REFERENCES

• American Psychiatric Association.Diagnostic and Statistical Manual of Mental Disorders. 5th ed. Arlington, VA: American Psychiatric Publishing;2013
   Google Scholar
• BandelowB.MichaelisS.Epidemiology of anxiety disorders in the 21st century.Dialogues Clin Neurosci.201517332733526487813
   PubMed Web of Science ®Google Scholar
• NewmanSC.BlandRC.A population-based family study of DSM-III generalized anxiety disorder.Psychol Med.20063691275128116700965
   PubMed Web of Science ®Google Scholar
• HettemaJM.NealeMC.KendlerKS.A review and meta-analysis of the genetic epidemiology of anxiety disorders.Am J Psychiatry.2001158101568157811578982
   PubMed Web of Science ®Google Scholar
• HettemaJM.PrescottCA.MyersJM.NealeMC.KendlerKS.The structure of genetic and environmental risk factors for anxiety disorders in men and women.Arch Gen Psychiatry.200562218218915699295
   PubMed Web of Science ®Google Scholar
• WaszczukMA.ZavosHM.GregoryAM.EleyTC.The phenotypic and genetic structure of depression and anxiety disorder symptoms in childhood, adolescence, and young adulthood.JAMA Psychiatry201471890591624920372
   PubMed Web of Science ®Google Scholar
• KendlerKS.MyersJ.The boundaries of the internalizing and externalizing genetic spectra in men and women.Psychol Med.201444364765523574685
   PubMed Web of Science ®Google Scholar
• CosgroveVE.RheeSH.GelhornHL.et alStructure and etiology of co-occurring internalizing and externalizing disorders in adolescents.J Abnorm Child Psychol.201139110912320683651
   PubMed Web of Science ®Google Scholar
• MatherL.BlomV.BergstromG.SvedbergP.An underlying common factor, influenced by genetics and unique environment, explains the covariation between major depressive disorder, generalized anxiety disorder, and burnout: a Swedish Twin Study.Twin Res Hum Genet.201619661962727620693
   PubMed Web of Science ®Google Scholar
• ChantarujikapongSI.ScherrerJF.XianH.et alA twin study of generalized anxiety disorder symptoms, panic disorder symptoms and posttraumatic stress disorder in men.Psychiatry Res.20011032-313314511549402
   PubMed Web of Science ®Google Scholar
• DellavaJE.KendlerKS.NealeMC.Generalized anxiety disorder and anorexia nervosa: evidence of shared genetic variation.Depress Anxiety.201128872873321618670
   PubMed Web of Science ®Google Scholar
• GiddensJL.XianH.ScherrerJF.EisenSA.PotenzaMN.Shared genetic contributions to anxiety disorders and pathological gambling in a male population.J Affect Disord.2011132340641221481943
   PubMed Web of Science ®Google Scholar
• HettemaJM.PrescottCA.KendlerKS.Genetic and environmental sources of covariation between generalized anxiety disorder and neuroticism.Am J Psychiatry.200416191581158715337647
   PubMed Web of Science ®Google Scholar
• HettemaJM.NealeMC.MyersJM.PrescottCA.KendlerKS.A population-based twin study of the relationship between neuroticism and internalizing disorders.Am J Psychiatry.2006163585786416648327
   PubMed Web of Science ®Google Scholar
• MackintoshMA.GatzM.WetherellJL.PedersenNL.A twin study of lifetime generalized anxiety disorder (GAD) in older adults: genetic and environmental influences shared by neuroticism and GAD.Twin Res Hum Genet200691303716611465
   PubMed Web of Science ®Google Scholar
• AminN.SchuurM.GusarevaES.et alA genome-wide linkage study of individuals with high scores on NEO personality traits.Mol Psychiatry201217101031104121826060
   PubMed Web of Science ®Google Scholar
• WebbBT.GuoAY.MaherBS.et alMeta-analyses of genome-wide linkage scans of anxiety-related phenotypes.Eur J Hum Genet.201220101078108422473089
   PubMed Web of Science ®Google Scholar
• DunnEC.SoferT.GalloLC.et alGenome-wide association study of generalized anxiety symptoms in the Hispanic Community Health Study/Study of Latinos.Am J Med Genet B Neuropsychiatr Genet.2017174213214327159506
