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Translational Research

Functional neuroimaging and schizophrenia: a view towards effective connectivity modeling and polygenic risk

Neuroimágenes funcionales y esquizofrenia: una mirada hacia el modelo de conectividad efectiva y el riesgo poligénico

Schizophrénie et neuroimagerie fonctionnelle: point de vue sur la modélisation de la connectivité effective et le risque polygénique

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Pages 279-289 | Published online: 01 Apr 2022

REFERENCES

  • WeinbergerDR.MattayV.CallicottJ.et alfMRI applications in schizophrenia research.Neuroimage.19964S118S1269345536
  • BookheimerSY.StrojwasMH.CohenMS.et alPatterns of brain activation in people at risk for Alzheimer's disease.N Engl J Med.200034345045610944562
  • EganMR.GoldbergTE.KolachanaBS.et alEffect of COMT Val108/1 58 Met genotype on frontal lobe function and risk for schizophrenia.Proc Natl Acad Sci U S A.2001986917692211381111
  • EganMF.WeinbergerDR.Neurobiology of schizophrenia.Curr Opin Neurobiol.199777017079384552
  • CastelliWP.AndersonK.WilsonPW.LevyD.Lipids and risk of coronary heart disease. The Framingham Study.Ann Epidemiol.1992223281342260
  • O'ConnorDT.InselPA.ZieglerMG.et alHeredity and the autonomic nervous system in human hypertension.Curr Hypertens Rep.20002162210982526
  • GottesmanII.GouldTD.The endophenotype concept in psychiatry: etymology and strategic intentions.Am J Psychiatry.200316063664512668349
  • TanHY.CallicottJH.WeinbergerDR.Intermediate phenotypes in schizophrenia genetics redux: is it a no brainer?Mol Psychiatry.20081323323818285755
  • CannonTD.ZorrillaLE.ShtaselD.et alNeuropsychological functioning in siblings discordant for schizophrenia and healthy volunteers.Arch Gen Psychiatry.1994516516618042914
  • GoldbergTE.TorreyEF.GoldJM.et alGenetic risk of neuropsychological impairment in schizophrenia: a study of monozygotic twins discordant and concordant for the disorder.Schizophr Res.19951777848541253
  • ToulopoulouT.PicchioniM.RijsdijkF.et alSubstantial genetic overlap between neurocognition and schizophrenia: genetic modeling in twin samples.Arch Gen Psychiatry.2007641348135518056542
  • EganMF.GoldbergTE.GscheidleT.et alRelative risk for cognitive impairments in siblings of patients with schizophrenia.Biol Psychiatry.2001509810711527000
  • CallicottJH.EganMF.MattayVS.et alAbnormal fMRI response of the dorsolateral prefrontal cortex in cognitively intact siblings of patients with schizophrenia. AmJ Psychiatry.2003160709719
  • RasettiR.WeinbergerDR.Intermediate phenotypes in psychiatric disorders.CurrOpin Genet Dev.201121340348
  • HoneaR.CrowTJ.PassinghamD.MackayCE.Regional deficits in brain volume in schizophrenia: a meta-analysis of voxel-based morphometry studies.Am J Psychiatry.20051622233224516330585
  • ShentonME.DickeyCC.FruminM.McCarleyRW.A review of MRI findings in schizophrenia.Schizophr Res.20014915211343862
  • WrightIC.Rabe-HeskethS.WoodruffPW.DavidAS.MurrayRM.BullmoreET.Meta-analysis of regional brain volumes in schizophrenia.Am J Psychiatry.2000157162510618008
  • WeinbergerDR.McClureRK.Neurotoxicity, neuroplasticity, and magnetic resonance imaging morphometry: what is happening in the schizophrenic brain?Arch Gen Psychiatry.20025955355812044198
  • HajnalJV.SaeedN.OatridgeA.et alDetection of subtle brain changes using subvoxel registration and subtraction of serial MR images.J Comput Assist Tomogr.1995196776917560311
  • SwayzeVW 2nd.AndersenA.ArndtS.et alReversibility of brain tissue loss in anorexia nervosa assessed with a computerized Talairach 3-D proportional grid.Psychol Med.1996263813908685294
  • SchrothG.NaegeleT.KloseU.MannK.PetersenD.Reversible brain shrinkage in abstinent alcoholics, measured by MRI.Neuroradiology.1988303853893211313
  • DentonER.HoldenM.ChristE.et alThe identification of cerebral volume changes in treated growth hormone-deficient adults using serial 3D MR image processing.J Comput Assist Tomogr.20002413914510667673
  • MooreGJ.BebchukJM.WildsIB.ChenG.ManjiHK.Lithium-induced increase in human brain grey matter.Lancet.20003561241124211072948
  • ScheepersFE.de WiedCC.HulshoffPol HE.et alThe effect of clozapine on caudate nucleus volume in schizophrenic patients previously treated with typical antipsychotics.Neuropsychopharmacology.200124475411106875
  • CorsonPW.NopoulosP.MillerDD.ArndtS.AndreasenNC.Change in basal ganglia volume over 2 years in patients with schizophrenia: typical versus atypical neuroleptics.Am J Psychiatry.19991561200120410450260
