REFERENCES
- YoungWC.GoyRW.PhoenixCH.Hormones and sexual behavior.Science.1964143360321221814077548
- HarrisGW.Electrical stimulation of the hypothalamus and the mechanism of neural control of the adenohypophysis.J Physiol.1948107441842916991822
- MeitesJ.Short history of neuroendocrinology and the International Society of Neuroendocrinology.Neuroendocrinology.19925611101641067
- SchallyAV.ArimuraA.KastinAJ.Hypothalamic regulatory hormones.Science.1973179713413504345570
- GuilleminR.Peptides in the brain: the new endocrinology of the neuron.Science.19782024366390402212832
- JensenE.GreeneGL.ClossLE.DeSombreER.NadjiM.Receptors reconsidered a 20-year perspective.Recent Prog Harm Res.198238140
- ToftD.GorskiJ.A receptor molecule for estrogens: isolation from the rat uterus and preliminary characterization.Proc Natl Acad Sci U S A.1966556157415815227676
- PfaffDW.KeinerM.Atlas of estradiol-concentrating cells in the central nervous system of the female rat.J Comp Neurol.197315121211584744471
- StumpfWE.SarM.Steroid hormone target sites in the brain: the differential distribution of estrogen, progestin, androgen and glucocorticosteroid.J Steroid Biochem.1976711-12116311701025363
- YoungW.The Hormones and Mating Behavior. In: Young W, ed.Sex and Internal Secretions. 7th ed. Baltimore.MD: Williams and Wilkins 196111731239
- McEwenBS.AlvesSH.Estrogen actions in the central nervous system.Endocr Rev.199920327930710368772
- McEwenBS.DeKloetER.RosteneW.Adrenal steroid receptors and actions in the nervous system.Physiol Rev.1986664112111883532143
- LoyR.GerlachJ.McEwenBS.Autoradiographic localization of estradiol-binding neurons in rat hippocampal formation and entorhinal cortex.Brain Res.198846722452513378173
- McEwenBS.MilnerTA.Hippocampal formation: shedding light on the influence of sex and stress on the brain.Brain Res Rev.200755234335517395265
- KellyMJ.LevinER.Rapid actions of plasma membrane estrogen receptors.Trends Endocrinol Metab.200112415215611295570
- BlissTV.LomoT.Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.J Physiology.19732322331356
- ParnavelasJ.LynchG.BrechaN.CotmanC.GlobusA.Spine loss and regrowth in hippocampus following deafferentation.Nature.1974248544371734818565
- BennettE.DiamondM.KrechD.RosenzweigM.Chemical and anatomical plasticity of brain.Science.1964146364461061914191699
- GreenoughWT.VolkmarFR.Pattern of dendritic branching in occipital cortex of rats reared in complex environments.Exp Neurol.19734024915044730268
- ArnoldA.BreedloveS.Organizational and activational effects of sex steroids on brain and behavior: a reanalysis.Horm Behav19851944694983910535
- DeVoogdT.NottebohmF.Gonadal hormones induce dendritic growth in the adult avian brain.Science.198121445172022047280692
- NottebohmF.Why are some neurons replaced in adult brain?J Neurosci.200222362462811826090
- AltmanJ.DasGD.Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats.J Comp Neurol.196512433193365861717
- KaplanMS.BellDH.Neuronal proliferation in the 9-month-old rodent-radioautographic study of granule cells in the hippocampus.Exp Brain Res.1983521156628589
- CameronHA.GouldE.Adult neurogenesis is regulated by adrenal steroids in the dentate gyrus.Neuroscience.19946122032097969902
- KaplanMS.Environment complexity stimulates visual cortex neurogenesis: death of a dogma and a research career.Trends Neurosci.2001241061762011576677
- SpaldingKL.BergmannO.AlkassK.et alDynamics of hippocampal neurogenesis in adult humans.Cell.201315361219122723746839
- NakamuraNH.AkamaKT.YuenGS.McEwenBS.Thinking outside the pyramidal cell: unexplored contributions of interneurons and neuropeptide Y to estrogen-induced synapse formation in the hippocampus.Rev Neurosci.200718111317405448
