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Archives of Environmental Health: An International Journal Volume 58, 2003 - Issue 8
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Original Article

Organophosphorus Ester-Induced Chronic Neurotoxicity

Mohamed B. Abou-Donia Duke University Medical Center Department of Pharmacology and Cancer Biology Durham, North Carolina
Pages 484-497 | Published online: 07 Aug 2010

  • Petras JM. Soman neurotoxicity. Fundam Appl Toxicol 1981; 1:242-49.
  • Johnson MK. The delayed neurotoxic effect of some organophosphorus compounds. Br Med Bull 1969; 114:711-17.
  • Lotti M. The pathogenesis of organophosphate delayed neuropathy. Crit Rev Toxicol 1992; 21:465-87.
  • Faro MD, Windle WF. Transneuronal degeneration in brains of monkeys asphyxiated at birth. Exp Neurol 1969; 24:38-53.
  • Savage EP, Keefe TF, Mounce LM, et al. Chronic neurological sequelae of acute organophosphates pesticide poisoning. Arch Environ Health 1988; 43:38-45.
  • Maroni M, Jarvisalo J, La Ferla L. The WHO-UNDP edidemiological study on the health effects of exposure to organophosphorous pesticides. Toxicol Lett 1986; 33:115-23.
  • McConell R, Keifer M, Rosenstock L. Elevated quantitative vibrotactile threshold among workers previously poisoned with methamidophos and other organophosphate pesticides. Am J Ind Med 1994; 25:325-34.
  • Stephens R, Spurgeon A, Calvert IA, et al. Neuropsychological effects of long-term exposure to organophosphates in sheep dip. Lancet 1995; 345:1135-39.
  • Colosio C, Tiramani M, Maroni M. Neurobehavioral effects of pesticides: state of the art. Neurotoxicology 2003; 24:577-91.
  • Scremin O, Shih TM, Huynh L, et al. Delayed neurologic and behavioral effects of subtoxic doses of cholinesterase inhibitors. J Pharmacol Exp Ther 2003; 304:1111-19.
  • Echbichon DJ, Joy RM. Pesticides and Neurological Diseases. 2nd ed. Boston and London: CRC Press, 1995.
  • Yokoyama K, Araki K, Murata K, et al. A preliminary study on delayed vestibulo-cerebellar effects of Tokyo Subway sarin poisoning in relation to gender difference: frequency analysis of postural sway. J Occup Environ Med 1998; 40(1):17-21.
  • Rodnitzky RL, Levin HS, Mick DL. Occupational exposure to organophosphate pesticides. Arch Environ Health 1975; 30:98-103.
  • Maizlish N, Schenker M, Weisskopf C, et al. A behavioral evaluation of pest control workers with short-term, low-level exposure to the organophosphate diazinon. Am J Indust Med 1987; 12:153-72.
  • Daniell W, Barnhart S, Demers P, et al. Neuropsychological performance among agricultural pesticide applicators. Environ Res 1992; 59(1):217-28.
  • Beach JR, Spurgeon A, Stephens R, et al. Abnormalities on neurological examination among sheep farmers exposed to organophosphate pesticides. Occup Environ Med 1996; 53(8):520-25.
  • London L, Myers JE, Neil V, et al. An investigation into neurological and neurobehavioral effects of long-term agrochemical use among deciduous fruit farm workers in the Western Cape, South Africa. Environ Res 1997; 73(1-2):132-45.
  • Gupta RP, Bing G, Hong JS, et al. cDNA cloning and sequencing of Ca2+ /calmodulin-dependent protein kinase_subunit and its mRNA expression in diisopropyl phosphorofluoridate (DFP)-treated hen central nervous system. Mol Cell Biochem 1998; 181:29-39.
  • Gupta RP, Abou-Donia MB. Tau phosphorylation by diisopropyl phosphorofluoridate (DFP)-treated hen brain supernatant inhibits its binding with microtubules: role of Ca2+/calmodulin-dependent protein kinase II in tau phosphorylation. Biochem Pharmacol 1999; 53:1799-1806.
  • Gupta RP, Damodaran TV, Abou-Donia MB. C-fos mRNA induction in the central and peripheral nervous systems of diisopropyl phosphorofluoridate (DFP)-treated hens. Neurochem Res 2000; 25(3):327-34.