  • HoneaRA.Meyer-LindenbergA.HobbsKB.et alIs gray matter volume an intermediate phenotype for schizophrenia? A voxel-based morphometry study of patients with schizophrenia and their healthy siblings.Biol Psychiatry.20086346547417689500
  • OwensSF.PicchioniMM.EttingerU.et alPrefrontal deviations in function but not volume are putative endophenotypes for schizophrenia.Brain.20121352231224422693145
  • GreiciusMD.KrasnowB.ReissAL.MenonV.Functional connectivity in the resting brain: a network analysis of the default mode hypothesis.Proc Natl Acad Sci USA.200310025325812506194
  • BroydSJ.DemanueleC.DebenerS.HelpsSK.JamesCJ.Sonuga-BarkeEJ.Default-mode brain dysfunction in mental disorders: a systematic review.Neurosci Biobehav Rev.20093327929618824195
  • van den HeuvelMP.Hulshoff PolHE.Exploring the brain network: a review on resting-state fMRI functional connectivity.Eur Neuropsychopharmacol.20102051953420471808
  • SamartzisL.DimaD.Fusar-PoliP.KyriakopoulosM.White matter alterations in early stages of schizophrenia: a systematic review of diffusion tensor imaging studies.J Neuroimag. In press.2013doi 10.1 111/J.15526569
  • WhitfordTJ.KubickiM.ShentonME.Diffusion tensor imaging, structural connectivity, and schizophrenia.Schizophr Res Treatment. In press.2011doi 10.1155/2011/709523
  • BucknerRL.KrienenFM.YeoBT.Opportunities and limitations of intrinsic functional connectivity MRI.Nat Neurosci.20131683283723799476
  • JonesDK.KnoscheTR.TurnerR.White matter integrity, fiber count, and other fallacies: the do's and don'ts of diffusion MRI.Neuroimage.20137323925422846632
  • LogothetisNK.What we can do and what we cannot do with fMRI.Nature.200845386987818548064
  • DouglasRJ.MartinKA.Neuronal circuits of the neocortex.Annu Rev Neurosci.20042741945115217339
  • BruneiN.WangXJ.Effects of neuromodulation in a cortical network model of object working memory dominated by recurrent inhibition.J Comput Neurosci.200111638511524578
  • RockelAJ.HiornsRW.PowellTP.The basic uniformity in structure of the neocortex.Brain.19801032212446772266
  • EganMF.StraubRE.GoldbergTE.et alVariation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia.Proc Natl Acad Sci U S A.2004101126041260915310849
  • HaririAR.MattayVS.TessitoreA.et alSerotonin transporter genetic variation and the response of the human amygdala.Science.200229740040312130784
  • RasettiR.WeinbergerDR.Intermediate phenotypes in psychiatric disorders.Curr Opin Genet Dev.201121348340
  • SambataroF.MattayVS.ThurinK.et alAltered cerebral response during cognitive control: a potential indicator of genetic liability for schizophrenia.Neuropsychopharmacology.20133884685323299932
  • Di GiorgioA.GelaoB.CaforioG.et alEvidence that hippocampalparahippocampal dysfunction is related to genetic risk for schizophrenia.Psychol Med.2012111
  • FristonKJ.Functional and effective connectivity in neuroimaging: a synthesis. Hum.Brain Mapp.199425678
  • Meyer-LindbergA.BullmoreE.Functional brain imaging in schizophrenia. In:Schizophrenia.Third Ed. Oxford, UK: Blackwell Publishing Ltd2011;334353
  • HoneyGD.BullmoreET.SharmaT.De-coupling of cognitive performance and cerebral functional response during working memory in schizophrenia.Schizophr Res.200253455611728837
  • AnticevicA.RepovsG.CrystalJH.BarchDM.A broken filter: prefrontal functional connectivity abnormalities in schizophrenia during working memory interference.Schizophr Res.201214181422863548
  • WolfDH.GurRC.ValdezJN.et alAlterations of fronto-temporal connectivity during word encoding in schizophrenia.Psychiatry Res.200715422123217360163
  • WolfRC.VasicN.SambataroF.et alTemporally anticorrelated brain networks during working memory performance reveal aberrant prefrontal and hippocampal connectivity in patients with schizophrenia.Prog Neuropsychopharmacol Biol Psychiatry.2009331464147319666074
  • TanHY.ChenQ.GoldbergTE.et alCatechol-O-methyltransferase Val158Met modulation of prefrontal-parietal-striatal brain systems during arithmetic and temporal transformations in working memory.J Neurosci.200727133931340118057197
  • KempfL.NlcodemusKK.KolachanaB.et alFunctional polymorphisms in PRODH are associated with risk and protection for schizophrenia and fronto-striatal structure and function.PLoS Genet.20084e100025218989458
  • Meyer-LindenbergA.StraubRE.LipskaBK.et alGenetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognition.J Clin Invest.200711767268217290303