- TerasawaE.TimirasP.Electrical activity during the estrous cycle of the rat: cyclic changes in limbic structures.Endocrinology.19688322072164874282
- SherwinBB.Estrogen and/or androgen replacement therapy and cognitive functioning in surgically menopausal women.Psychoneuroendocrinology19881343453573067252
- WoolleyC.GouldE.FrankfurtM.McEwenBS.Naturally occurring fluctuation in dendritic spine density on adult hippocampal pyramidal neurons.J Neurosci.19901012403540392269895
- McEwenBS.AkamaKT.Spencer-SegalJL.MilnerTA.WatersEM.Estrogen effects on the brain: actions beyond the hypothalamus via novel mechanisms.Behav Neurosci.2012126141622289042
- TaboriNE.StewartLS.ZnamenskyV.et alUltrastructural evidence that androgen receptors are located at extranuclear sites in the rat hippocampal formation.Neuroscience.2005130115116315561432
- RomeoRD.StaubD.JasnowAM.KaratsoreosIN.ThorntonJE.McEwenBS.Dihydrotestosterone increases hippocampal N-methyl-D-aspartate binding but does not affect choline acetyltransferase cell number in the forebrain or choline transporter levels in the CA1 region of adult male rats.Endocrinology.200514642091209715661864
- ChristensenA.DewingP.MicevychP.Membrane-initiated estradiol signaling induces spinogenesis required for female sexual receptivity.J Neurosci.20113148175831758922131419
- McEwenBS.GrayJD.Nasca C 60 years of neuroendocrinology: redefining neuroendocrinology: stress, sex and cognitive and emotional regulation.J Endocrinol.20152262T67T8325934706
- HaraY.WatersEM.McEwenBS.MorrisonJH.Estrogen Effects on cognitive and synaptic health over the lifecourse.Physiol Rev.201595378580726109339
- HaoJ.RappPR.JanssenWG.et alInteractive effects of age and estrogen on cognition and pyramidal neurons in monkey prefrontal cortex.Proc Natl Acad Sci U S A.2007104271146511470 17592140
- ChenJR.YanYT.WangTJ.ChenLJ.WangYJ.TsengGF.Gonadal hormones modulate the dendritic spine densities of primary cortical pyramidal neurons in adult female rat.Cerebral Cortex.200919112719272719293395
- McCarthyMM.ArnoldAP.Reframing sexual differentiation of the brain.Nat Neurosci.201114667768321613996
- GorskiRA.GordonJH.ShryneJE.SouthamAM.Evidence for a morphological sex difference within the medial preoptic area of the rat brain.Brain Res.19781482333346656937
- WitelsonSF.GlezerII.KigarDL.Women have greater density of neurons in posterior temporal cortex.J Neurosci.199515 pt 134183428
- McEwenB.MilnerTA.Understanding the broad influence of sex hormones and sex differences in the brainJ Neurosci Res.2017951-22439.doi:10.1002/jnr.23809.27870427
- ForgerNG.Epigenetic mechanisms in sexual differentiation of the brain and behaviour.Philos Trans R Soc Lond B Biol Sci.201637116882015011426833835
- EilandL.RamroopJ.HillMN.ManleyJ.McEwenBS.Chronic juvenile stress produces corticolimbic dendritic architectural remodeling and modulates emotional behavior in male and female rats.Psychoneuroendocrinology.2012371394721658845
- ParschJ.EllegrenH.The evolutionary causes and consequences of sex-biased gene expression.Nat Rev Genet.2013142838723329110
- LeunerB.Mendolia-loffredoS.ShorsTJ.Males and females respond differently to controllability and antidepressant treatment.Biol Psychiatry.2004561296497015601607
- GaleaLA.WainwrightSR.RoesMM.Duarte-GutermanP.ChowC.HamsonDK.Sex, hormones and neurogenesis in the hippocampus: hormonal modulation of neurogenesis and potential functional implications.J Neuroendocrinol.201325111039106123822747
- BangasserDA.CurtisA.ReyesBA.et alSex differences in corticotropin-releasing factor receptor signaling and trafficking: potential role in female vulnerability to stress-related psychopathology.Mol Psychiatry.2010159877:89690420548297
- ShanskyRM.HamoC.HofPR.LouW.McEwenBS.MorrisonJH.Estrogen promotes stress sensitivity in a prefrontal cortex-amygdala pathway.Cereb Cortex.201020112560256720139149