  • Gupta RP, Abdel-Rahman AA, Jensen KF, et al. Altered expression of neurofilament subunits in diisopropyl phosphorofluoridate (DFP)-treated hen spinal cord and their presence in axonal aggregates. Forthcoming.
  • Damodaran TV, Abou-Donia MB. Alterations in levels of mRNAs coding for glial fibrillary acidic protein (GFAP) and vimentin genes in the central nervous system of hens treats with diisopropyl phosphorofluoridate (DFP). Neurochem Res 2000; 25:809-16.
  • Jensen KF, Lapadula DM, Anderson JK, et al. Anomalous phosphorylated neurofilament aggregations in central and peripheral axons of hens treated with tri-ortho-cresyl phosphate (TOCP). J Neurosci Res 1992; 33:455-60.
  • Abou-Donia MB, et al. Unpublished results, 2004.
  • Jamal G. Neurological syndromes of organophosphorus compounds. Adverse Drug React Toxicol Rev 1997; 16:133-70.
  • Gershon S, Shaw FB. Psychiatric sequelae of chronic exposure to organophosphorous insecticides. Lancet 1961; 1:1371-74.
  • Dille JR, Smith PW. Central nervous system effects of chronic exposure to organophosphate insecticides. Aerosp Med 1964; 35:475-78.
  • Metcalf DR, Holmes JH. EEG, psychological and neurological alterations in humans with organophosphorous exposure. Ann NY Acad Sci 1969; 160:357-65.
  • Duffy FH, Burchfield JL, Bartels PH, et al. Long-term effects of an organophosphate upon the human electroencephalogram. Toxicol Appl Pharmacol 1979; 47:161-76.
  • Pilkington A, Buchanan D, Jamal GA, et al. An epidemological study of the relations between exposure to organophosphate pesticides and indices of chronic peripheral neuropathy and neuropsychological abnormalities in sheep farmers and dippers. Occup Environ Med 2001; 58(11):702-10.
  • Russell R, Macri J. Central cholinergic involvement hyper-reactivity. Pharmocol Biochem Behav 1979; 10:43-48.
  • Joubert J, Joubert PH. Chorea and psychiatric changes in organophosphate poisoning. A report of 2 further studies. S Afr Med J 1988; 74:32-34.
  • Rosenstock L, Keifer M, Daniell WE, et al. Chronic central nervous system effects of acute organophosphate pesticide intoxication. Lancet 1991; 338:223-27.
  • Steenland K, Jenkins B, Ames RG, et al. Chronic neurological sequelae to organophosphate pesticide poisoning. Am J Public Health 1994; 84:731-36.
  • Callender TJ, Morrow L, Subramanian K. Evaluation of chronic neurological sequelae after acute pesticide exposure using SPECT brain scans. J Toxicol Environ Health 1994; 41:275-84.
  • Srivastava AK, Gupta BN, Bihari V, et al. Clinical, biochemical and neurobehavioral studies on workers engaged in the manufacture of quinalphos. Food Chem Toxicol 2000; 38(1):65-69.
  • Nishiwaki Y, Maekawa K, Ogawa Y, et al. Effects of sarin on the nervous system in rescue team staff members and police officers 3 years after the Tokyo subway sarin attack. Environ Health Perspect 2001; 109:1169-73.
  • Durham WF, Wolfe HR, Quinby GE. Organophosphorus insecticides and mental alertness. Arch Environ Health 1965; 10:55-66.
  • Tabershaw IR, Cooper WC. Sequelae of acute organic phosphate poisoning. J Occup Med 1966; 8:5-20.
  • McDonough JH, Dochterman LW, Smith CD, et al. Protection against nerve agent-induced neuropathology, but not cardiac pathology, is associated with the anti-convulsant action of drug treatment. Neurotoxicology 1995; 15:123-32.
  • Kadar T, Cohen G, Sarah R, et al. Long-term study of brain lesions following soman, in comparison to DFP and metrazol poisoning. Hum Exp Toxicol 1992; 11:517-23.
  • Kadar T, Shapira S, Cohen G, et al. Sarin induced neuropathology in rats. Hum Exp Toxicol 1995; 14:252-59.
  • Kaplan JG, Kessler J, Rosenberg N, et al. Sensory neuropathy associated with Dursban (chlorpyrifos) exposure. Neurology 1993; 43:2193-96.
  • Stokes L, Stark A, Marshall E, et al. Neurotoxicity among pesticide applicators exposed to organophosphates. Occup Environ Health 1995; 52:648-53.
