
• KueblerJF.YokoyamaY.JarrarD.et al.Administration of progesterone after trauma and hemorrhagic shock prevents hepatocellular injury.Arch Surg.200313872773412860753
   PubMed Web of Science ®Google Scholar
• ChenG.ShiJ.DingY.YinH.HangC.Progesterone prevents traumatic brain injury-induced intestinal nuclear factor kappa B activation and proinflammatory cytokines expression in male rats.Mediators inflamm.200720079343118274644
   PubMed Web of Science ®Google Scholar
• PanDS.LiuWG.YangXF.CaoF.Inhibitory effect of progesterone on inflammatory factors after experimental traumatic brain injury.Biomed Environ Sci.20072043243818188998
   PubMed Web of Science ®Google Scholar
• ChenG.ShiJX.QiM.WangHX.HangCH.Effects of progesterone on intestinal inflammatory response, mucosa structure alterations, and apoptosis following traumatic brain injury in male rats.J Surg Res.2008147929817868700
   PubMed Web of Science ®Google Scholar
• BaulieuEE.RobelP.SchumacherM.edsNeurosteroids: A New Regulatory Function in the Nervous System. Totawa, New Jersey: Humana Press Inc.;1999
   Google Scholar
• TeitelbaumP.Functional recovery after lesions of the nervous system. V. Neural plasticity and behavioral recovery in the central nervous system. The use of recovery of function to analyze the organization of motivated behavior in the nervous system.Neurosci Res Program Bull.1974122552604858684
   PubMedGoogle Scholar
• GolaniI.WolginDL.TeitelbaumP.A proposed natural geometry of recovery from akinesia in the lateral hypothalamic rat.Brain Res.1979164237267570872
   PubMed Web of Science ®Google Scholar
• LoselRM.FalkensteinE.FeuringM.et al.Nongenomlc steroid action: controversies, questions, and answers.Physiol Rev.200383965101612843413
   PubMed Web of Science ®Google Scholar
• FalkensteinE.TillmannHC.ChristM.FeuringM.WehlingM.Multiple actions of steroid hormones- -a focus on rapid, nongenomic effects.Pharmacol Rev.20005251355611121509
   PubMed Web of Science ®Google Scholar