- McCarthyMM.Multifaceted origins of sex differences in the brain.Philos Trans R Soc Lond B Biol Sci.201637116882015010626833829
- BabbJA.MasiniCV.DayHE.CampeauS.Stressor-specific effects of sex on HPA axis hormones and activation of stress-related neurocircuitry.Stress.201316666467723992519
- BohacekJ.ManuellaF.RoszkowskiM.MansuyIM.Hippocampal gene expression induced by cold swim stress depends on sex and handling.Psychoneuroendocrinology20155211225459888
- NugentBM.WrightCL.ShettyAC.et alBrain feminization requires active repression of masculinization via DNA methylation.Nat Neurosci.201518569069725821913
- McCarthyMM.ArnoldAP.BallGF.BlausteinJD.De VriesGJ.Sex differences in the brain: the not so inconvenient truth.J Neurosci.20123272241224722396398
- DumanRS.MonteggiaLM.A neurotrophic model for stress-related mood disorders.Biol Psychiatry.200659121116112716631126
- MagarinosAM.LiCJ.Gal TothJ.et alEffect of brain-derived neurotrophic factor haploinsufficiency on stress-induced remodeling of hippocampal neurons.Hippocampus.201121325326420095008
- BathKG.SchilitA.LeeFS.Stress effects on BDNF expression: effects of age, sex, and form of stress.Neuroscience.201323914915623402850
- SenS.DumanR.SanacoraG.Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications.Biol Psychiatry.200864652753218571629
- NotarasM.HillR.van den BuuseM.The BDNF gene Val66Met polymorphism as a modifier of psychiatric disorder susceptibility: progress and controversy.Mol Psychiatry.201520891693025824305
- ShiL.ZhangZ.SuB.Sex biased gene expression profiling of human brains at major developmental stages.Sci Rep.201662118126880485
- DuclotF.KabbajM.The estrous cycle surpasses sex differences in regulating the transcriptome in the rat medial prefrontal cortex and reveals an underlying role of early growth response 1.Genome Biol.20151625626628058
- HodesGE.PfauML.PurushothamanI.et alSex differences in nucleus accumbens transcriptome profiles associated with susceptibility versus resilience to subchronic variable stress.J Neurosci.20153550163621637626674863
- HeimanM.SchaeferA.GongS.et alA translational profiling approach for the molecular characterization of CNS cell types.Cell.2008135473874819013281
- GaleaLA.McEwenBS.TanapatP.DeakT.SpencerRL.DhabharFS.Sex differences in dendritic atrophy of CA3 pyramidal neurons in response to chronic restraint stress.Neuroscience.19978136896979316021
- BowmanRE.BeckKD.LuineVN.Chronic stress effects on memory: sex differences in performance and monoaminergic activity.Horm Behav.2003431485912614634
- WoodGE.ShorsTJ.Stress facilitates classical conditioning in males, but impairs classical conditioning in females through activational effects of ovarian hormones.Proc Natl Acad Sci USA.1998957406640719520494
- ShorsTJ.ChuaC.FaldutoJ.Sex differences and opposite effects of stress on dendritic spine density in the male versus female hippocampus.J Neurosci.200121166292629711487652
- ShorsTJ.A trip down memory lane about sex differences in the brain.Philos Trans R Soc Lond B Biol Sci.201637116882015012426833842
- BeckerJB.MonteggiaLM.Perrot-SinalTS.et alStress and disease: is being female a predisposing factor?J Neurosci.20072744118511185517978023
- MilnerTA.BursteinSR.MarroneGF.et alStress differentially alters mu opioid receptor density and trafficking in parvalbumin-containing interneurons in the female and male rat hippocampus.Synapse.2013671175777223720407
- LuineVN.BeckKD.BowmanRE.FrankfurtM.MacLuskyNJ.Chronic stress and neural function: accounting for sex and age.J Neuroendocrinol.2007191074375117850456
- McEwenBS.MorrisonJH.The brain on stress: vulnerability and plasticity of the prefrontal cortex over the life course.Neuron.2013791162923849196