  • Fielder N, Feldman RG, Jacobson J, et al. The assessment of neurobehavioral toxicity: SOGOMSEC joint report. Environ Health Perspect 1996; 104(Suppl 2):179-91.
  • Veronesi B, Jones K, Pope C. The neurotoxicity of subchronic acetylcholinesterase (AChE) inhibition in rat hippocampus. Toxicol Appl Pharmacol 1990; 104:440-56.
  • Abdel-Rahman A, Shetty AK, Abou-Donia MB. Acute exposure to sarin increases blood brain barrier permeability and induces neuropathological changes in the rat brain: dose-response relationships. Neuroscience 2002; 113(3):721-41.
  • McDonald BE, Costa LG, Murphy SD. Spatial memory impairment and central muscarinic receptor loss following prolonged treatment with organophosphates. Toxicol Lett 1988; 40:47-56.
  • Rafaelle K, Olton D, Annau Z. Repeated exposure to diisopropylfluorophosphate (DFP) produces increased sensitivity to cholinergic antagonists in discrimination retention and reversal. Psychopharmacology (Berl) 1990; 100:267-74.
  • Bushnell PJ, Padilla SS, Ward T, et al. Behavioral and neurochemical changes in rats dosed repeatedly with diisopropyl fluorophosphate. J Pharmacol Exp Ther 1991; 256:741-50.
  • Kassa J, Koupilova M, Vachek J. The influence of low-level sarin inhalation exposure on spatial memory in rats. Pharmacol Biochem Behav 2001; 70:175-79.
  • Prendergast MA, Terry AV Jr, Buccafusco JJ. Chronic, low-level exposure to diisopropyl fluorophosphate causes protracted impairment of spatial navigation learning. Psychopharmacology (Berl) 1997; 130:276-84.
  • Prendergast MA, Terry AV Jr, Buccafusco JJ. Effects of chronic low-level organophosphate exposure on delayed recall, discrimination and spatial learning in monkeys and rats. Neurotoxicol Teratol 1998; 20:115-22.
  • Shih TM, Duniho SM, McDonough JH. Control of nerve agent-induced seizures is critical for neuroprotection and survival. Toxicol Appl Pharmacol 2003; 188:69-80.
  • Lemercier G, Carpentier P, Setenac-Roumanou H, et al. Histological and histochemical changes in the central nervous system of the rat poisoned by an irreversible anticholinesterase organophosphorous compound. Acta Neuropathol 1983; 61:123-29.
  • Petras JM. Neurology and neuropathology of soman-induced brain injury: an overview. J Exp Anal Behav 1994; 61:319-29.
  • Carpentier P, Delamanche IS, Lebert M, et al. Seizure-related opening of the blood brain barrier induced by soman: possible correlation with the acute neuropathology observed in poisoned rats. Neurotoxicology 1990; 11:493-508.
  • Clement JG, Broxup B. Efficacy of diazepam and avizafone against soman-induced neuropathology in brain of rats. Neurotoxicology 1993; 14:485-504.
  • Shih TM, Koviak TA, Capacio BR. Anticonvulsants for poisoning by the organophosphorous compound Soman: pharmacological mechanisms. Neurosci Biobehav Rev 1991; 15:349.
  • Churchill L, Pazdernik TL, Jackson JL. Soman-induced brain lesions demonstrated by muscarinic receptor autoradiography. Neurotoxicology 1985; 6:81-90.
  • Baille V, Dorandeu F, Carpentier P, et al. Acute exposure to a low or mild dose of soman: biochemical, behavioral and histopathological effects. Pharmacol Biochem Behav 2001; 69:561-69.
  • Sidell FR. Soman and sarin: clinical manifestations and treatment of accidental poisoning by organophosphates. Clin Toxicol 1974; 7(1):1-17.
  • West I. Sequelae of poisoning from phosphate ester pesticides. Ind Med Surg 1968; 37(11):832.
  • Namba T, Nolte CT, Jackrel J et al. Poisoning due to organophosphate insecticides. Am J Med 1971; 50:475.
  • Abou-Donia MB, Abdel-Rahman AA, Goldstein LB, et al. Sensorimotor deficits and increased brain nicotinic acetylcholine receptors following exposure to chlorpyrifos and/or nicotine in rats. Arch Toxicol 2003; 77:452-58.