   PubMed Web of Science ®Google Scholar
• OtowaT.HekK.LeeM.et alMeta-analysis of genome-wide association studies of anxiety disorders.Mol Psychiatry201621101391139926754954
   PubMed Web of Science ®Google Scholar
• Genetics of Personality Consortiumde MoorMH.van den BergSM.et alMeta-analysis of genome-wide association studies for neuroticism, and the polygenic association with major depressive disorder.JAMA Psychiatry201572764265025993607
   PubMed Web of Science ®Google Scholar
• SmithDJ.Escott-PriceV.DaviesG.et alGenome-wide analysis of over 106 000 individuals identifies 9 neuroticism-associated loci.Mol Psychiatry201621674975727067015
   PubMed Web of Science ®Google Scholar
• OkbayA.BaselmansBM.De NeveJE.et alGenetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.Nat Genet.201648662463327089181
   PubMed Web of Science ®Google Scholar
• YouJS.HuSY.ChenB.ZhangHG.Serotonin transporter and tryptophan hydroxylase gene polymorphisms in Chinese patients with generalized anxiety disorder.Psychiatr Genet.200515171115722951
   PubMed Web of Science ®Google Scholar
• ChangCC.ChangHA.FangWH.ChangTC.HuangSY.Gender-specific association between serotonin transporter polymorphisms (5-HTTLPR and rs25531) and neuroticism, anxiety and depression in well-defined healthy Han Chinese.J Affect Disord.201720742242827788383
   PubMed Web of Science ®Google Scholar
• SenS.BurmeisterM.GhoshD.Meta-analysis of the association between a serotonin transporter promoter polymorphism (5-HTTLPR) and anxiety-related personality traits.Am J Med Genet B Neuropsychiatr Genet.2004127B1858915108187
   PubMed Web of Science ®Google Scholar
• MunafoMR.FreimerNB.NgW.et al5-HTTLPR genotype and anxiety-related personality traits: a meta-analysis and new data.Am J Med Genet B Neuropsychiatr Genet.2009150B227128118546120
   PubMed Web of Science ®Google Scholar
• SchinkaJA.BuschRM.Robichaux-KeeneN.A meta-analysis of the association between the serotonin transporter gene polymorphism (5-HTTLPR) and trait anxiety.Mol Psychiatry.20049219720214966478
   PubMed Web of Science ®Google Scholar
• MolinaE.CervillaJ.RiveraM.et alPolymorphic variation at the serotonin 1-A receptor gene is associated with comorbid depression and generalized anxiety.Psychiatr Genet.201121419520121512427
   PubMed Web of Science ®Google Scholar
• VoltasN.AparicioE.ArijaV.CanalsJ.Association study of monoamine oxidase-A gene promoter polymorphism (MAOA-uVNTR) with self-reported anxiety and other psychopathological symptoms in a community sample of early adolescents.J Anxiety Disord.201531657225747527
   PubMed Web of Science ®Google Scholar
• TadicA.RujescuD.SzegediA.et alAssociation of a MAOA gene variant with generalized anxiety disorder, but not with panic disorder or major depression.Am J Med Genet B Neuropsychiatr Genet.2003117B11612555227
   PubMed Web of Science ®Google Scholar
• TochigiM.HibinoH.OtowaT.et alAssociation between dopamine D4 receptor (DRD4) exon III polymorphism and neuroticism in the Japanese population.Neurosci Lett.2006398333333616472910
   PubMed Web of Science ®Google Scholar
• EnochMA.XuK.FerroE.HarrisCR.GoldmanD.Genetic origins of anxiety in women: a role for a functional catechol-O-methyltransferase polymorphism.Psychiatr Genet.2003131334112605099
   PubMed Web of Science ®Google Scholar
• MontagC.BastenU.StelzelC.FiebachCJ.ReuterM.The BDNF Val66Met polymorphism and anxiety: support for animal knock-in studies from a genetic association study in humans.Psychiatry Res.20101791869020478625
   PubMed Web of Science ®Google Scholar
• MoreiraFP.FabiaoJD.BittencourtG.et alThe Met allele of BDNF Val66Met polymorphism is associated with increased BDNF levels in generalized anxiety disorder.Psychiatr Genet.201525520120726110341
   PubMed Web of Science ®Google Scholar