- MermelsteinPG.BeckerJB.SurmeierDJ.Estradiol reduces calcium currents in rat neostriatal neurons via a membrane receptor.J Neurosci.19961625956048551343
- AlmeyA.MilnerTA.BrakeWG.Estrogen receptors in the central nervous system and their implication for dopamine-dependent cognition in females.Horm Behav.20157412513826122294
- BedardPJ.LangelierP.VilleneuveA.Oestrogens and the extrapyramidal system.Lancet.197728052-805313671368
- BourqueM.DluzenDE.Di PaoloT.Signaling pathways mediating the neuroprotective effects of sex steroids and SERMs in Parkinson's disease.Front Neuroendocrinol.201233216917822387674
- DeanSL.McCarthyMM.Steroids, sex and the cerebellar cortex: implications for human disease.Cerebellum.200871384718418672
- HedgesVL.EbnerTJ.MeiselRL.MermelsteinPG.The cerebellum as a target for estrogen action.Front Neuroendocrinol.201233440341122975197
- LabrenzF.IcenhourA.ThurlingM.et alSex differences in cerebellar mechanisms involved in pain-related safety learning.Neurobiol Learn Mem.2015123929926004678
- LoydDR.MurphyAZ.The neuroanatomy of sexual dimorphism in opioid analgesia.Exp Neurol.2014259576324731947
- MogilJS.Sex differences in pain and pain inhibition: multiple explanations of a controversial phenomenon.Nat Rev Neurosci.2012131285986623165262
- MalekiN.LinnmanC.BrawnJ.BursteinR.BecerraL.BorsookD.Her versus his migraine: multiple sex differences in brain function and structure.Brain.2012135 pt 82546255922843414
- DerntlB.FinkelmeyerA.EickhoffS.et alMultidimensional assessment of empathic abilities: neural correlates and gender differences.Psychoneuroendocrinology.2010351678219914001
- McEwenBS.LasleyEN.The End Of Sex As We Know It. Cerebrum: The Dana Forum on Brain Science; vol 7. Washington, DC: Dana Press.2005
- McCulloughLD.BlizzardK.SimpsonER.OzOK.HumPD.Aromatase cytochrome P450 and extragonadal estrogen play a role in ischemic neuroprotection.J Neurosci.200323258701870514507969
- NakamuraNH.ResellDR.AkamaKT.McEwenBS.Estrogen and ovariectomy regulate mRNA and protein of glutamic acid decarboxylases and cation-chloride cotransporters in the adult rat hippocampus.Neuroendocrinology.200480530832315677881
- LedouxVA.SmejkalovaT.MayRM.CookeBM.WoolleyCS.Estradiol facilitates the release of neuropeptide Y to suppress hippocampus-dependent seizures.J Neurosci.20092951457146819193892
- NilsenJ.BrintonRD.Mitochondria as therapeutic targets of estrogen action in the central nervous system.Curr Drug Targets CNS Neurol Disord.20043429731315379606
- HojoY.HattoriTA.EnamiT.et alAdult male rat hippocampus synthesizes estradiol from pregnenolone by cytochromes P45017α and P450 aromatase localized in neurons.Proc Natl Acad Sci U S A.2004101386587014694190
- PikeCJ.NguyenTV.RamsdenM.YaoM.MurphyMP.RosarioER.Androgen cell signaling pathways involved in neuroprotective actions.Horm Behav.200853569370518222446
- OkamotoM.HojoY.InoueK.et alMild exercise increases dihydrotestosterone in hippocampus providing evidence for androgenic mediation of neurogenesis.Proc Natl Acad Sci U S A.201210932131001310522807478
- AdamsMM.FinkSE.ShahRA.et alEstrogen and aging affect the subcellular distribution of estrogen receptor-α in the hippocampus of female rats.J Neurosci.20022293608361411978836
- YildirimM.JanssenWG.TaboriNE.et alEstrogen and aging affect synaptic distribution of phosphorylated LIM kinase (pLIMK) in CA1 region of female rat hippocampus.Neuroscience.2008152236037018294775
- HaraY.YukF.PuriR.JanssenWG.RappPR.MorrisonJH.Presynaptic mitochondrial morphology in monkey prefrontal cortex correlates with working memory and is improved with estrogen treatment.Proc Natl Acad Sci U S A.2014111148649124297907
- PicardM.McEwenBS.Mitochondria impact brain function and cognitionProc Natl Acad Sci U S A.201411117824367081