  • Abdel-Rahman AA, Dechkovskaia AM, Mehta-Simmons H, et al. Increased expression of glial fibrillary acidic protein in cerebellum and hippocampus: differential effects on neonatal brain regional acetylcholinesterase following maternal exposure to combined chlorpyrifos and nicotine. J Toxicol Environ Health A, 2003; 66:2047-66.
  • Eng LF, Ghirnikar RS. GFAP and astrogliosis. Brain Pathol 1994; 4:229-37.
  • Pazdernik TL, Emerson MR, Cross R, et al. Soman-induced seizures: limbic activity, oxidative stress, and neuroprotective proteins. J Appl Toxicol 2001; 21:S87-S94.
  • deGroot DMG, Bierman EPB, Bruijnzeel PLB, et al. Beneficial effects of TCP on soman intoxication in guinea pigs: seizures, brain damage, and learning behavior. J Appl Toxicol 2001; 21:S57-S65.
  • Taysee L, Calvet JH, Buee J, et al. Comparative efficacy of diazepam and avizafone against sarin-induced neuropathology and respiratory failure in guinea pigs: influence of atropine dose. Toxicology 2003; 188:197-209.
  • Abou-Donia MB, et al. Unpublished results, 2004.
  • Kim YB, Hur GH, Shin S, et al. Organophosphate-induced brain injuries: delayed apoptosis mediated by nitric oxide. Environ Toxicol Pharmacol 1999; 7:147-52.
  • Abdel-Rahman AA, Dechkovskaia AM, Goldstein LB, et al. Neurological deficits induced by malathion, DEET and permethrin, alone or in combination in adult rats. J Toxicol Environ Health A 2004; 67:331-56.
  • McLeod CG, Singer AW, Harrington DG. Acute neuropathology in soman-poisoned rats. Neurotoxicology 1984; 5:53-58.
  • Olney JW, de Gubareff T, Labruyere J. Seizure-related brain damage induced by cholinergic agents. Nature 1983; 301:520-22.
  • Dawson VL, Dawson TM, Lonedon ED, et al. Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc Natl Acad Sci USA 1991; 88:6368-71.
  • Solberg Y, Belkin M. The role of excitotoxicity in organophosphorus nerve agents central poisoning. Trends Pharmacol Sci 1997; 8:183-85.
  • Bagetta G, Massoud R, Rodino P, et al. Systematic administration of lithium chloride and tacrine increases nitric oxide synthase activity in the hippocampus of rats. Eur J Pharmacol 1993; 237:61-64.
  • Kim YB, Hui GH, Lee YS, et al. A role of nitric acid oxide in organophosphate-induced convulsions. Environ Toxicol Pharmacol 1997; 1(3):53-56.
  • Thompson CB. Apoptosis in the pathogenesis and treatment of disease. Science 1995; 267:1456-62.
  • Tsujimoto Y. Apoptosis and necrosis: intracellular ATP level as a determinant for cell death modes. Cell Death Differ 1997; 4:429-34.
  • Raveh L, Chapman S, Cohen G, et al. The involvement of the NMDA receptor complex in the protective effect of anticholinergic drugs against soman poisoning. Neurotoxicology 1999; 20:551-60.
  • Dawson TM, Dawson VL, Snyder SH. A novel neuronal messenger molecule in brain: the free radical, nitric oxide. Ann Neurol 1992; 32:297-31.
  • Montague PR, Gancayco CD, Winn MJ., et al. Role of NO production in NMDA receptor-mediated neuro-transmitter release in cerebral cortex. Science 1994; 263(5149):973-77.
  • Murphy AN, Fiskum G, Beal MF. Mitochondria in neurodegeneration: cell life and death. J Cereb Blood Flow Metab 1999; 19:231-45.
  • Floyd RA. Antioxidants, oxidative stress, and degenerative neurological disorders. Proc Soc Exp Biol Med 1999; 222:236-45.
  • Gupta RP, Milatovic D, Dettbarn WD. Depletion of energy metabolites following acetylcholinesterase inhibitor-induced status epilepticus: protection by antioxidants. Neurotoxicology 2001; 22:271-82.
  • Lieberman AD, Craven MR, Lewis HA, et al. Genotoxicity from domestic use of organophosphate pesticides. J Occup Environ Med 1998; 40(11):954-57.
  • Abou-Donia MB, et al. Unpublished data, 2004.
  • Abou-Donia MB, et al. Unpublished results, 2004.