• WangY.ZhangH.LiY.et alBDNF Val66Met polymorphism and plasma levels in Chinese Han population with obsessive-compulsive disorder and generalized anxiety disorder.J Affect Disord.201518671226209750
   PubMed Web of Science ®Google Scholar
• BredemeierK.BeeversCG.McGearyJE.Serotonin transporter and BDNF polymorphisms interact to predict trait worry.Anxiety Stress Coping.201427671272124679122
   PubMed Web of Science ®Google Scholar
• KruschwitzJD.WalterM.VarikutiD.et al5-HTTLPR/rs25531 polymorphism and neuroticism are linked by resting state functional connectivity of amygdala and fusiform gyrus.Brain Struct Fund.2015220423732385
   PubMed Web of Science ®Google Scholar
• ZhouZ.ZhuG.HaririAR.et alGenetic variation in human NPY expression affects stress response and emotionNature.20084527190997100118385673
   PubMed Web of Science ®Google Scholar
• HettemaJM.KettenmannB.AhluwaliaV.et alPilot multimodal twin imaging study of generalized anxiety disorder.Depress Anxiety.201229320220921994092
   PubMed Web of Science ®Google Scholar
• OathesDJ.HiltLM.NitschkeJB.Affective neural responses modulated by serotonin transporter genotype in clinical anxiety and depression.PLoS One.2015102e011582025675343
   PubMed Web of Science ®Google Scholar
• FogelmanN.MikhailikA.Mueller-AlcazarA.BernardK.CanliT.Stressing over anxiety: a novel interaction of 5-HTTPLR genotype and anxiety-related phenotypes in older adults.Psychoneuroendocrinology.201671364227235638
   PubMed Web of Science ®Google Scholar
• ShalevI.MoffittTE.BraithwaiteAW.et alInternalizing disorders and leukocyte telomere erosion: a prospective study of depression, generalized anxiety disorder and post-traumatic stress disorder.Mol Psychiatry201419111163117024419039
   PubMed Web of Science ®Google Scholar
• KuhnM.HaakerJ.Glotzbach-SchoonE.et alConverging evidence for an impact of a functional NOS gene variation on anxiety-related processes.Soc Cogn Affect Neurosci.201611580381226746182
   PubMed Web of Science ®Google Scholar
• KlaukeB.DeckertJ.ReifA.et alSerotonin transporter gene and childhood trauma--a G x E effect on anxiety sensitivity.Depress Anxiety.201128121048105721681867
   PubMed Web of Science ®Google Scholar
• BaumannC.KlaukeB.WeberH.et alThe interaction of early life experiences with COMT val158met affects anxiety sensitivity.Genes Brain Behav.201312882182924118915
   PubMed Web of Science ®Google Scholar
• KlaukeB.DeckertJ.ZwanzgerP.et alNeuropeptide S receptor gene (NPSR) and life events: G x E effects on anxiety sensitivity and its subdimensions.World J Biol Psychiatry.2014151172522404660
   PubMed Web of Science ®Google Scholar
• DeYoungCG.CicchettiD.RogoschFA.Moderation of the association between childhood maltreatment and neuroticism by the corticotropin-releasing hormone receptor 1 gene.J Child Psychol Psychiatry.201152889890621438878
   PubMed Web of Science ®Google Scholar
• AmstadterAB.KoenenKC.RuggieroKJ.et alNPY moderates the relation between hurricane exposure and generalized anxiety disorder in an epidemiologic sample of hurricane-exposed adults.Depress Anxiety.201027327027520037921
   PubMed Web of Science ®Google Scholar
• KoenenKC.AmstadterAB.RuggieroKJ.et al RGS2 and generalized anxiety disorder in an epidemiologic sample of hurricane-exposed adults.Depress Anxiety.200926430931518833580
   PubMed Web of Science ®Google Scholar
• GunthertKC.ConnerTS.ArmeliS.TennenH.CovaultJ.KranzlerHR.Serotonin transporter gene polymorphism (5-HTTLPR) and anxiety reactivity in daily life: a daily process approach to gene-environment interaction.Psychosom Med.200769876276817942837
   PubMed Web of Science ®Google Scholar
• PluessM.BelskyJ.WayBM.TaylorSE.5-HTTLPR moderates effects of current life events on neuroticism: differential susceptibility to environmental influences.Prog Neuropsychopharmacol Biol Psychiatry.20103461070107420573579
