REFERENCES

• KesslerRC.MerikangasKR.WangPS.Prevalence, comorbidity, and service utilization for mood disorders in the United States at the beginning of the twenty-first century.Ann Rev Clin Psychol.2007313715817716051
   PubMed Web of Science ®Google Scholar
• InselTR.WangPS.The STAR*D trial: revealing the need for better treatments.Psychiatr Serv.2009601466146719880463
   PubMed Web of Science ®Google Scholar
• SmithDF.Quest for biomarkers of treatment-resistant depression: shifting the paradigm toward risk.Front Psychiatry.201345723785338
   PubMedGoogle Scholar
• ThaseME.HowlandR.Biological processes in depression: updated review and integration. In: Beckham EE, Leber WR, eds.Handbook of Depression. New York, NY: Guilford Press.1995213279
   Google Scholar
• RibeiroSC.TandonR.GrunhausL.GredenJF.The DST as a predictor of outcome in depression: a meta-analysis.Am J Psychiatry.1993150161816298214170
   PubMed Web of Science ®Google Scholar
• OwensM.HerbertJ.JonesPB.et alElevated morning Cortisol is a stratified population-level biomarker for major depression in boys only with high depressive symptoms.Proc Natl Acad Sci U S A.20141113638364324550453
   PubMed Web of Science ®Google Scholar
• ThaseME.DubéS.BowlerK.HowlandRH.MyersJE.FriedmanE.JarrettDB.Hypothalamic-pituitary-adrenocortical activity and response to cognitive behavior therapy in unmedicated, hospitalized depressed patients.Am J Psychiatry.19961538868918659610
   PubMed Web of Science ®Google Scholar
• ThaseME.KupferDJ.Current status of EEG sleep in the assessment and treatment of depression. In: Burrows GD, Werry JW, eds.Advances in Human Psychopharmacology. Volume 4. Greenwich, CT: JAI Press, Inc.198793148
   Google Scholar
• BencaRM.ObermeyerWH.ThistedRA.GillinJC.Sleep and psychiatric disorders. A meta-analysis.Arch Gen Psychiatry.1992496516681386215
   PubMed Web of Science ®Google Scholar
• ThaseME.BuysseDJ.FrankE.et alWhich depressed patients will respond to interpersonal psychotherapy? The role of abnormal EEG sleep profiles.Am J Psychiatry.19971545025099090337
   PubMed Web of Science ®Google Scholar
• ThaseME.SimonsAD.ReynoldsCF 3rd.Abnormal electroencephalographic sleep profiles in major depression: association with response to cognitive behavior therapy.Arch Gen Psychiatry.199653991088629894
   PubMed Web of Science ®Google Scholar
• ThaseME.KupferDJ.FasiczkaAJ.BuysseDJ.SimonsAD.FrankE.Identifying an abnormal electroencephalographic sleep profile to characterize major depressive disorder.Biol Psychiatry.1997419649739110102
   PubMed Web of Science ®Google Scholar
• ThaseME.FasiczkaAL.BermanSR.SimonsAD.ReynoldsCF 3rd.Electroencephalographic sleep profiles before and after cognitive behavior therapy of depression.Arch Gen Psychiatry.1998551381449477927
   PubMed Web of Science ®Google Scholar
• MillerAH.HaroonE.RaisonCL.FelgerJC.Cytokine targets in the brain: impact on neurotransmitters and neurocircuits.Depress Anxiety.20133029730623468190
   PubMed Web of Science ®Google Scholar
• CarvalhoLA.TorreJP.PapadopoulosAS.et alLack of clinical therapeutic benefit of antidepressants is associated overall activation of the inflammatory system.J Affect Disord.201314813614023200297
   PubMed Web of Science ®Google Scholar
• RaisonCL.RutherfordRE.WoolwineBJ.et alA randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: the role of baseline inflammatory biomarkers.JAMA.2013703141
   Google Scholar
• UherR.TanseyKE.DewT.et alAn inflammatory biomarker as a differential predictor of outcome of depression treatment with escitalopram and nortriptyline.Am J Psychiatry. Epub ahead of print: doi: 10.1176/ appi.ajp. 2014.14010094.2014