  • Sberna G, Saez-Valero J, Li QX, et al. Acetylcholinesterase is increased in the brains of transgenic mice expressing the C-terminal fragment (CT100) of the B-amyloid protein precursor of Alzheimer's Disease. J Neurochem 1998; 71:723-31.
  • Calderon FH, von Bernhardi R, De Ferrari G, et al. Toxic effects of acetylcholinesterase on neuronal and glial-like cells in vitro. Mol Psychiatry 1998; 3:247-55.
  • Damodaran TV, Jones KH, Patel AG, et al. Sarin (nerve agent GB)-induced differential expression of mRNA coding for the acetylcholinesterase gene in the rat central nervous system. Biochem Pharmacol 2003; 65:2041-47.
  • Yang L, Heng-Yi H, Zhang XJ. Increased expression of intranuclear AChE involved in apoptosis of SK-N-SH cells. Neurosci Res 2002; 42:261-68.
  • Andres C, Seidman S, Beeri R, et al. Transgenic acetylcholinesterase induces enlargement of murine neuro-muscular junctions but leaves spinal cord synapses intact. Neurochem Int 1998; 32:449-56.
  • Abou-Donia MB, Wilmarth KR, Jensen KF. Neurotoxicity resulting from coexposure to pyridostigmine bromide, DEET, and permethrin: implications of Gulf War chemical exposures. J Toxicol Environ Health 1996; 48:35-56.
  • Rae WJ. Chemical Sensitivity. Vol 1. Boca Raton, FL:Lewis Publishers, 1992; pp 47-154.
  • Kurt TL. Epidemiological association in U.S. veterans between Gulf War illiness and exposure to anti-cholinesterases. Toxicol Lett 1998; 11:1-5.
  • Abou-Donia MB. Organophosphorus pesticides. In: Chang LW, Dyer RS (Eds). Handbook of Neurotoxicology. New York: Marcel Dekker, 1994; pp 419-47.
  • Koelle GB. Protection of cholinesterase against inevitable inactivation by diisopropyl fluorophosphate in vitro. J Pharmacol Exp Ther 1946; 88:232-37.
  • Abou-Donia MB. Neurotoxicology. Boca Raton, FL: CRC Press, 1992; pp 3-24.
  • Mackness B, Mackness Ml, Arrol S, et al. Effect of the molecular polymorphisms of human paraoxonase (PONI) on the rate of hydrolysis of paraoxon, Br J Pharmacol 1997; 122:265-68.
  • Davies HG, Richter RJ, Keifer M, et al. The effect of the human serum paraoxonase polymorphism is reversed with diazoxon, soman, and sarin. Nat Genet 1996; 14: 334-36.
  • Morita H, Yanagisawa N, Nakajima T, et al. Sarin poisoning in Matsumoto, Japan. Lancet 1995; 346:290-93.
  • Okumura T, Takasu N, Ishimatsu S, et al. Report on 640 victims of the Tokyo subway sarin attack. Ann Emerg Med 1995; 28:129-35.
  • Yokoyama K, Araki S, Murata K, et al. Chronic neu-robehavioral effects of Tokyo subway sarin poisoning in relation to posttraumatic stress disorder. Arch Environ Health 1998; 53:249-56.
  • Masuda N, Takatsu M, Morinari H. Sarin poisoning in Tokyo subway. Lancet 1995; 345:1446-47.
  • Smith Ml, Elvove E, Frazier WH. The pharmacological action of certain phenol esters with special reference to the etiology of so-called ginger paralysis. Public Health Rep 1930; 45:2509-24.
  • Johnson MK. The delayed neuropathology caused by some organophosphorous esters: mechanism and challenge. Crit Rev Toxicol 1975; 2:289-316.
  • Abou-Donia MB, Lapadula LM. Mechanisms of organophosphorus ester-induced delayed neurotoxicity: type I and type II. Annu Rev Pharmacol Toxicol 1990; 30:405-40.
  • Cavanagh JB, Patangia GN. Changes in the central nervous system in the cat as the result of tri-ocresylphosphate poisoning. Brain 1995; 88:165-80.
  • Himuro K, Murayama S, Nishiyama K, et al. Distal sensory axonopathy after sarin intoxification. Neurology 1998; 51:1195-97.
  • Sussman JL, Harel M, Frolow F. Atomic structure of acetylcholinesterase from Torpedo californica. A prototypic acetylcholine-binding protein. Science 1992; 253:872-78.