   PubMed Web of Science ®Google Scholar
• LaasK.ReifA.AkkermannK.et alInteraction of the neuropeptide S receptor gene Asn107lle variant and environment: contribution to affective and anxiety disorders, and suicidal behaviour.Int J Neuropsychopharmacol.201417454155224331455
   PubMed Web of Science ®Google Scholar
• KurrikoffT.LeschKP.KiiveE.et alAssociation of a functional variant of the nitric oxide synthase 1 gene with personality, anxiety, and depressiveness.Dev Psychopathol.20122441225123523062293
   PubMed Web of Science ®Google Scholar
• LenzeEJ.GoateAM.NowotnyP.et alRelation of serotonin transporter genetic variation to efficacy of escitalopram for generalized anxiety disorder in older adults.J Clin Psychopharmacol.201030667267721105279
   PubMed Web of Science ®Google Scholar
• LenzeEJ.MantellaRC.ShiP.et alElevated Cortisol in older adults with generalized anxiety disorder is reduced by treatment: a placebo-controlled evaluation of escitalopram.Am J Geriatr Psychiatry.201119548249020808146
   PubMed Web of Science ®Google Scholar
• LenzeEJ.DixonD.NowotnyP.et alEscitalopram reduces attentional performance in anxious older adults with high-expression genetic variants at serotonin 2A and 1B receptors.Int J Neuropsychopharmacol.201316227928822717018
   PubMed Web of Science ®Google Scholar
• LohoffFW.NarasimhanS.RickelsK.Interaction between polymorphisms in serotonin transporter. (SLC6A4) and serotonin receptor 2A (HTR2A) genes predict treatment response to venlafaxine XR in generalized anxiety disorder.Pharmacogenomics J.2013135465469
   Web of Science ®Google Scholar
• LohoffFW.AquinoTD.NarasimhanS.MultaniPK.EtemadB.RickelsK.Serotonin receptor 2A (HTR2A) gene polymorphism predicts treatment response to venlafaxine XR in generalized anxiety disorder.Pharmacogenomics J.2013131212622006095
   PubMed Web of Science ®Google Scholar
• NarasimhanS.AquinoTD.MultaniPK.RickelsK.LohoffFW.Variation in the catechol-O-methyltransferase (COMT) gene and treatment response to venlafaxine XR in generalized anxiety disorder.Psychiatry Res.2012198111211522417933
   PubMed Web of Science ®Google Scholar
• NarasimhanS.AquinoTD.HodgeR.RickelsK.LohoffFW.Association analysis between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene and treatment response to venlafaxine XR in generalized anxiety disorder.Neurosci Lett.2011503320020221889574
   PubMed Web of Science ®Google Scholar
• SaungWT.NarasimhanS.LohoffFW.Lack of influence of DAT1 and DRD2 gene variants on antidepressant response in generalized anxiety disorder.Hum Psychopharmacol.201429431632124723432
   PubMed Web of Science ®Google Scholar
• PerlisRH.FijalB.DhariaS.HoustonJP.Pharmacogenetic investigation of response to duloxetine treatment in generalized anxiety disorder.Pharmacogenomics J.201313328028522249355
   PubMed Web of Science ®Google Scholar
• GoldmanD.DomschkeK.Making sense of deep sequencing.Int J Neuropsychopharmacol.201417101717172524925306
   PubMed Web of Science ®Google Scholar
• SchieleMA.ZieglerC.HolitschkeK.et alInfluence of 5-HTT variation, childhood trauma and self-efficacy on anxiety traits: a gene-environment-coping interaction study.J Neural Transm.2016123889590427145764
   PubMed Web of Science ®Google Scholar
• SchuebelK.GitikM.DomschkeK.GoldmanD.Making sense of epigenetics.Int J Neuropsychopharmacol.20161911doi: 10.1093/ijnp/pyw058
   Web of Science ®Google Scholar
• LuekenU.ZierhutKC.HahnT.et alNeurobiological markers predicting treatment response in anxiety disorders: a systematic review and implications for clinical application.Neurosci Biobehav Rev.20166614316227168345
   PubMed Web of Science ®Google Scholar
• GottschalkMG.DomschkeK.Novel developments in genetic and epigenetic mechanisms of anxiety.Curr Opin Psychiatry.2016291323826575296
   PubMed Web of Science ®Google Scholar