   Google Scholar
• PajerK.AndrusBM.GardnerW.et alDiscovery of blood transcriptomic markers for depression in animal models and pilot validation in subjects with early-onset major depression.Transl Psychiatry. http:// dx.doi.org/10.1038/tp.2012.26.2012
   Google Scholar
• RedeiEE.AndrusBM.KwasnyMJ.SeokJ.CaiX.HoJ.MohrDC.Blood transcriptomic biomarkers in adult primary care patients with major depressive disorder undergoing cognitive behavioral therapy.Transl Psychiatry. (http://dx.doi.org/10.1038/tp.2014.66).2014
   Google Scholar
• HoltzheimerPE.MaybergHS.Stuck in a rut: rethinking depression and its treatment.Trends Neurosci.2011341921067824
   PubMed Web of Science ®Google Scholar
• KennedySH.KonarskiJZ.SegalZV.et alDifferences in brain glucose metabolism between responders to CBT and venlafaxine in a 16-week randomized controlled trial.Am J Psychiatry.200716477878817475737
   PubMed Web of Science ®Google Scholar
• FalesCL.BarchDM.RundleMM.et alAntidepressant treatment normalizes hypoactivity in dorsolateral prefrontal cortex during emotional interference processing in major depression.J Affect Disord.200911220621118559283
   PubMed Web of Science ®Google Scholar
• DownarJ.GeraciJ.SalomonsTV.et alAnhedonia and reward-circuit connectivity distinguish nonresponders from responders to dorsomedial prefrontal repetitive transcranial magnetic stimulation in major depression.Biol Psychiatry.20147617618524388670
   PubMed Web of Science ®Google Scholar
• HarmerCJ.CowenPJ.GoodwinGM.Efficacy markers in depression.Psychopharmacol.20112511481158
   Web of Science ®Google Scholar
• SiegleGJ.CarterCS.ThaseME.Use of FMRI to predict recovery from unipolar depression with cognitive behavior therapy.Am J Psychiatry.200616373573816585452
   PubMed Web of Science ®Google Scholar
• SiegleGJ.ThompsonWK.CollierA.et alToward clinically useful neuroimaging in depression treatment: prognostic utility of subgenual cingulate activity for determining depression outcome in cognitive therapy across studies, scanners, and patient characteristics.Arch Gen Psychiatry.20126991392422945620
   PubMed Web of Science ®Google Scholar
• SiegleGJ.SteinhauerSR.FriedmanES.ThompsonWS.ThaseME.Remission prognosis for cognitive therapy for recurrent depression using the pupil: utility and neural correlates.Biol Psychiatry.20116972673321447417
   PubMed Web of Science ®Google Scholar
• McGrathCL.KelleyME.HoltzheimerPE.DunlopBW.CraigheadWE.FrancoAR.CraddockRC.MaybergHS.Toward a neuroimaging treatment selection biomarker for major depressive disorder.JAMA.201370821829
   Google Scholar
• TrivediMH.McGrathP.FavaM.et alEstablishing moderators and biosignatures of antidepressant response in clinical care (EMBARC): rationale and design.J Psych Res. In press.
   Google Scholar
• GENDEP Investigators. MARS Investigators. STAR*D Investigators. Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.Am J Psychiatry.201317020721723377640
   PubMed Web of Science ®Google Scholar
• LobelloKW.PreskornSH.Guico-PabiaCJ.et alCytochrome P450 2D6 phenotype predicts antidepressant efficacy of venlafaxine: a secondary analysis of 4 studies in major depressive disorder.J Clin Psychiatry.2010711482148720441720
   PubMed Web of Science ®Google Scholar
• PapakostasGl.SheltonRC.ZajeckaJM.et alEffect of adjunctive L-methylfolate 15 mg among inadequate responders to SSRIs in depressed patients who were stratified by biomarker levels and genotype: results from a randomized clinical trial.J Clin Psychiatry.20147585586324813065
   PubMed Web of Science ®Google Scholar