  • BuckholtzJW.Meyer-LindenbergA.HoneaRA.et alAllelic variation in RGS4 impacts functional and structural connectivity in the human brain.J Neurosci.2007271584159317301167
  • PaulusFM.BedenbenderJ.KrachS.et alAssociation of rs1006737 in CACIMA1C with alterations in prefrontal activation and fronto-hippocampal connectivity.Hum Brain Mapp.20133430431322042765
  • FristonKJ.BuechelC.FinkGR.MorrisJ.RollsE.DolanRJ.Psychophysiological and modulatory interactions in neuroimaging.Neurolmage.19976218229
  • RasettiR.SambataroF.ChenQ.CallicottJH.MattayVS.WeinbergerDR.Altered cortical network dynamics: a potential intermediate phenotype for schizophrenia and association with ZNF804A.Arch Gen Psychiatry.2011681207121721810628
  • KJFriston.BLi.JDaunizeau.KEStephan.Network discovery with DCM.Neurolmage.20115612021221
  • TostH.BilekE.Meyer-LindenbergA.Brain connectivity in psychiatric imaging genetics.Neuroimage.2012622250226022100419
  • FristonKJ.HarrisonL.PennyW.Dynamic causal modelling.Neuroimage.2003191273130212948688
  • StephanKE.PennyWD.MoranRJ.den OudenHE.DaunizeauJ.FristonKJ.Ten simple rules for dynamic causal modeling.Neuroimage.2010493099310919914382
  • TanHY.ChenAG.KolachanaB.et alEffective connectivity of AKT1mediated dopaminergic working memory networks and pharmacogenetics of anti-dopaminergic treatment.Brain.20121351436144522525159
  • DauvermannMR.WhalleyHC.RomaniukL.et alThe application of nonlinear Dynamic Causal Modelling for fMRI in subjects at high genetic risk of schizophrenia.Neuroimage.201373162923384525
  • Curcic-BlakeB.SwartM.Ter HorstGJ.LangersDR.KemaIP.AlemanA.Variation of the gene coding for DARPP-32 (PPP1R1B) and brain connectivity during associative emotional learning.Neuroimage.2012591540155021878394
  • AchardS.SalvadorR.WhitcherB.SucklingJ.BullmoreE.A resilient, low-frequency, small-world human brain functional network with highly connected association cortical hubs.J Neurosci.200626637216399673
  • BullmoreE.BassettD.Brain graphs: graphical models of the human brain connectome.Annu Rev Clin Psychol.2011711314021128784
  • BassettDS.NelsonBG.MuellerBA.CamchongJ.LimKO.Altered resting state complexity in schizophrenia.Neuroimage.2012592196220722008374
  • BullmoreET.BassettDS.Brain graphs: graphical models of the human brain connectome.Annu Rev Clin Psychol.2011711314021128784
  • LiuY.LiangM.ZhouY.et alDisrupted small-world networks in schizophrenia.Brain.2008131(Pt 4)94596118299296
  • BassettDS.BullmoreE.VerchinskiBA.et alHierarchical organization of human cortical networks in health and schizophrenia.J Neurosci.2008289239924818784304
  • SmitDJ.StamCJ.PosthumaD.BoomsmaDl.de GeusEJ.Heritability of “small-world” networks in the brain: a graph theoretical analysis of resting-state EEG functional connectivity.Hum Brain Mapp.2008291368137818064590
  • International Schizophrenia Consortium: Purcell SM, Wray NR, Stone JL, et al. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder.Nature.200946074875219571811
  • TanHY.ChenQ.SustS.et alEpistasis between catechol-O-methyltransferase and type II metabotropic glutamate receptor 3 genes on working memory brain function.Proc Natl Acad Sci US A.20071041253612541
  • NicodemusKK.LawAJ.RadulescuE.et alBiological validation of increased schizophrenia risk with NRG1, ERBB4, and AKT1 epistasis via functional neuroimaging in healthy controls.Arch Gen Psychiatry.201067991100120921115
  • NicodemusKK.CallicottJH.HigierRG.et alEvidence of statistical epistasis between DISCI, CITand NDEL1 impacting risk for schizophrenia: biological validation with functional neuroimaging.Hum Genet.201012744145220084519
  • RoffmanJL.WeissAP.DeckersbachT.et alInteractive effects of COMT Val108/158Met and MTHFR C677T on executive function in schizophrenia.Am J Med Genet B Neuropsychiatr Genet.2008147B99099518186041
  • BuckholtzJW.SustS.TanHY.et alfMRI evidence for functional epistasis between COMT and RGS4.Mol Psychiatry.200712893895,88517895922
  • DudbridgeF.Power and predictive accuracy of polygenic risk scores.PLoS Genet.20139e100334823555274
  • WaltonE.TurnerJ.GollubRL.et alCumulative genetic risk and prefrontal activity in patients with schizophrenia.Schizophr Bull.20133970371122267534
  • HolmesAJ.LeePH.HollinsheadMO.et alIndividual differences in amygdala-medial prefrontal anatomy link negative affect, impaired social functioning, and polygenic depression risk.J Neurosci.201232180871810023238724
  • WhalleyHC.PapmeyerM.SprootenE.et alThe influence of polygenic risk for bipolar disorder on neural activation assessed using fMRI.Transl Psychiatry.20122e13022760554