  • Whittaker M. The pseudocholinesterase variants: esterase levels and increased resistance to fluoride. Acta Genet Basel 1994; 14:281-85.
  • Lockridge O. Genetic variants of human serum cholinesterase influence metabolism of the muscle relaxant succinylcholine, Pharmacol Ther 1990; 47:35-60.
  • Davies OR, Holland PR. Effect of oximes and atropine upon the development of delayed neurotoxic signs in chickens following poisoning by DFP and sarin. Biochem Pharmacol 1972; 21:3145-51.
  • Abou-Donia MB. Triphenyl phosphite: a type II organophosphorus compound-induced delayed neurotoxic agent. In: Chambers JE, Levi PE (Eds). Organo-phosphates: Chemistry, Fates, and Effects. Part IV: Toxic Effects - Organismal. San Diego, CA: Academic Press, 1992; pp 327-51.
  • Abou-Donia MB, Wilmarth KR, Jansen KF, et al. Triphenylphosphine (TPP): a type III organophosphorous compound-induced delayed neurotoxic agent (OPIDN). Toxicologist 1996; 30:311.
  • Abdel-Rahman AA, Jensen KF, Farr CH, et al. Daily treatment of triphenylphosphine (TPP) produces organophosphorous-induced delayed neurotoxicity (OPIDN). Toxicologist 1997; 36:19.
  • Bloch H, Hottinger A. Uber die spezifitat der cholinesterase-hemmung durch tri-o-kresyl phosphat. Int Z Vitaminforsch 1943; 13:90.
  • Earl CJ, Thompson RHS. The inhibitory action of tri-ortho-cresyl phosphate and cholinesterases. Br J Pharmacol 1952; 7:261-69.
  • Curtes JP, Develay P, Hubert JP. Late peripheral neuropathy due to acute voluntary intoxication by organophosphorous compounds, Clin Toxicol 1981; 18:1453.
  • de Jager AE, van Weerden TW, Houthoff HJ, et al. Polyneuropathy after massive exposure to parathion. Neurology 1981; 31:603-05.
  • Stamboulis E, Psimaras A, Vassilopoulos D. Neuropathy following acute intoxication, with mercarbam (Opester). Acta Neurol Scand 1991; 83:198.
  • Winrow CJ, Hemming ML, Allen DA, et al. Loss of neuropathy target esterase in mice links organophosphate exposure to hyperactivity. Nat Genet 2003; 33:477-85.
  • O'Callahan JP. Neurotoxic esterase: not so toxic? Nat Genet 2003; 33:1-2.
  • Bus J, Maurissen J, Marable B, et al. Association between organophosphate exposure and hyperactivity? Nat Genet 2003; 34(3):235.
  • Abou-Donia MB. Involvement of cytoskeletal proteins in the mechanisms of organophosphorous ester delayed neurotoxicity. Clin Exp Pharmacol Physiol 1995; 22:358-59.
  • Schulman H. Advances in Second Messenger and Phosphorylation Research. New York: Raven Press, 1988; pp 39-111.
  • Patton SE, Lapadula DM, Abou-Donia MB. Relationship of tri-o-cresyl phosphate-induced delayed neurotoxicity to enhancement of in vitro phosphorylation of hen brain and spinal cord. J Pharmacol Exp Ther 1986; 239: 597-605.
  • Suwita E, Lapadula DM, Abou-Donia MB. Calcium and calmodulin-enhanced in vitro phosphorylation of hen brain cold-stable microtubules and spinal cord neuro-filament triplet proteins after a single oral dose of tri-o-cresyl phosphate. Proc Natl Acad Sci USA 1986; 83: 6174-78.
  • Gupta RP, Abou-Donia MB. In vivo and in vitro effects of diisopropyl phosphorofluoridate (DFP) on the rate of hen brain tubulin polymerization. Neurochem Res 1994; 19:435-44.
  • Gupta RP, Abou-Donia MB. Neurofilament phosphorylation and [1251] calmodulin binding by Ca2+/calmodulin-dependent protein kinase in the brain subcellular fractions of diisopropyl phosphorofluoridate (DFP)-treated hen. Neurochem Res 1995; 20(9):1095-105.
  • Gupta RP, Abou-Donia, MB. Diisopropyl phosphorofluoridate (DFP) treatment alters calcium-activated proteinase activity and cytoskeletal proteins of the hen sciatic nerve. Brain Res 1995; 677:162-66.
  • Abou-Donia MB. Organophosphorous ester-induced delayed neurotoxicity. Annu Rev Pharmacol Toxicol 1981; 21:511-48.
  • Anger WK, Storzbach D, Binder LM. Neurobehavioral deficits in Persian Gulf veterans: evidence from a population-based study. J Int Neuropsychol Soc 1999; 5:203-12
  • McCauley LA, Rischitelli G, Lambert WE. Symptoms of Gulf War vertrans possibly exposed to organophosphate chemical warfare agents at Khamisiyah, Iraq. Int J Occup Environ Health 2001; 7:3170-75.
  • Storzbach D, Campbell KA, Binder LM. Psychological differences between veterans with and without Gulf War unexplained symptoms. Psychosom Med 2000; 726-35.
  • Abou-Donia MB, Viana ME, Gupta RP, et al. Enhanced calmodulin binding concurrent with increased kinase-dependent phosphorylation of cytoskeletal proteins following a single subcutaneous injection of diisopropyl phosphorofluoridate in hens. Neurochem Res 1993; 22:165-73.
  • Gupta RP, Abou-Donia MB. Tau proteins-enhanced Ca2+/calmodulin (CaM)-dependent phosphorylation by the brain supernatant of diisopropyl phosphorofluoridate (DFP)-treated hen: tau mutants indicate phosphorylation of more amino acids in tau by CaM kinase II. Brain Res 1998; 813:32-43.
  • Bazylewicz-Walckzak B, Majzakova W, Szymczak M. Behavioral effects of occupational exposure to organophosphorous pesticides in female greenhouse plantin workers. Neurotoxicology 1999; 20(5):819-26.
  • Steenland M. Chronic neurological effects of organophosphate pesticides. Br Med J 1996; 312:1311-12.
  • Levin HS, Rodnitzsky RL, Mick DL, et al. Anxiety associated with exposure to organophosphorous compounds. Arch Gen Psychiatry 1976; 33:225-28.
  • Hyams KC, Wignall FS, Roswell R. War syndromes and their evaluation: from the U.S. Civil War to the Persian Gulf War. Ann Intern Med 1995; 125:398-405.
  • Baker DG, Mendenhall CL, Simbart LA. Relationship between posttraumatic stress disorder and self-reported physical symptoms in Persian Gulf War veterans. Arch Intern Med 1997; 157:2076-78.
  • Horner RD, Kamins KG, Feussner JR, et al. Occurrence of amyotrophic lateral sclerosis among Gulf War veterans. Neurology 2003; 61:742-49.
  • Haley RW. Excess incidence of ALS in young Gulf War veterans. Neurology 2003; 61:750-56.
  • Freudenthal RL, Rausch L, Gerhart JK, et al. Subchronic neurotoxicity of oil formulations containing either tricresyl phosphate or tri-orthocresyl phosphate. J Am Coll Toxicol 1993; 12:409-16.
  • Daughtrey W, Biles R, Jortner B. Subchronic delayed neurotoxicity evaluation of jet engine lubricants containing phosphorus additives. Fundam Appl Toxicol 1996; 32:244-49.
  • Aldridge WN, Barnes JM. Further observations on the neurotoxicity of organophosphorus compounds. Biochem Pharmacol 1966; 15:541-47.
  • White RF, Proctor SP, Heeren T. Neuropshchological functions in Gulf War veterans: relationship to self-reported toxicant exposures. Amer J Ind Med 2001; 40:42-44.
  • Institute of Medicine of the National Academies. Health Consequences of Service during the Persian Gulf War: Initial Findings and Recommendation for Immediate Action. Washington, DC: National Academies Press, 1995.
  • Augerson WS. A Review of The Scientific Literature as it Pertains to Gulf War Illnesses. Vol 5. Chemical and Biological Warfare Agents. Santa Monica, CA: Rand Corporation, 2000.
  • Blondell J, Dobozy VA. Review of Chlorpyrifos Poisoning Data. Washington, DC: U.S. Environmental Protection Agency, 14 Jan 1997.
  • Kilburn KH. Evidence for chronic neurobehavioral impairment from chlorpyrifosa, and organophosphate insecticide (Dursban) used indoors. Environ Epidemiol Toxicol 1999; 1:153-62.

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